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Jiang Chang - One of the best experts on this subject based on the ideXlab platform.

  • Novel bioactive composite bone cements based on the beta-tricalcium Phosphate-Monocalcium Phosphate monohydrate composite cement system.
    Acta biomaterialia, 2008
    Co-Authors: Zhiguang Huan, Jiang Chang
    Abstract:

    Bioactive composite bone cements were obtained by incorporation of tricalcium silicate (Ca3SiO5, C3S) into a brushite bone cement composed of beta-tricalcium Phosphate [beta-Ca3(PO4)2, beta-TCP] and Monocalcium Phosphate monohydrate [Ca(H2PO4)2.H2O, MCPM], and the properties of the new cements were studied and compared with pure brushite cement. The results indicated that the injectability, setting time and short- and long-term mechanical strength of the material are higher than those of pure brushite cement, and the compressive strength of the TCP/MCPM/C3S composite paste increased with increasing aging time. Moreover, the TCP/MCPM/C3S specimens showed significantly improved in vitro bioactivity in simulated body fluid and similar degradability in Phosphate-buffered saline as compared with brushite cement. Additionally, the reacted TCP/MCPM/C3S paste possesses the ability to stimulate osteoblast proliferation and promote osteoblastic differentiation of the bone marrow stromal cells. The results indicated that the TCP/MCPM/C3S cements may be used as a bioactive material for bone regeneration, and might have significant clinical advantage over the traditional beta-TCP/MCPM brushite cement.

  • novel tricalcium silicate Monocalcium Phosphate monohydrate composite bone cement
    Journal of Biomedical Materials Research Part B, 2007
    Co-Authors: Zhiguang Huan, Jiang Chang
    Abstract:

    In this paper, we obtained a novel bone cement composed of tricalcium silicate (Ca3SiO5; C3S) and Monocalcium Phosphate monohydrate (MCPM). The weight ratio of MCPM in the cement is 0, 10, 20, and 30%. The initial setting time was dramatically reduced from 90 min to 30 min as the content of MCPM reached 20%. The workable paste with a liquid/powder (L/P) ratio of 0.8 mL/g could be injected for 2–20 min (nozzle diameter 2.0 mm). The pH variation of the composite cement in simulated body environment was obviously lowered. The compressive strength of the composite cement after setting for 4–28 days was slightly lower than that of the tricalcium silicate paste. The in vitro bioactivity was investigated by soaking in simulated body fluid for 7 days. The result showed that the novel bone cement had good bioactivity and could degrade in tris-(hydroxymethyl)-aminomethane-hydrochloric-acid (Tris-HCl) solution. Our result indicated that the Ca3SiO5/MCPM paste had good hydraulic properties, bioactivity, and degradability. The novel bone cement could be a potential candidate as bone substitute. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2007

  • Novel tricalcium silicate/Monocalcium Phosphate monohydrate composite bone cement.
    Journal of biomedical materials research. Part B Applied biomaterials, 2007
    Co-Authors: Zhiguang Huan, Jiang Chang
    Abstract:

    In this paper, we obtained a novel bone cement composed of tricalcium silicate (Ca3SiO5; C3S) and Monocalcium Phosphate monohydrate (MCPM). The weight ratio of MCPM in the cement is 0, 10, 20, and 30%. The initial setting time was dramatically reduced from 90 min to 30 min as the content of MCPM reached 20%. The workable paste with a liquid/powder (L/P) ratio of 0.8 mL/g could be injected for 2–20 min (nozzle diameter 2.0 mm). The pH variation of the composite cement in simulated body environment was obviously lowered. The compressive strength of the composite cement after setting for 4–28 days was slightly lower than that of the tricalcium silicate paste. The in vitro bioactivity was investigated by soaking in simulated body fluid for 7 days. The result showed that the novel bone cement had good bioactivity and could degrade in tris-(hydroxymethyl)-aminomethane-hydrochloric-acid (Tris-HCl) solution. Our result indicated that the Ca3SiO5/MCPM paste had good hydraulic properties, bioactivity, and degradability. The novel bone cement could be a potential candidate as bone substitute. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2007

Zhiguang Huan - One of the best experts on this subject based on the ideXlab platform.

