The Experts below are selected from a list of 822 Experts worldwide ranked by ideXlab platform
Philip J. Kadowitz - One of the best experts on this subject based on the ideXlab platform.
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opyright © American Society of Andrology [Tyr’]-Nociceptin and Nociceptin Have Similar Naloxone- Insensitive Erectile Activity in the Cat
2013Co-Authors: Hunter C. Champion, Trinity J. Bivalacqua, Run Wang, Wayne J. G. Hellstrom, Philip J. KadowitzAbstract:ABSTRACT: The heptadecapeptide nociceptin, also known as Orphania FQ, is a newly discovered endogenous ligand for the opioidlike G-protein-coupled receptor ORL,. The present study was undertaken to investigate responses to intracavernosal injections of the nociceptin analog [Tyr’]-nociceptin and to investigate the effects of naloxone on erectile responses in anesthetized cats to [Tyr1]-nociceptin and to nociceptin. Intracavernosal injections of [Tyr1]-nociceptin and of nociceptin in doses of 0.3-30 nmol elicited dose-related increases in cavernosal pressure, which, at the highest dose studied, were comparable to increases induced by the triple-drug standard (papaverine, phentolamine, and prostaglandin E1), a preparation used in the treatment of erectile dysfunction. Responses to [Tyr1]-nociceptin were rapid in onset and had a time course similar to responses to nociceptin. Metenkephalin increased cavemosal pressure, whereas injections of nociceptin-(2-17), dynorphin A, and 13-endorphin did not alter cavemosal pressure. Erectile responses to nociceptin and to (Tyr1]-nociceptin were not altered after administration of the opioid receptor antagonist naloxone at a time when erectile responses to Metenkephalin were attenuated. These data show that [Tyr1]-nociceptin and nociceptin have similar naloxone-insensitive erectile activity in the cat
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[Tyr1]-Nociceptin and Nociceptin Have Similar Naloxone Insensitive Erectile Activity in the Cat
Journal of andrology, 1998Co-Authors: Hunter C. Champion, Trinity J. Bivalacqua, Run Wang, Wayne J. G. Hellstrom, Philip J. KadowitzAbstract:The heptadecapeptide nociceptin, also known as Orphanin FQ, is a newly discovered endogenous ligand for the opioid-like G-protein-coupled receptor ORL 1 . The present study was undertaken to investigate responses to intracavernosal injections of the nociceptin analog [Tyr 1 ]-nociceptin and to investigate the effects of naloxone on erectile responses in anesthetized cats to [Tyr 1 ]-nociceptin and to nociceptin. Intracavernosal injections of [Tyr 1 ]-nociceptin and of nociceptin in doses of 0.3-30 nmol elicited dose-related increases in cavernosal pressure, which, at the highest dose studied, were comparable to increases induced by the triple-drug standard (papaverine, phentolamine, and prostaglandin E 1 ), a preparation used in the treatment of erectile dysfunction. Responses to [Tyr 1 ]-nociceptin were rapid in onset and had a time course similar to responses to nociceptin. Metenkephalin increased cavernosal pressure, whereas injections of nociceptin-(2-17), dynorphin A, and β-endorphin did not alter cavernosal pressure. Erectile responses to nociceptin and to [Tyr 1 ]-nociceptin were not altered after administration of the opioid receptor antagonist naloxone at a time when erectile responses to Metenkephalin were attenuated. These data show that [Tyr 1 ]-nociceptin and nociceptin have similar naloxone-insensitive erectile activity in the cat.
Hunter C. Champion - One of the best experts on this subject based on the ideXlab platform.
