The Experts below are selected from a list of 108 Experts worldwide ranked by ideXlab platform

Hidemitsu Minegishi - One of the best experts on this subject based on the ideXlab platform.

  • methyl 3 6 methoxy 1 4 dihydroindeno 1 2 c pyrazol 3 yl amino benzoate gn39482 as a tubulin polymerization inhibitor identified by morphobase and chemproteobase profiling methods
    Journal of Medicinal Chemistry, 2015
    Co-Authors: Hidemitsu Minegishi, Yushi Futamura, Shinji Fukashiro, Makoto Muroi, Makoto Kawatani, Hiroyuki Osada, Hiroyuki Nakamura
    Abstract:

    A series of indenopyrazoles was synthesized from the corresponding indanones and phenyl isothiocyanates in two steps. Among the compounds synthesized, methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate 6m (GN39482) was found to possess a promising antiproliferative activity toward human cancer cells without affecting any antimicrobial and antimalarial activities at 100 nM. Both a methoxy Group at R1 position and a Methoxycarbonyl Group at R2 position of the anilinoquinazoline framework are essential for the high cell growth inhibition. Both MorphoBase and ChemProteoBase profiling analyses suggested that compound 6m was classified as a tubulin inhibitor. Indeed, compound 6m inhibited the acetylated tubulin accumulation and the microtubule formation and induced G2/M cell cycle arrest in HeLa cells, revealing that a promising antiproliferative activity of compound 6m toward human cancer cells is probably caused by the tubulin polymerization inhibition.

  • Methyl 3‑((6-Methoxy-1,4-dihydroindeno[1,2‑c]pyrazol-3-yl)­amino)­benzoate (GN39482) as a Tubulin Polymerization Inhibitor Identified by MorphoBase and ChemProteoBase Profiling Methods
    2015
    Co-Authors: Hidemitsu Minegishi, Yushi Futamura, Shinji Fukashiro, Makoto Muroi, Makoto Kawatani, Hiroyuki Osada, Hiroyuki Nakamura
    Abstract:

    A series of indenopyrazoles was synthesized from the corresponding indanones and phenyl isothiocyanates in two steps. Among the compounds synthesized, methyl 3-((6-methoxy-1,4-dihydroindeno­[1,2-c]­pyrazol-3-yl)­amino)­benzoate 6m (GN39482) was found to possess a promising antiproliferative activity toward human cancer cells without affecting any antimicrobial and antimalarial activities at 100 nM. Both a methoxy Group at R1 position and a Methoxycarbonyl Group at R2 position of the anilinoquinazoline framework are essential for the high cell growth inhibition. Both MorphoBase and ChemProteoBase profiling analyses suggested that compound 6m was classified as a tubulin inhibitor. Indeed, compound 6m inhibited the acetylated tubulin accumulation and the microtubule formation and induced G2/M cell cycle arrest in HeLa cells, revealing that a promising antiproliferative activity of compound 6m toward human cancer cells is probably caused by the tubulin polymerization inhibition

Hiroyuki Nakamura - One of the best experts on this subject based on the ideXlab platform.

  • methyl 3 6 methoxy 1 4 dihydroindeno 1 2 c pyrazol 3 yl amino benzoate gn39482 as a tubulin polymerization inhibitor identified by morphobase and chemproteobase profiling methods
    Journal of Medicinal Chemistry, 2015
    Co-Authors: Hidemitsu Minegishi, Yushi Futamura, Shinji Fukashiro, Makoto Muroi, Makoto Kawatani, Hiroyuki Osada, Hiroyuki Nakamura
    Abstract:

    A series of indenopyrazoles was synthesized from the corresponding indanones and phenyl isothiocyanates in two steps. Among the compounds synthesized, methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate 6m (GN39482) was found to possess a promising antiproliferative activity toward human cancer cells without affecting any antimicrobial and antimalarial activities at 100 nM. Both a methoxy Group at R1 position and a Methoxycarbonyl Group at R2 position of the anilinoquinazoline framework are essential for the high cell growth inhibition. Both MorphoBase and ChemProteoBase profiling analyses suggested that compound 6m was classified as a tubulin inhibitor. Indeed, compound 6m inhibited the acetylated tubulin accumulation and the microtubule formation and induced G2/M cell cycle arrest in HeLa cells, revealing that a promising antiproliferative activity of compound 6m toward human cancer cells is probably caused by the tubulin polymerization inhibition.

