The Experts below are selected from a list of 1950 Experts worldwide ranked by ideXlab platform

Gouranga Charan Mohanty - One of the best experts on this subject based on the ideXlab platform.

S. Acharya - One of the best experts on this subject based on the ideXlab platform.

Georgios Ritzoulis - One of the best experts on this subject based on the ideXlab platform.

Earle Stellwagen - One of the best experts on this subject based on the ideXlab platform.

  • the sensitivity of the cis trans isomerization of enalapril and enalaprilat to solvent conditions
    Journal of Pharmacy and Pharmacology, 2005
    Co-Authors: Robin Ledger, Earle Stellwagen
    Abstract:

    The cis- and trans-isomers of enalapril and enalaprilat can be resolved by HPLC and by capillary electrophoresis. The isomeric content of enalapril is perturbed by the ionization of both its carboxyl and amine groups, while the isomeric content of enalaprilat is only perturbed by the ionization of its amine group. Increasing the hydrophobicity of the analyte solvent, as reflected in its Molar Polarization, increases the Z (cis) content of enalapril and markedly decreases the kinetics for isomerization. Far UV circular dichroic measurements suggest that the increase in Z (cis) content of enalapril is due to protonation of its carboxylate group. Taken together, the in-vitro properties of enalapril and enalaprilat suggest that the in-vivo transformation of the prodrug enalapril to the inhibitor enalaprilat and its delivery to angiotensin-converting enzyme should not be significantly limited by cis/trans-isomerization.

  • The sensitivity of the cis/trans-isomerization of enalapril and enalaprilat to solvent conditions.
    Journal of Pharmacy and Pharmacology, 2005
    Co-Authors: Robin Ledger, Earle Stellwagen
    Abstract:

    The cis- and trans-isomers of enalapril and enalaprilat can be resolved by HPLC and by capillary electrophoresis. The isomeric content of enalapril is perturbed by the ionization of both its carboxyl and amine groups, while the isomeric content of enalaprilat is only perturbed by the ionization of its amine group. Increasing the hydrophobicity of the analyte solvent, as reflected in its Molar Polarization, increases the Z (cis) content of enalapril and markedly decreases the kinetics for isomerization. Far UV circular dichroic measurements suggest that the increase in Z (cis) content of enalapril is due to protonation of its carboxylate group. Taken together, the in-vitro properties of enalapril and enalaprilat suggest that the in-vivo transformation of the prodrug enalapril to the inhibitor enalaprilat and its delivery to angiotensin-converting enzyme should not be significantly limited by cis/trans-isomerization.

N V Sastry - One of the best experts on this subject based on the ideXlab platform.