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Suzanne C. Cannegieter - One of the best experts on this subject based on the ideXlab platform.

  • hematologic variables and venous thrombosis red cell distribution width and blood Monocyte Count are associated with an increased risk
    Haematologica, 2014
    Co-Authors: Suely M. Rezende, Willem M. Lijfering, Frits R. Rosendaal, Suzanne C. Cannegieter
    Abstract:

    Recent studies suggest that leukocytes and erythrocytes play a role in coagulation. However, whether leukocytes, erythrocytes and other hematologic variables are associated with risk of venous thrombosis is not well known. To study this, we used data from 2473 patients with venous thrombosis and 2935 controls. The variables assessed were: total leukocytes, granulocytes, lymphocytes, Monocytes, hematocrit, hemoglobin, erythrocytes and red cell indices (mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration and red cell distribution width). We found a strong dose-response relation for higher red cell distribution width and Monocyte Count with risk of venous thrombosis, with odds ratios of 3.1 (95% confidence interval, 2.0–4.8) and 2.8 (95% confidence interval, 1.3–5.8), respectively, after adjustment for age, sex, C-reactive protein level, malignancy and co-morbidities. Monocyte Count and red cell distribution width were associated with venous thrombosis even within reference ranges. A low Monocyte Count (<0.12×109/L) was associated with a lower risk of venous thrombosis after full adjustment (odds ratios 0.6; 95% confidence interval, 0.4–0.8). In summary, high red cell distribution width and blood Monocyte Count, two parameters that are inexpensive and easily obtainable, were clearly associated with an increased risk of venous thrombosis. Future studies should evaluate the underlying mechanism and the use of these variables in prediction models for first and recurrent thrombosis.

  • Hematologic variables and venous thrombosis: red cell distribution width and blood Monocyte Count are associated with an increased risk
    Haematologica, 2013
    Co-Authors: Suely M. Rezende, Willem M. Lijfering, Frits R. Rosendaal, Suzanne C. Cannegieter
    Abstract:

    Recent studies suggest that leukocytes and erythrocytes play a role in coagulation. However, whether leukocytes, erythrocytes and other hematologic variables are associated with risk of venous thrombosis is not well known. To study this, we used data from 2473 patients with venous thrombosis and 2935 controls. The variables assessed were: total leukocytes, granulocytes, lymphocytes, Monocytes, hematocrit, hemoglobin, erythrocytes and red cell indices (mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration and red cell distribution width). We found a strong dose-response relation for higher red cell distribution width and Monocyte Count with risk of venous thrombosis, with odds ratios of 3.1 (95% confidence interval, 2.0-4.8) and 2.8 (95% confidence interval, 1.3-5.8), respectively, after adjustment for age, sex, C-reactive protein level, malignancy and co-morbidities. Monocyte Count and red cell distribution width were associated with venous thrombosis even within reference ranges. A low Monocyte Count (

Jost B Jonas - One of the best experts on this subject based on the ideXlab platform.

  • peripheral Monocyte Count and age related macular degeneration the tongren health care study blood Monocyte Count and age related macular degeneration
    American Journal of Ophthalmology, 2021
    Co-Authors: Can Can Xue, Jing Cui, Li Qin Gao, Chun Zhang, Hong Liang Dou, Dong Ning Chen, Ya Xing Wang, Jost B Jonas
    Abstract:

