The Experts below are selected from a list of 1005 Experts worldwide ranked by ideXlab platform

Castro Elena - One of the best experts on this subject based on the ideXlab platform.

  • Long-term treatment with fluoxetine induces desensitization of 5-HT4 Receptors in rat hippocampus
    'Wiley', 2013
    Co-Authors: Vidal Rebeca, Valdizán, Elsa M., Mostany Ricardo, Pazos Ángel, Castro Elena
    Abstract:

    Trabajo presentado al EPHAR 2008 Congress celebrado en Manchester.The mode of action of antidepressant drugs may be related to mechanisms of Monoamines Receptor adaptation, including serotonin 5-HT4 Receptor subtypes. Here we investigated the effects of repeated treatment with the selective serotonin reuptake inhibitor fluoxetine for 21 days (5 and 10 mg/kg, p.o., once daily) on the sensitivity of 5-HT4 Receptors by using Receptor autoradiography, adenylate cyclase assays and extracellular recording techniques in rat brain. Fluoxetine treatment decreased the density of 5-HT4 Receptor binding in the CA1 field of hippocampus as well as in several areas of the striatum over the doses of 5–10 mg/kg. In a similar way, we found a significant lower response to zacopride-stimulated adenylate cyclase activity in the fluoxetine 10 mg/kg/day treated group. Furthermore, post-synaptic 5-HT4 Receptor activity in hippocampus-measured as the excitatory action of zacopride in the pyramidal cells of CA1 evoked by Schaffer collateral stimulation was attenuated in rats treated with both doses of fluoxetine. Taken together, these results support the concept that a net decrease in the signalization pathway of 5-HT4 Receptors occurs after chronic selective serotonin reuptake inhibitor treatment: this effect may underlie the therapeutic efficacy of these drugs.This research was supported by Ministry of Science, SAF04-00941, SAF07-61862, Fundación Alicia Koplowitz, Fundación de Investigación Médica Mutua Madrileña, Instituto de Salud Carlos III and University of Cantabria-FAES research contract. RV is in receipt of a fellowship from University of Cantabria-FAES.Peer Reviewe

  • Long-term treatment with fluoxetine induces desensitization of 5-HT 4 Receptor-dependent signalling and functionality in rat brain
    'Wiley', 2012
    Co-Authors: Vidal Rebeca, Valdizán, Elsa M., Mostany Ricardo, Pazos Ángel, Castro Elena
    Abstract:

    El pdf del artículo es la versión pre-print.The mode of action of antidepressant drugs may be related to mechanisms of Monoamines Receptor adaptation, including serotonin 5-HT4 Receptor subtypes. Here we investigated the effects of repeated treatment with the selective serotonin reuptake inhibitor fluoxetine for 21 days (5 and 10 mg/kg, p.o., once daily) on the sensitivity of 5-HT4 Receptors by using Receptor autoradiography, adenylate cyclase assays and extracellular recording techniques in rat brain. Fluoxetine treatment decreased the density of 5-HT 4 Receptor binding in the CA1 field of hippocampus as well as in several areas of the striatum over the doses of 5-10 mg/kg. In a similar way, we found a significant lower response to zacopride-stimulated adenylate cyclase activity in the fluoxetine 10 mg/kg/day treated group. Furthermore, post-synaptic 5-HT4 Receptor activity in hippocampus-measured as the excitatory action of zacopride in the pyramidal cells of CA1 evoked by Schaffer collateral stimulation was attenuated in rats treated with both doses of fluoxetine. Taken together, these results support the concept that a net decrease in the signalization pathway of 5-HT4 Receptors occurs after chronic selective serotonin reuptake inhibitor treatment: this effect may underlie the therapeutic efficacy of these drugs. © 2009 International Society for Neurochemistry.This research was supported by Ministry of Science, SAF04-00941, SAF07-61862, Fundación Alicia Koplowitz, Fundación de Investigación Médica Mutua Madrileña, Instituto de Salud Carlos III and University of Cantabria-FAES research contract. RV is in receipt of a fellowship from University of Cantabria - FAES .Peer Reviewe

Vidal Rebeca - One of the best experts on this subject based on the ideXlab platform.

