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Molly E Steed - One of the best experts on this subject based on the ideXlab platform.

  • vancomycin 24 hour area under the curve Minimum Bactericidal Concentration ratio as a novel predictor of mortality in methicillin resistant staphylococcus aureus bacteremia
    Antimicrobial Agents and Chemotherapy, 2016
    Co-Authors: Nicholas S Britt, Nimish Patel, Rebecca T Horvat, Molly E Steed
    Abstract:

    ABSTRACT While previous studies have examined the association between vancomycin (VAN) exposure and MIC with regard to outcomes in methicillin-resistant Staphylococcus aureus bacteremia (MRSA-B), none have explored if a relationship exists with the VAN Minimum Bactericidal Concentration (MBC). The objective of this study was to evaluate the VAN 24-h area under the curve (AUC 24 )/MBC ratio as a pharmacodynamic predictor of mortality. This retrospective cohort study included patients treated with VAN for MRSA-B with the primary outcome of 30-day all-cause mortality. Data collected included patient demographics, comorbidities, antimicrobial treatment data, therapeutic drug levels, and laboratory and microbiological data. Vancomycin MICs and MBCs were determined by Etest (MIC only) and broth microdilution (BMD). The vancomycin AUC 24 was determined by pharmacokinetic maximum a posteriori probability Bayesian (MAP-Bayesian) analysis. The most significant breakpoint for 30-day mortality was determined by classification and regression tree (CART) analysis. The association between pharmacodynamic parameters (VAN AUC 24 /MIC BMD , VAN AUC 24 /MIC Etest , and AUC 24 /MBC BMD ) and mortality were determined by χ 2 and multivariable Poisson regression. Overall mortality in this cohort ( n = 53) was 20.8% ( n = 11/53), and all corresponding MRSA blood isolates were VAN susceptible (MIC range, 0.5 to 2 μg/ml; MIC 50 , 1 μg/ml; MIC 90 , 1 μg/ml). The CART-derived breakpoints for mortality were 176 (VAN AUC 24 /MBC) and 334 (VAN AUC 24 /MIC BMD ). In multivariable analysis, the association between a VAN AUC 24 /MBC of ≥176 and survival persisted, but VAN AUC 24 /MIC BMD values (≥334 or ≥400) were not associated with improved mortality. In conclusion, VAN AUC 24 /MBC was a more important predictor of 30-day mortality than VAN AUC 24 /MIC for MRSA-B.

  • Vancomycin 24-Hour Area under the Curve/Minimum Bactericidal Concentration Ratio as a Novel Predictor of Mortality in Methicillin-Resistant Staphylococcus aureus Bacteremia.
    Antimicrobial Agents and Chemotherapy, 2016
    Co-Authors: Nicholas S Britt, Nimish Patel, Rebecca T Horvat, Molly E Steed
    Abstract:

    While previous studies have examined the association between vancomycin (VAN) exposure and MIC with regard to outcomes in methicillin-resistant Staphylococcus aureus bacteremia (MRSA-B), none have explored if a relationship exists with the VAN Minimum Bactericidal Concentration (MBC). The objective of this study was to evaluate the VAN 24-h area under the curve (AUC24)/MBC ratio as a pharmacodynamic predictor of mortality. This retrospective cohort study included patients treated with VAN for MRSA-B with the primary outcome of 30-day all-cause mortality. Data collected included patient demographics, comorbidities, antimicrobial treatment data, therapeutic drug levels, and laboratory and microbiological data. Vancomycin MICs and MBCs were determined by Etest (MIC only) and broth microdilution (BMD). The vancomycin AUC24 was determined by pharmacokinetic maximum a posteriori probability Bayesian (MAP-Bayesian) analysis. The most significant breakpoint for 30-day mortality was determined by classification and regression tree (CART) analysis. The association between pharmacodynamic parameters (VAN AUC24/MICBMD, VAN AUC24/MICEtest, and AUC24/MBCBMD) and mortality were determined by χ(2) and multivariable Poisson regression. Overall mortality in this cohort (n = 53) was 20.8% (n = 11/53), and all corresponding MRSA blood isolates were VAN susceptible (MIC range, 0.5 to 2 μg/ml; MIC50, 1 μg/ml; MIC90, 1 μg/ml). The CART-derived breakpoints for mortality were 176 (VAN AUC24/MBC) and 334 (VAN AUC24/MICBMD). In multivariable analysis, the association between a VAN AUC24/MBC of ≥176 and survival persisted, but VAN AUC24/MICBMD values (≥334 or ≥400) were not associated with improved mortality. In conclusion, VAN AUC24/MBC was a more important predictor of 30-day mortality than VAN AUC24/MIC for MRSA-B.

