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J H Mestman - One of the best experts on this subject based on the ideXlab platform.
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A comparison of propylthiouracil versus Methimazole in the treatment of hyperthyroidism in pregnancy.
American journal of obstetrics and gynecology, 1994Co-Authors: D A Wing, L K Millar, P P Koonings, M N Montoro, J H MestmanAbstract:Our purpose was to demonstrate that propylthiouracil and Methimazole are equally effective and safe in the treatment of hyperthyroidism during pregnancy. Between 1974 and 1990 records were available on 185 pregnant patients with a history or diagnosis of hyperthyroidism. Ninety-nine patients were treated with propylthiouracil and 36 with Methimazole. The response to therapy was compared with respect to the time to normalization of the free thyroxine index and the incidences of congenital anomalies and hypothyroidism. The time to normalization of the free thyroxine index was compared in the two groups by means of survival analysis. The median time to normalization of the free thyroxine index on propylthiouracil and Methimazole was 7 and 8 weeks, respectively (p = 0.34, log-rank test). The incidence of major congenital malformations in mothers treated with propylthiouracil and Methimazole was 3.0% and 2.7%, respectively. No neonatal scalp defects were seen. One infant was overtly hypothyroid at delivery. Propylthiouracil and Methimazole are equally effective and safe in the treatment of hyperthyroidism in pregnancy.
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A comparison of propylthiouracil versus Methimazole in the treatment of hyperthyroidism in pregnancy
American Journal of Obstetrics and Gynecology, 1994Co-Authors: D A Wing, L K Millar, Martin Montoro, J H MestmanAbstract:Objective: Our purpose was to demonstrate that propylthiouracil and Methimazole are equally effective and safe in the treatment of hyperthyroidism during pregnancy. Study Design: Between 1974 and 1990 records were available on 185 pregnant patients with a history or diagnosis of hyperthyroidism. Ninety-nine patients were treated with propylthiouracil and 36 with Methimazole. The response to therapy was compared with respect to the time to normalization of the free thyroxine index and the incidences of congenital anomalies and hypothyroidism. Results: The time to normalization of the free thyroxine index was compared in the two groups by means of survival analysis. The median time to normalization of the free thyroxine index on propylthiouracil and Methimazole was 7 and 8 weeks, respectively ( p = 0.34, log-rank test). The incidence of major congenital malformations in mothers treated with propylthiouracil and Methimazole was 3.0% and 2.7%, respectively. No neonatal scalp defects were seen. One infant was overtly hypothyroid at delivery. Conclusion: Propylthiouracil and Methimazole are equally effective and safe in the treatment of hyperthyroidism in pregnancy.
D A Wing - One of the best experts on this subject based on the ideXlab platform.
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A comparison of propylthiouracil versus Methimazole in the treatment of hyperthyroidism in pregnancy.
American journal of obstetrics and gynecology, 1994Co-Authors: D A Wing, L K Millar, P P Koonings, M N Montoro, J H MestmanAbstract:Our purpose was to demonstrate that propylthiouracil and Methimazole are equally effective and safe in the treatment of hyperthyroidism during pregnancy. Between 1974 and 1990 records were available on 185 pregnant patients with a history or diagnosis of hyperthyroidism. Ninety-nine patients were treated with propylthiouracil and 36 with Methimazole. The response to therapy was compared with respect to the time to normalization of the free thyroxine index and the incidences of congenital anomalies and hypothyroidism. The time to normalization of the free thyroxine index was compared in the two groups by means of survival analysis. The median time to normalization of the free thyroxine index on propylthiouracil and Methimazole was 7 and 8 weeks, respectively (p = 0.34, log-rank test). The incidence of major congenital malformations in mothers treated with propylthiouracil and Methimazole was 3.0% and 2.7%, respectively. No neonatal scalp defects were seen. One infant was overtly hypothyroid at delivery. Propylthiouracil and Methimazole are equally effective and safe in the treatment of hyperthyroidism in pregnancy.
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A comparison of propylthiouracil versus Methimazole in the treatment of hyperthyroidism in pregnancy
American Journal of Obstetrics and Gynecology, 1994Co-Authors: D A Wing, L K Millar, Martin Montoro, J H MestmanAbstract:Objective: Our purpose was to demonstrate that propylthiouracil and Methimazole are equally effective and safe in the treatment of hyperthyroidism during pregnancy. Study Design: Between 1974 and 1990 records were available on 185 pregnant patients with a history or diagnosis of hyperthyroidism. Ninety-nine patients were treated with propylthiouracil and 36 with Methimazole. The response to therapy was compared with respect to the time to normalization of the free thyroxine index and the incidences of congenital anomalies and hypothyroidism. Results: The time to normalization of the free thyroxine index was compared in the two groups by means of survival analysis. The median time to normalization of the free thyroxine index on propylthiouracil and Methimazole was 7 and 8 weeks, respectively ( p = 0.34, log-rank test). The incidence of major congenital malformations in mothers treated with propylthiouracil and Methimazole was 3.0% and 2.7%, respectively. No neonatal scalp defects were seen. One infant was overtly hypothyroid at delivery. Conclusion: Propylthiouracil and Methimazole are equally effective and safe in the treatment of hyperthyroidism in pregnancy.
Teresa B Klepser - One of the best experts on this subject based on the ideXlab platform.