  • Long-term treatment with fluoxetine induces desensitization of 5-HT4 Receptors in rat hippocampus
    'Wiley', 2013
    Co-Authors: Vidal Rebeca, Valdizán, Elsa M., Mostany Ricardo, Pazos Ángel, Castro Elena
    Abstract:

    Trabajo presentado al EPHAR 2008 Congress celebrado en Manchester.The mode of action of antidepressant drugs may be related to mechanisms of Monoamines Receptor adaptation, including serotonin 5-HT4 Receptor subtypes. Here we investigated the effects of repeated treatment with the selective serotonin reuptake inhibitor fluoxetine for 21 days (5 and 10 mg/kg, p.o., once daily) on the sensitivity of 5-HT4 Receptors by using Receptor autoradiography, adenylate cyclase assays and extracellular recording techniques in rat brain. Fluoxetine treatment decreased the density of 5-HT4 Receptor binding in the CA1 field of hippocampus as well as in several areas of the striatum over the doses of 5–10 mg/kg. In a similar way, we found a significant lower response to zacopride-stimulated adenylate cyclase activity in the fluoxetine 10 mg/kg/day treated group. Furthermore, post-synaptic 5-HT4 Receptor activity in hippocampus-measured as the excitatory action of zacopride in the pyramidal cells of CA1 evoked by Schaffer collateral stimulation was attenuated in rats treated with both doses of fluoxetine. Taken together, these results support the concept that a net decrease in the signalization pathway of 5-HT4 Receptors occurs after chronic selective serotonin reuptake inhibitor treatment: this effect may underlie the therapeutic efficacy of these drugs.This research was supported by Ministry of Science, SAF04-00941, SAF07-61862, Fundación Alicia Koplowitz, Fundación de Investigación Médica Mutua Madrileña, Instituto de Salud Carlos III and University of Cantabria-FAES research contract. RV is in receipt of a fellowship from University of Cantabria-FAES.Peer Reviewe

  • Long-term treatment with fluoxetine induces desensitization of 5-HT 4 Receptor-dependent signalling and functionality in rat brain
    'Wiley', 2012
    Co-Authors: Vidal Rebeca, Valdizán, Elsa M., Mostany Ricardo, Pazos Ángel, Castro Elena
    Abstract:

    El pdf del artículo es la versión pre-print.The mode of action of antidepressant drugs may be related to mechanisms of Monoamines Receptor adaptation, including serotonin 5-HT4 Receptor subtypes. Here we investigated the effects of repeated treatment with the selective serotonin reuptake inhibitor fluoxetine for 21 days (5 and 10 mg/kg, p.o., once daily) on the sensitivity of 5-HT4 Receptors by using Receptor autoradiography, adenylate cyclase assays and extracellular recording techniques in rat brain. Fluoxetine treatment decreased the density of 5-HT 4 Receptor binding in the CA1 field of hippocampus as well as in several areas of the striatum over the doses of 5-10 mg/kg. In a similar way, we found a significant lower response to zacopride-stimulated adenylate cyclase activity in the fluoxetine 10 mg/kg/day treated group. Furthermore, post-synaptic 5-HT4 Receptor activity in hippocampus-measured as the excitatory action of zacopride in the pyramidal cells of CA1 evoked by Schaffer collateral stimulation was attenuated in rats treated with both doses of fluoxetine. Taken together, these results support the concept that a net decrease in the signalization pathway of 5-HT4 Receptors occurs after chronic selective serotonin reuptake inhibitor treatment: this effect may underlie the therapeutic efficacy of these drugs. © 2009 International Society for Neurochemistry.This research was supported by Ministry of Science, SAF04-00941, SAF07-61862, Fundación Alicia Koplowitz, Fundación de Investigación Médica Mutua Madrileña, Instituto de Salud Carlos III and University of Cantabria-FAES research contract. RV is in receipt of a fellowship from University of Cantabria - FAES .Peer Reviewe

Valdizán, Elsa M. - One of the best experts on this subject based on the ideXlab platform.