  • Methyl 3‑((6-Methoxy-1,4-dihydroindeno[1,2‑c]pyrazol-3-yl)­amino)­benzoate (GN39482) as a Tubulin Polymerization Inhibitor Identified by MorphoBase and ChemProteoBase Profiling Methods
    2015
    Co-Authors: Hidemitsu Minegishi, Yushi Futamura, Shinji Fukashiro, Makoto Muroi, Makoto Kawatani, Hiroyuki Osada, Hiroyuki Nakamura
    Abstract:

    A series of indenopyrazoles was synthesized from the corresponding indanones and phenyl isothiocyanates in two steps. Among the compounds synthesized, methyl 3-((6-methoxy-1,4-dihydroindeno­[1,2-c]­pyrazol-3-yl)­amino)­benzoate 6m (GN39482) was found to possess a promising antiproliferative activity toward human cancer cells without affecting any antimicrobial and antimalarial activities at 100 nM. Both a methoxy Group at R1 position and a Methoxycarbonyl Group at R2 position of the anilinoquinazoline framework are essential for the high cell growth inhibition. Both MorphoBase and ChemProteoBase profiling analyses suggested that compound 6m was classified as a tubulin inhibitor. Indeed, compound 6m inhibited the acetylated tubulin accumulation and the microtubule formation and induced G2/M cell cycle arrest in HeLa cells, revealing that a promising antiproliferative activity of compound 6m toward human cancer cells is probably caused by the tubulin polymerization inhibition

Makoto Muroi - One of the best experts on this subject based on the ideXlab platform.

  • methyl 3 6 methoxy 1 4 dihydroindeno 1 2 c pyrazol 3 yl amino benzoate gn39482 as a tubulin polymerization inhibitor identified by morphobase and chemproteobase profiling methods
    Journal of Medicinal Chemistry, 2015
    Co-Authors: Hidemitsu Minegishi, Yushi Futamura, Shinji Fukashiro, Makoto Muroi, Makoto Kawatani, Hiroyuki Osada, Hiroyuki Nakamura
    Abstract:

    A series of indenopyrazoles was synthesized from the corresponding indanones and phenyl isothiocyanates in two steps. Among the compounds synthesized, methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate 6m (GN39482) was found to possess a promising antiproliferative activity toward human cancer cells without affecting any antimicrobial and antimalarial activities at 100 nM. Both a methoxy Group at R1 position and a Methoxycarbonyl Group at R2 position of the anilinoquinazoline framework are essential for the high cell growth inhibition. Both MorphoBase and ChemProteoBase profiling analyses suggested that compound 6m was classified as a tubulin inhibitor. Indeed, compound 6m inhibited the acetylated tubulin accumulation and the microtubule formation and induced G2/M cell cycle arrest in HeLa cells, revealing that a promising antiproliferative activity of compound 6m toward human cancer cells is probably caused by the tubulin polymerization inhibition.

  • Methyl 3‑((6-Methoxy-1,4-dihydroindeno[1,2‑c]pyrazol-3-yl)­amino)­benzoate (GN39482) as a Tubulin Polymerization Inhibitor Identified by MorphoBase and ChemProteoBase Profiling Methods
    2015
    Co-Authors: Hidemitsu Minegishi, Yushi Futamura, Shinji Fukashiro, Makoto Muroi, Makoto Kawatani, Hiroyuki Osada, Hiroyuki Nakamura
    Abstract:

    A series of indenopyrazoles was synthesized from the corresponding indanones and phenyl isothiocyanates in two steps. Among the compounds synthesized, methyl 3-((6-methoxy-1,4-dihydroindeno­[1,2-c]­pyrazol-3-yl)­amino)­benzoate 6m (GN39482) was found to possess a promising antiproliferative activity toward human cancer cells without affecting any antimicrobial and antimalarial activities at 100 nM. Both a methoxy Group at R1 position and a Methoxycarbonyl Group at R2 position of the anilinoquinazoline framework are essential for the high cell growth inhibition. Both MorphoBase and ChemProteoBase profiling analyses suggested that compound 6m was classified as a tubulin inhibitor. Indeed, compound 6m inhibited the acetylated tubulin accumulation and the microtubule formation and induced G2/M cell cycle arrest in HeLa cells, revealing that a promising antiproliferative activity of compound 6m toward human cancer cells is probably caused by the tubulin polymerization inhibition

Yushi Futamura - One of the best experts on this subject based on the ideXlab platform.

  • methyl 3 6 methoxy 1 4 dihydroindeno 1 2 c pyrazol 3 yl amino benzoate gn39482 as a tubulin polymerization inhibitor identified by morphobase and chemproteobase profiling methods
    Journal of Medicinal Chemistry, 2015
    Co-Authors: Hidemitsu Minegishi, Yushi Futamura, Shinji Fukashiro, Makoto Muroi, Makoto Kawatani, Hiroyuki Osada, Hiroyuki Nakamura
    Abstract:

    A series of indenopyrazoles was synthesized from the corresponding indanones and phenyl isothiocyanates in two steps. Among the compounds synthesized, methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate 6m (GN39482) was found to possess a promising antiproliferative activity toward human cancer cells without affecting any antimicrobial and antimalarial activities at 100 nM. Both a methoxy Group at R1 position and a Methoxycarbonyl Group at R2 position of the anilinoquinazoline framework are essential for the high cell growth inhibition. Both MorphoBase and ChemProteoBase profiling analyses suggested that compound 6m was classified as a tubulin inhibitor. Indeed, compound 6m inhibited the acetylated tubulin accumulation and the microtubule formation and induced G2/M cell cycle arrest in HeLa cells, revealing that a promising antiproliferative activity of compound 6m toward human cancer cells is probably caused by the tubulin polymerization inhibition.