    PURPOSE To assess potential associations between the prevalence of age-related macular degeneration (AMD) and systemic parameters in a Chinese population. DESIGN Cross-sectional study. METHODS The Tongren Health Care Study included individuals attending regular health care check-up examinations in the Beijing Tongren Hospital from 2017 to 2019. Detailed medical examinations and ophthalmic examinations were applied, including fundus photography. AMD was evaluated according to the Beckman Initiative guidelines. RESULTS The study included 7,719 participants (mean age: 60.5 ± 8.1 years; range: 50-97 years). The prevalence of any, early, intermediate, and late AMD was 1,607 of 7,719 (20.8%; 95% confidence interval [CI]: 20.1%, 21.9%), 832 of 7,719 (10.8%; 95% CI: 10.1%, 11.5%), 733 of 7,719 (9.5%; 95% CI: 8.9%, 10.2%), and 42 of 7,719 (0.50%; 95% CI: 0.40%, 0.70%), respectively. In multivariate analysis, the prevalence of any AMD increased with higher blood Monocyte Count (odds ratio [OR]:3.49; 95% CI: 2.26, 5.38; P < .001), after adjusting for older age (OR: 1.06; 95% CI: 1.05, 1.07; P < .001), higher serum concentration of calcium (OR: 2.52; 95% CI: 1.32, 4.84; P = .005), high-density lipoproteins (OR: 1.39; 95% CI: 1.19, 1.61; P < .001), and lower lipoprotein a (OR: 0.99; 95% CI: 0.98, 0.99; P = .02). Similar findings were obtained for the prevalence of intermediate and late AMD combined. The association between higher Monocyte Count and higher AMD prevalence showed the highest odds ratio for the age group of 50-59 years (any AMD: OR: 4.35, P < .001; intermediate and late AMD: OR: 6.14, P < .001). Individuals with a Monocyte Count of ≥0.5 × 109/L as compared to participants with a Monocyte of 0.1-0.4 × 109/L had a 1.45-fold increased risk for any AMD (OR: 1.45; 95% CI: 1.27, 1.64; P < .001) and 1.58 fold increase risk for intermediate/late AMD (OR: 1.58; 95% CI: 1.33, 1.87; P < .001). CONCLUSION A higher prevalence of early AMD, intermediate AMD, late AMD, and any AMD was associated with a higher peripheral Monocyte Count. In agreement with previous studies, the observation suggests Monocytes playing a role in the pathogenesis of AMD.

  • Peripheral Monocyte Count and Age-Related Macular Degeneration. The Tongren Health Care Study: Blood Monocyte Count and Age-Related Macular Degeneration.
    American journal of ophthalmology, 2021
    Co-Authors: Can Can Xue, Jing Cui, Li Qin Gao, Chun Zhang, Hong Liang Dou, Dong Ning Chen, Ya Xing Wang, Jost B Jonas
    Abstract:

    PURPOSE To assess potential associations between the prevalence of age-related macular degeneration (AMD) and systemic parameters in a Chinese population. DESIGN Cross-sectional study METHODS: : The Tongren Health Care Study included individuals attending regular health care check-up examinations in the Beijing Tongren Hospital from 2017 to 2019. Detailed medical examinations and ophthalmic examinations were applied, including fundus photography. AMD was evaluated according to the Beckman Initiative guidelines. RESULTS The study included 7719 participants (mean age:60.5±8.1years; range:50-97years). The prevalence of any, early, intermediate and late AMD was 1607/7719 (20.8%;95% confidence interval (CI):20.1,21.9%), 832/7719 (10.8%;95%CI:10.1,11.5%), 733/7719 (9.5%;95%CI:8.9,10.2%), and 42/7719 (0.50%;95%CI:0.40,0.70%), respectively. In multivariate analysis, the prevalence of any AMD increased with higher blood Monocyte Count (odds ratio (OR):3.49;95%CI:2.26,5.38;P

Joseph Hung - One of the best experts on this subject based on the ideXlab platform.

  • Monocyte Count but not c reactive protein or interleukin 6 is an independent risk marker for subclinical carotid atherosclerosis
    Stroke, 2004
    Co-Authors: Caroline M L Chapman, John Beilby, Brendan Mcquillan, Peter L Thompson, Joseph Hung
    Abstract:

    Background and Purpose— Systemic inflammatory markers have been shown to predict future cardiovascular events, but whether they are associated with early atherosclerosis is uncertain. We investigated the relationship of inflammatory markers interleukin-6 (IL-6), high-sensitive C-reactive protein (hs-CRP), fibrinogen, Monocyte Count, and white cell Count (WCC) with subclinical carotid atherosclerosis in a healthy community population. Methods— B-mode carotid ultrasound was performed on 1111 randomly selected male and female subjects aged 27 to 77 years. Serum IL-6, hs-CRP, plasma fibrinogen, Monocyte Count, and WCC were measured on all subjects, along with conventional cardiovascular risk factors. Results— Multivariate analysis showed that IL-6 (P<0.0001), fibrinogen (P=0.007), and Monocyte Count (P=0.001) were associated with carotid plaque formation in the whole population. Monocyte Count remained associated independently with carotid plaque formation when adjusted further for conventional risk factors (...