Ratih Dewi Dwiyanti - One of the best experts on this subject based on the ideXlab platform.

  • Inhibition Strength of Rosella (Hibiscus sabdariffa L.) Boiled Water on Salmonella typhi in vitro
    Tropical Health and Medical Research, 2019
    Co-Authors: Ayu Sutiany, Ratih Dewi Dwiyanti, Neni Oktiyani
    Abstract:

    Rosella (Hibiscus sabdariffa L.) is a plant that can use as herbal medicine. Roselle calyx contains active compounds flavonoids, saponins, and tannins. These compounds can use as an antibacterial against Salmonella typhi. This study aims to determine the Minimum Inhibitory Concentration and Minimum Bactericidal Concentration and the effect of rosella cooking water Concentration on Salmonella typhi in vitro. Experimental research with posttest only controls group design through dilution method. The results of the Minimum Inhibitory Concentration (MIC) study showed clarity at Concentrations of 60%, 70%, 80%, 90%, and 100%. Minimum Bactericidal Concentration (MBC) results obtained the number of colonies at a Concentration of 60% by one colony, at a level of 70%, 80%, 90%, and 100% showed no colony growth. Based on the results of the study concluded that there was an influence of rosella cooking water Concentration on the growth of Salmonella typhi in vitro.

  • Effectiveness of Cinnamon (Cinnamomum burmannii) Ethanol Extract Against Staphylococcus aureus Growth
    Tropical Health and Medical Research, 2019
    Co-Authors: Nurul Huda, Ratih Dewi Dwiyanti, Anny Thuraidah
    Abstract:

    Cinnamon (Cinnamomum burmannii) is widely used by the public as a food ingredient and contains chemical compounds such as alkaloids, flavonoids, polyphenols, saponins, and terpenoids which function as an antibacterial against Staphylococcus aureus. This study aims to determine the Minimum Inhibitory Concentration and Minimum Bactericidal Concentration of cinnamon ethanol extract on Staphyloccocus aureus. This research is experimental with posttest only control group design through the tube dilution method. The results of the Minimum Inhibitory Concentration (MIC) study showed no clarity at Concentrations of 30% and 40%. The results of the Minimum Bactericidal Concentration (MBC) obtained the number of colonies at a level of 10% by 51 CFU / plate, 20% by 27 CFU / plate, 30% by 6 CFU / plate and 40% by 0 CFU / plate. Based on the results of this study concluded that MIC cinnamon ethanol extract was 30%, and MBC cinnamon ethanol extract was 40%.

  • Effect Minimum Inhibitory Concentration and Minimum Bactericidal Concentration of Honey Bee Trigona spp on Streptococcus pyogenes
    Indian Journal of Public Health Research and Development, 2019
    Co-Authors: Ratih Dewi Dwiyanti, Yulia Tri Andini, Leka Lutpiatina
    Abstract:

    Streptococcus pyogenes one cause of respiratory tract infections including pharyngitis. Seventy-three percent of doctors prescribe antibiotics for pharyngitis. In developing countries, antibiotics are prescribed for 44–97% of hospitalized patients, sometimes with inappropriate doses. Improper antibiotic use can cause side effects such as allergies or diarrhea, increase health care costs, and increase the possibility of selection for antibiotic resistance. Research needs to be done on natural antibiotics found in natural ingredients. One of the natural ingredients empirically has many properties and is relatively safe is honey from bees. Honey has substances that are Bactericidal and bacteriostatic like antibiotics. This study aimed Minimum inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) honey bee Trigona spp against Streptococcus pyogenes in vitro. In Concentration of 2.5%, 5%, 7.5%, 10%, and 12, 5% and knowing the effect of honey bee Trigona spp with a Concentration of 2.5%, 5%, 7.5%, 10%, and 12.5% against Streptococcus pyogenes in vitro. Type of research is the experiment with the Posttest-Only Control Group Design, the research material of honey from Trigona spp independent variable is the Concentration of honeybees Trigona spp. The dependent variable is the level of turbidity produced in a tube to measure MIC and the number of colonies Streptococcus pyogenes on Blood Agar Plate media to measure MBC. The results of the MIC determination showed that all Concentrations showed clear, MBC results the largest number of colonies occurred at a Concentration of 2.5% of the total colony colonies and colonies growth the smallest occurred at a Concentration of 10% of the number of colonies 0 colonies, Conclusions of MIC cone honey bee Trigona spp against bacteria Streptococcus pyogenes occurred at a Concentration of 2.5%., MBC moth honey Trigona spp against bacteria Streptococcus pyogenes occurred at a Concentration of 10%. There is an influence of the honey Trigona spp on the bacteria Streptococcus pyogenes, which is indicated by the value of p

