The Experts below are selected from a list of 10461 Experts worldwide ranked by ideXlab platform
Hyunjoon Kong - One of the best experts on this subject based on the ideXlab platform.
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water hydrogel binding affinity modulates freeze drying induced Micropore architecture and skeletal myotube formation
Biomacromolecules, 2015Co-Authors: Max H Rich, Nicholas M Marshall, Nicholas E Clay, Jinrong Chen, Ziad Mahmassani, Marni D Boppart, Hyunjoon KongAbstract:Freeze-dried hydrogels are increasingly used to create 3D interconnected Micropores that facilitate biomolecular and cellular transports. However, freeze-drying is often plagued by variance in Micropore architecture based on polymer choice. We hypothesized that water–polymer binding affinity plays a significant role in sizes and numbers of Micropores formed through freeze-drying, influencing cell-derived tissue quality. Poly(ethylene glycol)diacrylate (PEGDA) hydrogels with alginate methacrylate (AM) were used due to AM’s higher binding affinity for water than PEGDA. PEGDA-AM hydrogels with larger AM concentrations resulted in larger sizes and numbers of Micropores than pure PEGDA hydrogels, attributed to the increased mass of water binding to the PEGDA-AM gel. Skeletal myoblasts loaded in microporous PEGDA-AM hydrogels were active to produce 3D muscle-like tissue, while those loaded in pure PEGDA gels were localized on the gel surface. We propose that this study will be broadly useful in designing and im...
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water hydrogel binding affinity modulates freeze drying induced Micropore architecture and skeletal myotube formation
Biomacromolecules, 2015Co-Authors: Max H Rich, Nicholas M Marshall, Nicholas E Clay, Jinrong Chen, Ziad Mahmassani, Marni D Boppart, Min Kyung Lee, Hyunjoon KongAbstract:Freeze-dried hydrogels are increasingly used to create 3D interconnected Micropores that facilitate biomolecular and cellular transports. However, freeze-drying is often plagued by variance in Micropore architecture based on polymer choice. We hypothesized that water-polymer binding affinity plays a significant role in sizes and numbers of Micropores formed through freeze-drying, influencing cell-derived tissue quality. Poly(ethylene glycol)diacrylate (PEGDA) hydrogels with alginate methacrylate (AM) were used due to AM's higher binding affinity for water than PEGDA. PEGDA-AM hydrogels with larger AM concentrations resulted in larger sizes and numbers of Micropores than pure PEGDA hydrogels, attributed to the increased mass of water binding to the PEGDA-AM gel. Skeletal myoblasts loaded in microporous PEGDA-AM hydrogels were active to produce 3D muscle-like tissue, while those loaded in pure PEGDA gels were localized on the gel surface. We propose that this study will be broadly useful in designing and improving the performance of various microporous gels.
Max H Rich - One of the best experts on this subject based on the ideXlab platform.
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water hydrogel binding affinity modulates freeze drying induced Micropore architecture and skeletal myotube formation
Biomacromolecules, 2015Co-Authors: Max H Rich, Nicholas M Marshall, Nicholas E Clay, Jinrong Chen, Ziad Mahmassani, Marni D Boppart, Hyunjoon KongAbstract:Freeze-dried hydrogels are increasingly used to create 3D interconnected Micropores that facilitate biomolecular and cellular transports. However, freeze-drying is often plagued by variance in Micropore architecture based on polymer choice. We hypothesized that water–polymer binding affinity plays a significant role in sizes and numbers of Micropores formed through freeze-drying, influencing cell-derived tissue quality. Poly(ethylene glycol)diacrylate (PEGDA) hydrogels with alginate methacrylate (AM) were used due to AM’s higher binding affinity for water than PEGDA. PEGDA-AM hydrogels with larger AM concentrations resulted in larger sizes and numbers of Micropores than pure PEGDA hydrogels, attributed to the increased mass of water binding to the PEGDA-AM gel. Skeletal myoblasts loaded in microporous PEGDA-AM hydrogels were active to produce 3D muscle-like tissue, while those loaded in pure PEGDA gels were localized on the gel surface. We propose that this study will be broadly useful in designing and im...
