The Experts below are selected from a list of 3 Experts worldwide ranked by ideXlab platform

Liliana R. Orelli - One of the best experts on this subject based on the ideXlab platform.

  • Microwave-Enhanced Synthesis of Phosphonoacetamides
    Synthetic Communications, 2011
    Co-Authors: Nadia Gruber, Maria C. Mollo, Mariana Zani, Liliana R. Orelli
    Abstract:

    Abstract An efficient microwave protocol is described for the Michaelis–Arbuzov Synthesis of secondary and tertiary N-aryl (and alkyl) (diethylphosphono)acetamides 1, by reaction of chloro- and bromoacetamides with triethyl phosphite in the presence of catalytic amounts of sodium iodide. Remarkable acceleration of the reaction (minutes vs. several hours) over conventional heating was achieved, together with improved product yields and purity, when bromoacetamides were employed as the substrates. Chloroacetamides were comparatively less reactive, leading to satisfactory yields only when a high excess of the reagent was employed.

Nadia Gruber - One of the best experts on this subject based on the ideXlab platform.

  • Microwave-Enhanced Synthesis of Phosphonoacetamides
    Synthetic Communications, 2011
    Co-Authors: Nadia Gruber, Maria C. Mollo, Mariana Zani, Liliana R. Orelli
    Abstract:

    Abstract An efficient microwave protocol is described for the Michaelis–Arbuzov Synthesis of secondary and tertiary N-aryl (and alkyl) (diethylphosphono)acetamides 1, by reaction of chloro- and bromoacetamides with triethyl phosphite in the presence of catalytic amounts of sodium iodide. Remarkable acceleration of the reaction (minutes vs. several hours) over conventional heating was achieved, together with improved product yields and purity, when bromoacetamides were employed as the substrates. Chloroacetamides were comparatively less reactive, leading to satisfactory yields only when a high excess of the reagent was employed.

Maria C. Mollo - One of the best experts on this subject based on the ideXlab platform.

  • Microwave-Enhanced Synthesis of Phosphonoacetamides
    Synthetic Communications, 2011
    Co-Authors: Nadia Gruber, Maria C. Mollo, Mariana Zani, Liliana R. Orelli
    Abstract:

    Abstract An efficient microwave protocol is described for the Michaelis–Arbuzov Synthesis of secondary and tertiary N-aryl (and alkyl) (diethylphosphono)acetamides 1, by reaction of chloro- and bromoacetamides with triethyl phosphite in the presence of catalytic amounts of sodium iodide. Remarkable acceleration of the reaction (minutes vs. several hours) over conventional heating was achieved, together with improved product yields and purity, when bromoacetamides were employed as the substrates. Chloroacetamides were comparatively less reactive, leading to satisfactory yields only when a high excess of the reagent was employed.

Mariana Zani - One of the best experts on this subject based on the ideXlab platform.

  • Microwave-Enhanced Synthesis of Phosphonoacetamides
    Synthetic Communications, 2011
    Co-Authors: Nadia Gruber, Maria C. Mollo, Mariana Zani, Liliana R. Orelli
    Abstract:

    Abstract An efficient microwave protocol is described for the Michaelis–Arbuzov Synthesis of secondary and tertiary N-aryl (and alkyl) (diethylphosphono)acetamides 1, by reaction of chloro- and bromoacetamides with triethyl phosphite in the presence of catalytic amounts of sodium iodide. Remarkable acceleration of the reaction (minutes vs. several hours) over conventional heating was achieved, together with improved product yields and purity, when bromoacetamides were employed as the substrates. Chloroacetamides were comparatively less reactive, leading to satisfactory yields only when a high excess of the reagent was employed.