  • Novel bioactive composite bone cements based on the beta-tricalcium Phosphate-Monocalcium Phosphate monohydrate composite cement system.
    Acta biomaterialia, 2008
    Co-Authors: Zhiguang Huan, Jiang Chang
    Abstract:

    Bioactive composite bone cements were obtained by incorporation of tricalcium silicate (Ca3SiO5, C3S) into a brushite bone cement composed of beta-tricalcium Phosphate [beta-Ca3(PO4)2, beta-TCP] and Monocalcium Phosphate monohydrate [Ca(H2PO4)2.H2O, MCPM], and the properties of the new cements were studied and compared with pure brushite cement. The results indicated that the injectability, setting time and short- and long-term mechanical strength of the material are higher than those of pure brushite cement, and the compressive strength of the TCP/MCPM/C3S composite paste increased with increasing aging time. Moreover, the TCP/MCPM/C3S specimens showed significantly improved in vitro bioactivity in simulated body fluid and similar degradability in Phosphate-buffered saline as compared with brushite cement. Additionally, the reacted TCP/MCPM/C3S paste possesses the ability to stimulate osteoblast proliferation and promote osteoblastic differentiation of the bone marrow stromal cells. The results indicated that the TCP/MCPM/C3S cements may be used as a bioactive material for bone regeneration, and might have significant clinical advantage over the traditional beta-TCP/MCPM brushite cement.

  • novel tricalcium silicate Monocalcium Phosphate monohydrate composite bone cement
    Journal of Biomedical Materials Research Part B, 2007
    Co-Authors: Zhiguang Huan, Jiang Chang
    Abstract:

    In this paper, we obtained a novel bone cement composed of tricalcium silicate (Ca3SiO5; C3S) and Monocalcium Phosphate monohydrate (MCPM). The weight ratio of MCPM in the cement is 0, 10, 20, and 30%. The initial setting time was dramatically reduced from 90 min to 30 min as the content of MCPM reached 20%. The workable paste with a liquid/powder (L/P) ratio of 0.8 mL/g could be injected for 2–20 min (nozzle diameter 2.0 mm). The pH variation of the composite cement in simulated body environment was obviously lowered. The compressive strength of the composite cement after setting for 4–28 days was slightly lower than that of the tricalcium silicate paste. The in vitro bioactivity was investigated by soaking in simulated body fluid for 7 days. The result showed that the novel bone cement had good bioactivity and could degrade in tris-(hydroxymethyl)-aminomethane-hydrochloric-acid (Tris-HCl) solution. Our result indicated that the Ca3SiO5/MCPM paste had good hydraulic properties, bioactivity, and degradability. The novel bone cement could be a potential candidate as bone substitute. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2007

  • Novel tricalcium silicate/Monocalcium Phosphate monohydrate composite bone cement.
    Journal of biomedical materials research. Part B Applied biomaterials, 2007
    Co-Authors: Zhiguang Huan, Jiang Chang
    Abstract:

    In this paper, we obtained a novel bone cement composed of tricalcium silicate (Ca3SiO5; C3S) and Monocalcium Phosphate monohydrate (MCPM). The weight ratio of MCPM in the cement is 0, 10, 20, and 30%. The initial setting time was dramatically reduced from 90 min to 30 min as the content of MCPM reached 20%. The workable paste with a liquid/powder (L/P) ratio of 0.8 mL/g could be injected for 2–20 min (nozzle diameter 2.0 mm). The pH variation of the composite cement in simulated body environment was obviously lowered. The compressive strength of the composite cement after setting for 4–28 days was slightly lower than that of the tricalcium silicate paste. The in vitro bioactivity was investigated by soaking in simulated body fluid for 7 days. The result showed that the novel bone cement had good bioactivity and could degrade in tris-(hydroxymethyl)-aminomethane-hydrochloric-acid (Tris-HCl) solution. Our result indicated that the Ca3SiO5/MCPM paste had good hydraulic properties, bioactivity, and degradability. The novel bone cement could be a potential candidate as bone substitute. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2007

Ronald Verbeeck - One of the best experts on this subject based on the ideXlab platform.

  • the effect of a photopolymerizable poly e caprolactone co glycolide matrix on the cement reactions of tetracalcium Phosphate and tetracalcium Phosphate Monocalcium Phosphate monohydrate mixtures
    Journal of Materials Chemistry B, 2013
    Co-Authors: Natasja Van Den Vreken, Peter Dubruel, Ronald Verbeeck
    Abstract:

    In this study, the influence of a biodegradable polymer matrix on the conversion of tetracalcium Phosphate (TTCP) or TTCP–Monocalcium Phosphate monohydrate (MCPM) powders was investigated. As a reference, the properties of three calcium Phosphate cements (CPCs) based on TTCP or TTCP–MCPM mixtures were discussed. Additionally, the influence of these calcium Phosphate (CP) reacting powders on the polymer degradation was studied. Composites were formulated by mixing cross-linkable dimethacrylates of the e-caprolactone/glycolide co-polymer with hydroxyethylmethacrylate, a photo-initiator and TTCP or TTCP–MCPM. The composite samples were set by visible light irradiation. CPC and composite samples were immersed in HEPES at 37 °C. The CPC based on TTCP converted to a carbonated apatite. Adding MCPM to the TTCP powder improved the conversion of TTCP. By varying the MCPM/TTCP ratio it was possible to tailor the conversion reactions so that an apatitic phase could be formed via intermediate products like DPC, DCPD and OCP. In the composites, a mutual interaction between the CP reacting powders and the polymer was observed. The co-polymer and its degradation products influenced the conversion reactions of the CP reacting powders. The degradation products tend to enhance the TTCP conversion after a long immersion time. The conversion of the TTCP–MCPM mixtures was retarded by the polymer matrix although the intermediate products were not altered. The basicity or acidity of the CP reacting powders and their conversion reactions were the main cause for the retarded polymer degradation, which was more pronounced when the basicity of the CP reacting powders increased.