  • effect Minimum inhibitory Concentration and Minimum Bactericidal Concentration of honey bee trigona spp on streptococcus pyogenes
    Indian Journal of Public Health Research and Development, 2019
    Co-Authors: Ratih Dewi Dwiyanti, Yulia Tri Andini, Leka Lutpiatina
    Abstract:

    Streptococcus pyogenes one cause of respiratory tract infections including pharyngitis. Seventy-three percent of doctors prescribe antibiotics for pharyngitis. In developing countries, antibiotics are prescribed for 44–97% of hospitalized patients, sometimes with inappropriate doses. Improper antibiotic use can cause side effects such as allergies or diarrhea, increase health care costs, and increase the possibility of selection for antibiotic resistance. Research needs to be done on natural antibiotics found in natural ingredients. One of the natural ingredients empirically has many properties and is relatively safe is honey from bees. Honey has substances that are Bactericidal and bacteriostatic like antibiotics. This study aimed Minimum inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) honey bee Trigona spp against Streptococcus pyogenes in vitro. In Concentration of 2.5%, 5%, 7.5%, 10%, and 12, 5% and knowing the effect of honey bee Trigona spp with a Concentration of 2.5%, 5%, 7.5%, 10%, and 12.5% against Streptococcus pyogenes in vitro. Type of research is the experiment with the Posttest-Only Control Group Design, the research material of honey from Trigona spp independent variable is the Concentration of honeybees Trigona spp. The dependent variable is the level of turbidity produced in a tube to measure MIC and the number of colonies Streptococcus pyogenes on Blood Agar Plate media to measure MBC. The results of the MIC determination showed that all Concentrations showed clear, MBC results the largest number of colonies occurred at a Concentration of 2.5% of the total colony colonies and colonies growth the smallest occurred at a Concentration of 10% of the number of colonies 0 colonies, Conclusions of MIC cone honey bee Trigona spp against bacteria Streptococcus pyogenes occurred at a Concentration of 2.5%., MBC moth honey Trigona spp against bacteria Streptococcus pyogenes occurred at a Concentration of 10%. There is an influence of the honey Trigona spp on the bacteria Streptococcus pyogenes, which is indicated by the value of p <0.05, which is 0, 000 using the Linear Regression test.

Nicholas S Britt - One of the best experts on this subject based on the ideXlab platform.

  • vancomycin 24 hour area under the curve Minimum Bactericidal Concentration ratio as a novel predictor of mortality in methicillin resistant staphylococcus aureus bacteremia
    Antimicrobial Agents and Chemotherapy, 2016
    Co-Authors: Nicholas S Britt, Nimish Patel, Rebecca T Horvat, Molly E Steed
    Abstract:

