The Experts below are selected from a list of 291 Experts worldwide ranked by ideXlab platform

Zhi-hao Cao - One of the best experts on this subject based on the ideXlab platform.

Jiekun Xuan - One of the best experts on this subject based on the ideXlab platform.

Fanping Yang - One of the best experts on this subject based on the ideXlab platform.

Manupat Lohitnavy - One of the best experts on this subject based on the ideXlab platform.

  • association between hla b 5901 and Methazolamide induced stevens johnson syndrome toxic epidermal necrolysis a systematic review and meta analysis
    Pharmacogenomics Journal, 2019
    Co-Authors: Wimonchat Tangamornsuksan, Manupat Lohitnavy
    Abstract:

    Methazolamide-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are life-threatening adverse drug reactions. Based on previous studies, HLA genotypes may play an important role in Methazolamide-induced SJS/TEN. Therefore, to identify the associations between HLA genotypes and Methazolamide-induced cutaneous adverse drug reactions (cADRs) (i.e., SJS/TEN and hypersensitivity syndrome), a systematic review and meta-analysis were performed. Two studies (one study in Korean and another in Han Chinese) met the inclusion criteria. The studies included 13 patients with Methazolamide-induced SJS/TEN, 30 Methazolamide-tolerant, and 768 population controls. Associations between HLA-B*5901, HLA-B*5901-Cw*0102 haplotype, and Methazolamide-induced SJS/TEN were identified in Methazolamide-tolerant and population controls. Overall ORs were 305.0 (95% CI = 11.3-8, 259.4) in Methazolamide-tolerant and 715.3 (95% CI = 83.1-6,158.5) in population control. In addition, statistically significant associations between the HLA-Cw*0102 and Methazolamide-induced SJS/TEN were found in Methazolamide-tolerant (OR = 12.1; 95% CI = 1.3-111.7) and population control (OR = 17.5; 95% CI = 3.2-96.6). Since HLA-B*5901 and HLA-B*5901-Cw*0102 haplotype are associated with Methazolamide-induced SJS/TEN, genetic screening prior to Methazolamide therapy in Asian populations is warranted.

  • Association between HLA-B*5901 and Methazolamide-induced Stevens-Johnson syndrome/toxic epidermal necrolysis: a systematic review and meta-analysis.
    The pharmacogenomics journal, 2018
    Co-Authors: Wimonchat Tangamornsuksan, Manupat Lohitnavy
    Abstract:

    Methazolamide-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are life-threatening adverse drug reactions. Based on previous studies, HLA genotypes may play an important role in Methazolamide-induced SJS/TEN. Therefore, to identify the associations between HLA genotypes and Methazolamide-induced cutaneous adverse drug reactions (cADRs) (i.e., SJS/TEN and hypersensitivity syndrome), a systematic review and meta-analysis were performed. Two studies (one study in Korean and another in Han Chinese) met the inclusion criteria. The studies included 13 patients with Methazolamide-induced SJS/TEN, 30 Methazolamide-tolerant, and 768 population controls. Associations between HLA-B*5901, HLA-B*5901-Cw*0102 haplotype, and Methazolamide-induced SJS/TEN were identified in Methazolamide-tolerant and population controls. Overall ORs were 305.0 (95% CI = 11.3-8, 259.4) in Methazolamide-tolerant and 715.3 (95% CI = 83.1-6,158.5) in population control. In addition, statistically significant associations between the HLA-Cw*0102 and Methazolamide-induced SJS/TEN were found in Methazolamide-tolerant (OR = 12.1; 95% CI = 1.3-111.7) and population control (OR = 17.5; 95% CI = 3.2-96.6). Since HLA-B*5901 and HLA-B*5901-Cw*0102 haplotype are associated with Methazolamide-induced SJS/TEN, genetic screening prior to Methazolamide therapy in Asian populations is warranted.

Young Koo Jee - One of the best experts on this subject based on the ideXlab platform.

  • hla b 5901 is strongly associated with Methazolamide induced stevens johnson syndrome toxic epidermal necrolysis
    Pharmacogenomics, 2010
    Co-Authors: Sae-hoon Kim, Myunghwa Kim, Kyung Wha Lee, Sang-heon Kim, Hye Ryun Kang, Heung-woo Park, Young Koo Jee
    Abstract:

    Aims: The carbonic anhydrase inhibitor Methazolamide infrequently causes Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). An association between these diseases and the HLA-B59 serotype has been suggested in case reports. This study examined the disease-associated B*59 allele and investigated the association of these diseases with other HLA class I alleles. Methods: We performed high-resolution HLA-A, -B and -C genotyping in five patients with Methazolamide-induced SJS/TEN using a PCR-sequencing-based typing method and analyzed the association between HLA-class I alleles and occurrence of Methazolamide-induced SJS/TEN. Results: B*5901 and Cw*0102 alleles were observed in all patients and A*2402 was observed in four patients. The B*5901 allele showed the strongest association with Methazolamide-induced SJS/TEN (p < 0.001; odds ratio: 249.8; 95% CI: 13.4–4813.5), followed by Cw*0102 (p = 0.004; odds ratio: 22.1; 95% CI: 1.2–414.3), when compared with the general population as a control. T...

  • HLA-B*5901 is strongly associated with Methazolamide-induced Stevens–Johnson syndrome/toxic epidermal necrolysis
    Pharmacogenomics, 2010
    Co-Authors: Sae-hoon Kim, Myunghwa Kim, Kyung Wha Lee, Sang-heon Kim, Hye Ryun Kang, Heung-woo Park, Young Koo Jee
    Abstract:

    Aims: The carbonic anhydrase inhibitor Methazolamide infrequently causes Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). An association between these diseases and the HLA-B59 serotype has been suggested in case reports. This study examined the disease-associated B*59 allele and investigated the association of these diseases with other HLA class I alleles. Methods: We performed high-resolution HLA-A, -B and -C genotyping in five patients with Methazolamide-induced SJS/TEN using a PCR-sequencing-based typing method and analyzed the association between HLA-class I alleles and occurrence of Methazolamide-induced SJS/TEN. Results: B*5901 and Cw*0102 alleles were observed in all patients and A*2402 was observed in four patients. The B*5901 allele showed the strongest association with Methazolamide-induced SJS/TEN (p < 0.001; odds ratio: 249.8; 95% CI: 13.4–4813.5), followed by Cw*0102 (p = 0.004; odds ratio: 22.1; 95% CI: 1.2–414.3), when compared with the general population as a control. T...