The Experts below are selected from a list of 294 Experts worldwide ranked by ideXlab platform
Willehad Boemke - One of the best experts on this subject based on the ideXlab platform.
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Angiotensin-converting enzyme inhibition and blood pressure response during total intravenous anaesthesia for Minor Surgery
Acta anaesthesiologica Scandinavica, 2011Co-Authors: E. Schulte, D. Ziegler, C. Philippi-höhne, Gabriele Kaczmarczyk, Willehad BoemkeAbstract:Background: This study investigates whether long-term treatment with an angiotensin-converting enzyme inhibitor (ACEI) impairs the haemodynamic regulation during total intravenous anaesthesia (TIVA) for Minor Surgery. Methods: In a prospective, two-armed observational study, 36 patients undergoing TIVA for Minor Surgery were studied. Seventeen were taking ACEIs regularly but no other antihypertensive medication (ACEI group); 19 patients without any cardiovascular medication served as controls (non-ACEI group). Haemodynamic variables were measured every minute during induction and every 5 min during Surgery. The plasma levels of renin, angiotensin II, vasopressin and catecholamines were measured before and 18 min after the induction of anaesthesia. Results: The mean arterial pressure decreased to the same extent in both the groups during the induction of TIVA. There were also no differences between the groups regarding the heart rate, systolic and diastolic arterial pressure, as well as the use of vasoconstrictors, and fluids during induction and throughout Surgery. In the ACEI group, the plasma renin concentration was higher at baseline and after the induction of anaesthesia presumably due to the interruption of the negative renin–angiotensin feedback loop (P
S. Liukko-sipi - One of the best experts on this subject based on the ideXlab platform.
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Propofol infusion anaesthesia and immune response in Minor Surgery
Anaesthesia, 1994Co-Authors: C.-o. Pirttikangas, J. Perttilä, Matti Salo, O. Vainio, S. Liukko-sipiAbstract:Summary This study was set up to evaluate the effects of propofol infusion anaesthesia on immunological function in Minor Surgery. Twenty-seven patients (median age 51 years, ASA 1-2) scheduled for Minor breast Surgery were randomly assigned to two groups. Anaesthesia was induced in group 1 with propofol 2.5 mg.kg-1 and maintained with propofol 12 mg.kg-1.h-1 and 30% O2 in air, whereas in group 2 anaesthesia was induced with thiopentone 4 mg.kg-1 and maintained with 70% N2O in O2. Fentanyl and vecuronium were used in both groups. The percentages of T cells (p < 0.001), B cells (p < 0.01) and memory T cells increased (p < 0.01) in both groups. T helper cell percentages increased in the propofol but not in the thiopentone group (p < 0.05). The percentages of natural killer cells decreased from pre-induction values in both groups (p < 0.001). No changes were seen in lymphocyte proliferative responses. Minor breast Surgery under propofol or conventional combined anaesthesia had only Minor effects on the immune response. The higher percentage of T helper cells after propofol anaesthesia compared to conventional combined anaesthesia is beneficial, but its clinical importance remains to be determined.
Uriel Martinowitz - One of the best experts on this subject based on the ideXlab platform.
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Home therapy with continuous infusion of factor VIII after Minor Surgery or serious haemorrhage.
Haemophilia, 1996Co-Authors: David Varon, Sam Schulman, D. Bashari, Uriel MartinowitzAbstract:Summary. Administration of factor VIII (F VIII) concentrates by continuous infusion is now routinely used at several haemophilia centers but almost exclusively for hospitalized patients. We evaluated various aspects of home therapy with continuous infusion of an immunoaffinity purified F VIII concentrate (Monoclate P®, Armour) in patients who would normally have been treated with high doses in bolus injections or with continuous infusion as in-patients. Twenty haemophilia A patients, eight after Minor Surgery and 12 for serious haemorrhage, received continuous infusion with undiluted F VIII by a minipump for a mean of 0.9 days in the hospital, followed by 3.3 days at home. Infusion bags were exchanged every 2.5 days. No haemorrhagic complications occurred, and five haemorrhages that had been resistant to treatment with bolus injections responded promptly to the continuous infusion. There were no technical problems and patient compliance and acceptance was good. We find this mode of therapy safe, efficacious and convenient for the patients as well as for the staff.
E. Schulte - One of the best experts on this subject based on the ideXlab platform.
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Angiotensin-converting enzyme inhibition and blood pressure response during total intravenous anaesthesia for Minor Surgery
Acta anaesthesiologica Scandinavica, 2011Co-Authors: E. Schulte, D. Ziegler, C. Philippi-höhne, Gabriele Kaczmarczyk, Willehad BoemkeAbstract:Background: This study investigates whether long-term treatment with an angiotensin-converting enzyme inhibitor (ACEI) impairs the haemodynamic regulation during total intravenous anaesthesia (TIVA) for Minor Surgery. Methods: In a prospective, two-armed observational study, 36 patients undergoing TIVA for Minor Surgery were studied. Seventeen were taking ACEIs regularly but no other antihypertensive medication (ACEI group); 19 patients without any cardiovascular medication served as controls (non-ACEI group). Haemodynamic variables were measured every minute during induction and every 5 min during Surgery. The plasma levels of renin, angiotensin II, vasopressin and catecholamines were measured before and 18 min after the induction of anaesthesia. Results: The mean arterial pressure decreased to the same extent in both the groups during the induction of TIVA. There were also no differences between the groups regarding the heart rate, systolic and diastolic arterial pressure, as well as the use of vasoconstrictors, and fluids during induction and throughout Surgery. In the ACEI group, the plasma renin concentration was higher at baseline and after the induction of anaesthesia presumably due to the interruption of the negative renin–angiotensin feedback loop (P
C.-o. Pirttikangas - One of the best experts on this subject based on the ideXlab platform.
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Propofol infusion anaesthesia and immune response in Minor Surgery
Anaesthesia, 1994Co-Authors: C.-o. Pirttikangas, J. Perttilä, Matti Salo, O. Vainio, S. Liukko-sipiAbstract:Summary This study was set up to evaluate the effects of propofol infusion anaesthesia on immunological function in Minor Surgery. Twenty-seven patients (median age 51 years, ASA 1-2) scheduled for Minor breast Surgery were randomly assigned to two groups. Anaesthesia was induced in group 1 with propofol 2.5 mg.kg-1 and maintained with propofol 12 mg.kg-1.h-1 and 30% O2 in air, whereas in group 2 anaesthesia was induced with thiopentone 4 mg.kg-1 and maintained with 70% N2O in O2. Fentanyl and vecuronium were used in both groups. The percentages of T cells (p < 0.001), B cells (p < 0.01) and memory T cells increased (p < 0.01) in both groups. T helper cell percentages increased in the propofol but not in the thiopentone group (p < 0.05). The percentages of natural killer cells decreased from pre-induction values in both groups (p < 0.001). No changes were seen in lymphocyte proliferative responses. Minor breast Surgery under propofol or conventional combined anaesthesia had only Minor effects on the immune response. The higher percentage of T helper cells after propofol anaesthesia compared to conventional combined anaesthesia is beneficial, but its clinical importance remains to be determined.