    ABSTRACT While previous studies have examined the association between vancomycin (VAN) exposure and MIC with regard to outcomes in methicillin-resistant Staphylococcus aureus bacteremia (MRSA-B), none have explored if a relationship exists with the VAN Minimum Bactericidal Concentration (MBC). The objective of this study was to evaluate the VAN 24-h area under the curve (AUC 24 )/MBC ratio as a pharmacodynamic predictor of mortality. This retrospective cohort study included patients treated with VAN for MRSA-B with the primary outcome of 30-day all-cause mortality. Data collected included patient demographics, comorbidities, antimicrobial treatment data, therapeutic drug levels, and laboratory and microbiological data. Vancomycin MICs and MBCs were determined by Etest (MIC only) and broth microdilution (BMD). The vancomycin AUC 24 was determined by pharmacokinetic maximum a posteriori probability Bayesian (MAP-Bayesian) analysis. The most significant breakpoint for 30-day mortality was determined by classification and regression tree (CART) analysis. The association between pharmacodynamic parameters (VAN AUC 24 /MIC BMD , VAN AUC 24 /MIC Etest , and AUC 24 /MBC BMD ) and mortality were determined by χ 2 and multivariable Poisson regression. Overall mortality in this cohort ( n = 53) was 20.8% ( n = 11/53), and all corresponding MRSA blood isolates were VAN susceptible (MIC range, 0.5 to 2 μg/ml; MIC 50 , 1 μg/ml; MIC 90 , 1 μg/ml). The CART-derived breakpoints for mortality were 176 (VAN AUC 24 /MBC) and 334 (VAN AUC 24 /MIC BMD ). In multivariable analysis, the association between a VAN AUC 24 /MBC of ≥176 and survival persisted, but VAN AUC 24 /MIC BMD values (≥334 or ≥400) were not associated with improved mortality. In conclusion, VAN AUC 24 /MBC was a more important predictor of 30-day mortality than VAN AUC 24 /MIC for MRSA-B.

  • Vancomycin 24-Hour Area under the Curve/Minimum Bactericidal Concentration Ratio as a Novel Predictor of Mortality in Methicillin-Resistant Staphylococcus aureus Bacteremia.
    Antimicrobial Agents and Chemotherapy, 2016
    Co-Authors: Nicholas S Britt, Nimish Patel, Rebecca T Horvat, Molly E Steed
    Abstract:

    While previous studies have examined the association between vancomycin (VAN) exposure and MIC with regard to outcomes in methicillin-resistant Staphylococcus aureus bacteremia (MRSA-B), none have explored if a relationship exists with the VAN Minimum Bactericidal Concentration (MBC). The objective of this study was to evaluate the VAN 24-h area under the curve (AUC24)/MBC ratio as a pharmacodynamic predictor of mortality. This retrospective cohort study included patients treated with VAN for MRSA-B with the primary outcome of 30-day all-cause mortality. Data collected included patient demographics, comorbidities, antimicrobial treatment data, therapeutic drug levels, and laboratory and microbiological data. Vancomycin MICs and MBCs were determined by Etest (MIC only) and broth microdilution (BMD). The vancomycin AUC24 was determined by pharmacokinetic maximum a posteriori probability Bayesian (MAP-Bayesian) analysis. The most significant breakpoint for 30-day mortality was determined by classification and regression tree (CART) analysis. The association between pharmacodynamic parameters (VAN AUC24/MICBMD, VAN AUC24/MICEtest, and AUC24/MBCBMD) and mortality were determined by χ(2) and multivariable Poisson regression. Overall mortality in this cohort (n = 53) was 20.8% (n = 11/53), and all corresponding MRSA blood isolates were VAN susceptible (MIC range, 0.5 to 2 μg/ml; MIC50, 1 μg/ml; MIC90, 1 μg/ml). The CART-derived breakpoints for mortality were 176 (VAN AUC24/MBC) and 334 (VAN AUC24/MICBMD). In multivariable analysis, the association between a VAN AUC24/MBC of ≥176 and survival persisted, but VAN AUC24/MICBMD values (≥334 or ≥400) were not associated with improved mortality. In conclusion, VAN AUC24/MBC was a more important predictor of 30-day mortality than VAN AUC24/MIC for MRSA-B.

Leka Lutpiatina - One of the best experts on this subject based on the ideXlab platform.

