The Experts below are selected from a list of 239598 Experts worldwide ranked by ideXlab platform
Fabio B Daga - One of the best experts on this subject based on the ideXlab platform.
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macular pigment and visual function in patients with glaucoma the san diego macular pigment study
2018Co-Authors: Fabio B Daga, Nara G Ogata, Felipe A Medeiros, Rachel Moran, Jeffrey S Morris, Linda M Zangwill, Robert N WeinrebAbstract:Author(s): Daga, Fabio B; Ogata, Nara G; Medeiros, Felipe A; Moran, Rachel; Morris, Jeffrey; Zangwill, Linda M; Weinreb, Robert N; Nolan, John M | Abstract: PurposeAlthough recent studies have shown that macular pigment (MP) is significantly lower in glaucoma patients, this relationship merits further investigation.MethodsThis cross-sectional study included 85 glaucoma patients and 22 controls. All subjects had standard automated perimetry (SAP) and retinal nerve fiber layer (RNFL) thickness measurements. Intake of lutein (L) and zeaxanthin (Z) was estimated using a novel dietary screener. The Heidelberg Spectralis dual-wavelength autofluorescence (AF) technology was employed to study the relationship between MP and glaucoma. The association between MP volume and glaucoma was investigated using linear regression Models accounting for potential confounding factors.ResultsGlaucoma patients had significantly worse SAP mean deviation (MD) and lower RNFL thickness in the study eye compared to control subjects (P l 0.001 for both). MP (volume) was comparable between groups (P = 0.436). In the univariable Model, Diagnosis of glaucoma was not associated with MP volume (R2 = 1.22%; P = 0.257). Dietary intake of L and Z was positively and significantly related to MP in the univariable (P = 0.022) and multivariable (P = 0.020) Models.ConclusionsThese results challenge previous studies that reported that glaucoma is associated with low MP. Dietary habits were found to be the main predictor of MP in this sample. Further research is merited to better understand the relationship between glaucoma, MP, and visual performance in these patients.
Michael Lautenschlager - One of the best experts on this subject based on the ideXlab platform.
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quality assessment concept of the world data center for climate and its application to cmip5 data
2012Co-Authors: M. Stockhause, Frank Toussaint, H. Höck, Michael LautenschlagerAbstract:Abstract. The preservation of data in a high state of quality which is suitable for interdisciplinary use is one of the most pressing and challenging current issues in long-term archiving. For high volume data such as climate Model data, the data and data replica are no longer stored centrally but distributed over several local data repositories, e.g. the data of the Climate Model Intercomparison Project Phase 5 (CMIP5). The most important part of the data is to be archived, assigned a DOI, and published according to the World Data Center for Climate's (WDCC) application of the DataCite regulations. The integrated part of WDCC's data publication process, the data quality assessment, was adapted to the requirements of a federated data infrastructure. A concept of a distributed and federated quality assessment procedure was developed, in which the workload and responsibility for quality control is shared between the three primary CMIP5 data centers: Program for Climate Model Diagnosis and Intercomparison (PCMDI), British Atmospheric Data Centre (BADC), and WDCC. This distributed quality control concept, its pilot implementation for CMIP5, and first experiences are presented. The distributed quality control approach is capable of identifying data inconsistencies and to make quality results immediately available for data creators, data users and data infrastructure managers. Continuous publication of new data versions and slow data replication prevents the quality control from check completion. This together with ongoing developments of the data and metadata infrastructure requires adaptations in code and concept of the distributed quality control approach.
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the earth system grid federation delivering globally accessible petascale data for cmip5
2011Co-Authors: Dean N Williams, Michael Lautenschlager, Bryan Lawrence, Don Middleton, V BalajiAbstract:The fifth Coupled Model Intercomparison Project (CMIP5) will involve the global production and analysis of petabytes of data. The Program for Climate Model Diagnosis and Intercomparison (PCMDI), with responsibility for archival for CMIP5, has established the global “Earth System Grid Federation” (ESGF) of data producers and data archives to support CMIP5. ESGF will provide a set of globally synchronised views of globally distributed data – including some large cache replicants which will be persisted for (at least) decades. Here we describe the archive requirements and key aspects of the resulting architecture. ESGF will stress international networks, as well as the data archives themselves – but significantly less than would have been the case of a centralised archive. Developing and deploying the ESGF has exploited good will and best efforts, but future developments are likely to require more formalised architecture and management.
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the earth system grid federation software framework supporting cmip5 data analysis and dissemination
2011Co-Authors: Dean N Williams, Michael Lautenschlager, Karl E Taylor, Luca Cinquini, Ben Evans, Michio Kawamiya, Bryan Lawrence, Don Middleton, Esgf ContributorsAbstract:1 Program for Climate Model Diagnosis and Intercomparison (PCMDI), Lawrence Livermore National Laboratory (LLNL). 2 Jet Propulsion Laboratory (JPL), National Aeronautics and Space Administration (NASA). 3 Australia National University (ANU) National Computational Infrastructure (NCI). 4 Japan Agency for Marine-Earth Science and Technology (JAMSTEC) 5 German Climate Computing Centre (DKRZ). 6 National Centre for Atmospheric Science / British Atmospheric Data Centre (BADC). 7 National Center for Atmospheric Research (NCAR).
Robert N Weinreb - One of the best experts on this subject based on the ideXlab platform.