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water hydrogel binding affinity modulates freeze drying induced Micropore architecture and skeletal myotube formation
Biomacromolecules, 2015Co-Authors: Max H Rich, Nicholas M Marshall, Nicholas E Clay, Jinrong Chen, Ziad Mahmassani, Marni D Boppart, Min Kyung Lee, Hyunjoon KongAbstract:Freeze-dried hydrogels are increasingly used to create 3D interconnected Micropores that facilitate biomolecular and cellular transports. However, freeze-drying is often plagued by variance in Micropore architecture based on polymer choice. We hypothesized that water-polymer binding affinity plays a significant role in sizes and numbers of Micropores formed through freeze-drying, influencing cell-derived tissue quality. Poly(ethylene glycol)diacrylate (PEGDA) hydrogels with alginate methacrylate (AM) were used due to AM's higher binding affinity for water than PEGDA. PEGDA-AM hydrogels with larger AM concentrations resulted in larger sizes and numbers of Micropores than pure PEGDA hydrogels, attributed to the increased mass of water binding to the PEGDA-AM gel. Skeletal myoblasts loaded in microporous PEGDA-AM hydrogels were active to produce 3D muscle-like tissue, while those loaded in pure PEGDA gels were localized on the gel surface. We propose that this study will be broadly useful in designing and improving the performance of various microporous gels.
Nicholas M Marshall - One of the best experts on this subject based on the ideXlab platform.
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water hydrogel binding affinity modulates freeze drying induced Micropore architecture and skeletal myotube formation
Biomacromolecules, 2015Co-Authors: Max H Rich, Nicholas M Marshall, Nicholas E Clay, Jinrong Chen, Ziad Mahmassani, Marni D Boppart, Hyunjoon KongAbstract:Freeze-dried hydrogels are increasingly used to create 3D interconnected Micropores that facilitate biomolecular and cellular transports. However, freeze-drying is often plagued by variance in Micropore architecture based on polymer choice. We hypothesized that water–polymer binding affinity plays a significant role in sizes and numbers of Micropores formed through freeze-drying, influencing cell-derived tissue quality. Poly(ethylene glycol)diacrylate (PEGDA) hydrogels with alginate methacrylate (AM) were used due to AM’s higher binding affinity for water than PEGDA. PEGDA-AM hydrogels with larger AM concentrations resulted in larger sizes and numbers of Micropores than pure PEGDA hydrogels, attributed to the increased mass of water binding to the PEGDA-AM gel. Skeletal myoblasts loaded in microporous PEGDA-AM hydrogels were active to produce 3D muscle-like tissue, while those loaded in pure PEGDA gels were localized on the gel surface. We propose that this study will be broadly useful in designing and im...
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water hydrogel binding affinity modulates freeze drying induced Micropore architecture and skeletal myotube formation
Biomacromolecules, 2015Co-Authors: Max H Rich, Nicholas M Marshall, Nicholas E Clay, Jinrong Chen, Ziad Mahmassani, Marni D Boppart, Min Kyung Lee, Hyunjoon KongAbstract:Freeze-dried hydrogels are increasingly used to create 3D interconnected Micropores that facilitate biomolecular and cellular transports. However, freeze-drying is often plagued by variance in Micropore architecture based on polymer choice. We hypothesized that water-polymer binding affinity plays a significant role in sizes and numbers of Micropores formed through freeze-drying, influencing cell-derived tissue quality. Poly(ethylene glycol)diacrylate (PEGDA) hydrogels with alginate methacrylate (AM) were used due to AM's higher binding affinity for water than PEGDA. PEGDA-AM hydrogels with larger AM concentrations resulted in larger sizes and numbers of Micropores than pure PEGDA hydrogels, attributed to the increased mass of water binding to the PEGDA-AM gel. Skeletal myoblasts loaded in microporous PEGDA-AM hydrogels were active to produce 3D muscle-like tissue, while those loaded in pure PEGDA gels were localized on the gel surface. We propose that this study will be broadly useful in designing and improving the performance of various microporous gels.
Nicholas E Clay - One of the best experts on this subject based on the ideXlab platform.
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water hydrogel binding affinity modulates freeze drying induced Micropore architecture and skeletal myotube formation
Biomacromolecules, 2015Co-Authors: Max H Rich, Nicholas M Marshall, Nicholas E Clay, Jinrong Chen, Ziad Mahmassani, Marni D Boppart, Hyunjoon KongAbstract:Freeze-dried hydrogels are increasingly used to create 3D interconnected Micropores that facilitate biomolecular and cellular transports. However, freeze-drying is often plagued by variance in Micropore architecture based on polymer choice. We hypothesized that water–polymer binding affinity plays a significant role in sizes and numbers of Micropores formed through freeze-drying, influencing cell-derived tissue quality. Poly(ethylene glycol)diacrylate (PEGDA) hydrogels with alginate methacrylate (AM) were used due to AM’s higher binding affinity for water than PEGDA. PEGDA-AM hydrogels with larger AM concentrations resulted in larger sizes and numbers of Micropores than pure PEGDA hydrogels, attributed to the increased mass of water binding to the PEGDA-AM gel. Skeletal myoblasts loaded in microporous PEGDA-AM hydrogels were active to produce 3D muscle-like tissue, while those loaded in pure PEGDA gels were localized on the gel surface. We propose that this study will be broadly useful in designing and im...