  • Effect Minimum Inhibitory Concentration and Minimum Bactericidal Concentration of Honey Bee Trigona spp on Streptococcus pyogenes
    Indian Journal of Public Health Research and Development, 2019
    Co-Authors: Ratih Dewi Dwiyanti, Yulia Tri Andini, Leka Lutpiatina
    Abstract:

    Streptococcus pyogenes one cause of respiratory tract infections including pharyngitis. Seventy-three percent of doctors prescribe antibiotics for pharyngitis. In developing countries, antibiotics are prescribed for 44–97% of hospitalized patients, sometimes with inappropriate doses. Improper antibiotic use can cause side effects such as allergies or diarrhea, increase health care costs, and increase the possibility of selection for antibiotic resistance. Research needs to be done on natural antibiotics found in natural ingredients. One of the natural ingredients empirically has many properties and is relatively safe is honey from bees. Honey has substances that are Bactericidal and bacteriostatic like antibiotics. This study aimed Minimum inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) honey bee Trigona spp against Streptococcus pyogenes in vitro. In Concentration of 2.5%, 5%, 7.5%, 10%, and 12, 5% and knowing the effect of honey bee Trigona spp with a Concentration of 2.5%, 5%, 7.5%, 10%, and 12.5% against Streptococcus pyogenes in vitro. Type of research is the experiment with the Posttest-Only Control Group Design, the research material of honey from Trigona spp independent variable is the Concentration of honeybees Trigona spp. The dependent variable is the level of turbidity produced in a tube to measure MIC and the number of colonies Streptococcus pyogenes on Blood Agar Plate media to measure MBC. The results of the MIC determination showed that all Concentrations showed clear, MBC results the largest number of colonies occurred at a Concentration of 2.5% of the total colony colonies and colonies growth the smallest occurred at a Concentration of 10% of the number of colonies 0 colonies, Conclusions of MIC cone honey bee Trigona spp against bacteria Streptococcus pyogenes occurred at a Concentration of 2.5%., MBC moth honey Trigona spp against bacteria Streptococcus pyogenes occurred at a Concentration of 10%. There is an influence of the honey Trigona spp on the bacteria Streptococcus pyogenes, which is indicated by the value of p

  • effect Minimum inhibitory Concentration and Minimum Bactericidal Concentration of honey bee trigona spp on streptococcus pyogenes
    Indian Journal of Public Health Research and Development, 2019
    Co-Authors: Ratih Dewi Dwiyanti, Yulia Tri Andini, Leka Lutpiatina
    Abstract:

    Streptococcus pyogenes one cause of respiratory tract infections including pharyngitis. Seventy-three percent of doctors prescribe antibiotics for pharyngitis. In developing countries, antibiotics are prescribed for 44–97% of hospitalized patients, sometimes with inappropriate doses. Improper antibiotic use can cause side effects such as allergies or diarrhea, increase health care costs, and increase the possibility of selection for antibiotic resistance. Research needs to be done on natural antibiotics found in natural ingredients. One of the natural ingredients empirically has many properties and is relatively safe is honey from bees. Honey has substances that are Bactericidal and bacteriostatic like antibiotics. This study aimed Minimum inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) honey bee Trigona spp against Streptococcus pyogenes in vitro. In Concentration of 2.5%, 5%, 7.5%, 10%, and 12, 5% and knowing the effect of honey bee Trigona spp with a Concentration of 2.5%, 5%, 7.5%, 10%, and 12.5% against Streptococcus pyogenes in vitro. Type of research is the experiment with the Posttest-Only Control Group Design, the research material of honey from Trigona spp independent variable is the Concentration of honeybees Trigona spp. The dependent variable is the level of turbidity produced in a tube to measure MIC and the number of colonies Streptococcus pyogenes on Blood Agar Plate media to measure MBC. The results of the MIC determination showed that all Concentrations showed clear, MBC results the largest number of colonies occurred at a Concentration of 2.5% of the total colony colonies and colonies growth the smallest occurred at a Concentration of 10% of the number of colonies 0 colonies, Conclusions of MIC cone honey bee Trigona spp against bacteria Streptococcus pyogenes occurred at a Concentration of 2.5%., MBC moth honey Trigona spp against bacteria Streptococcus pyogenes occurred at a Concentration of 10%. There is an influence of the honey Trigona spp on the bacteria Streptococcus pyogenes, which is indicated by the value of p <0.05, which is 0, 000 using the Linear Regression test.

Nimish Patel - One of the best experts on this subject based on the ideXlab platform.