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macular pigment and visual function in patients with glaucoma the san diego macular pigment study
2018Co-Authors: Fabio B Daga, Nara G Ogata, Felipe A Medeiros, Rachel Moran, Jeffrey S Morris, Linda M Zangwill, Robert N WeinrebAbstract:Author(s): Daga, Fabio B; Ogata, Nara G; Medeiros, Felipe A; Moran, Rachel; Morris, Jeffrey; Zangwill, Linda M; Weinreb, Robert N; Nolan, John M | Abstract: PurposeAlthough recent studies have shown that macular pigment (MP) is significantly lower in glaucoma patients, this relationship merits further investigation.MethodsThis cross-sectional study included 85 glaucoma patients and 22 controls. All subjects had standard automated perimetry (SAP) and retinal nerve fiber layer (RNFL) thickness measurements. Intake of lutein (L) and zeaxanthin (Z) was estimated using a novel dietary screener. The Heidelberg Spectralis dual-wavelength autofluorescence (AF) technology was employed to study the relationship between MP and glaucoma. The association between MP volume and glaucoma was investigated using linear regression Models accounting for potential confounding factors.ResultsGlaucoma patients had significantly worse SAP mean deviation (MD) and lower RNFL thickness in the study eye compared to control subjects (P l 0.001 for both). MP (volume) was comparable between groups (P = 0.436). In the univariable Model, Diagnosis of glaucoma was not associated with MP volume (R2 = 1.22%; P = 0.257). Dietary intake of L and Z was positively and significantly related to MP in the univariable (P = 0.022) and multivariable (P = 0.020) Models.ConclusionsThese results challenge previous studies that reported that glaucoma is associated with low MP. Dietary habits were found to be the main predictor of MP in this sample. Further research is merited to better understand the relationship between glaucoma, MP, and visual performance in these patients.
Felipe A Medeiros - One of the best experts on this subject based on the ideXlab platform.
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macular pigment and visual function in patients with glaucoma the san diego macular pigment study
2018Co-Authors: Fabio B Daga, Nara G Ogata, Felipe A Medeiros, Rachel Moran, Jeffrey S Morris, Linda M Zangwill, Robert N WeinrebAbstract:Author(s): Daga, Fabio B; Ogata, Nara G; Medeiros, Felipe A; Moran, Rachel; Morris, Jeffrey; Zangwill, Linda M; Weinreb, Robert N; Nolan, John M | Abstract: PurposeAlthough recent studies have shown that macular pigment (MP) is significantly lower in glaucoma patients, this relationship merits further investigation.MethodsThis cross-sectional study included 85 glaucoma patients and 22 controls. All subjects had standard automated perimetry (SAP) and retinal nerve fiber layer (RNFL) thickness measurements. Intake of lutein (L) and zeaxanthin (Z) was estimated using a novel dietary screener. The Heidelberg Spectralis dual-wavelength autofluorescence (AF) technology was employed to study the relationship between MP and glaucoma. The association between MP volume and glaucoma was investigated using linear regression Models accounting for potential confounding factors.ResultsGlaucoma patients had significantly worse SAP mean deviation (MD) and lower RNFL thickness in the study eye compared to control subjects (P l 0.001 for both). MP (volume) was comparable between groups (P = 0.436). In the univariable Model, Diagnosis of glaucoma was not associated with MP volume (R2 = 1.22%; P = 0.257). Dietary intake of L and Z was positively and significantly related to MP in the univariable (P = 0.022) and multivariable (P = 0.020) Models.ConclusionsThese results challenge previous studies that reported that glaucoma is associated with low MP. Dietary habits were found to be the main predictor of MP in this sample. Further research is merited to better understand the relationship between glaucoma, MP, and visual performance in these patients.
Nara G Ogata - One of the best experts on this subject based on the ideXlab platform.
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macular pigment and visual function in patients with glaucoma the san diego macular pigment study
2018Co-Authors: Fabio B Daga, Nara G Ogata, Felipe A Medeiros, Rachel Moran, Jeffrey S Morris, Linda M Zangwill, Robert N WeinrebAbstract:Author(s): Daga, Fabio B; Ogata, Nara G; Medeiros, Felipe A; Moran, Rachel; Morris, Jeffrey; Zangwill, Linda M; Weinreb, Robert N; Nolan, John M | Abstract: PurposeAlthough recent studies have shown that macular pigment (MP) is significantly lower in glaucoma patients, this relationship merits further investigation.MethodsThis cross-sectional study included 85 glaucoma patients and 22 controls. All subjects had standard automated perimetry (SAP) and retinal nerve fiber layer (RNFL) thickness measurements. Intake of lutein (L) and zeaxanthin (Z) was estimated using a novel dietary screener. The Heidelberg Spectralis dual-wavelength autofluorescence (AF) technology was employed to study the relationship between MP and glaucoma. The association between MP volume and glaucoma was investigated using linear regression Models accounting for potential confounding factors.ResultsGlaucoma patients had significantly worse SAP mean deviation (MD) and lower RNFL thickness in the study eye compared to control subjects (P l 0.001 for both). MP (volume) was comparable between groups (P = 0.436). In the univariable Model, Diagnosis of glaucoma was not associated with MP volume (R2 = 1.22%; P = 0.257). Dietary intake of L and Z was positively and significantly related to MP in the univariable (P = 0.022) and multivariable (P = 0.020) Models.ConclusionsThese results challenge previous studies that reported that glaucoma is associated with low MP. Dietary habits were found to be the main predictor of MP in this sample. Further research is merited to better understand the relationship between glaucoma, MP, and visual performance in these patients.