  • Long-term treatment with fluoxetine induces desensitization of 5-HT4 Receptors in rat hippocampus
    'Wiley', 2013
    Co-Authors: Vidal Rebeca, Valdizán, Elsa M., Mostany Ricardo, Pazos Ángel, Castro Elena
    Abstract:

    Trabajo presentado al EPHAR 2008 Congress celebrado en Manchester.The mode of action of antidepressant drugs may be related to mechanisms of Monoamines Receptor adaptation, including serotonin 5-HT4 Receptor subtypes. Here we investigated the effects of repeated treatment with the selective serotonin reuptake inhibitor fluoxetine for 21 days (5 and 10 mg/kg, p.o., once daily) on the sensitivity of 5-HT4 Receptors by using Receptor autoradiography, adenylate cyclase assays and extracellular recording techniques in rat brain. Fluoxetine treatment decreased the density of 5-HT4 Receptor binding in the CA1 field of hippocampus as well as in several areas of the striatum over the doses of 5–10 mg/kg. In a similar way, we found a significant lower response to zacopride-stimulated adenylate cyclase activity in the fluoxetine 10 mg/kg/day treated group. Furthermore, post-synaptic 5-HT4 Receptor activity in hippocampus-measured as the excitatory action of zacopride in the pyramidal cells of CA1 evoked by Schaffer collateral stimulation was attenuated in rats treated with both doses of fluoxetine. Taken together, these results support the concept that a net decrease in the signalization pathway of 5-HT4 Receptors occurs after chronic selective serotonin reuptake inhibitor treatment: this effect may underlie the therapeutic efficacy of these drugs.This research was supported by Ministry of Science, SAF04-00941, SAF07-61862, Fundación Alicia Koplowitz, Fundación de Investigación Médica Mutua Madrileña, Instituto de Salud Carlos III and University of Cantabria-FAES research contract. RV is in receipt of a fellowship from University of Cantabria-FAES.Peer Reviewe

  • Long-term treatment with fluoxetine induces desensitization of 5-HT 4 Receptor-dependent signalling and functionality in rat brain
    'Wiley', 2012
    Co-Authors: Vidal Rebeca, Valdizán, Elsa M., Mostany Ricardo, Pazos Ángel, Castro Elena
    Abstract:

    El pdf del artículo es la versión pre-print.The mode of action of antidepressant drugs may be related to mechanisms of Monoamines Receptor adaptation, including serotonin 5-HT4 Receptor subtypes. Here we investigated the effects of repeated treatment with the selective serotonin reuptake inhibitor fluoxetine for 21 days (5 and 10 mg/kg, p.o., once daily) on the sensitivity of 5-HT4 Receptors by using Receptor autoradiography, adenylate cyclase assays and extracellular recording techniques in rat brain. Fluoxetine treatment decreased the density of 5-HT 4 Receptor binding in the CA1 field of hippocampus as well as in several areas of the striatum over the doses of 5-10 mg/kg. In a similar way, we found a significant lower response to zacopride-stimulated adenylate cyclase activity in the fluoxetine 10 mg/kg/day treated group. Furthermore, post-synaptic 5-HT4 Receptor activity in hippocampus-measured as the excitatory action of zacopride in the pyramidal cells of CA1 evoked by Schaffer collateral stimulation was attenuated in rats treated with both doses of fluoxetine. Taken together, these results support the concept that a net decrease in the signalization pathway of 5-HT4 Receptors occurs after chronic selective serotonin reuptake inhibitor treatment: this effect may underlie the therapeutic efficacy of these drugs. © 2009 International Society for Neurochemistry.This research was supported by Ministry of Science, SAF04-00941, SAF07-61862, Fundación Alicia Koplowitz, Fundación de Investigación Médica Mutua Madrileña, Instituto de Salud Carlos III and University of Cantabria-FAES research contract. RV is in receipt of a fellowship from University of Cantabria - FAES .Peer Reviewe

Mostany Ricardo - One of the best experts on this subject based on the ideXlab platform.