  • The effect of a photopolymerizable poly(ε-caprolactone-co-glycolide) matrix on the cement reactions of tetracalcium Phosphate and tetracalcium Phosphate–Monocalcium Phosphate monohydrate mixtures
    Journal of materials chemistry. B, 2013
    Co-Authors: Natasja Van Den Vreken, Peter Dubruel, Ronald Verbeeck
    Abstract:

    In this study, the influence of a biodegradable polymer matrix on the conversion of tetracalcium Phosphate (TTCP) or TTCP–Monocalcium Phosphate monohydrate (MCPM) powders was investigated. As a reference, the properties of three calcium Phosphate cements (CPCs) based on TTCP or TTCP–MCPM mixtures were discussed. Additionally, the influence of these calcium Phosphate (CP) reacting powders on the polymer degradation was studied. Composites were formulated by mixing cross-linkable dimethacrylates of the e-caprolactone/glycolide co-polymer with hydroxyethylmethacrylate, a photo-initiator and TTCP or TTCP–MCPM. The composite samples were set by visible light irradiation. CPC and composite samples were immersed in HEPES at 37 °C. The CPC based on TTCP converted to a carbonated apatite. Adding MCPM to the TTCP powder improved the conversion of TTCP. By varying the MCPM/TTCP ratio it was possible to tailor the conversion reactions so that an apatitic phase could be formed via intermediate products like DPC, DCPD and OCP. In the composites, a mutual interaction between the CP reacting powders and the polymer was observed. The co-polymer and its degradation products influenced the conversion reactions of the CP reacting powders. The degradation products tend to enhance the TTCP conversion after a long immersion time. The conversion of the TTCP–MCPM mixtures was retarded by the polymer matrix although the intermediate products were not altered. The basicity or acidity of the CP reacting powders and their conversion reactions were the main cause for the retarded polymer degradation, which was more pronounced when the basicity of the CP reacting powders increased.

B Flautre - One of the best experts on this subject based on the ideXlab platform.

  • resorption of and bone formation from new β tricalcium Phosphate Monocalcium Phosphate cements an in vivo study
    Journal of Biomedical Materials Research, 1996
    Co-Authors: K Ohura, Marc Bohner, P Hardouin, Jacques Lemaitre, Gilles Pasquier, B Flautre
    Abstract:

    Hard cylinders (4.7 × 10 mm) of two kinds of β-tricalcium Phosphate-Monocalcium Phosphate monohydrate-calcium sulfate hemihydrate (β-TCP-MCPM-CSH) cements with and without β-TCP granules (500–1000 μm) were implanted into holes drilled in rabbit femoral condyles for up to 16 weeks. Empty cavities were used as control. Cement resorption and new bone formation in the cylinders were evaluated with contact microradiography and quantified through an automatic image analysis system. At 4 weeks, both kinds of cement cylinders were surrounded by new bone. At 8 weeks, except for β-TCP granules, both cement cylinders were almost completely resorbed and replaced by bone tissue. At 16 weeks the bone in the cavities of both cements recovered a trabecular pattern, but only the bone trabeculae in the initial cavity of the cement with β-TCP granules became thick and mature. However, the cavities of the empty control were still empty and large. These results show that the β-TCP-MCPM-CSH cements stimulate bone formation and are rapidly replaced by bone tissue. When added with nonresorbable β-TCP granules, this cement maintains bone formation for a longer time. © 1996 John Wiley & Sons, Inc.