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opyright © American Society of Andrology [Tyr’]-Nociceptin and Nociceptin Have Similar Naloxone- Insensitive Erectile Activity in the Cat
2013Co-Authors: Hunter C. Champion, Trinity J. Bivalacqua, Run Wang, Wayne J. G. Hellstrom, Philip J. KadowitzAbstract:ABSTRACT: The heptadecapeptide nociceptin, also known as Orphania FQ, is a newly discovered endogenous ligand for the opioidlike G-protein-coupled receptor ORL,. The present study was undertaken to investigate responses to intracavernosal injections of the nociceptin analog [Tyr’]-nociceptin and to investigate the effects of naloxone on erectile responses in anesthetized cats to [Tyr1]-nociceptin and to nociceptin. Intracavernosal injections of [Tyr1]-nociceptin and of nociceptin in doses of 0.3-30 nmol elicited dose-related increases in cavernosal pressure, which, at the highest dose studied, were comparable to increases induced by the triple-drug standard (papaverine, phentolamine, and prostaglandin E1), a preparation used in the treatment of erectile dysfunction. Responses to [Tyr1]-nociceptin were rapid in onset and had a time course similar to responses to nociceptin. Metenkephalin increased cavemosal pressure, whereas injections of nociceptin-(2-17), dynorphin A, and 13-endorphin did not alter cavemosal pressure. Erectile responses to nociceptin and to (Tyr1]-nociceptin were not altered after administration of the opioid receptor antagonist naloxone at a time when erectile responses to Metenkephalin were attenuated. These data show that [Tyr1]-nociceptin and nociceptin have similar naloxone-insensitive erectile activity in the cat
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[Tyr1]-Nociceptin and Nociceptin Have Similar Naloxone Insensitive Erectile Activity in the Cat
Journal of andrology, 1998Co-Authors: Hunter C. Champion, Trinity J. Bivalacqua, Run Wang, Wayne J. G. Hellstrom, Philip J. KadowitzAbstract:The heptadecapeptide nociceptin, also known as Orphanin FQ, is a newly discovered endogenous ligand for the opioid-like G-protein-coupled receptor ORL 1 . The present study was undertaken to investigate responses to intracavernosal injections of the nociceptin analog [Tyr 1 ]-nociceptin and to investigate the effects of naloxone on erectile responses in anesthetized cats to [Tyr 1 ]-nociceptin and to nociceptin. Intracavernosal injections of [Tyr 1 ]-nociceptin and of nociceptin in doses of 0.3-30 nmol elicited dose-related increases in cavernosal pressure, which, at the highest dose studied, were comparable to increases induced by the triple-drug standard (papaverine, phentolamine, and prostaglandin E 1 ), a preparation used in the treatment of erectile dysfunction. Responses to [Tyr 1 ]-nociceptin were rapid in onset and had a time course similar to responses to nociceptin. Metenkephalin increased cavernosal pressure, whereas injections of nociceptin-(2-17), dynorphin A, and β-endorphin did not alter cavernosal pressure. Erectile responses to nociceptin and to [Tyr 1 ]-nociceptin were not altered after administration of the opioid receptor antagonist naloxone at a time when erectile responses to Metenkephalin were attenuated. These data show that [Tyr 1 ]-nociceptin and nociceptin have similar naloxone-insensitive erectile activity in the cat.
Trinity J. Bivalacqua - One of the best experts on this subject based on the ideXlab platform.
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opyright © American Society of Andrology [Tyr’]-Nociceptin and Nociceptin Have Similar Naloxone- Insensitive Erectile Activity in the Cat
2013Co-Authors: Hunter C. Champion, Trinity J. Bivalacqua, Run Wang, Wayne J. G. Hellstrom, Philip J. KadowitzAbstract:ABSTRACT: The heptadecapeptide nociceptin, also known as Orphania FQ, is a newly discovered endogenous ligand for the opioidlike G-protein-coupled receptor ORL,. The present study was undertaken to investigate responses to intracavernosal injections of the nociceptin analog [Tyr’]-nociceptin and to investigate the effects of naloxone on erectile responses in anesthetized cats to [Tyr1]-nociceptin and to nociceptin. Intracavernosal injections of [Tyr1]-nociceptin and of nociceptin in doses of 0.3-30 nmol elicited dose-related increases in cavernosal pressure, which, at the highest dose studied, were comparable to increases induced by the triple-drug standard (papaverine, phentolamine, and prostaglandin E1), a preparation used in the treatment of erectile dysfunction. Responses to [Tyr1]-nociceptin were rapid in onset and had a time course similar to responses to nociceptin. Metenkephalin increased cavemosal pressure, whereas injections of nociceptin-(2-17), dynorphin A, and 13-endorphin did not alter cavemosal pressure. Erectile responses to nociceptin and to (Tyr1]-nociceptin were not altered after administration of the opioid receptor antagonist naloxone at a time when erectile responses to Metenkephalin were attenuated. These data show that [Tyr1]-nociceptin and nociceptin have similar naloxone-insensitive erectile activity in the cat
