The Experts below are selected from a list of 243 Experts worldwide ranked by ideXlab platform

Jolanta H. Kotlinska - One of the best experts on this subject based on the ideXlab platform.

  • Assessment of spatial learning and memory in the Barnes maze task in rodents—Methodological Consideration
    Naunyn-Schmiedeberg's Archives of Pharmacology, 2019
    Co-Authors: Kinga Gawel, Ewa Gibula, Marta Marszalek-grabska, Joanna Filarowska, Jolanta H. Kotlinska
    Abstract:

    Among the methods valuable for assessing spatial learning and memory impairments in rodents, the Barnes maze (BM) task deserves special attention. It is based on the assumption that the animal placed into the aversive environment should learn and remember the location of an escape box located below the surface of the platform. Different phases of the task allow to measure spatial learning, memory retrieval, and cognitive flexibility. Herein, we summarize current knowledge about the BM procedure, its variations and critical parameters measured in the task. We highlight confounding factors which should be taken into account when conducting BM task, discussing briefly its advantages and disadvantages. We then propose an extended version of the BM protocol which allows to measure different aspects of spatial learning and memory in rodents. We believe that this review will help to standardize the BM methodology across the laboratories and eventually make the results comparable.

  • assessment of spatial learning and memory in the barnes maze task in rodents Methodological Consideration
    Naunyn-schmiedebergs Archives of Pharmacology, 2019
    Co-Authors: Kinga Gawel, Ewa Gibula, Joanna Filarowska, Marta Marszalekgrabska, Jolanta H. Kotlinska
    Abstract:

    Among the methods valuable for assessing spatial learning and memory impairments in rodents, the Barnes maze (BM) task deserves special attention. It is based on the assumption that the animal placed into the aversive environment should learn and remember the location of an escape box located below the surface of the platform. Different phases of the task allow to measure spatial learning, memory retrieval, and cognitive flexibility. Herein, we summarize current knowledge about the BM procedure, its variations and critical parameters measured in the task. We highlight confounding factors which should be taken into account when conducting BM task, discussing briefly its advantages and disadvantages. We then propose an extended version of the BM protocol which allows to measure different aspects of spatial learning and memory in rodents. We believe that this review will help to standardize the BM methodology across the laboratories and eventually make the results comparable.

Kinga Gawel - One of the best experts on this subject based on the ideXlab platform.

  • Assessment of spatial learning and memory in the Barnes maze task in rodents—Methodological Consideration
    Naunyn-Schmiedeberg's Archives of Pharmacology, 2019
    Co-Authors: Kinga Gawel, Ewa Gibula, Marta Marszalek-grabska, Joanna Filarowska, Jolanta H. Kotlinska
    Abstract:

    Among the methods valuable for assessing spatial learning and memory impairments in rodents, the Barnes maze (BM) task deserves special attention. It is based on the assumption that the animal placed into the aversive environment should learn and remember the location of an escape box located below the surface of the platform. Different phases of the task allow to measure spatial learning, memory retrieval, and cognitive flexibility. Herein, we summarize current knowledge about the BM procedure, its variations and critical parameters measured in the task. We highlight confounding factors which should be taken into account when conducting BM task, discussing briefly its advantages and disadvantages. We then propose an extended version of the BM protocol which allows to measure different aspects of spatial learning and memory in rodents. We believe that this review will help to standardize the BM methodology across the laboratories and eventually make the results comparable.

  • assessment of spatial learning and memory in the barnes maze task in rodents Methodological Consideration
    Naunyn-schmiedebergs Archives of Pharmacology, 2019
    Co-Authors: Kinga Gawel, Ewa Gibula, Joanna Filarowska, Marta Marszalekgrabska, Jolanta H. Kotlinska
    Abstract:

    Among the methods valuable for assessing spatial learning and memory impairments in rodents, the Barnes maze (BM) task deserves special attention. It is based on the assumption that the animal placed into the aversive environment should learn and remember the location of an escape box located below the surface of the platform. Different phases of the task allow to measure spatial learning, memory retrieval, and cognitive flexibility. Herein, we summarize current knowledge about the BM procedure, its variations and critical parameters measured in the task. We highlight confounding factors which should be taken into account when conducting BM task, discussing briefly its advantages and disadvantages. We then propose an extended version of the BM protocol which allows to measure different aspects of spatial learning and memory in rodents. We believe that this review will help to standardize the BM methodology across the laboratories and eventually make the results comparable.

Joanna Filarowska - One of the best experts on this subject based on the ideXlab platform.

