The Experts below are selected from a list of 35607 Experts worldwide ranked by ideXlab platform
Da-ming Du - One of the best experts on this subject based on the ideXlab platform.
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chiral squaramide catalyzed highly enantioselective Michael Addition of 2 hydroxy 1 4 naphthoquinones to nitroalkenes
Advanced Synthesis & Catalysis, 2011Co-Authors: Wen Yang, Da-ming DuAbstract:A chiral squaramide-organocatalyzed, highly enantioselective Michael Addition of 2-hydroxy-1,4-naphthoquinones to nitroalkenes has been developed. This reaction afforded the chiral naphthoquinones in excellent yields (up to 99%) and excellent enantioselectivity (up to 98% ee) under very low catalyst loading (0.25 mol%). This organocatalytic asymmetric Michael Addition provides an efficient alternative route toward the synthesis of chiral functionalized naphthoquinones.
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highly enantioselective Michael Addition of nitroalkanes to chalcones using chiral squaramides as hydrogen bonding organocatalysts
Organic Letters, 2010Co-Authors: Wen Yang, Da-ming DuAbstract:A series of squaramide-based organocatalysts were facilely synthesized and applied as hydrogen bonding organocatalysts in the enantioselective Michael Addition of nitroalkanes to chalcones. These organocatalysts promoted the Michael Addition with low catalyst loading under high temperature (80 °C), affording the desired R or S enantiomers of the products flexibly in high yields with excellent enantioselectivities (93−96% ee) by the appropriate choice of organocatalysts.
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Organocatalytic Highly Enantioselective Michael Addition of 2-Hydroxy-1,4-naphthoquinones to Nitroalkenes
Organic Letters, 2008Co-Authors: Wen-ming Zhou, Da-ming DuAbstract:The first organocatalytic enantioselective Michael Addition of 2-hydroxy-1,4-naphthoquinones to nitroalkenes for the direct synthesis of chiral nitroalkylated naphthoquinone derivatives was investigated. Good yields and excellent enantioselectivities (up to >99% ee) could be achieved. This organocatalytic asymmetric Michael Addition provides an efficient route torward the synthesis of optically active functionalized naphthoquinones.
Wen Yang - One of the best experts on this subject based on the ideXlab platform.
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chiral squaramide catalyzed highly enantioselective Michael Addition of 2 hydroxy 1 4 naphthoquinones to nitroalkenes
Advanced Synthesis & Catalysis, 2011Co-Authors: Wen Yang, Da-ming DuAbstract:A chiral squaramide-organocatalyzed, highly enantioselective Michael Addition of 2-hydroxy-1,4-naphthoquinones to nitroalkenes has been developed. This reaction afforded the chiral naphthoquinones in excellent yields (up to 99%) and excellent enantioselectivity (up to 98% ee) under very low catalyst loading (0.25 mol%). This organocatalytic asymmetric Michael Addition provides an efficient alternative route toward the synthesis of chiral functionalized naphthoquinones.
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highly enantioselective Michael Addition of nitroalkanes to chalcones using chiral squaramides as hydrogen bonding organocatalysts
Organic Letters, 2010Co-Authors: Wen Yang, Da-ming DuAbstract:A series of squaramide-based organocatalysts were facilely synthesized and applied as hydrogen bonding organocatalysts in the enantioselective Michael Addition of nitroalkanes to chalcones. These organocatalysts promoted the Michael Addition with low catalyst loading under high temperature (80 °C), affording the desired R or S enantiomers of the products flexibly in high yields with excellent enantioselectivities (93−96% ee) by the appropriate choice of organocatalysts.
Wei Wang - One of the best experts on this subject based on the ideXlab platform.
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Enantioselective Organocatalytic Double Michael Addition Reactions
Organic Letters, 2007Co-Authors: Hao Li, Liansuo Zu, Jian Wang, Wei Jiang, Wei WangAbstract:A novel organocatalytic, enantioselective domino double Michael Addition reaction of α,β-unsaturated aldehydes with ethyl 4-mercapto-2-butenoate has been developed. The process is promoted by chiral diphenylprolinol TMS ether to give chiral tetrahydrothiophenes in high to excellent levels of enantioselectivities.
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Organocatalytic enantioselective Michael Addition of thioacetic acid to enones
Tetrahedron Letters, 2006Co-Authors: Hao Li, Liansuo Zu, Jian Wang, Wei WangAbstract:An enantioselective, organocatalytic Michael Addition reaction of thioacetic acid with enones has been developed. The process, catalyzed by a chiral bifunctional amine thiourea, furnishes products in excellent yields with up to 63% ee.
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organocatalytic asymmetric Michael Addition of 2 4 pentandione to nitroolefins
Organic Letters, 2005Co-Authors: Jian Wang, Hao Li, Liansuo Zu, Wenhu Duan, Wei WangAbstract:A novel binaphthyl-derived amine thiourea organocatalyst has been developed and demonstrated to efficiently catalyze Michael Addition reactions (using as low as 1 mol % loading) of diketones to nitroalkenes with remarkably high enantioselectivities.
Samuel H Gellman - One of the best experts on this subject based on the ideXlab platform.
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enantioselective organocatalytic Michael Addition of aldehydes to nitroethylene efficient access to γ2 amino acids
Journal of the American Chemical Society, 2008Co-Authors: Nathan A Kopf, Samuel H GellmanAbstract:Enantioselective organocatalytic Michael Addition of aldehydes to nitroethylene catalyzed by (S)-diphenylprolinol silyl ether provides β-substituted-δ-nitroalcohols in nearly optically pure form (96−99% ee). The Michael adducts bear a single substituent adjacent to the carbonyl and can be efficiently converted to protected γ2-amino acids, which are essential for the systematic conformational studies of γ-peptide foldamers.
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diphenylprolinol methyl ether a highly enantioselective catalyst for Michael Addition of aldehydes to simple enones
Organic Letters, 2005Co-Authors: Samuel H GellmanAbstract:Diphenylprolinol methyl ether catalyzes intermolecular Michael Addition of simple aldehydes to relatively nonactivated enones with the highest enantioselectivities reported to date (95−99% ee) and significantly lower catalyst loadings than have been typical in this arena.
Jian Wang - One of the best experts on this subject based on the ideXlab platform.
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Enantioselective Organocatalytic Double Michael Addition Reactions
Organic Letters, 2007Co-Authors: Hao Li, Liansuo Zu, Jian Wang, Wei Jiang, Wei WangAbstract:A novel organocatalytic, enantioselective domino double Michael Addition reaction of α,β-unsaturated aldehydes with ethyl 4-mercapto-2-butenoate has been developed. The process is promoted by chiral diphenylprolinol TMS ether to give chiral tetrahydrothiophenes in high to excellent levels of enantioselectivities.
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Organocatalytic enantioselective Michael Addition of thioacetic acid to enones
Tetrahedron Letters, 2006Co-Authors: Hao Li, Liansuo Zu, Jian Wang, Wei WangAbstract:An enantioselective, organocatalytic Michael Addition reaction of thioacetic acid with enones has been developed. The process, catalyzed by a chiral bifunctional amine thiourea, furnishes products in excellent yields with up to 63% ee.
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organocatalytic asymmetric Michael Addition of 2 4 pentandione to nitroolefins
Organic Letters, 2005Co-Authors: Jian Wang, Hao Li, Liansuo Zu, Wenhu Duan, Wei WangAbstract:A novel binaphthyl-derived amine thiourea organocatalyst has been developed and demonstrated to efficiently catalyze Michael Addition reactions (using as low as 1 mol % loading) of diketones to nitroalkenes with remarkably high enantioselectivities.
