The Experts below are selected from a list of 300 Experts worldwide ranked by ideXlab platform
Andrew D. Parent - One of the best experts on this subject based on the ideXlab platform.
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endovascular embolization of prominent intercavernous sinuses for successful transsphenoidal resection of cushing Microadenoma case report
Neurosurgery, 2012Co-Authors: Ludwig D. Orozco, Razvan F. Buciuc, Andrew D. ParentAbstract:BACKGROUND AND IMPORTANCE: Prominent intercavernous sinuses may result in vigorous bleeding during transsphenoidal resection of pituitary Microadenomas and lead to incomplete or aborted tumor resection. We report the use of coil embolization of the intercavernous sinuses to prevent uncontrollable bleeding before transsphenoidal surgery is reattempted. CLINICAL PRESENTATION: A 40-year-old man with Cushing disease underwent an attempt for transsphenoidal resection of an adrenocorticotrophic hormone― producing pituitary Microadenoma. This approach was aborted secondary to profuse intercavernous sinus bleeding. The patient underwent endovascular coil embolization of the anterior intercavernous sinuses with complete obliteration. Six weeks later, he underwent successful transsphenoidal resection of the Microadenoma. CONCLUSION: To the best of our knowledge, this is the first report of successful coil embolization of the intercavernous sinuses to prevent uncontrolled bleeding before transsphenoidal resection of pituitary Microadenomas.
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Endovascular Embolization of Prominent Intercavernous Sinuses for Successful Transsphenoidal Resection of Cushing Microadenoma
Operative Neurosurgery, 2012Co-Authors: Ludwig D. Orozco, Razvan F. Buciuc, Andrew D. ParentAbstract:Abstract BACKGROUND AND IMPORTANCE: Prominent intercavernous sinuses may result in vigorous bleeding during transsphenoidal resection of pituitary Microadenomas and lead to incomplete or aborted tumor resection. We report the use of coil embolization of the intercavernous sinuses to prevent uncontrollable bleeding before transsphenoidal surgery is reattempted. CLINICAL PRESENTATION: A 40-year-old man with Cushing disease underwent an attempt for transsphenoidal resection of an adrenocorticotrophic hormone--producing pituitary Microadenoma. This approach was aborted secondary to profuse intercavernous sinus bleeding. The patient underwent endovascular coil embolization of the anterior intercavernous sinuses with complete obliteration. Six weeks later, he underwent successful transsphenoidal resection of the Microadenoma. CONCLUSION: To the best of our knowledge, this is the first report of successful coil embolization of the intercavernous sinuses to prevent uncontrolled bleeding before transsphenoidal resection of pituitary Microadenomas.
Ludwig D. Orozco - One of the best experts on this subject based on the ideXlab platform.
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endovascular embolization of prominent intercavernous sinuses for successful transsphenoidal resection of cushing Microadenoma case report
Neurosurgery, 2012Co-Authors: Ludwig D. Orozco, Razvan F. Buciuc, Andrew D. ParentAbstract:BACKGROUND AND IMPORTANCE: Prominent intercavernous sinuses may result in vigorous bleeding during transsphenoidal resection of pituitary Microadenomas and lead to incomplete or aborted tumor resection. We report the use of coil embolization of the intercavernous sinuses to prevent uncontrollable bleeding before transsphenoidal surgery is reattempted. CLINICAL PRESENTATION: A 40-year-old man with Cushing disease underwent an attempt for transsphenoidal resection of an adrenocorticotrophic hormone― producing pituitary Microadenoma. This approach was aborted secondary to profuse intercavernous sinus bleeding. The patient underwent endovascular coil embolization of the anterior intercavernous sinuses with complete obliteration. Six weeks later, he underwent successful transsphenoidal resection of the Microadenoma. CONCLUSION: To the best of our knowledge, this is the first report of successful coil embolization of the intercavernous sinuses to prevent uncontrolled bleeding before transsphenoidal resection of pituitary Microadenomas.
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Endovascular Embolization of Prominent Intercavernous Sinuses for Successful Transsphenoidal Resection of Cushing Microadenoma
Operative Neurosurgery, 2012Co-Authors: Ludwig D. Orozco, Razvan F. Buciuc, Andrew D. ParentAbstract:Abstract BACKGROUND AND IMPORTANCE: Prominent intercavernous sinuses may result in vigorous bleeding during transsphenoidal resection of pituitary Microadenomas and lead to incomplete or aborted tumor resection. We report the use of coil embolization of the intercavernous sinuses to prevent uncontrollable bleeding before transsphenoidal surgery is reattempted. CLINICAL PRESENTATION: A 40-year-old man with Cushing disease underwent an attempt for transsphenoidal resection of an adrenocorticotrophic hormone--producing pituitary Microadenoma. This approach was aborted secondary to profuse intercavernous sinus bleeding. The patient underwent endovascular coil embolization of the anterior intercavernous sinuses with complete obliteration. Six weeks later, he underwent successful transsphenoidal resection of the Microadenoma. CONCLUSION: To the best of our knowledge, this is the first report of successful coil embolization of the intercavernous sinuses to prevent uncontrolled bleeding before transsphenoidal resection of pituitary Microadenomas.
