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Carsten Finke - One of the best experts on this subject based on the ideXlab platform.
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Magnetic resonance T1w/T2w ratio in the Middle Cerebellar Peduncle might be a sensitive biomarker for multiple system atrophy.
European radiology, 2020Co-Authors: Atsuhiko Sugiyama, Hajime Yokota, Shigeki Hirano, Graham Cooper, Hiroki Mukai, Kyosuke Koide, Jiaqi Wang, Shoichi Ito, Carsten Finke, Alexander U BrandtAbstract:We aimed to investigate the use of a myelin-sensitive MRI contrast, the standardized T1-weighted/T2-weighted (sT1w/T2w) ratio, for detecting early changes in the Middle Cerebellar Peduncle (MCP) in Cerebellar subtype multiple system atrophy (MSA-C) patients. We included 28 MSA-C patients, including a subset of 17 MSA-C patients within 2 years of disease onset (early MSA-C), and 28 matched healthy controls. T1w and T2w scans were acquired using a 3-T MR system. The sT1w/T2w ratio in MCP was analyzed using SPM12 by utilizing a region-of-interest approach in normalized space. The diagnostic performance of the MCP sT1w/T2w ratio in discriminating MSA-C and the subgroup of early MSA-C from the matched controls was assessed. Correlation analyses were performed to evaluate the relationship between the MCP sT1w/T2w ratio and other clinical parameters including the International Cooperative Ataxia Scale (ICARS) score for quantifying Cerebellar ataxia. Compared to controls, the sT1w/T2w ratio in the MCP was markedly lower in all (p < 0.001) MSA-C patients and 17 early (p < 0.001) MSA-C patients. The MCP sT1w/T2w ratio had high sensitivity (96%) and specificity (100%) to distinguish MSA-C from controls (area under the curve = 0.99), even for the early MSA-C group (area under the curve = 0.99; sensitivity = 94%, specificity = 100%). The MCP sT1w/T2w ratio correlated with the ICARS score in early MSA-C. The sT1w/T2w ratio can detect MSA-C-related changes in the MCP, even in the early stages of the disorder, and could be a sensitive biomarker for MSA-C. • The sT1w/T2w ratio can detect MSA-C-related changes in the Middle Cerebellar Peduncle, even in the early stages of the disorder. • The Middle Cerebellar Peduncle sT1w/T2w ratio correlated with a Cerebellar ataxia score in early MSA-C patients.
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Magnetic resonance T1w/T2w ratio in the Middle Cerebellar Peduncle might be a sensitive biomarker for multiple system atrophy
European Radiology, 2020Co-Authors: Atsuhiko Sugiyama, Hajime Yokota, Shigeki Hirano, Graham Cooper, Hiroki Mukai, Kyosuke Koide, Jiaqi Wang, Shoichi Ito, Carsten Finke, Alexander U BrandtAbstract:Objective We aimed to investigate the use of a myelin-sensitive MRI contrast, the standardized T1-weighted/T2-weighted (sT1w/T2w) ratio, for detecting early changes in the Middle Cerebellar Peduncle (MCP) in Cerebellar subtype multiple system atrophy (MSA-C) patients. Methods We included 28 MSA-C patients, including a subset of 17 MSA-C patients within 2 years of disease onset (early MSA-C), and 28 matched healthy controls. T1w and T2w scans were acquired using a 3-T MR system. The sT1w/T2w ratio in MCP was analyzed using SPM12 by utilizing a region-of-interest approach in normalized space. The diagnostic performance of the MCP sT1w/T2w ratio in discriminating MSA-C and the subgroup of early MSA-C from the matched controls was assessed. Correlation analyses were performed to evaluate the relationship between the MCP sT1w/T2w ratio and other clinical parameters including the International Cooperative Ataxia Scale (ICARS) score for quantifying Cerebellar ataxia. Results Compared to controls, the sT1w/T2w ratio in the MCP was markedly lower in all ( p < 0.001) MSA-C patients and 17 early ( p < 0.001) MSA-C patients. The MCP sT1w/T2w ratio had high sensitivity (96%) and specificity (100%) to distinguish MSA-C from controls (area under the curve = 0.99), even for the early MSA-C group (area under the curve = 0.99; sensitivity = 94%, specificity = 100%). The MCP sT1w/T2w ratio correlated with the ICARS score in early MSA-C. Conclusions The sT1w/T2w ratio can detect MSA-C-related changes in the MCP, even in the early stages of the disorder, and could be a sensitive biomarker for MSA-C. Key Points • The sT1w/T2w ratio can detect MSA-C-related changes in the Middle Cerebellar Peduncle, even in the early stages of the disorder. • The Middle Cerebellar Peduncle sT1w/T2w ratio correlated with a Cerebellar ataxia score in early MSA-C patients.
