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Jay Hertel - One of the best experts on this subject based on the ideXlab platform.
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immediate effects of anterior to posterior talocrural joint Mobilizations following acute lateral ankle sprain
Journal of Manual & Manipulative Therapy, 2011Co-Authors: Nicole L. Cosby, Michael Koroch, William R Parente, Terry L Grindstaff, Jay HertelAbstract:Restrictions in ankle dorsiflexion range of motion (ROM) have been associated with decreased posterior talar glide in individuals with an acute lateral ankle sprain. Talocrural joint Mobilizations may be used to restore joint arthrokinematics. Our purpose was to examine the effects of a single bout of anterior to posterior (AP) talocrural joint Mobilization on self-reported function, dorsiflexion ROM, and posterior talar translation in individuals with an acute lateral ankle sprain. This single-blinded, randomized controlled trial utilized 17 volunteers (nine treatment and eight control) with an acute lateral ankle sprain (grade I/II) who were immobilized for a period of 1–7 days. The treatment group received a single 30-second bout of grade III AP talocrural joint Mobilization the day their imMobilization device was removed, while the control group did not receive any intervention. Active dorsiflexion ROM and posterior talar translation were assessed before, immediately after, and 24 hours after receipt of the treatment or control interventions. Self-reported function and pain were assessed before and 24 hours after the receipt of the treatment or control interventions using the foot and ankle disability index. Collectively all groups demonstrated improved dorsiflexion ROM and self-reported function. There was a significant decrease in pain perception at 24-hour follow-up for the treatment group. A single bout of AP talocrural joint Mobilizations may not have an immediate effect on ankle dorsiflexion ROM, posterior talar translation, or self-reported function; however, they may have an immediate effect on pain perception in individuals with an acute lateral ankle sprain.
Y Gazitt - One of the best experts on this subject based on the ideXlab platform.
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Homing and Mobilization of hematopoietic stem cells and hematopoietic cancer cells are mirror image processes, utilizing similar signaling pathways and occurring concurrently: circulating cancer cells constitute an ideal target for concurrent treatme
Leukemia, 2004Co-Authors: Y GazittAbstract:Adhesion molecules and stromal cell-derived factor-1 (SDF-1)/CXCR4 signaling play key role in homing and Mobilization of hematopoietic progenitor (HPC) and hematopoietic cancer clonogenic cells (HCC). High expression of VLA-4 is required for homing of HPC and HCC, whereas downregulation of these molecules is required for successful Mobilization of HPC and HCC. Upregulation and activation of the SDF-1/CXCR4 signaling is required for homing of HPC and HCC, whereas disruption of the SDF-1 signaling is required for Mobilization of HPC and HCC. Hence, Mobilizations of HPC and HCC occur concurrently. It is proposed that drug resistance evolves as a result of repeated cycles of chemotherapy. Following each cycle of chemotherapy, HCC lose adhesion molecules and SDF-1 signaling. Surviving cells, released from tumor sites, circulate until re-expression of adhesion molecules and CXCR4 occurs, then homing to stroma of distal tissues occurs. Cytokines secreted by cells in the new microenvironment induce proliferation and drug resistance of HCC. This process is amplified in each cycle of chemotherapy resulting in disease progression. A novel model for treatment is proposed in which circulating HCC are the target for clinical intervention, and concurrent treatment with chemotherapy and antilineage-specific antibodies will result in abrogation of the ‘vicious cycle’ of conventional anticancer therapy.
Neil Andersson - One of the best experts on this subject based on the ideXlab platform.