  • Monocyte Count, But Not C-Reactive Protein or Interleukin-6, Is an Independent Risk Marker for Subclinical Carotid Atherosclerosis
    Stroke, 2004
    Co-Authors: Caroline M L Chapman, John Beilby, Brendan Mcquillan, Peter L Thompson, Joseph Hung
    Abstract:

    Background and Purpose— Systemic inflammatory markers have been shown to predict future cardiovascular events, but whether they are associated with early atherosclerosis is uncertain. We investigated the relationship of inflammatory markers interleukin-6 (IL-6), high-sensitive C-reactive protein (hs-CRP), fibrinogen, Monocyte Count, and white cell Count (WCC) with subclinical carotid atherosclerosis in a healthy community population. Methods— B-mode carotid ultrasound was performed on 1111 randomly selected male and female subjects aged 27 to 77 years. Serum IL-6, hs-CRP, plasma fibrinogen, Monocyte Count, and WCC were measured on all subjects, along with conventional cardiovascular risk factors. Results— Multivariate analysis showed that IL-6 (P

Suely M. Rezende - One of the best experts on this subject based on the ideXlab platform.

  • hematologic variables and venous thrombosis red cell distribution width and blood Monocyte Count are associated with an increased risk
    Haematologica, 2014
    Co-Authors: Suely M. Rezende, Willem M. Lijfering, Frits R. Rosendaal, Suzanne C. Cannegieter
    Abstract:

    Recent studies suggest that leukocytes and erythrocytes play a role in coagulation. However, whether leukocytes, erythrocytes and other hematologic variables are associated with risk of venous thrombosis is not well known. To study this, we used data from 2473 patients with venous thrombosis and 2935 controls. The variables assessed were: total leukocytes, granulocytes, lymphocytes, Monocytes, hematocrit, hemoglobin, erythrocytes and red cell indices (mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration and red cell distribution width). We found a strong dose-response relation for higher red cell distribution width and Monocyte Count with risk of venous thrombosis, with odds ratios of 3.1 (95% confidence interval, 2.0–4.8) and 2.8 (95% confidence interval, 1.3–5.8), respectively, after adjustment for age, sex, C-reactive protein level, malignancy and co-morbidities. Monocyte Count and red cell distribution width were associated with venous thrombosis even within reference ranges. A low Monocyte Count (<0.12×109/L) was associated with a lower risk of venous thrombosis after full adjustment (odds ratios 0.6; 95% confidence interval, 0.4–0.8). In summary, high red cell distribution width and blood Monocyte Count, two parameters that are inexpensive and easily obtainable, were clearly associated with an increased risk of venous thrombosis. Future studies should evaluate the underlying mechanism and the use of these variables in prediction models for first and recurrent thrombosis.

  • Hematologic variables and venous thrombosis: red cell distribution width and blood Monocyte Count are associated with an increased risk
    Haematologica, 2013
    Co-Authors: Suely M. Rezende, Willem M. Lijfering, Frits R. Rosendaal, Suzanne C. Cannegieter
    Abstract:

    Recent studies suggest that leukocytes and erythrocytes play a role in coagulation. However, whether leukocytes, erythrocytes and other hematologic variables are associated with risk of venous thrombosis is not well known. To study this, we used data from 2473 patients with venous thrombosis and 2935 controls. The variables assessed were: total leukocytes, granulocytes, lymphocytes, Monocytes, hematocrit, hemoglobin, erythrocytes and red cell indices (mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration and red cell distribution width). We found a strong dose-response relation for higher red cell distribution width and Monocyte Count with risk of venous thrombosis, with odds ratios of 3.1 (95% confidence interval, 2.0-4.8) and 2.8 (95% confidence interval, 1.3-5.8), respectively, after adjustment for age, sex, C-reactive protein level, malignancy and co-morbidities. Monocyte Count and red cell distribution width were associated with venous thrombosis even within reference ranges. A low Monocyte Count (

Can Can Xue - One of the best experts on this subject based on the ideXlab platform.