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magnetic resonance t1w t2w ratio in the Middle Cerebellar Peduncle might be a sensitive biomarker for multiple system atrophy
European Radiology, 2020Co-Authors: Atsuhiko Sugiyama, Hajime Yokota, Shigeki Hirano, Graham Cooper, Hiroki Mukai, Kyosuke Koide, Jiaqi Wang, Shoichi Ito, Carsten FinkeAbstract:OBJECTIVE We aimed to investigate the use of a myelin-sensitive MRI contrast, the standardized T1-weighted/T2-weighted (sT1w/T2w) ratio, for detecting early changes in the Middle Cerebellar Peduncle (MCP) in Cerebellar subtype multiple system atrophy (MSA-C) patients. METHODS We included 28 MSA-C patients, including a subset of 17 MSA-C patients within 2 years of disease onset (early MSA-C), and 28 matched healthy controls. T1w and T2w scans were acquired using a 3-T MR system. The sT1w/T2w ratio in MCP was analyzed using SPM12 by utilizing a region-of-interest approach in normalized space. The diagnostic performance of the MCP sT1w/T2w ratio in discriminating MSA-C and the subgroup of early MSA-C from the matched controls was assessed. Correlation analyses were performed to evaluate the relationship between the MCP sT1w/T2w ratio and other clinical parameters including the International Cooperative Ataxia Scale (ICARS) score for quantifying Cerebellar ataxia. RESULTS Compared to controls, the sT1w/T2w ratio in the MCP was markedly lower in all (p < 0.001) MSA-C patients and 17 early (p < 0.001) MSA-C patients. The MCP sT1w/T2w ratio had high sensitivity (96%) and specificity (100%) to distinguish MSA-C from controls (area under the curve = 0.99), even for the early MSA-C group (area under the curve = 0.99; sensitivity = 94%, specificity = 100%). The MCP sT1w/T2w ratio correlated with the ICARS score in early MSA-C. CONCLUSIONS The sT1w/T2w ratio can detect MSA-C-related changes in the MCP, even in the early stages of the disorder, and could be a sensitive biomarker for MSA-C. KEY POINTS • The sT1w/T2w ratio can detect MSA-C-related changes in the Middle Cerebellar Peduncle, even in the early stages of the disorder. • The Middle Cerebellar Peduncle sT1w/T2w ratio correlated with a Cerebellar ataxia score in early MSA-C patients.
Alexander Radbruch - One of the best experts on this subject based on the ideXlab platform.
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pediatric brain no increased signal intensity in the dentate nucleus on unenhanced t1 weighted mr images after consecutive exposure to a macrocyclic gadolinium based contrast agent
Radiology, 2017Co-Authors: Robert Haase, Philipp Kickingereder, Alexander Radbruch, Philipp Baumer, Sebastian Bickelhaupt, Daniel Paech, Wolfgang WickAbstract:In our study, no significant increase of the dentate nucleus (DN)-to-pons or DN-to-Middle Cerebellar Peduncle ratio was found in 41 children after a mean of 8.6 consecutive intravenous injections of the macrocyclic gadolinium-based contrast agent gadoterate meglumine (0.1 mmol per kg body weight), with on average 4.5 months between each injection and a mean injected total gadolinium dose of 32.1 mmol.
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no signal intensity increase in the dentate nucleus on unenhanced t1 weighted mr images after more than 20 serial injections of macrocyclic gadolinium based contrast agents
Radiology, 2017Co-Authors: Robert Haase, Pascal J Kieslich, Lukas D Weberling, Philipp Kickingereder, Alexander Radbruch, Wolfgang WickAbstract:In our study, no increase of the dentate nucleus-to-pons or dentate nucleus-to-Middle Cerebellar Peduncle ratio was found after a mean of 23.0 serial injections of the macrocyclic gadolinium-based contrast agents gadobutrol and gadoterate meglumine, with on average 3 months between each injection and a mean injected total gadolinium dose of 245.6 mmol.
Atsuhiko Sugiyama - One of the best experts on this subject based on the ideXlab platform.
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Magnetic resonance T1w/T2w ratio in the Middle Cerebellar Peduncle might be a sensitive biomarker for multiple system atrophy.
