The Experts below are selected from a list of 202674 Experts worldwide ranked by ideXlab platform
Lei Xu - One of the best experts on this subject based on the ideXlab platform.
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fiber taper coupled l band er3 doped tellurite glass Microsphere laser
Applied Physics Letters, 2003Co-Authors: Xiang Peng, Nasser N Peyghambarian, Shibin Jiang, Makoto Kuwatagonokami, Feng Song, Lei XuAbstract:Er3+-doped tellurite glass Microspheres were fabricated. The Microspheres were made by a spin method. A tapered fiber was used to couple the pump into the Microsphere and couple out the laser. L-band Microsphere laser is demonstrated. This miniature Er3+-doped tellurite glass Microsphere laser can be used in photonic microdevices.
Aldo R Boccaccini - One of the best experts on this subject based on the ideXlab platform.
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preparation and characterization of phbv Microsphere 45s5 bioactive glass composite scaffolds with vancomycin releasing function
Materials Science and Engineering: C, 2014Co-Authors: Wei Li, Yaping Ding, Judith A Roether, Dirk W Schubert, Aldo R BoccacciniAbstract:Abstract PHBV Microsphere/45S5 bioactive glass (BG) composite scaffolds with drug release function were developed for bone tissue engineering. BG-based glass-ceramic scaffolds with high porosity (94%) and interconnected pore structure prepared by foam replication method were coated with PHBV Microspheres (nominal diameter = 3.5 μm) produced by water-in-oil-in-water double emulsion solvent evaporation method. A homogeneous Microsphere coating throughout the porous structure of scaffolds was obtained by a simple dip coating method, using the slurry of PHBV Microspheres in hexane. Compressive strength tests showed that the Microsphere coating slightly improved the mechanical properties of the scaffolds. It was confirmed that the Microsphere coating did not inhibit the bioactivity of the scaffolds in SBF. Hydroxyapatite crystals homogeneously grew not only on the struts of the scaffolds but also on the surface of Microspheres within 7 days of immersion in SBF. Vancomycin was successfully encapsulated into the PHBV Microspheres. The encapsulated vancomycin was released with a dual release profile involving a relatively low initial burst release (21%) and a sustained release (1 month), which is favorable compared to the high initial burst release (77%) and short release period (4 days) measured on uncoated scaffolds. The developed bioactive composite scaffold with drug delivery function has thus the potential to be used advantageously in bone tissue engineering.
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multi functional p 3hb Microsphere 45s5 bioglass based composite scaffolds for bone tissue engineering
Acta Biomaterialia, 2010Co-Authors: Lydia Francis, Aldo R Boccaccini, Decheng Meng, Jonathan C Knowles, Ipsita RoyAbstract:Novel multi-functional P(3HB) Microsphere/45S5 Bioglass((R))-based composite scaffolds exhibiting potential for drug delivery were developed for bone tissue engineering. 45S5 Bioglass((R))-based glass-ceramic scaffolds of high interconnected porosity produced using the foam-replication technique were coated with biodegradable Microspheres (size < 2 mum) made from poly(3-hydroxybutyrate), P(3HB), produced using Bacillus cereus SPV. A solid-oil-in-water emulsion solvent extraction /evaporation technique was used to produce these P(3HB) Microspheres. A simple slurry-dipping method, using a 1 wt % suspension of P(3HB) Microspheres in water, dispersed by an ultrasonic bath, was used to coat the scaffold, producing a uniform Microsphere-coating throughout the 3D scaffold structure. Compressive strength tests confirmed that the Microsphere-coating slightly enhanced the scaffold mechanical strength. It was also confirmed that the Microsphere-coating did not inhibit the bioactivity of the scaffold when immersed in simulated body fluid (SBF) for up to 4 weeks. The hydroxyapatite (HA) growth rate on P(3HB) Microsphere coated 45S5 Bioglass((R)) composite scaffolds was very similar to that on the uncoated control sample, qualitatively indicating similar bioactivity. However, the surface topography of the HA surface layer was affected as shown by results obtained from white light interferometry. The roughness of the surface was much higher for the P(3HB) Microsphere-coated scaffolds than for the uncoated samples, after seven days in SBF. This feature would facilitate cell attachment and proliferation. Finally, gentamycin was successfully encapsulated into the P(3HB) Microspheres to demonstrate the drug delivery capability of the scaffolds. Gentamycin release kinetics was determined using liquid chromatography-mass spectrometry (LC-MS). The release of the drug from the coated composite scaffolds was slow and controlled when compared to the observed fast and relatively uncontrolled drug release from the bone scaffold (without Microsphere coating). Thus, this unique multifunctional bioactive composite scaffold has the potential to enhance cell attachment and to provide controlled delivery of relevant drugs for bone tissue engineering.