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Assessing the effects of interventions for Aedes aegypti control: systematic review and meta-analysis of cluster randomised controlled trials
BMC Public Health, 2017Co-Authors: Víctor Alvarado-castro, Sergio Paredes-solís, Elizabeth Nava-aguilera, Arcadio Morales-pérez, Lidia Alarcón-morales, Norma Alejandra Balderas-vargas, Neil AnderssonAbstract:Background The Aedes aegypti mosquito is the vector for dengue fever, yellow fever, chikungunya, and zika viruses. Inadequate vector control has contributed to persistence and increase of these diseases. This review assesses the evidence of effectiveness of different control measures in reducing Aedes aegypti proliferation, using standard entomological indices. Methods A systematic search of Medline, Ovid, BVS, LILACS, ARTEMISA, IMBIOMED and MEDIGRAPHIC databases identified cluster randomised controlled trials (CRCTs) of interventions to control Aedes aegypti published between January 2003 and October 2016. Eligible studies were CRCTs of chemical or biological control measures, or community Mobilization, with entomological indices as an endpoint. A meta-analysis of eligible studies, using a random effects model, assessed the impact on household index (HI), container index (CI), and Breteau index (BI). Results From 848 papers identified by the search, eighteen met the inclusion criteria: eight for chemical control, one for biological control and nine for community mobilisation. Seven of the nine CRCTs of community mobilisation reported significantly lower entomological indices in intervention than control clusters; findings from the eight CRCTs of chemical control were more mixed. The CRCT of biological control reported a significant impact on the pupae per person index only. Ten papers provided enough detail for meta-analysis. Community mobilisation (four studies) was consistently effective, with an overall intervention effectiveness estimate of −0.10 (95%CI -0.20 – 0.00) for HI, −0.03 (95%CI -0.05 – -0.01) for CI, and −0.13 (95%CI -0.22 – -0.05) for BI. The single CRCT of biological control had effectiveness of −0.02 (95%CI -0.07– 0.03) for HI, −0.02 (95%CI -0.04– -0.01) for CI and −0.08 (95%CI -0.15– -0.01) for BI. The five studies of chemical control did not show a significant impact on indices: the overall effectiveness was −0.01 (95%CI -0.05– 0.03) for HI, 0.01 (95% CI -0.01– 0.02) for CI, and 0.01 (95%CI -0.03 – 0.05) for BI. Conclusion Governments that rely on chemical control of Aedes aegypti should consider adding community Mobilization to their prevention efforts. More well-conducted CRCTs of complex interventions, including those with biological control, are needed to provide evidence of real life impact. Trials of all interventions should measure impact on dengue risk.
Nicole L. Cosby - One of the best experts on this subject based on the ideXlab platform.
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immediate effects of anterior to posterior talocrural joint Mobilizations following acute lateral ankle sprain
Journal of Manual & Manipulative Therapy, 2011Co-Authors: Nicole L. Cosby, Michael Koroch, William R Parente, Terry L Grindstaff, Jay HertelAbstract:Restrictions in ankle dorsiflexion range of motion (ROM) have been associated with decreased posterior talar glide in individuals with an acute lateral ankle sprain. Talocrural joint Mobilizations may be used to restore joint arthrokinematics. Our purpose was to examine the effects of a single bout of anterior to posterior (AP) talocrural joint Mobilization on self-reported function, dorsiflexion ROM, and posterior talar translation in individuals with an acute lateral ankle sprain. This single-blinded, randomized controlled trial utilized 17 volunteers (nine treatment and eight control) with an acute lateral ankle sprain (grade I/II) who were immobilized for a period of 1–7 days. The treatment group received a single 30-second bout of grade III AP talocrural joint Mobilization the day their imMobilization device was removed, while the control group did not receive any intervention. Active dorsiflexion ROM and posterior talar translation were assessed before, immediately after, and 24 hours after receipt of the treatment or control interventions. Self-reported function and pain were assessed before and 24 hours after the receipt of the treatment or control interventions using the foot and ankle disability index. Collectively all groups demonstrated improved dorsiflexion ROM and self-reported function. There was a significant decrease in pain perception at 24-hour follow-up for the treatment group. A single bout of AP talocrural joint Mobilizations may not have an immediate effect on ankle dorsiflexion ROM, posterior talar translation, or self-reported function; however, they may have an immediate effect on pain perception in individuals with an acute lateral ankle sprain.
David M. Hallman - One of the best experts on this subject based on the ideXlab platform.