  • Methyl 3‑((6-Methoxy-1,4-dihydroindeno[1,2‑c]pyrazol-3-yl)­amino)­benzoate (GN39482) as a Tubulin Polymerization Inhibitor Identified by MorphoBase and ChemProteoBase Profiling Methods
    2015
    Co-Authors: Hidemitsu Minegishi, Yushi Futamura, Shinji Fukashiro, Makoto Muroi, Makoto Kawatani, Hiroyuki Osada, Hiroyuki Nakamura
    Abstract:

    A series of indenopyrazoles was synthesized from the corresponding indanones and phenyl isothiocyanates in two steps. Among the compounds synthesized, methyl 3-((6-methoxy-1,4-dihydroindeno­[1,2-c]­pyrazol-3-yl)­amino)­benzoate 6m (GN39482) was found to possess a promising antiproliferative activity toward human cancer cells without affecting any antimicrobial and antimalarial activities at 100 nM. Both a methoxy Group at R1 position and a Methoxycarbonyl Group at R2 position of the anilinoquinazoline framework are essential for the high cell growth inhibition. Both MorphoBase and ChemProteoBase profiling analyses suggested that compound 6m was classified as a tubulin inhibitor. Indeed, compound 6m inhibited the acetylated tubulin accumulation and the microtubule formation and induced G2/M cell cycle arrest in HeLa cells, revealing that a promising antiproliferative activity of compound 6m toward human cancer cells is probably caused by the tubulin polymerization inhibition

Shinji Fukashiro - One of the best experts on this subject based on the ideXlab platform.

  • methyl 3 6 methoxy 1 4 dihydroindeno 1 2 c pyrazol 3 yl amino benzoate gn39482 as a tubulin polymerization inhibitor identified by morphobase and chemproteobase profiling methods
    Journal of Medicinal Chemistry, 2015
    Co-Authors: Hidemitsu Minegishi, Yushi Futamura, Shinji Fukashiro, Makoto Muroi, Makoto Kawatani, Hiroyuki Osada, Hiroyuki Nakamura
    Abstract:

    A series of indenopyrazoles was synthesized from the corresponding indanones and phenyl isothiocyanates in two steps. Among the compounds synthesized, methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate 6m (GN39482) was found to possess a promising antiproliferative activity toward human cancer cells without affecting any antimicrobial and antimalarial activities at 100 nM. Both a methoxy Group at R1 position and a Methoxycarbonyl Group at R2 position of the anilinoquinazoline framework are essential for the high cell growth inhibition. Both MorphoBase and ChemProteoBase profiling analyses suggested that compound 6m was classified as a tubulin inhibitor. Indeed, compound 6m inhibited the acetylated tubulin accumulation and the microtubule formation and induced G2/M cell cycle arrest in HeLa cells, revealing that a promising antiproliferative activity of compound 6m toward human cancer cells is probably caused by the tubulin polymerization inhibition.

  • Methyl 3‑((6-Methoxy-1,4-dihydroindeno[1,2‑c]pyrazol-3-yl)­amino)­benzoate (GN39482) as a Tubulin Polymerization Inhibitor Identified by MorphoBase and ChemProteoBase Profiling Methods
    2015
    Co-Authors: Hidemitsu Minegishi, Yushi Futamura, Shinji Fukashiro, Makoto Muroi, Makoto Kawatani, Hiroyuki Osada, Hiroyuki Nakamura
    Abstract:

    A series of indenopyrazoles was synthesized from the corresponding indanones and phenyl isothiocyanates in two steps. Among the compounds synthesized, methyl 3-((6-methoxy-1,4-dihydroindeno­[1,2-c]­pyrazol-3-yl)­amino)­benzoate 6m (GN39482) was found to possess a promising antiproliferative activity toward human cancer cells without affecting any antimicrobial and antimalarial activities at 100 nM. Both a methoxy Group at R1 position and a Methoxycarbonyl Group at R2 position of the anilinoquinazoline framework are essential for the high cell growth inhibition. Both MorphoBase and ChemProteoBase profiling analyses suggested that compound 6m was classified as a tubulin inhibitor. Indeed, compound 6m inhibited the acetylated tubulin accumulation and the microtubule formation and induced G2/M cell cycle arrest in HeLa cells, revealing that a promising antiproliferative activity of compound 6m toward human cancer cells is probably caused by the tubulin polymerization inhibition