The Experts below are selected from a list of 24 Experts worldwide ranked by ideXlab platform

M Hussain And M S K Saidapur - One of the best experts on this subject based on the ideXlab platform.

K P Joy - One of the best experts on this subject based on the ideXlab platform.

  • Methallibure inhibition of testicular and seminal vesicle activity in catfish clarias batrachus linn a study correlating changes in serum sex steroid profiles
    Acta Biologica Hungarica, 2000
    Co-Authors: Madhu Singh, K P Joy
    Abstract:

    The administration of Methallibure (2 microg/g BW, daily for 15 days) in Clarias batrachus in prespawning phase (May-June) resulted in decreased weights of seminal vesicle (SV) and testis, and reductions in the concentrations of total proteins, fructose, hexosamines, and sialic acid in SV and testis. The inhibitory changes can be attributed to impairment of steroidogenesis, serum levels of testosterone and estradiol -17beta decreased significantly. Withdrawal of Methallibure treatment for 7 and 15 days resulted in gradual recovery and restoration of all the above parameters except the sialic acid levels in the SV and testis, and fructose level in the SV. The Methallibure induced regressive changes in the SV and testis were discussed in the light of its GTH inhibiting property.

  • Methallibure induced inhibition of hypothalamo hypophyseal ovarian activity in the catfish heteropneustes fossilis involves changes in hypothalamic monoamine activity
    Fish Physiology and Biochemistry, 1998
    Co-Authors: B Senthilkumaran, K P Joy
    Abstract:

    Administration of Methallibure, a non-steroidal gonadotropin (GTH) inhibitor 20 μg g−1 body weight; i.p., daily for 10 days, to prespawning phase female Heteropneustes fossilis inhibited the brain-pituitary-ovarian axis as indicated by significant reductions in plasma and pituitary levels of GTH-II, and plasma levels of 17β-estradiol (E2) and testosterone. Concurrently, the treatment resulted in significant reductions in the hypothalamic content of serotonin, noradrenaline (and adrenaline) that stimulate, and a significant elevation of dopamine that inhibits GTH-II release in this species. Activities of the monoamine degrading enzymes, monoamine oxidase and catechol-O-methyltransferase were significantly increased, while that of the synthesizing enzymes, dopamine-β-hydroxylase and phenylethanolamine-N-methyltransferase were significantly decreased. These results suggest that the mechanism of inhibition of GTH-II secretion includes, among others, differential actions of the drug on hypothalamic monoamine metabolism.

J Rzαsa - One of the best experts on this subject based on the ideXlab platform.

  • serotonin levels in the hen ovarian follicles after Methallibure i c i 33 828 treatment
    Journal of Veterinary Medicine Series A-physiology Pathology Clinical Medicine, 1991
    Co-Authors: H Paczoskaeliasiewicz, J Rzαsa
    Abstract:

    The purpose of the present study was to examine the effect of Methallibure (MLB), a non-steroid inhibitor of pituitary gonadotrophic activity on serotonin (5-HT) levels in the wall of preovulatory follicles (F1-F4) in the domestic hen. 5-HT was determined spectrofluorometrically. Hens were treated with MLB (10 mg/hen per os) twice a day for 3 successive days. 5-HT was determined in F1-F4 (F1 greater than F2 greater than F3 greater than F4) follicles of the control group, on the next day (MLB-1 group) and 6 days following cessation of MLB administration (MLB-6 group). During MLB treatment egg production was inhibited in all hens. In the MLB-6 group, five hens out of seven took up egg laying on the sixth day after MLB administration. Within each examined group there were no significant differences in 5-HT concentration between F1-F4 follicles. In comparison to the control, MLB caused a significant (P less than 0.01-0.05) increase of 5-HT concentration in F1 (MLB-1 group) and F4 (both MLB-groups). The results obtained indicate that there is a relationship between pituitary activity and 5-HT levels in the preovulatory follicles of the domestic hen.

T R Ramaiah - One of the best experts on this subject based on the ideXlab platform.

B Senthilkumaran - One of the best experts on this subject based on the ideXlab platform.

  • Methallibure induced inhibition of hypothalamo hypophyseal ovarian activity in the catfish heteropneustes fossilis involves changes in hypothalamic monoamine activity
    Fish Physiology and Biochemistry, 1998
    Co-Authors: B Senthilkumaran, K P Joy
    Abstract:

    Administration of Methallibure, a non-steroidal gonadotropin (GTH) inhibitor 20 μg g−1 body weight; i.p., daily for 10 days, to prespawning phase female Heteropneustes fossilis inhibited the brain-pituitary-ovarian axis as indicated by significant reductions in plasma and pituitary levels of GTH-II, and plasma levels of 17β-estradiol (E2) and testosterone. Concurrently, the treatment resulted in significant reductions in the hypothalamic content of serotonin, noradrenaline (and adrenaline) that stimulate, and a significant elevation of dopamine that inhibits GTH-II release in this species. Activities of the monoamine degrading enzymes, monoamine oxidase and catechol-O-methyltransferase were significantly increased, while that of the synthesizing enzymes, dopamine-β-hydroxylase and phenylethanolamine-N-methyltransferase were significantly decreased. These results suggest that the mechanism of inhibition of GTH-II secretion includes, among others, differential actions of the drug on hypothalamic monoamine metabolism.