  • Resorption of, and bone formation from, new beta-tricalcium Phosphate-Monocalcium Phosphate cements: an in vivo study.
    Journal of biomedical materials research, 1996
    Co-Authors: K Ohura, Marc Bohner, P Hardouin, Jacques Lemaitre, Gilles Pasquier, B Flautre
    Abstract:

    Hard cylinders (4.7 x 10 mm) of two kinds of beta-tricalcium Phosphate-Monocalcium Phosphate monohydrate-calcium sulfate hemihydrate (beta-TCP-MCPM-CSH) cements with and without beta-TCP granules (500-1000 microns) were implanted into holes drilled in rabbit femoral condyles for up to 16 weeks. Empty cavities were used as control. Cement resorption and new bone formation in the cylinders were evaluated with contact microradiography and quantified through an automatic image analysis system. At 4 weeks, both kinds of cement cylinders were surrounded by new bone. At 8 weeks, except for beta-TCP granules, both cement cylinders were almost completely resorbed and replaced by bone tissue. At 16 weeks the bone in the cavities of both cements recovered a trabecular pattern, but only the bone trabeculae in the initial cavity of the cement with beta-TCP granules became thick and mature. However, the cavities of the empty control were still empty and large. These results show that the beta-TCP-MCPM-CSH cements stimulate bone formation and are rapidly replaced by bone tissue. When added with nonresorbable beta-TCP granules, this cement maintains bone formation for a longer time.

Natasja Van Den Vreken - One of the best experts on this subject based on the ideXlab platform.

  • the effect of a photopolymerizable poly e caprolactone co glycolide matrix on the cement reactions of tetracalcium Phosphate and tetracalcium Phosphate Monocalcium Phosphate monohydrate mixtures
    Journal of Materials Chemistry B, 2013
    Co-Authors: Natasja Van Den Vreken, Peter Dubruel, Ronald Verbeeck
    Abstract:

    In this study, the influence of a biodegradable polymer matrix on the conversion of tetracalcium Phosphate (TTCP) or TTCP–Monocalcium Phosphate monohydrate (MCPM) powders was investigated. As a reference, the properties of three calcium Phosphate cements (CPCs) based on TTCP or TTCP–MCPM mixtures were discussed. Additionally, the influence of these calcium Phosphate (CP) reacting powders on the polymer degradation was studied. Composites were formulated by mixing cross-linkable dimethacrylates of the e-caprolactone/glycolide co-polymer with hydroxyethylmethacrylate, a photo-initiator and TTCP or TTCP–MCPM. The composite samples were set by visible light irradiation. CPC and composite samples were immersed in HEPES at 37 °C. The CPC based on TTCP converted to a carbonated apatite. Adding MCPM to the TTCP powder improved the conversion of TTCP. By varying the MCPM/TTCP ratio it was possible to tailor the conversion reactions so that an apatitic phase could be formed via intermediate products like DPC, DCPD and OCP. In the composites, a mutual interaction between the CP reacting powders and the polymer was observed. The co-polymer and its degradation products influenced the conversion reactions of the CP reacting powders. The degradation products tend to enhance the TTCP conversion after a long immersion time. The conversion of the TTCP–MCPM mixtures was retarded by the polymer matrix although the intermediate products were not altered. The basicity or acidity of the CP reacting powders and their conversion reactions were the main cause for the retarded polymer degradation, which was more pronounced when the basicity of the CP reacting powders increased.

  • The effect of a photopolymerizable poly(ε-caprolactone-co-glycolide) matrix on the cement reactions of tetracalcium Phosphate and tetracalcium Phosphate–Monocalcium Phosphate monohydrate mixtures
    Journal of materials chemistry. B, 2013
    Co-Authors: Natasja Van Den Vreken, Peter Dubruel, Ronald Verbeeck
    Abstract:

    In this study, the influence of a biodegradable polymer matrix on the conversion of tetracalcium Phosphate (TTCP) or TTCP–Monocalcium Phosphate monohydrate (MCPM) powders was investigated. As a reference, the properties of three calcium Phosphate cements (CPCs) based on TTCP or TTCP–MCPM mixtures were discussed. Additionally, the influence of these calcium Phosphate (CP) reacting powders on the polymer degradation was studied. Composites were formulated by mixing cross-linkable dimethacrylates of the e-caprolactone/glycolide co-polymer with hydroxyethylmethacrylate, a photo-initiator and TTCP or TTCP–MCPM. The composite samples were set by visible light irradiation. CPC and composite samples were immersed in HEPES at 37 °C. The CPC based on TTCP converted to a carbonated apatite. Adding MCPM to the TTCP powder improved the conversion of TTCP. By varying the MCPM/TTCP ratio it was possible to tailor the conversion reactions so that an apatitic phase could be formed via intermediate products like DPC, DCPD and OCP. In the composites, a mutual interaction between the CP reacting powders and the polymer was observed. The co-polymer and its degradation products influenced the conversion reactions of the CP reacting powders. The degradation products tend to enhance the TTCP conversion after a long immersion time. The conversion of the TTCP–MCPM mixtures was retarded by the polymer matrix although the intermediate products were not altered. The basicity or acidity of the CP reacting powders and their conversion reactions were the main cause for the retarded polymer degradation, which was more pronounced when the basicity of the CP reacting powders increased.