John D. Louie - One of the best experts on this subject based on the ideXlab platform.
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Comparison between resin and glass Microspheres for Yttrium-90 radioembolization treatment of hepatocellular carcinoma
Journal of Vascular and Interventional Radiology, 2013Co-Authors: Beatrijs A. Seinstra, M. A. A. J. Van Den Bosch, John D. LouieAbstract:Purpose Yttrium-90 radioembolization (RE) treatment of hepatocellular carcinoma (HCC) may be performed with either resin or glass Microspheres. Differences include specific activity, Microsphere size and density, embolic effect, and dose calculation. We retrospectively reviewed the differences in outcome between patients treated with glass Microspheres and patients treated with resin Microspheres prior to availability of glass Microspheres at two centers. Materials and Methods All patients with HCC treated with either resin or glass Microspheres at two collaborating centers were reviewed, including patients treated with glass Microspheres at one institution. Dose calculation was based on body surface area (resin) or liver weight partition model (glass). Radiographic response was measured at 3 and 6 months according to mRECIST criteria. Laboratory and clinical follow-up was performed at 2, 4, 8 and 12 weeks. Parameters of toxicity and efficacy were compared. Results Seventy patients were treated (54 M, 16 F; median age 61; 18 resin, 52 glass Microspheres). Baseline laboratory, tumor, and clinical parameters were comparable between groups, with the exception of a higher ECOG-score in the glass Microsphere patients (p = 0.001). Patients treated with resin Microspheres received less activity (1.41 versus 3.76 GBq; p Conclusion Higher dose glass Microspheres may have a subtle response and survival advantage for yttrium-90 RE of HCC.
Jiazuan Ni - One of the best experts on this subject based on the ideXlab platform.
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synthesis and characteristic of the fe3o4 sio2 eu dbm 3 2h2o sio2 luminomagnetic Microspheres with core shell structure
Talanta, 2010Co-Authors: Ping Lu, Jilin Zhang, Guangyan Hong, Jiazuan NiAbstract:The core-shell structured luminomagnetic Microsphere composed of a Fe3O4 magnetic core and a continuous SiO2 nanoshell doped with Eu(DBM)(3)center dot 2H(2)O fluorescent molecules was fabricated by a modified Stober method combined with a layer-by-layer assembly technique. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), confocal microscopy, photoluminescence (PL), and superconducting quantum interface device (SQUID) were employed to characterize the Fe3O4@SiO2@Eu(DBM)(3)center dot 2H(2)O/SiO2 Microspheres. The experimental results show that the microshpere has a typical diameter of ca. 500 nm consisting of the magnetic core with about 340 nm in diameter and silica shell doped with europium complex with an average thickness of about 80 nm. It possesses magnetism with a saturation magnetization of 25.84 emu/g and negligible coercivity and remanence at room temperature and exhibits strong red emission peak originating from electric-dipole transition D-5(0) -> F-7(2) (611 nm) of Eu3+ ions. The luminomagnetic Microspheres can be uptaken by HeLa cells and there is no adverse cell reaction. These results suggest that the luminomagnetic Microspheres with magnetic resonance response and fluorescence probe property may be useful in biomedical imaging and diagnostic applications. (C) 2010 Elsevier B.V. All rights reserved.
Riad Salem - One of the best experts on this subject based on the ideXlab platform.
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Yttrium-90 radioembolization of hepatocellular carcinoma and metastatic disease to the liver.
Seminars in interventional radiology, 2006Co-Authors: Robert J Lewandowski, Riad SalemAbstract:Yttrium-90 (90Y) radioembolization is a catheter-based therapy that delivers internal radiation to hepatic tumors in the form of Microspheres. 90Y can be delivered to the hepatic tumor as either a constituent of a glass Microsphere, TheraSphere®, or as a biocompatible resin-based Microsphere, SIR-Spheres®. Once embedded within the tumor microcirculation, these Microspheres emit β-radiation at therapeutic levels. While the technical aspects of radioembolization are quite complex, the collective clinical experience presented in the literature supports the use of 90Y radioembolization for unresectable hepatic malignancies.