  • peripheral Monocyte Count and age related macular degeneration the tongren health care study blood Monocyte Count and age related macular degeneration
    American Journal of Ophthalmology, 2021
    Co-Authors: Can Can Xue, Jing Cui, Li Qin Gao, Chun Zhang, Hong Liang Dou, Dong Ning Chen, Ya Xing Wang, Jost B Jonas
    Abstract:

    PURPOSE To assess potential associations between the prevalence of age-related macular degeneration (AMD) and systemic parameters in a Chinese population. DESIGN Cross-sectional study. METHODS The Tongren Health Care Study included individuals attending regular health care check-up examinations in the Beijing Tongren Hospital from 2017 to 2019. Detailed medical examinations and ophthalmic examinations were applied, including fundus photography. AMD was evaluated according to the Beckman Initiative guidelines. RESULTS The study included 7,719 participants (mean age: 60.5 ± 8.1 years; range: 50-97 years). The prevalence of any, early, intermediate, and late AMD was 1,607 of 7,719 (20.8%; 95% confidence interval [CI]: 20.1%, 21.9%), 832 of 7,719 (10.8%; 95% CI: 10.1%, 11.5%), 733 of 7,719 (9.5%; 95% CI: 8.9%, 10.2%), and 42 of 7,719 (0.50%; 95% CI: 0.40%, 0.70%), respectively. In multivariate analysis, the prevalence of any AMD increased with higher blood Monocyte Count (odds ratio [OR]:3.49; 95% CI: 2.26, 5.38; P < .001), after adjusting for older age (OR: 1.06; 95% CI: 1.05, 1.07; P < .001), higher serum concentration of calcium (OR: 2.52; 95% CI: 1.32, 4.84; P = .005), high-density lipoproteins (OR: 1.39; 95% CI: 1.19, 1.61; P < .001), and lower lipoprotein a (OR: 0.99; 95% CI: 0.98, 0.99; P = .02). Similar findings were obtained for the prevalence of intermediate and late AMD combined. The association between higher Monocyte Count and higher AMD prevalence showed the highest odds ratio for the age group of 50-59 years (any AMD: OR: 4.35, P < .001; intermediate and late AMD: OR: 6.14, P < .001). Individuals with a Monocyte Count of ≥0.5 × 109/L as compared to participants with a Monocyte of 0.1-0.4 × 109/L had a 1.45-fold increased risk for any AMD (OR: 1.45; 95% CI: 1.27, 1.64; P < .001) and 1.58 fold increase risk for intermediate/late AMD (OR: 1.58; 95% CI: 1.33, 1.87; P < .001). CONCLUSION A higher prevalence of early AMD, intermediate AMD, late AMD, and any AMD was associated with a higher peripheral Monocyte Count. In agreement with previous studies, the observation suggests Monocytes playing a role in the pathogenesis of AMD.

  • Peripheral Monocyte Count and Age-Related Macular Degeneration. The Tongren Health Care Study: Blood Monocyte Count and Age-Related Macular Degeneration.
    American journal of ophthalmology, 2021
    Co-Authors: Can Can Xue, Jing Cui, Li Qin Gao, Chun Zhang, Hong Liang Dou, Dong Ning Chen, Ya Xing Wang, Jost B Jonas
    Abstract:

    PURPOSE To assess potential associations between the prevalence of age-related macular degeneration (AMD) and systemic parameters in a Chinese population. DESIGN Cross-sectional study METHODS: : The Tongren Health Care Study included individuals attending regular health care check-up examinations in the Beijing Tongren Hospital from 2017 to 2019. Detailed medical examinations and ophthalmic examinations were applied, including fundus photography. AMD was evaluated according to the Beckman Initiative guidelines. RESULTS The study included 7719 participants (mean age:60.5±8.1years; range:50-97years). The prevalence of any, early, intermediate and late AMD was 1607/7719 (20.8%;95% confidence interval (CI):20.1,21.9%), 832/7719 (10.8%;95%CI:10.1,11.5%), 733/7719 (9.5%;95%CI:8.9,10.2%), and 42/7719 (0.50%;95%CI:0.40,0.70%), respectively. In multivariate analysis, the prevalence of any AMD increased with higher blood Monocyte Count (odds ratio (OR):3.49;95%CI:2.26,5.38;P