European radiology, 2020Co-Authors: Atsuhiko Sugiyama, Hajime Yokota, Shigeki Hirano, Graham Cooper, Hiroki Mukai, Kyosuke Koide, Jiaqi Wang, Shoichi Ito, Carsten Finke, Alexander U BrandtAbstract:We aimed to investigate the use of a myelin-sensitive MRI contrast, the standardized T1-weighted/T2-weighted (sT1w/T2w) ratio, for detecting early changes in the Middle Cerebellar Peduncle (MCP) in Cerebellar subtype multiple system atrophy (MSA-C) patients. We included 28 MSA-C patients, including a subset of 17 MSA-C patients within 2 years of disease onset (early MSA-C), and 28 matched healthy controls. T1w and T2w scans were acquired using a 3-T MR system. The sT1w/T2w ratio in MCP was analyzed using SPM12 by utilizing a region-of-interest approach in normalized space. The diagnostic performance of the MCP sT1w/T2w ratio in discriminating MSA-C and the subgroup of early MSA-C from the matched controls was assessed. Correlation analyses were performed to evaluate the relationship between the MCP sT1w/T2w ratio and other clinical parameters including the International Cooperative Ataxia Scale (ICARS) score for quantifying Cerebellar ataxia. Compared to controls, the sT1w/T2w ratio in the MCP was markedly lower in all (p < 0.001) MSA-C patients and 17 early (p < 0.001) MSA-C patients. The MCP sT1w/T2w ratio had high sensitivity (96%) and specificity (100%) to distinguish MSA-C from controls (area under the curve = 0.99), even for the early MSA-C group (area under the curve = 0.99; sensitivity = 94%, specificity = 100%). The MCP sT1w/T2w ratio correlated with the ICARS score in early MSA-C. The sT1w/T2w ratio can detect MSA-C-related changes in the MCP, even in the early stages of the disorder, and could be a sensitive biomarker for MSA-C. • The sT1w/T2w ratio can detect MSA-C-related changes in the Middle Cerebellar Peduncle, even in the early stages of the disorder. • The Middle Cerebellar Peduncle sT1w/T2w ratio correlated with a Cerebellar ataxia score in early MSA-C patients.
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Magnetic resonance T1w/T2w ratio in the Middle Cerebellar Peduncle might be a sensitive biomarker for multiple system atrophy
European Radiology, 2020Co-Authors: Atsuhiko Sugiyama, Hajime Yokota, Shigeki Hirano, Graham Cooper, Hiroki Mukai, Kyosuke Koide, Jiaqi Wang, Shoichi Ito, Carsten Finke, Alexander U BrandtAbstract:Objective We aimed to investigate the use of a myelin-sensitive MRI contrast, the standardized T1-weighted/T2-weighted (sT1w/T2w) ratio, for detecting early changes in the Middle Cerebellar Peduncle (MCP) in Cerebellar subtype multiple system atrophy (MSA-C) patients. Methods We included 28 MSA-C patients, including a subset of 17 MSA-C patients within 2 years of disease onset (early MSA-C), and 28 matched healthy controls. T1w and T2w scans were acquired using a 3-T MR system. The sT1w/T2w ratio in MCP was analyzed using SPM12 by utilizing a region-of-interest approach in normalized space. The diagnostic performance of the MCP sT1w/T2w ratio in discriminating MSA-C and the subgroup of early MSA-C from the matched controls was assessed. Correlation analyses were performed to evaluate the relationship between the MCP sT1w/T2w ratio and other clinical parameters including the International Cooperative Ataxia Scale (ICARS) score for quantifying Cerebellar ataxia. Results Compared to controls, the sT1w/T2w ratio in the MCP was markedly lower in all ( p < 0.001) MSA-C patients and 17 early ( p < 0.001) MSA-C patients. The MCP sT1w/T2w ratio had high sensitivity (96%) and specificity (100%) to distinguish MSA-C from controls (area under the curve = 0.99), even for the early MSA-C group (area under the curve = 0.99; sensitivity = 94%, specificity = 100%). The MCP sT1w/T2w ratio correlated with the ICARS score in early MSA-C. Conclusions The sT1w/T2w ratio can detect MSA-C-related changes in the MCP, even in the early stages of the disorder, and could be a sensitive biomarker for MSA-C. Key Points • The sT1w/T2w ratio can detect MSA-C-related changes in the Middle Cerebellar Peduncle, even in the early stages of the disorder. • The Middle Cerebellar Peduncle sT1w/T2w ratio correlated with a Cerebellar ataxia score in early MSA-C patients.