Tetsuya Tagami - One of the best experts on this subject based on the ideXlab platform.
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successful treatment of cushing s disease caused by ectopic intracavernous Microadenoma
Pituitary, 2011Co-Authors: Mitsuteru Koizumi, Takeshi Usui, Shozo Yamada, I Fujisawa, Tsunehisa Tsuru, Kazutaka Nanba, Hanae Hagiwara, Takashi Kimura, Tamiko Tamanaha, Tetsuya TagamiAbstract:Adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas are sometimes difficult to visualize, even with high-quality magnetic resonance imaging, due to their small size and variable location. Sampling the cavernous or inferior petrosal sinus is helpful for confirming the central origin of a tumor, but ectopic corticotroph adenomas in the paraseller region also typically exhibit a high central/peripheral plasma ACTH ratio. We experienced an extremely rare case of Cushing’s disease caused by an ACTH-secreting Microadenoma located entirely inside the left cavernous sinus attached to the medial wall (ectopic pituitary adenoma) that was not visible by preoperative MRI. In this case, the Microadenoma was completely removed and an endocrinologic cure was achieved. This case reveals that in addition to meticulous sectioning of the pituitary gland, bilateral periglandular inspection with visualization of the medial wall of the cavernous sinus and of the diaphragm should always be performed to detect ectopic parasellar Microadenomas when no adenoma is visible by preoperative MRI.
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Successful treatment of Cushing’s disease caused by ectopic intracavernous Microadenoma
Pituitary, 2008Co-Authors: Mitsuteru Koizumi, Takeshi Usui, Shozo Yamada, I Fujisawa, Tsunehisa Tsuru, Kazutaka Nanba, Hanae Hagiwara, Takashi Kimura, Tamiko Tamanaha, Tetsuya TagamiAbstract:Adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas are sometimes difficult to visualize, even with high-quality magnetic resonance imaging, due to their small size and variable location. Sampling the cavernous or inferior petrosal sinus is helpful for confirming the central origin of a tumor, but ectopic corticotroph adenomas in the paraseller region also typically exhibit a high central/peripheral plasma ACTH ratio. We experienced an extremely rare case of Cushing’s disease caused by an ACTH-secreting Microadenoma located entirely inside the left cavernous sinus attached to the medial wall (ectopic pituitary adenoma) that was not visible by preoperative MRI. In this case, the Microadenoma was completely removed and an endocrinologic cure was achieved. This case reveals that in addition to meticulous sectioning of the pituitary gland, bilateral periglandular inspection with visualization of the medial wall of the cavernous sinus and of the diaphragm should always be performed to detect ectopic parasellar Microadenomas when no adenoma is visible by preoperative MRI.
Shozo Yamada - One of the best experts on this subject based on the ideXlab platform.
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successful treatment of cushing s disease caused by ectopic intracavernous Microadenoma
Pituitary, 2011Co-Authors: Mitsuteru Koizumi, Takeshi Usui, Shozo Yamada, I Fujisawa, Tsunehisa Tsuru, Kazutaka Nanba, Hanae Hagiwara, Takashi Kimura, Tamiko Tamanaha, Tetsuya TagamiAbstract:Adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas are sometimes difficult to visualize, even with high-quality magnetic resonance imaging, due to their small size and variable location. Sampling the cavernous or inferior petrosal sinus is helpful for confirming the central origin of a tumor, but ectopic corticotroph adenomas in the paraseller region also typically exhibit a high central/peripheral plasma ACTH ratio. We experienced an extremely rare case of Cushing’s disease caused by an ACTH-secreting Microadenoma located entirely inside the left cavernous sinus attached to the medial wall (ectopic pituitary adenoma) that was not visible by preoperative MRI. In this case, the Microadenoma was completely removed and an endocrinologic cure was achieved. This case reveals that in addition to meticulous sectioning of the pituitary gland, bilateral periglandular inspection with visualization of the medial wall of the cavernous sinus and of the diaphragm should always be performed to detect ectopic parasellar Microadenomas when no adenoma is visible by preoperative MRI.