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propylthiouracil versus Methimazole in treatment of graves disease during pregnancy
Annals of Pharmacotherapy, 2007Co-Authors: Jeanne M Chattaway, Teresa B KlepserAbstract:OBJECTIVE:To evaluate the evidence supporting the use of propylthiouracil (PTU) versus Methimazole for the treatment of Graves' disease during pregnancy.DATA SOURCES:An English-language literature search was conducted using MEDLINE (1966–March 2007). Identified articles were then reviewed for additional sources. Search terms included hyperthyroidism, Graves' disease, pregnancy, propylthiouracil, and Methimazole.STUDY SELECTION AND DATA EXTRACTION:All clinical trials and case reports that were published in English and reported either subjective or objective outcomes were reviewed.DATA SYNTHESIS:Rationale supporting the use of PTU over Methimazole in treatment of Graves' disease during pregnancy is limited. Theories suggesting that PTU has less placental transfer to the fetus than Methimazole are not supported by current literature. Studies demonstrating a causal relationship between Methimazole use during pregnancy and congenital anomalies and/or fetal hypothyroidism do not exist.CONCLUSIONS:The selection ...
Sharifian Maryam - One of the best experts on this subject based on the ideXlab platform.
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THE EFFECT OF Methimazole ON THYROID GLAND UPTAKE OF TECHNETIUM IN HYPERTHYROID PATIENTS
Galen Medical Journal, 2012Co-Authors: Gheisari Farshid, Pishdad Gholamreza, Emami Mehrdad, Behdad Kasra, Karimpour Aida, Sharifian MaryamAbstract:Introduction: The aim of this study was to investigate the effect of Methimazole on Technetium-99m reabsorbing by thyroid gland , it may be possible to perform thyroid scan when the patients are on the Methimazole, this can be time saving and decrease the adverse effects of discontinuing Methimazole Patients and Methods: Among all the patients with hyperthyroidism who referred to nuclear medicine ward of Shiraz University of medical sciences, 50 patients were randomly selected. we asked the patients who were on Methimazole, to discontinue the usage of all drugs (not Methimazole) and foods which are effective on thyroid gland for 1 week, after that thyroid scan was performed for these patients. In The other episode, we asked them to discontinue the usage of all drugs (also Methimazole) and foods which are effective on thyroid gland for 1 week and then thyroid scan was performed again .Revealed data was analyzed under supervision of statistical specialist with descriptive methods on SPSS.Results: 34 patients were males (68%) and other was females. Mean age of the patients was 53.5 years. (Min: 39 years and max: 75 years) Although The ROI (Region of Interest) of thyroid was increased in the patients who used Methimazole before scan 398.72(SD: 191.73) than the patients who discontinued for one week 380.15 (SD: 112.49), but the difference wasn’t statistically significant. The ROI of peripheral tissue of the thyroid was decreased in the patients who used Methimazole before scan 26.44(SD: 5.42) than the patients who discontinued for one week 27.0414 (SD: 5.57), but the difference wasn’t statistically significant. Discussion: In conclusion, we demonstrated that Methimazole pretreatment does not interfere with either the efficacy of ROI and reabsorbing of Technetium-99m in thyroid gland and peripheral tissues. A possible limitation of this study is the number of patients in the sample.So it seems that it may be possible to perform thyroid scan when the patients are on the Methimazole, this can be time saving and decrease the adverse effects of discontinuing Methimazole. [GMJ. 2012;1(1):8-12]
L K Millar - One of the best experts on this subject based on the ideXlab platform.
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A comparison of propylthiouracil versus Methimazole in the treatment of hyperthyroidism in pregnancy.
American journal of obstetrics and gynecology, 1994Co-Authors: D A Wing, L K Millar, P P Koonings, M N Montoro, J H MestmanAbstract:Our purpose was to demonstrate that propylthiouracil and Methimazole are equally effective and safe in the treatment of hyperthyroidism during pregnancy. Between 1974 and 1990 records were available on 185 pregnant patients with a history or diagnosis of hyperthyroidism. Ninety-nine patients were treated with propylthiouracil and 36 with Methimazole. The response to therapy was compared with respect to the time to normalization of the free thyroxine index and the incidences of congenital anomalies and hypothyroidism. The time to normalization of the free thyroxine index was compared in the two groups by means of survival analysis. The median time to normalization of the free thyroxine index on propylthiouracil and Methimazole was 7 and 8 weeks, respectively (p = 0.34, log-rank test). The incidence of major congenital malformations in mothers treated with propylthiouracil and Methimazole was 3.0% and 2.7%, respectively. No neonatal scalp defects were seen. One infant was overtly hypothyroid at delivery. Propylthiouracil and Methimazole are equally effective and safe in the treatment of hyperthyroidism in pregnancy.
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A comparison of propylthiouracil versus Methimazole in the treatment of hyperthyroidism in pregnancy
American Journal of Obstetrics and Gynecology, 1994Co-Authors: D A Wing, L K Millar, Martin Montoro, J H MestmanAbstract:Objective: Our purpose was to demonstrate that propylthiouracil and Methimazole are equally effective and safe in the treatment of hyperthyroidism during pregnancy. Study Design: Between 1974 and 1990 records were available on 185 pregnant patients with a history or diagnosis of hyperthyroidism. Ninety-nine patients were treated with propylthiouracil and 36 with Methimazole. The response to therapy was compared with respect to the time to normalization of the free thyroxine index and the incidences of congenital anomalies and hypothyroidism. Results: The time to normalization of the free thyroxine index was compared in the two groups by means of survival analysis. The median time to normalization of the free thyroxine index on propylthiouracil and Methimazole was 7 and 8 weeks, respectively ( p = 0.34, log-rank test). The incidence of major congenital malformations in mothers treated with propylthiouracil and Methimazole was 3.0% and 2.7%, respectively. No neonatal scalp defects were seen. One infant was overtly hypothyroid at delivery. Conclusion: Propylthiouracil and Methimazole are equally effective and safe in the treatment of hyperthyroidism in pregnancy.
