The Experts below are selected from a list of 1170 Experts worldwide ranked by ideXlab platform
Thomas W. Griffin - One of the best experts on this subject based on the ideXlab platform.
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Synthesis and radioiodination of a nido-1,2-carboranyl derivative of 2-nitroimidazole
Nuclear medicine and biology, 1994Co-Authors: D. Scott Wilbur, Donald K. Hamlin, John C. Livesey, R. R. Srivastava, George E. Laramore, Thomas W. GriffinAbstract:Abstract The synthesis of a nido -carboranyl congener of Misonidazole, 1-(3′- nido -carboranyl-2′-hydroxy)propyl-2-nitroimidazole, has been carried out. Alternative methods of preparations were conducted to optimize the chemical yield, with a five step synthesis giving an overall yield (from 1,2-carborane) of 36%. A diastereomeric pair of nido -carboranyl compounds was obtained. The diastereomeric nido -carboranyl Misonidazole congeners were (radio)iodinated to yield (> 90%) a mixture of diastereomeric compounds in which the iodine had bonded to a boron atom on the nido -carborane moiety. These compounds will be investigated for their application to boron neutron capture therapy (BNCT) and hypoxia imaging of cancer.
D. Scott Wilbur - One of the best experts on this subject based on the ideXlab platform.
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Synthesis and radioiodination of a nido-1,2-carboranyl derivative of 2-nitroimidazole
Nuclear medicine and biology, 1994Co-Authors: D. Scott Wilbur, Donald K. Hamlin, John C. Livesey, R. R. Srivastava, George E. Laramore, Thomas W. GriffinAbstract:Abstract The synthesis of a nido -carboranyl congener of Misonidazole, 1-(3′- nido -carboranyl-2′-hydroxy)propyl-2-nitroimidazole, has been carried out. Alternative methods of preparations were conducted to optimize the chemical yield, with a five step synthesis giving an overall yield (from 1,2-carborane) of 36%. A diastereomeric pair of nido -carboranyl compounds was obtained. The diastereomeric nido -carboranyl Misonidazole congeners were (radio)iodinated to yield (> 90%) a mixture of diastereomeric compounds in which the iodine had bonded to a boron atom on the nido -carborane moiety. These compounds will be investigated for their application to boron neutron capture therapy (BNCT) and hypoxia imaging of cancer.
George E. Laramore - One of the best experts on this subject based on the ideXlab platform.
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Synthesis and radioiodination of a nido-1,2-carboranyl derivative of 2-nitroimidazole
Nuclear medicine and biology, 1994Co-Authors: D. Scott Wilbur, Donald K. Hamlin, John C. Livesey, R. R. Srivastava, George E. Laramore, Thomas W. GriffinAbstract:Abstract The synthesis of a nido -carboranyl congener of Misonidazole, 1-(3′- nido -carboranyl-2′-hydroxy)propyl-2-nitroimidazole, has been carried out. Alternative methods of preparations were conducted to optimize the chemical yield, with a five step synthesis giving an overall yield (from 1,2-carborane) of 36%. A diastereomeric pair of nido -carboranyl compounds was obtained. The diastereomeric nido -carboranyl Misonidazole congeners were (radio)iodinated to yield (> 90%) a mixture of diastereomeric compounds in which the iodine had bonded to a boron atom on the nido -carborane moiety. These compounds will be investigated for their application to boron neutron capture therapy (BNCT) and hypoxia imaging of cancer.
R. R. Srivastava - One of the best experts on this subject based on the ideXlab platform.
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Synthesis and radioiodination of a nido-1,2-carboranyl derivative of 2-nitroimidazole
Nuclear medicine and biology, 1994Co-Authors: D. Scott Wilbur, Donald K. Hamlin, John C. Livesey, R. R. Srivastava, George E. Laramore, Thomas W. GriffinAbstract:Abstract The synthesis of a nido -carboranyl congener of Misonidazole, 1-(3′- nido -carboranyl-2′-hydroxy)propyl-2-nitroimidazole, has been carried out. Alternative methods of preparations were conducted to optimize the chemical yield, with a five step synthesis giving an overall yield (from 1,2-carborane) of 36%. A diastereomeric pair of nido -carboranyl compounds was obtained. The diastereomeric nido -carboranyl Misonidazole congeners were (radio)iodinated to yield (> 90%) a mixture of diastereomeric compounds in which the iodine had bonded to a boron atom on the nido -carborane moiety. These compounds will be investigated for their application to boron neutron capture therapy (BNCT) and hypoxia imaging of cancer.
John C. Livesey - One of the best experts on this subject based on the ideXlab platform.
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Synthesis and radioiodination of a nido-1,2-carboranyl derivative of 2-nitroimidazole
Nuclear medicine and biology, 1994Co-Authors: D. Scott Wilbur, Donald K. Hamlin, John C. Livesey, R. R. Srivastava, George E. Laramore, Thomas W. GriffinAbstract:Abstract The synthesis of a nido -carboranyl congener of Misonidazole, 1-(3′- nido -carboranyl-2′-hydroxy)propyl-2-nitroimidazole, has been carried out. Alternative methods of preparations were conducted to optimize the chemical yield, with a five step synthesis giving an overall yield (from 1,2-carborane) of 36%. A diastereomeric pair of nido -carboranyl compounds was obtained. The diastereomeric nido -carboranyl Misonidazole congeners were (radio)iodinated to yield (> 90%) a mixture of diastereomeric compounds in which the iodine had bonded to a boron atom on the nido -carborane moiety. These compounds will be investigated for their application to boron neutron capture therapy (BNCT) and hypoxia imaging of cancer.