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The acute effects of joint manipulative techniques on markers of autonomic nervous system activity: a systematic review and meta-analysis of randomized sham-controlled trials
Chiropractic & Manual Therapies, 2019Co-Authors: Mathieu Picchiottino, Charlotte Leboeuf-yde, Olivier Gagey, David M. HallmanAbstract:Background The autonomic nervous system (ANS) interests many chiropractors and manual therapists, because joint manipulative techniques (JMT), e.g. high velocity low amplitude (HVLA) manipulations and Mobilizations, appear to produce acute changes in ANS mediated physiology. The complexity of this issue justifies a systematic critical literature review. Objective To review the literature comparing the acute changes in markers of ANS activity between JMT applied on spinal or peripheral joints and a sham procedure in healthy or symptomatic subjects. Method We searched PsycINFO, PEDro, PubMed, Cochrane library, EMBASE, and Medline up to December 2017. We updated the search with PubMed, Cochrane library, EMBASE, and Medline including July 2018. Inclusion criteria were: randomized sham-controlled trials assessing the effect of JMT on markers of ANS activity; manually applied JMT, regardless of technique, applied on either healthy or symptomatic humans; outcome measurements recorded at baseline and repeated during and/or after interventions. Selection of articles and data extraction were performed independently by two reviewers. The quality of studies was assessed using the Cochrane ‘risk of bias’ tool and a technical check-list. Results were reported narratively with some meta-analyses. The Cochrane GRADE approach was used to assess the certainty of evidence. Results Twenty-nine of 2267 studies were included in the synthesis. Mobilizations (oscillatory technique) probably produce an immediate and short-term, bilateral increase in skin sympathetic nerve activity (reflected by an increase in skin conductance) regardless of the area treated (moderate-certainty evidence). It is uncertain whether the sympathetic arousal also explains an increase in respiratory rate (very low-certainty evidence). Our evaluation of the literature suggests that spinal sustained apophyseal glides (SNAGs) Mobilization and HVLA manipulation of the spine may have no acute effect on the studied markers of ANS activity (very low- to low-certainty evidence). Conclusion Some types of Mobilizations probably produce an immediate and short-term, statistically significant increase in skin sympathetic nerve activity when compared to a sham procedure, whereas spinal SNAGs and spinal HVLA techniques may have no acute effect on the studied markers of ANS activity. No region-specific results were noted. The literature suffers from several shortcomings, for which reason we strongly suggest further research. Introduction Le système nerveux autonome (SNA) intéresse de nombreux chiropracteurs et thérapeutes manuels car les techniques de manipulation articulaire, e.g. mobilisations ou manipulations de haute vélocité et faible amplitude (HVLA) semblent produire des changements immédiats de l’activité du SNA. La complexité de la littérature sur le sujet justifie une revue critique de la littérature. Objectif Examiner la littérature comparant les changements immédiats d’activité du SNA entre i) différentes techniques de manipulation articulaire appliquées sur le rachis ou les articulations périphériques et ii) une procédure placebo chez des sujets sains ou pathologiques. Méthode Nous avons cherché sur PsycINFO, PEDro jusqu’en décembre 2017 et sur PubMed, Cochrane library, EMBASE, Medline jusqu’en juillet 2018. Les critères d’inclusion étaient: essais randomisés contrôlés par un placebo évaluant l’effet d’une technique de manipulation articulaire sur l’activité du SNA, sans restriction concernant la technique ou la population, mesures de l’activité du SNA réalisées avant, pendant et/ou après l’intervention. La qualité des études était évaluée avec la grille de risque de biais de Cochrane et avec une grille d’évaluation technique. La sélection des études et l’extraction des données étaient effectuées indépendamment par deux chercheurs. Les résultats ont été rapportés narrativement, parfois avec des méta-analyses, en évaluant la certitude du niveau de preuve avec l’approche GRADE de Cochrane . Résultats Nous avons inclus 29 études sur les 2267 trouvées. Il y a des preuves de certitude modérée que les mobilisations (avec une technique d’oscillation) produisent une augmentation bilatérale, immédiate et à court terme de l’activité sympathique cutanée, indépendamment de la région mobilisée. Nous ne savons pas si l’excitation sympathique explique une augmentation de la fréquence respiratoire. Il y a des preuves de faible certitude que la manipulation spinale (HVLA) ainsi qu’une autre technique de mobilisation spinale n’ont pas d’effet sur l’activité autonome mesurée. Conclusion Certaines techniques de mobilisation articulaire produisent probablement une augmentation (statistiquement significative) immédiate et à court terme de l’activité sympathique cutanée comparées à une procédure placebo . Les manipulations spinales (HVLA) pourraient ne pas avoir d’effet immédiat sur l’activité autonome étudiée. Nous n’avons pas remarqué d’effet spécifique en fonction de la zone du traitement. Cette littérature montre des lacunes. Pour cette raison, nous suggérons (vivement) de nouvelles études.