  • Long-term treatment with fluoxetine induces desensitization of 5-HT4 Receptors in rat hippocampus
    'Wiley', 2013
    Co-Authors: Vidal Rebeca, Valdizán, Elsa M., Mostany Ricardo, Pazos Ángel, Castro Elena
    Abstract:

    Trabajo presentado al EPHAR 2008 Congress celebrado en Manchester.The mode of action of antidepressant drugs may be related to mechanisms of Monoamines Receptor adaptation, including serotonin 5-HT4 Receptor subtypes. Here we investigated the effects of repeated treatment with the selective serotonin reuptake inhibitor fluoxetine for 21 days (5 and 10 mg/kg, p.o., once daily) on the sensitivity of 5-HT4 Receptors by using Receptor autoradiography, adenylate cyclase assays and extracellular recording techniques in rat brain. Fluoxetine treatment decreased the density of 5-HT4 Receptor binding in the CA1 field of hippocampus as well as in several areas of the striatum over the doses of 5–10 mg/kg. In a similar way, we found a significant lower response to zacopride-stimulated adenylate cyclase activity in the fluoxetine 10 mg/kg/day treated group. Furthermore, post-synaptic 5-HT4 Receptor activity in hippocampus-measured as the excitatory action of zacopride in the pyramidal cells of CA1 evoked by Schaffer collateral stimulation was attenuated in rats treated with both doses of fluoxetine. Taken together, these results support the concept that a net decrease in the signalization pathway of 5-HT4 Receptors occurs after chronic selective serotonin reuptake inhibitor treatment: this effect may underlie the therapeutic efficacy of these drugs.This research was supported by Ministry of Science, SAF04-00941, SAF07-61862, Fundación Alicia Koplowitz, Fundación de Investigación Médica Mutua Madrileña, Instituto de Salud Carlos III and University of Cantabria-FAES research contract. RV is in receipt of a fellowship from University of Cantabria-FAES.Peer Reviewe

  • Long-term treatment with fluoxetine induces desensitization of 5-HT 4 Receptor-dependent signalling and functionality in rat brain
    'Wiley', 2012
    Co-Authors: Vidal Rebeca, Valdizán, Elsa M., Mostany Ricardo, Pazos Ángel, Castro Elena
    Abstract:

    El pdf del artículo es la versión pre-print.The mode of action of antidepressant drugs may be related to mechanisms of Monoamines Receptor adaptation, including serotonin 5-HT4 Receptor subtypes. Here we investigated the effects of repeated treatment with the selective serotonin reuptake inhibitor fluoxetine for 21 days (5 and 10 mg/kg, p.o., once daily) on the sensitivity of 5-HT4 Receptors by using Receptor autoradiography, adenylate cyclase assays and extracellular recording techniques in rat brain. Fluoxetine treatment decreased the density of 5-HT 4 Receptor binding in the CA1 field of hippocampus as well as in several areas of the striatum over the doses of 5-10 mg/kg. In a similar way, we found a significant lower response to zacopride-stimulated adenylate cyclase activity in the fluoxetine 10 mg/kg/day treated group. Furthermore, post-synaptic 5-HT4 Receptor activity in hippocampus-measured as the excitatory action of zacopride in the pyramidal cells of CA1 evoked by Schaffer collateral stimulation was attenuated in rats treated with both doses of fluoxetine. Taken together, these results support the concept that a net decrease in the signalization pathway of 5-HT4 Receptors occurs after chronic selective serotonin reuptake inhibitor treatment: this effect may underlie the therapeutic efficacy of these drugs. © 2009 International Society for Neurochemistry.This research was supported by Ministry of Science, SAF04-00941, SAF07-61862, Fundación Alicia Koplowitz, Fundación de Investigación Médica Mutua Madrileña, Instituto de Salud Carlos III and University of Cantabria-FAES research contract. RV is in receipt of a fellowship from University of Cantabria - FAES .Peer Reviewe

Pazos Ángel - One of the best experts on this subject based on the ideXlab platform.