  • vancomycin 24 hour area under the curve Minimum Bactericidal Concentration ratio as a novel predictor of mortality in methicillin resistant staphylococcus aureus bacteremia
    Antimicrobial Agents and Chemotherapy, 2016
    Co-Authors: Nicholas S Britt, Nimish Patel, Rebecca T Horvat, Molly E Steed
    Abstract:

    ABSTRACT While previous studies have examined the association between vancomycin (VAN) exposure and MIC with regard to outcomes in methicillin-resistant Staphylococcus aureus bacteremia (MRSA-B), none have explored if a relationship exists with the VAN Minimum Bactericidal Concentration (MBC). The objective of this study was to evaluate the VAN 24-h area under the curve (AUC 24 )/MBC ratio as a pharmacodynamic predictor of mortality. This retrospective cohort study included patients treated with VAN for MRSA-B with the primary outcome of 30-day all-cause mortality. Data collected included patient demographics, comorbidities, antimicrobial treatment data, therapeutic drug levels, and laboratory and microbiological data. Vancomycin MICs and MBCs were determined by Etest (MIC only) and broth microdilution (BMD). The vancomycin AUC 24 was determined by pharmacokinetic maximum a posteriori probability Bayesian (MAP-Bayesian) analysis. The most significant breakpoint for 30-day mortality was determined by classification and regression tree (CART) analysis. The association between pharmacodynamic parameters (VAN AUC 24 /MIC BMD , VAN AUC 24 /MIC Etest , and AUC 24 /MBC BMD ) and mortality were determined by χ 2 and multivariable Poisson regression. Overall mortality in this cohort ( n = 53) was 20.8% ( n = 11/53), and all corresponding MRSA blood isolates were VAN susceptible (MIC range, 0.5 to 2 μg/ml; MIC 50 , 1 μg/ml; MIC 90 , 1 μg/ml). The CART-derived breakpoints for mortality were 176 (VAN AUC 24 /MBC) and 334 (VAN AUC 24 /MIC BMD ). In multivariable analysis, the association between a VAN AUC 24 /MBC of ≥176 and survival persisted, but VAN AUC 24 /MIC BMD values (≥334 or ≥400) were not associated with improved mortality. In conclusion, VAN AUC 24 /MBC was a more important predictor of 30-day mortality than VAN AUC 24 /MIC for MRSA-B.

  • Vancomycin 24-Hour Area under the Curve/Minimum Bactericidal Concentration Ratio as a Novel Predictor of Mortality in Methicillin-Resistant Staphylococcus aureus Bacteremia.
    Antimicrobial Agents and Chemotherapy, 2016
    Co-Authors: Nicholas S Britt, Nimish Patel, Rebecca T Horvat, Molly E Steed
    Abstract:

    While previous studies have examined the association between vancomycin (VAN) exposure and MIC with regard to outcomes in methicillin-resistant Staphylococcus aureus bacteremia (MRSA-B), none have explored if a relationship exists with the VAN Minimum Bactericidal Concentration (MBC). The objective of this study was to evaluate the VAN 24-h area under the curve (AUC24)/MBC ratio as a pharmacodynamic predictor of mortality. This retrospective cohort study included patients treated with VAN for MRSA-B with the primary outcome of 30-day all-cause mortality. Data collected included patient demographics, comorbidities, antimicrobial treatment data, therapeutic drug levels, and laboratory and microbiological data. Vancomycin MICs and MBCs were determined by Etest (MIC only) and broth microdilution (BMD). The vancomycin AUC24 was determined by pharmacokinetic maximum a posteriori probability Bayesian (MAP-Bayesian) analysis. The most significant breakpoint for 30-day mortality was determined by classification and regression tree (CART) analysis. The association between pharmacodynamic parameters (VAN AUC24/MICBMD, VAN AUC24/MICEtest, and AUC24/MBCBMD) and mortality were determined by χ(2) and multivariable Poisson regression. Overall mortality in this cohort (n = 53) was 20.8% (n = 11/53), and all corresponding MRSA blood isolates were VAN susceptible (MIC range, 0.5 to 2 μg/ml; MIC50, 1 μg/ml; MIC90, 1 μg/ml). The CART-derived breakpoints for mortality were 176 (VAN AUC24/MBC) and 334 (VAN AUC24/MICBMD). In multivariable analysis, the association between a VAN AUC24/MBC of ≥176 and survival persisted, but VAN AUC24/MICBMD values (≥334 or ≥400) were not associated with improved mortality. In conclusion, VAN AUC24/MBC was a more important predictor of 30-day mortality than VAN AUC24/MIC for MRSA-B.