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water hydrogel binding affinity modulates freeze drying induced Micropore architecture and skeletal myotube formation
Biomacromolecules, 2015Co-Authors: Max H Rich, Nicholas M Marshall, Nicholas E Clay, Jinrong Chen, Ziad Mahmassani, Marni D Boppart, Min Kyung Lee, Hyunjoon KongAbstract:Freeze-dried hydrogels are increasingly used to create 3D interconnected Micropores that facilitate biomolecular and cellular transports. However, freeze-drying is often plagued by variance in Micropore architecture based on polymer choice. We hypothesized that water-polymer binding affinity plays a significant role in sizes and numbers of Micropores formed through freeze-drying, influencing cell-derived tissue quality. Poly(ethylene glycol)diacrylate (PEGDA) hydrogels with alginate methacrylate (AM) were used due to AM's higher binding affinity for water than PEGDA. PEGDA-AM hydrogels with larger AM concentrations resulted in larger sizes and numbers of Micropores than pure PEGDA hydrogels, attributed to the increased mass of water binding to the PEGDA-AM gel. Skeletal myoblasts loaded in microporous PEGDA-AM hydrogels were active to produce 3D muscle-like tissue, while those loaded in pure PEGDA gels were localized on the gel surface. We propose that this study will be broadly useful in designing and improving the performance of various microporous gels.
Jinrong Chen - One of the best experts on this subject based on the ideXlab platform.
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water hydrogel binding affinity modulates freeze drying induced Micropore architecture and skeletal myotube formation
Biomacromolecules, 2015Co-Authors: Max H Rich, Nicholas M Marshall, Nicholas E Clay, Jinrong Chen, Ziad Mahmassani, Marni D Boppart, Hyunjoon KongAbstract:Freeze-dried hydrogels are increasingly used to create 3D interconnected Micropores that facilitate biomolecular and cellular transports. However, freeze-drying is often plagued by variance in Micropore architecture based on polymer choice. We hypothesized that water–polymer binding affinity plays a significant role in sizes and numbers of Micropores formed through freeze-drying, influencing cell-derived tissue quality. Poly(ethylene glycol)diacrylate (PEGDA) hydrogels with alginate methacrylate (AM) were used due to AM’s higher binding affinity for water than PEGDA. PEGDA-AM hydrogels with larger AM concentrations resulted in larger sizes and numbers of Micropores than pure PEGDA hydrogels, attributed to the increased mass of water binding to the PEGDA-AM gel. Skeletal myoblasts loaded in microporous PEGDA-AM hydrogels were active to produce 3D muscle-like tissue, while those loaded in pure PEGDA gels were localized on the gel surface. We propose that this study will be broadly useful in designing and im...
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water hydrogel binding affinity modulates freeze drying induced Micropore architecture and skeletal myotube formation
Biomacromolecules, 2015Co-Authors: Max H Rich, Nicholas M Marshall, Nicholas E Clay, Jinrong Chen, Ziad Mahmassani, Marni D Boppart, Min Kyung Lee, Hyunjoon KongAbstract:Freeze-dried hydrogels are increasingly used to create 3D interconnected Micropores that facilitate biomolecular and cellular transports. However, freeze-drying is often plagued by variance in Micropore architecture based on polymer choice. We hypothesized that water-polymer binding affinity plays a significant role in sizes and numbers of Micropores formed through freeze-drying, influencing cell-derived tissue quality. Poly(ethylene glycol)diacrylate (PEGDA) hydrogels with alginate methacrylate (AM) were used due to AM's higher binding affinity for water than PEGDA. PEGDA-AM hydrogels with larger AM concentrations resulted in larger sizes and numbers of Micropores than pure PEGDA hydrogels, attributed to the increased mass of water binding to the PEGDA-AM gel. Skeletal myoblasts loaded in microporous PEGDA-AM hydrogels were active to produce 3D muscle-like tissue, while those loaded in pure PEGDA gels were localized on the gel surface. We propose that this study will be broadly useful in designing and improving the performance of various microporous gels.