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Liliane Rouquier - One of the best experts on this subject based on the ideXlab platform.

  • effect of local injection of 8 oh dpat into the dorsal or median Raphe nuclei on extracellular levels of serotonin in serotonergic projection areas in the rat brain
    Neuroscience Letters, 1992
    Co-Authors: Gilles Bonvento, Y. Claustre, Bernard Scatton, Liliane Rouquier
    Abstract:

    Using in vivo microdialysis, we have examined the effects of local administration of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) into either the dorsal (DRN) or the median (MRN) Raphe Nucleus on extracellular levels of serotonin (5-HT) in the corresponding projection fields, namely striatum and ventral hippocampus in the anaesthetized rat. Local injection of 8-OH-DPAT (0.5 μg/0.1 μl) in the DRN reduced extracellular 5-HT levels in the striatum (−55%) and to a lesser extent in the hippocampus (−22%). When injected at the same dose in the MRN, 8-OH-DPAT caused a marked decrease in 5-HT output in the hippocampus (−41%) and had no effect in the striatum. Autoradiographic studies performed on brains from animals that received a local injection of [8H]-OH-DPAT into either the DRN or MRN under similar experimental conditions indicated that the radioactivity remained localized within each Midbrain Raphe Nucleus. These results confirm anatomical data demonstrating that the striatum and the ventral hippocampus receive their serotonergic innervation preferentially from the DRN and the MRN, respectively.

Gilles Bonvento - One of the best experts on this subject based on the ideXlab platform.

  • effect of local injection of 8 oh dpat into the dorsal or median Raphe nuclei on extracellular levels of serotonin in serotonergic projection areas in the rat brain
    Neuroscience Letters, 1992
    Co-Authors: Gilles Bonvento, Y. Claustre, Bernard Scatton, Liliane Rouquier
    Abstract:

    Using in vivo microdialysis, we have examined the effects of local administration of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) into either the dorsal (DRN) or the median (MRN) Raphe Nucleus on extracellular levels of serotonin (5-HT) in the corresponding projection fields, namely striatum and ventral hippocampus in the anaesthetized rat. Local injection of 8-OH-DPAT (0.5 μg/0.1 μl) in the DRN reduced extracellular 5-HT levels in the striatum (−55%) and to a lesser extent in the hippocampus (−22%). When injected at the same dose in the MRN, 8-OH-DPAT caused a marked decrease in 5-HT output in the hippocampus (−41%) and had no effect in the striatum. Autoradiographic studies performed on brains from animals that received a local injection of [8H]-OH-DPAT into either the DRN or MRN under similar experimental conditions indicated that the radioactivity remained localized within each Midbrain Raphe Nucleus. These results confirm anatomical data demonstrating that the striatum and the ventral hippocampus receive their serotonergic innervation preferentially from the DRN and the MRN, respectively.

Stylianos Nicolaidis - One of the best experts on this subject based on the ideXlab platform.

  • synergistic effect of arcuate and Raphe nuclei graft to alleviate insulinemia and obesity in zucker rats
    Acta Diabetologica, 2000
    Co-Authors: Serguei O Fetissov, K Gerozissis, Martine Orosco, Stylianos Nicolaidis
    Abstract:

    The arcuate Nucleus (AN) of the hypothalamus is a key area in which endocrine messages are relayed to the brain, while Midbrain Raphe Nucleus (RN) is the source of brain serotonin. Both nuclei contribute to the central mechanism of energy homeostasis. This experiment aimed to determine the impact of AN and RN grafts on insulinemia and obesity in diabetic rats. AN and RN were dissected from 15-day (Fa/Fa) lean embryos and grafted separately or together into the third brain ventricle of obese (fa/fa) male Zucker rats. Histological analysis showed the functional maturity of grafts, which were vascularized, contained neurons reinnervating the periventricular hypothalamus and hypophysis, and expressed neuropeptide Y and enzymes for dopamine and serotonin synthesis. Three months after transplantation, the rats grafted with AN or RN had a lower body weight gain compared to sham-operated rats (19% and 17%, respectively). Rats grafted with AN together with RN gained significantly less body weight than rats grafted with AN or RN separately (31% vs. sham-operated rats), and showed a decreased plasma insulin concentration (132 ± 33 μU/ml) vs. sham-operated rats (459 ± 108 μU/ml, p < 0.05). A synergistic effect on alleviating obesity and insulinemia by double AN and RN grafts suggests that both these nuclei are functionally interrelated in maintaining energy homeostasis, and normal functioning of both nuclei is altered during obesity.

Bernard Scatton - One of the best experts on this subject based on the ideXlab platform.

  • effect of local injection of 8 oh dpat into the dorsal or median Raphe nuclei on extracellular levels of serotonin in serotonergic projection areas in the rat brain
    Neuroscience Letters, 1992
    Co-Authors: Gilles Bonvento, Y. Claustre, Bernard Scatton, Liliane Rouquier
    Abstract:

    Using in vivo microdialysis, we have examined the effects of local administration of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) into either the dorsal (DRN) or the median (MRN) Raphe Nucleus on extracellular levels of serotonin (5-HT) in the corresponding projection fields, namely striatum and ventral hippocampus in the anaesthetized rat. Local injection of 8-OH-DPAT (0.5 μg/0.1 μl) in the DRN reduced extracellular 5-HT levels in the striatum (−55%) and to a lesser extent in the hippocampus (−22%). When injected at the same dose in the MRN, 8-OH-DPAT caused a marked decrease in 5-HT output in the hippocampus (−41%) and had no effect in the striatum. Autoradiographic studies performed on brains from animals that received a local injection of [8H]-OH-DPAT into either the DRN or MRN under similar experimental conditions indicated that the radioactivity remained localized within each Midbrain Raphe Nucleus. These results confirm anatomical data demonstrating that the striatum and the ventral hippocampus receive their serotonergic innervation preferentially from the DRN and the MRN, respectively.

Y. Claustre - One of the best experts on this subject based on the ideXlab platform.

  • effect of local injection of 8 oh dpat into the dorsal or median Raphe nuclei on extracellular levels of serotonin in serotonergic projection areas in the rat brain
    Neuroscience Letters, 1992
    Co-Authors: Gilles Bonvento, Y. Claustre, Bernard Scatton, Liliane Rouquier
    Abstract:

    Using in vivo microdialysis, we have examined the effects of local administration of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) into either the dorsal (DRN) or the median (MRN) Raphe Nucleus on extracellular levels of serotonin (5-HT) in the corresponding projection fields, namely striatum and ventral hippocampus in the anaesthetized rat. Local injection of 8-OH-DPAT (0.5 μg/0.1 μl) in the DRN reduced extracellular 5-HT levels in the striatum (−55%) and to a lesser extent in the hippocampus (−22%). When injected at the same dose in the MRN, 8-OH-DPAT caused a marked decrease in 5-HT output in the hippocampus (−41%) and had no effect in the striatum. Autoradiographic studies performed on brains from animals that received a local injection of [8H]-OH-DPAT into either the DRN or MRN under similar experimental conditions indicated that the radioactivity remained localized within each Midbrain Raphe Nucleus. These results confirm anatomical data demonstrating that the striatum and the ventral hippocampus receive their serotonergic innervation preferentially from the DRN and the MRN, respectively.