  • Long-term treatment with fluoxetine induces desensitization of 5-HT4 Receptors in rat hippocampus
    'Wiley', 2013
    Co-Authors: Vidal Rebeca, Valdizán, Elsa M., Mostany Ricardo, Pazos Ángel, Castro Elena
    Abstract:

    Trabajo presentado al EPHAR 2008 Congress celebrado en Manchester.The mode of action of antidepressant drugs may be related to mechanisms of Monoamines Receptor adaptation, including serotonin 5-HT4 Receptor subtypes. Here we investigated the effects of repeated treatment with the selective serotonin reuptake inhibitor fluoxetine for 21 days (5 and 10 mg/kg, p.o., once daily) on the sensitivity of 5-HT4 Receptors by using Receptor autoradiography, adenylate cyclase assays and extracellular recording techniques in rat brain. Fluoxetine treatment decreased the density of 5-HT4 Receptor binding in the CA1 field of hippocampus as well as in several areas of the striatum over the doses of 5–10 mg/kg. In a similar way, we found a significant lower response to zacopride-stimulated adenylate cyclase activity in the fluoxetine 10 mg/kg/day treated group. Furthermore, post-synaptic 5-HT4 Receptor activity in hippocampus-measured as the excitatory action of zacopride in the pyramidal cells of CA1 evoked by Schaffer collateral stimulation was attenuated in rats treated with both doses of fluoxetine. Taken together, these results support the concept that a net decrease in the signalization pathway of 5-HT4 Receptors occurs after chronic selective serotonin reuptake inhibitor treatment: this effect may underlie the therapeutic efficacy of these drugs.This research was supported by Ministry of Science, SAF04-00941, SAF07-61862, Fundación Alicia Koplowitz, Fundación de Investigación Médica Mutua Madrileña, Instituto de Salud Carlos III and University of Cantabria-FAES research contract. RV is in receipt of a fellowship from University of Cantabria-FAES.Peer Reviewe

  • Long-term treatment with fluoxetine induces desensitization of 5-HT 4 Receptor-dependent signalling and functionality in rat brain
    'Wiley', 2012
    Co-Authors: Vidal Rebeca, Valdizán, Elsa M., Mostany Ricardo, Pazos Ángel, Castro Elena
    Abstract:

    El pdf del artículo es la versión pre-print.The mode of action of antidepressant drugs may be related to mechanisms of Monoamines Receptor adaptation, including serotonin 5-HT4 Receptor subtypes. Here we investigated the effects of repeated treatment with the selective serotonin reuptake inhibitor fluoxetine for 21 days (5 and 10 mg/kg, p.o., once daily) on the sensitivity of 5-HT4 Receptors by using Receptor autoradiography, adenylate cyclase assays and extracellular recording techniques in rat brain. Fluoxetine treatment decreased the density of 5-HT 4 Receptor binding in the CA1 field of hippocampus as well as in several areas of the striatum over the doses of 5-10 mg/kg. In a similar way, we found a significant lower response to zacopride-stimulated adenylate cyclase activity in the fluoxetine 10 mg/kg/day treated group. Furthermore, post-synaptic 5-HT4 Receptor activity in hippocampus-measured as the excitatory action of zacopride in the pyramidal cells of CA1 evoked by Schaffer collateral stimulation was attenuated in rats treated with both doses of fluoxetine. Taken together, these results support the concept that a net decrease in the signalization pathway of 5-HT4 Receptors occurs after chronic selective serotonin reuptake inhibitor treatment: this effect may underlie the therapeutic efficacy of these drugs. © 2009 International Society for Neurochemistry.This research was supported by Ministry of Science, SAF04-00941, SAF07-61862, Fundación Alicia Koplowitz, Fundación de Investigación Médica Mutua Madrileña, Instituto de Salud Carlos III and University of Cantabria-FAES research contract. RV is in receipt of a fellowship from University of Cantabria - FAES .Peer Reviewe