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[Tyr1]-Nociceptin and Nociceptin Have Similar Naloxone Insensitive Erectile Activity in the Cat
Journal of andrology, 1998Co-Authors: Hunter C. Champion, Trinity J. Bivalacqua, Run Wang, Wayne J. G. Hellstrom, Philip J. KadowitzAbstract:The heptadecapeptide nociceptin, also known as Orphanin FQ, is a newly discovered endogenous ligand for the opioid-like G-protein-coupled receptor ORL 1 . The present study was undertaken to investigate responses to intracavernosal injections of the nociceptin analog [Tyr 1 ]-nociceptin and to investigate the effects of naloxone on erectile responses in anesthetized cats to [Tyr 1 ]-nociceptin and to nociceptin. Intracavernosal injections of [Tyr 1 ]-nociceptin and of nociceptin in doses of 0.3-30 nmol elicited dose-related increases in cavernosal pressure, which, at the highest dose studied, were comparable to increases induced by the triple-drug standard (papaverine, phentolamine, and prostaglandin E 1 ), a preparation used in the treatment of erectile dysfunction. Responses to [Tyr 1 ]-nociceptin were rapid in onset and had a time course similar to responses to nociceptin. Metenkephalin increased cavernosal pressure, whereas injections of nociceptin-(2-17), dynorphin A, and β-endorphin did not alter cavernosal pressure. Erectile responses to nociceptin and to [Tyr 1 ]-nociceptin were not altered after administration of the opioid receptor antagonist naloxone at a time when erectile responses to Metenkephalin were attenuated. These data show that [Tyr 1 ]-nociceptin and nociceptin have similar naloxone-insensitive erectile activity in the cat.
Run Wang - One of the best experts on this subject based on the ideXlab platform.
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opyright © American Society of Andrology [Tyr’]-Nociceptin and Nociceptin Have Similar Naloxone- Insensitive Erectile Activity in the Cat
2013Co-Authors: Hunter C. Champion, Trinity J. Bivalacqua, Run Wang, Wayne J. G. Hellstrom, Philip J. KadowitzAbstract:ABSTRACT: The heptadecapeptide nociceptin, also known as Orphania FQ, is a newly discovered endogenous ligand for the opioidlike G-protein-coupled receptor ORL,. The present study was undertaken to investigate responses to intracavernosal injections of the nociceptin analog [Tyr’]-nociceptin and to investigate the effects of naloxone on erectile responses in anesthetized cats to [Tyr1]-nociceptin and to nociceptin. Intracavernosal injections of [Tyr1]-nociceptin and of nociceptin in doses of 0.3-30 nmol elicited dose-related increases in cavernosal pressure, which, at the highest dose studied, were comparable to increases induced by the triple-drug standard (papaverine, phentolamine, and prostaglandin E1), a preparation used in the treatment of erectile dysfunction. Responses to [Tyr1]-nociceptin were rapid in onset and had a time course similar to responses to nociceptin. Metenkephalin increased cavemosal pressure, whereas injections of nociceptin-(2-17), dynorphin A, and 13-endorphin did not alter cavemosal pressure. Erectile responses to nociceptin and to (Tyr1]-nociceptin were not altered after administration of the opioid receptor antagonist naloxone at a time when erectile responses to Metenkephalin were attenuated. These data show that [Tyr1]-nociceptin and nociceptin have similar naloxone-insensitive erectile activity in the cat
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[Tyr1]-Nociceptin and Nociceptin Have Similar Naloxone Insensitive Erectile Activity in the Cat
Journal of andrology, 1998Co-Authors: Hunter C. Champion, Trinity J. Bivalacqua, Run Wang, Wayne J. G. Hellstrom, Philip J. KadowitzAbstract:The heptadecapeptide nociceptin, also known as Orphanin FQ, is a newly discovered endogenous ligand for the opioid-like G-protein-coupled receptor ORL 1 . The present study was undertaken to investigate responses to intracavernosal injections of the nociceptin analog [Tyr 1 ]-nociceptin and to investigate the effects of naloxone on erectile responses in anesthetized cats to [Tyr 1 ]-nociceptin and to nociceptin. Intracavernosal injections of [Tyr 1 ]-nociceptin and of nociceptin in doses of 0.3-30 nmol elicited dose-related increases in cavernosal pressure, which, at the highest dose studied, were comparable to increases induced by the triple-drug standard (papaverine, phentolamine, and prostaglandin E 1 ), a preparation used in the treatment of erectile dysfunction. Responses to [Tyr 1 ]-nociceptin were rapid in onset and had a time course similar to responses to nociceptin. Metenkephalin increased cavernosal pressure, whereas injections of nociceptin-(2-17), dynorphin A, and β-endorphin did not alter cavernosal pressure. Erectile responses to nociceptin and to [Tyr 1 ]-nociceptin were not altered after administration of the opioid receptor antagonist naloxone at a time when erectile responses to Metenkephalin were attenuated. These data show that [Tyr 1 ]-nociceptin and nociceptin have similar naloxone-insensitive erectile activity in the cat.