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magnetic resonance t1w t2w ratio in the Middle Cerebellar Peduncle might be a sensitive biomarker for multiple system atrophy
European Radiology, 2020Co-Authors: Atsuhiko Sugiyama, Hajime Yokota, Shigeki Hirano, Graham Cooper, Hiroki Mukai, Kyosuke Koide, Jiaqi Wang, Shoichi Ito, Carsten FinkeAbstract:OBJECTIVE We aimed to investigate the use of a myelin-sensitive MRI contrast, the standardized T1-weighted/T2-weighted (sT1w/T2w) ratio, for detecting early changes in the Middle Cerebellar Peduncle (MCP) in Cerebellar subtype multiple system atrophy (MSA-C) patients. METHODS We included 28 MSA-C patients, including a subset of 17 MSA-C patients within 2 years of disease onset (early MSA-C), and 28 matched healthy controls. T1w and T2w scans were acquired using a 3-T MR system. The sT1w/T2w ratio in MCP was analyzed using SPM12 by utilizing a region-of-interest approach in normalized space. The diagnostic performance of the MCP sT1w/T2w ratio in discriminating MSA-C and the subgroup of early MSA-C from the matched controls was assessed. Correlation analyses were performed to evaluate the relationship between the MCP sT1w/T2w ratio and other clinical parameters including the International Cooperative Ataxia Scale (ICARS) score for quantifying Cerebellar ataxia. RESULTS Compared to controls, the sT1w/T2w ratio in the MCP was markedly lower in all (p < 0.001) MSA-C patients and 17 early (p < 0.001) MSA-C patients. The MCP sT1w/T2w ratio had high sensitivity (96%) and specificity (100%) to distinguish MSA-C from controls (area under the curve = 0.99), even for the early MSA-C group (area under the curve = 0.99; sensitivity = 94%, specificity = 100%). The MCP sT1w/T2w ratio correlated with the ICARS score in early MSA-C. CONCLUSIONS The sT1w/T2w ratio can detect MSA-C-related changes in the MCP, even in the early stages of the disorder, and could be a sensitive biomarker for MSA-C. KEY POINTS • The sT1w/T2w ratio can detect MSA-C-related changes in the Middle Cerebellar Peduncle, even in the early stages of the disorder. • The Middle Cerebellar Peduncle sT1w/T2w ratio correlated with a Cerebellar ataxia score in early MSA-C patients.
Alexander U Brandt - One of the best experts on this subject based on the ideXlab platform.
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Magnetic resonance T1w/T2w ratio in the Middle Cerebellar Peduncle might be a sensitive biomarker for multiple system atrophy.
European radiology, 2020Co-Authors: Atsuhiko Sugiyama, Hajime Yokota, Shigeki Hirano, Graham Cooper, Hiroki Mukai, Kyosuke Koide, Jiaqi Wang, Shoichi Ito, Carsten Finke, Alexander U BrandtAbstract:We aimed to investigate the use of a myelin-sensitive MRI contrast, the standardized T1-weighted/T2-weighted (sT1w/T2w) ratio, for detecting early changes in the Middle Cerebellar Peduncle (MCP) in Cerebellar subtype multiple system atrophy (MSA-C) patients. We included 28 MSA-C patients, including a subset of 17 MSA-C patients within 2 years of disease onset (early MSA-C), and 28 matched healthy controls. T1w and T2w scans were acquired using a 3-T MR system. The sT1w/T2w ratio in MCP was analyzed using SPM12 by utilizing a region-of-interest approach in normalized space. The diagnostic performance of the MCP sT1w/T2w ratio in discriminating MSA-C and the subgroup of early MSA-C from the matched controls was assessed. Correlation analyses were performed to evaluate the relationship between the MCP sT1w/T2w ratio and other clinical parameters including the International Cooperative Ataxia Scale (ICARS) score for quantifying Cerebellar ataxia. Compared to controls, the sT1w/T2w ratio in the MCP was markedly lower in all (p < 0.001) MSA-C patients and 17 early (p < 0.001) MSA-C patients. The MCP sT1w/T2w ratio had high sensitivity (96%) and specificity (100%) to distinguish MSA-C from controls (area under the curve = 0.99), even for the early MSA-C group (area under the curve = 0.99; sensitivity = 94%, specificity = 100%). The MCP sT1w/T2w ratio correlated with the ICARS score in early MSA-C. The sT1w/T2w ratio can detect MSA-C-related changes in the MCP, even in the early stages of the disorder, and could be a sensitive biomarker for MSA-C. • The sT1w/T2w ratio can detect MSA-C-related changes in the Middle Cerebellar Peduncle, even in the early stages of the disorder. • The Middle Cerebellar Peduncle sT1w/T2w ratio correlated with a Cerebellar ataxia score in early MSA-C patients.
