The Experts below are selected from a list of 30 Experts worldwide ranked by ideXlab platform
H. C. Holland - One of the best experts on this subject based on the ideXlab platform.
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An examination of the effects of stimulant and depressant drugs on escape-avoidance conditioning in strains of rats selectively bred for emotionality-non-emotionality: a multivariate analysis of the effects of drugs on conditioned avoidance responses
Neuropharmacology, 2002Co-Authors: B. D. Gupta, H. C. HollandAbstract:Abstract The effects of increasing doses of amphetamine, sodium amytal, adrenaline and Methylpentynol on 200 rats of the Maudsley Reactive and Non-Reactive strains were analyzed multivariately for scores of conditioned avoidance and intertrial crosses in an automatic shuttle box. The “dispersion” of the treatment, strains and dose groups was analyzed by use of a canonical analysis variance technique. Subsequently 2 “vectors” emerged; the first vector was denned as “conditionability” and the second “resistance to irrelevant activity”. An analysis of the vector scores revealed that the central stimulant and autonomic depressant drugs facilitated and the central depressant and autonomic stimulant drugs reduced the levels of conditionability but failed to affect the resistance to activity. The analysis of strain differences showed that the Non-Reactives were comparatively highly conditionable because of their lower resistance to activity. Further, it was only the Non-Reactive strain which differentiated the drug groups on both vectors; the Reactives were susceptible only to autonomic drugs. The treatment × dose interaction produced different dose-response relationships on both vectors.
B. D. Gupta - One of the best experts on this subject based on the ideXlab platform.
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An examination of the effects of stimulant and depressant drugs on escape-avoidance conditioning in strains of rats selectively bred for emotionality-non-emotionality: a multivariate analysis of the effects of drugs on conditioned avoidance responses
Neuropharmacology, 2002Co-Authors: B. D. Gupta, H. C. HollandAbstract:Abstract The effects of increasing doses of amphetamine, sodium amytal, adrenaline and Methylpentynol on 200 rats of the Maudsley Reactive and Non-Reactive strains were analyzed multivariately for scores of conditioned avoidance and intertrial crosses in an automatic shuttle box. The “dispersion” of the treatment, strains and dose groups was analyzed by use of a canonical analysis variance technique. Subsequently 2 “vectors” emerged; the first vector was denned as “conditionability” and the second “resistance to irrelevant activity”. An analysis of the vector scores revealed that the central stimulant and autonomic depressant drugs facilitated and the central depressant and autonomic stimulant drugs reduced the levels of conditionability but failed to affect the resistance to activity. The analysis of strain differences showed that the Non-Reactives were comparatively highly conditionable because of their lower resistance to activity. Further, it was only the Non-Reactive strain which differentiated the drug groups on both vectors; the Reactives were susceptible only to autonomic drugs. The treatment × dose interaction produced different dose-response relationships on both vectors.
F. Belal - One of the best experts on this subject based on the ideXlab platform.
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Anodic Polarographic Determination of Acetylenic Hypnotics Ethinamate and Methylpentynol Carbamate in Dosage Forms
Journal of AOAC International, 1991Co-Authors: F. BelalAbstract:Abstract The polarographic behavior of ethinamate and Methylpentynol carbamate was studied. Both drugs developed anodic waves in a supporting electrolyte composed of 1M sodium hydroxide and methanol (9 + 1). The relation between the limiting current and the concentration was rectilinear over the range 2.5 X 10-5-2.5 X 10-4M for both drugs. The characteristics of the waves were studied, and a model of the electrode reaction was suggested. The proposed method was successfully applied to the determination of the 2 drugs in their dosage forms, and the results were in agreement with those obtained with published methods.
Avat Arman Taherpour - One of the best experts on this subject based on the ideXlab platform.
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structural assessment of hydrogen bonds on Methylpentynol azide clusters to achieve regiochemical outcome of 1 3 dipolar cycloaddition reactions using density functional theory
ACS omega, 2020Co-Authors: Marzieh Hashemi, Avat Arman TaherpourAbstract:This study was focused on the geometries and properties of the structural isomers obtained from a random walk of Methylpentynol–HN3 clusters. The theoretical aspects of hydrogen bonding effects on ...
Yasumasa Kuwahara - One of the best experts on this subject based on the ideXlab platform.
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structural elucidation of twelve novel esters composed of five fatty acids and three new branched alcohols together with four monoterpenoids from sancassania shanghaiensis acari acaridae
Bioscience Biotechnology and Biochemistry, 2001Co-Authors: Tomoyo Sakata, Kimiko Okabe, Yasumasa KuwaharaAbstract:A total of 12 novel esters and four monoterpenoids (rosefuran, (2R,3R)-epoxyneral, and α- and β-acaridials) were detected by GC/MS analyses as the opisthonotal gland components of Sancassania shanghaiensis. The acidic fraction after hydrolysis was composed of five common fatty acids (palmitic, stearic, oleic, linoleic and arachidic acid), while the alcoholic fraction consisted of two major components (C6 and C8 alcohols with branched methyls), together with a trace amount of C9 alcohol. The Two major alcohols were identified as new alcohols [(S)-2-methylpentanol and (2S,4S)-2,4-dimethylhexanol] by comparing the physico-chemical data of their 3,5-dinitrobenzoates with those of regio-selectively synthesized alcohols. The C9 alcohol was suggested as (2S,4S)-2,4-dimethylheptanol, based on a structural and biogenetic analogy to the C6 and C8 alcohols. Five of the compounds were each identified by GC to be (S)-2-methylpentyl esters from five fatty acids, and the other five components likewise as (2S,4S)-2,4-dim...