Wayne J. G. Hellstrom - One of the best experts on this subject based on the ideXlab platform.
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opyright © American Society of Andrology [Tyr’]-Nociceptin and Nociceptin Have Similar Naloxone- Insensitive Erectile Activity in the Cat
2013Co-Authors: Hunter C. Champion, Trinity J. Bivalacqua, Run Wang, Wayne J. G. Hellstrom, Philip J. KadowitzAbstract:ABSTRACT: The heptadecapeptide nociceptin, also known as Orphania FQ, is a newly discovered endogenous ligand for the opioidlike G-protein-coupled receptor ORL,. The present study was undertaken to investigate responses to intracavernosal injections of the nociceptin analog [Tyr’]-nociceptin and to investigate the effects of naloxone on erectile responses in anesthetized cats to [Tyr1]-nociceptin and to nociceptin. Intracavernosal injections of [Tyr1]-nociceptin and of nociceptin in doses of 0.3-30 nmol elicited dose-related increases in cavernosal pressure, which, at the highest dose studied, were comparable to increases induced by the triple-drug standard (papaverine, phentolamine, and prostaglandin E1), a preparation used in the treatment of erectile dysfunction. Responses to [Tyr1]-nociceptin were rapid in onset and had a time course similar to responses to nociceptin. Metenkephalin increased cavemosal pressure, whereas injections of nociceptin-(2-17), dynorphin A, and 13-endorphin did not alter cavemosal pressure. Erectile responses to nociceptin and to (Tyr1]-nociceptin were not altered after administration of the opioid receptor antagonist naloxone at a time when erectile responses to Metenkephalin were attenuated. These data show that [Tyr1]-nociceptin and nociceptin have similar naloxone-insensitive erectile activity in the cat
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[Tyr1]-Nociceptin and Nociceptin Have Similar Naloxone Insensitive Erectile Activity in the Cat
Journal of andrology, 1998Co-Authors: Hunter C. Champion, Trinity J. Bivalacqua, Run Wang, Wayne J. G. Hellstrom, Philip J. KadowitzAbstract:The heptadecapeptide nociceptin, also known as Orphanin FQ, is a newly discovered endogenous ligand for the opioid-like G-protein-coupled receptor ORL 1 . The present study was undertaken to investigate responses to intracavernosal injections of the nociceptin analog [Tyr 1 ]-nociceptin and to investigate the effects of naloxone on erectile responses in anesthetized cats to [Tyr 1 ]-nociceptin and to nociceptin. Intracavernosal injections of [Tyr 1 ]-nociceptin and of nociceptin in doses of 0.3-30 nmol elicited dose-related increases in cavernosal pressure, which, at the highest dose studied, were comparable to increases induced by the triple-drug standard (papaverine, phentolamine, and prostaglandin E 1 ), a preparation used in the treatment of erectile dysfunction. Responses to [Tyr 1 ]-nociceptin were rapid in onset and had a time course similar to responses to nociceptin. Metenkephalin increased cavernosal pressure, whereas injections of nociceptin-(2-17), dynorphin A, and β-endorphin did not alter cavernosal pressure. Erectile responses to nociceptin and to [Tyr 1 ]-nociceptin were not altered after administration of the opioid receptor antagonist naloxone at a time when erectile responses to Metenkephalin were attenuated. These data show that [Tyr 1 ]-nociceptin and nociceptin have similar naloxone-insensitive erectile activity in the cat.