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Magnetic resonance T1w/T2w ratio in the Middle Cerebellar Peduncle might be a sensitive biomarker for multiple system atrophy
European Radiology, 2020Co-Authors: Atsuhiko Sugiyama, Hajime Yokota, Shigeki Hirano, Graham Cooper, Hiroki Mukai, Kyosuke Koide, Jiaqi Wang, Shoichi Ito, Carsten Finke, Alexander U BrandtAbstract:Objective We aimed to investigate the use of a myelin-sensitive MRI contrast, the standardized T1-weighted/T2-weighted (sT1w/T2w) ratio, for detecting early changes in the Middle Cerebellar Peduncle (MCP) in Cerebellar subtype multiple system atrophy (MSA-C) patients. Methods We included 28 MSA-C patients, including a subset of 17 MSA-C patients within 2 years of disease onset (early MSA-C), and 28 matched healthy controls. T1w and T2w scans were acquired using a 3-T MR system. The sT1w/T2w ratio in MCP was analyzed using SPM12 by utilizing a region-of-interest approach in normalized space. The diagnostic performance of the MCP sT1w/T2w ratio in discriminating MSA-C and the subgroup of early MSA-C from the matched controls was assessed. Correlation analyses were performed to evaluate the relationship between the MCP sT1w/T2w ratio and other clinical parameters including the International Cooperative Ataxia Scale (ICARS) score for quantifying Cerebellar ataxia. Results Compared to controls, the sT1w/T2w ratio in the MCP was markedly lower in all ( p < 0.001) MSA-C patients and 17 early ( p < 0.001) MSA-C patients. The MCP sT1w/T2w ratio had high sensitivity (96%) and specificity (100%) to distinguish MSA-C from controls (area under the curve = 0.99), even for the early MSA-C group (area under the curve = 0.99; sensitivity = 94%, specificity = 100%). The MCP sT1w/T2w ratio correlated with the ICARS score in early MSA-C. Conclusions The sT1w/T2w ratio can detect MSA-C-related changes in the MCP, even in the early stages of the disorder, and could be a sensitive biomarker for MSA-C. Key Points • The sT1w/T2w ratio can detect MSA-C-related changes in the Middle Cerebellar Peduncle, even in the early stages of the disorder. • The Middle Cerebellar Peduncle sT1w/T2w ratio correlated with a Cerebellar ataxia score in early MSA-C patients.
Wolfgang Wick - One of the best experts on this subject based on the ideXlab platform.
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pediatric brain no increased signal intensity in the dentate nucleus on unenhanced t1 weighted mr images after consecutive exposure to a macrocyclic gadolinium based contrast agent
Radiology, 2017Co-Authors: Robert Haase, Philipp Kickingereder, Alexander Radbruch, Philipp Baumer, Sebastian Bickelhaupt, Daniel Paech, Wolfgang WickAbstract:In our study, no significant increase of the dentate nucleus (DN)-to-pons or DN-to-Middle Cerebellar Peduncle ratio was found in 41 children after a mean of 8.6 consecutive intravenous injections of the macrocyclic gadolinium-based contrast agent gadoterate meglumine (0.1 mmol per kg body weight), with on average 4.5 months between each injection and a mean injected total gadolinium dose of 32.1 mmol.
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no signal intensity increase in the dentate nucleus on unenhanced t1 weighted mr images after more than 20 serial injections of macrocyclic gadolinium based contrast agents
Radiology, 2017Co-Authors: Robert Haase, Pascal J Kieslich, Lukas D Weberling, Philipp Kickingereder, Alexander Radbruch, Wolfgang WickAbstract:In our study, no increase of the dentate nucleus-to-pons or dentate nucleus-to-Middle Cerebellar Peduncle ratio was found after a mean of 23.0 serial injections of the macrocyclic gadolinium-based contrast agents gadobutrol and gadoterate meglumine, with on average 3 months between each injection and a mean injected total gadolinium dose of 245.6 mmol.