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increased expression of hmga1 correlates with tumour invasiveness and proliferation in human pituitary adenomas
Histopathology, 2010Co-Authors: Elaine Lu Wang, Shozo Yamada, Zhi Rong Qian, Mustafizur Rahman, Katsuhiko Yoshimoto, Eiji Kudo, Toshiaki SanoAbstract:Wang E L, Qian Z R, Rahman M M, Yoshimoto K, Yamada S, Kudo E & Sano T (2010) Histopathology56, 501–509 Increased expression of HMGA1 correlates with tumour invasiveness and proliferation in human pituitary adenomas Aims: High-mobility group A1 (HMGA1) is highly expressed in various benign and malignant tumours. The development of pituitary adenoma in Hmga1 transgenic mice has been reported. However, no studies have investigated HMGA1 expression and its clinical significance in human pituitary adenomas. Methods and results: Immunohistochemical expression of HMGA1 was analysed with respect to various clinicopathological factors in 95 pituitary adenomas. Nuclear expression of HMGA1 was observed in 62% of pituitary adenomas, whereas normal adenohypophysial tissues were negative. Although HMGA1 expression was frequently detected in clinically non-functioning adenomas – 90% of silent adrenocorticotropic hormone (ACTH), 76.2% of follicle-stimulating hormone/luteinizing hormone and 100% of null cell adenomas – it was also detected in 48.1% of growth hormone (GH), 60% of mixed GH/prolactin (PRL), 62.5% of PRL, 66.6% of thyroid-stimulating hormone and 37.5% of ACTH adenomas. HMGA1 expression was significantly higher in invasive adenomas or macroadenomas than in non-invasive adenomas or Microadenomas (invasive versus non-invasive, P < 0.05; macroadenoma versus Microadenoma, P < 0.05). In addition, HMGA1 showed the highest level in grade IV, more aggressive pituitary adenomas, than in grades I, II and III (IV versus I, P = 0.01; IV versus II, P = 0.01; IV versus III, P = 0.07). Furthermore, a significant correlation between HMGA1 expression and MIB-1 labelling index was observed (R = 0.368, P < 0.0002). Conclusions: These findings suggest that HMGA1 up-regulation has an important oncogenic role in pituitary tumorigenesis, as well as being a novel molecular marker of tumour proliferation and invasiveness.
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Successful treatment of Cushing’s disease caused by ectopic intracavernous Microadenoma
Pituitary, 2008Co-Authors: Mitsuteru Koizumi, Takeshi Usui, Shozo Yamada, I Fujisawa, Tsunehisa Tsuru, Kazutaka Nanba, Hanae Hagiwara, Takashi Kimura, Tamiko Tamanaha, Tetsuya TagamiAbstract:Adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas are sometimes difficult to visualize, even with high-quality magnetic resonance imaging, due to their small size and variable location. Sampling the cavernous or inferior petrosal sinus is helpful for confirming the central origin of a tumor, but ectopic corticotroph adenomas in the paraseller region also typically exhibit a high central/peripheral plasma ACTH ratio. We experienced an extremely rare case of Cushing’s disease caused by an ACTH-secreting Microadenoma located entirely inside the left cavernous sinus attached to the medial wall (ectopic pituitary adenoma) that was not visible by preoperative MRI. In this case, the Microadenoma was completely removed and an endocrinologic cure was achieved. This case reveals that in addition to meticulous sectioning of the pituitary gland, bilateral periglandular inspection with visualization of the medial wall of the cavernous sinus and of the diaphragm should always be performed to detect ectopic parasellar Microadenomas when no adenoma is visible by preoperative MRI.
Razvan F. Buciuc - One of the best experts on this subject based on the ideXlab platform.
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endovascular embolization of prominent intercavernous sinuses for successful transsphenoidal resection of cushing Microadenoma case report
Neurosurgery, 2012Co-Authors: Ludwig D. Orozco, Razvan F. Buciuc, Andrew D. ParentAbstract:BACKGROUND AND IMPORTANCE: Prominent intercavernous sinuses may result in vigorous bleeding during transsphenoidal resection of pituitary Microadenomas and lead to incomplete or aborted tumor resection. We report the use of coil embolization of the intercavernous sinuses to prevent uncontrollable bleeding before transsphenoidal surgery is reattempted. CLINICAL PRESENTATION: A 40-year-old man with Cushing disease underwent an attempt for transsphenoidal resection of an adrenocorticotrophic hormone― producing pituitary Microadenoma. This approach was aborted secondary to profuse intercavernous sinus bleeding. The patient underwent endovascular coil embolization of the anterior intercavernous sinuses with complete obliteration. Six weeks later, he underwent successful transsphenoidal resection of the Microadenoma. CONCLUSION: To the best of our knowledge, this is the first report of successful coil embolization of the intercavernous sinuses to prevent uncontrolled bleeding before transsphenoidal resection of pituitary Microadenomas.
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Endovascular Embolization of Prominent Intercavernous Sinuses for Successful Transsphenoidal Resection of Cushing Microadenoma
Operative Neurosurgery, 2012Co-Authors: Ludwig D. Orozco, Razvan F. Buciuc, Andrew D. ParentAbstract:Abstract BACKGROUND AND IMPORTANCE: Prominent intercavernous sinuses may result in vigorous bleeding during transsphenoidal resection of pituitary Microadenomas and lead to incomplete or aborted tumor resection. We report the use of coil embolization of the intercavernous sinuses to prevent uncontrollable bleeding before transsphenoidal surgery is reattempted. CLINICAL PRESENTATION: A 40-year-old man with Cushing disease underwent an attempt for transsphenoidal resection of an adrenocorticotrophic hormone--producing pituitary Microadenoma. This approach was aborted secondary to profuse intercavernous sinus bleeding. The patient underwent endovascular coil embolization of the anterior intercavernous sinuses with complete obliteration. Six weeks later, he underwent successful transsphenoidal resection of the Microadenoma. CONCLUSION: To the best of our knowledge, this is the first report of successful coil embolization of the intercavernous sinuses to prevent uncontrolled bleeding before transsphenoidal resection of pituitary Microadenomas.