  • Assessment of spatial learning and memory in the Barnes maze task in rodents—Methodological Consideration
    Naunyn-Schmiedeberg's Archives of Pharmacology, 2019
    Co-Authors: Kinga Gawel, Ewa Gibula, Marta Marszalek-grabska, Joanna Filarowska, Jolanta H. Kotlinska
    Abstract:

    Among the methods valuable for assessing spatial learning and memory impairments in rodents, the Barnes maze (BM) task deserves special attention. It is based on the assumption that the animal placed into the aversive environment should learn and remember the location of an escape box located below the surface of the platform. Different phases of the task allow to measure spatial learning, memory retrieval, and cognitive flexibility. Herein, we summarize current knowledge about the BM procedure, its variations and critical parameters measured in the task. We highlight confounding factors which should be taken into account when conducting BM task, discussing briefly its advantages and disadvantages. We then propose an extended version of the BM protocol which allows to measure different aspects of spatial learning and memory in rodents. We believe that this review will help to standardize the BM methodology across the laboratories and eventually make the results comparable.

  • assessment of spatial learning and memory in the barnes maze task in rodents Methodological Consideration
    Naunyn-schmiedebergs Archives of Pharmacology, 2019
    Co-Authors: Kinga Gawel, Ewa Gibula, Joanna Filarowska, Marta Marszalekgrabska, Jolanta H. Kotlinska
    Abstract:

    Among the methods valuable for assessing spatial learning and memory impairments in rodents, the Barnes maze (BM) task deserves special attention. It is based on the assumption that the animal placed into the aversive environment should learn and remember the location of an escape box located below the surface of the platform. Different phases of the task allow to measure spatial learning, memory retrieval, and cognitive flexibility. Herein, we summarize current knowledge about the BM procedure, its variations and critical parameters measured in the task. We highlight confounding factors which should be taken into account when conducting BM task, discussing briefly its advantages and disadvantages. We then propose an extended version of the BM protocol which allows to measure different aspects of spatial learning and memory in rodents. We believe that this review will help to standardize the BM methodology across the laboratories and eventually make the results comparable.

Ewa Gibula - One of the best experts on this subject based on the ideXlab platform.

  • Assessment of spatial learning and memory in the Barnes maze task in rodents—Methodological Consideration
    Naunyn-Schmiedeberg's Archives of Pharmacology, 2019
    Co-Authors: Kinga Gawel, Ewa Gibula, Marta Marszalek-grabska, Joanna Filarowska, Jolanta H. Kotlinska
    Abstract:

    Among the methods valuable for assessing spatial learning and memory impairments in rodents, the Barnes maze (BM) task deserves special attention. It is based on the assumption that the animal placed into the aversive environment should learn and remember the location of an escape box located below the surface of the platform. Different phases of the task allow to measure spatial learning, memory retrieval, and cognitive flexibility. Herein, we summarize current knowledge about the BM procedure, its variations and critical parameters measured in the task. We highlight confounding factors which should be taken into account when conducting BM task, discussing briefly its advantages and disadvantages. We then propose an extended version of the BM protocol which allows to measure different aspects of spatial learning and memory in rodents. We believe that this review will help to standardize the BM methodology across the laboratories and eventually make the results comparable.

  • assessment of spatial learning and memory in the barnes maze task in rodents Methodological Consideration
    Naunyn-schmiedebergs Archives of Pharmacology, 2019
    Co-Authors: Kinga Gawel, Ewa Gibula, Joanna Filarowska, Marta Marszalekgrabska, Jolanta H. Kotlinska
    Abstract:

    Among the methods valuable for assessing spatial learning and memory impairments in rodents, the Barnes maze (BM) task deserves special attention. It is based on the assumption that the animal placed into the aversive environment should learn and remember the location of an escape box located below the surface of the platform. Different phases of the task allow to measure spatial learning, memory retrieval, and cognitive flexibility. Herein, we summarize current knowledge about the BM procedure, its variations and critical parameters measured in the task. We highlight confounding factors which should be taken into account when conducting BM task, discussing briefly its advantages and disadvantages. We then propose an extended version of the BM protocol which allows to measure different aspects of spatial learning and memory in rodents. We believe that this review will help to standardize the BM methodology across the laboratories and eventually make the results comparable.

Lambertus A Kiemeney - One of the best experts on this subject based on the ideXlab platform.

  • spouse controls in family case control studies a Methodological Consideration
    Familial Cancer, 2003
    Co-Authors: Bas A J Verhage, Katja K H Aben, Huub Straatman, Andre L M Verbeek, Terri H Beaty, Lambertus A Kiemeney
    Abstract:

    In case-control studies on familial aggregation of disease, spouses may be chosen as convenient controls. In this article the pros and cons of this control group are discussed. It is argued that the use of spouse controls can be time- and cost-efficient, because of easy accessibility and their ability to provide proxy data on the patients' relatives if necessary. Furthermore, with spouse controls a higher response rate and less recall bias can be expected compared to population controls. A theoretical drawback is the possibility of assortative mating related to genetic susceptibility of the disease under study. Using a simulation study it is illustrated that even strong assortative mating on a factor, which is strongly correlated with a true risk factor under study, will have a negligible effect on the observed extent of familial aggregation.