The Experts below are selected from a list of 10749 Experts worldwide ranked by ideXlab platform
R Walker - One of the best experts on this subject based on the ideXlab platform.
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Consensus meeting: Monosodium Glutamate – an update
European Journal of Clinical Nutrition, 2007Co-Authors: K Beyreuther, H K Biesalski, J D Fernstrom, P Grimm, W P Hammes, U Heinemann, O Kempski, P Stehle, H Steinhart, R WalkerAbstract:Objective: Update of the Hohenheim consensus on Monosodium Glutamate from 1997: Summary and evaluation of recent knowledge with respect to physiology and safety of Monosodium Glutamate. Design: Experts from a range of relevant disciplines received and considered a series of questions related to aspects of the topic. Setting: University of Hohenheim, Stuttgart, Germany. Method: The experts met and discussed the questions and arrived at a consensus. Conclusion: Total intake of Glutamate from food in European countries is generally stable and ranged from 5 to 12 g/day (free: ca. 1 g, protein-bound: ca. 10 g, added as flavor: ca. 0.4 g). L -Glutamate (GLU) from all sources is mainly used as energy fuel in enterocytes. A maximum intake of 16.000 mg/kg body weight is regarded as safe. The general use of Glutamate salts (Monosodium- L -Glutamate and others) as food additive can, thus, be regarded as harmless for the whole population. Even in unphysiologically high doses GLU will not trespass into fetal circulation. Further research work should, however, be done concerning the effects of high doses of a bolus supply at presence of an impaired blood brain barrier function. In situations with decreased appetite (e.g., elderly persons) palatability can be improved by low dose use of Monosodium- L -Glutamate.
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consensus meeting Monosodium Glutamate an update
European Journal of Clinical Nutrition, 2007Co-Authors: K Beyreuther, H K Biesalski, J D Fernstrom, P Grimm, W P Hammes, U Heinemann, O Kempski, P Stehle, H Steinhart, R WalkerAbstract:Update of the Hohenheim consensus on Monosodium Glutamate from 1997: Summary and evaluation of recent knowledge with respect to physiology and safety of Monosodium Glutamate. Experts from a range of relevant disciplines received and considered a series of questions related to aspects of the topic. University of Hohenheim, Stuttgart, Germany. The experts met and discussed the questions and arrived at a consensus. Total intake of Glutamate from food in European countries is generally stable and ranged from 5 to 12 g/day (free: ca. 1 g, protein-bound: ca. 10 g, added as flavor: ca. 0.4 g). L-Glutamate (GLU) from all sources is mainly used as energy fuel in enterocytes. A maximum intake of 16.000 mg/kg body weight is regarded as safe. The general use of Glutamate salts (Monosodium-L-Glutamate and others) as food additive can, thus, be regarded as harmless for the whole population. Even in unphysiologically high doses GLU will not trespass into fetal circulation. Further research work should, however, be done concerning the effects of high doses of a bolus supply at presence of an impaired blood brain barrier function. In situations with decreased appetite (e.g., elderly persons) palatability can be improved by low dose use of Monosodium-L-Glutamate.
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Consensus meeting: Monosodium Glutamate – an update
European journal of clinical nutrition, 2006Co-Authors: K Beyreuther, H K Biesalski, J D Fernstrom, P Grimm, W P Hammes, U Heinemann, O Kempski, P Stehle, H Steinhart, R WalkerAbstract:Update of the Hohenheim consensus on Monosodium Glutamate from 1997: Summary and evaluation of recent knowledge with respect to physiology and safety of Monosodium Glutamate. Experts from a range of relevant disciplines received and considered a series of questions related to aspects of the topic. University of Hohenheim, Stuttgart, Germany. The experts met and discussed the questions and arrived at a consensus. Total intake of Glutamate from food in European countries is generally stable and ranged from 5 to 12 g/day (free: ca. 1 g, protein-bound: ca. 10 g, added as flavor: ca. 0.4 g). L-Glutamate (GLU) from all sources is mainly used as energy fuel in enterocytes. A maximum intake of 16.000 mg/kg body weight is regarded as safe. The general use of Glutamate salts (Monosodium-L-Glutamate and others) as food additive can, thus, be regarded as harmless for the whole population. Even in unphysiologically high doses GLU will not trespass into fetal circulation. Further research work should, however, be done concerning the effects of high doses of a bolus supply at presence of an impaired blood brain barrier function. In situations with decreased appetite (e.g., elderly persons) palatability can be improved by low dose use of Monosodium-L-Glutamate.
Chioli Pascal Chijioke - One of the best experts on this subject based on the ideXlab platform.
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Chronic toxicity of low dose Monosodium Glutamate in albino Wistar rats
BMC Research Notes, 2019Co-Authors: Josiah Okwudili Nnadozie, Udunma Olive Chijioke, Okechukwu Charles Okafor, Daniel Bankole Olusina, Patience Chiebonam Nwonu, Herbert Orji Mbagwu, Chioli Pascal ChijiokeAbstract:Objective The objective of this study was to observe the effects of chronic dosing with Monosodium Glutamate on mortality, fertility, major organ functions and histology in albino Wistar rats. Results 6 male and 6 female rats (age 6 weeks) were bred in a cage, feeding on standard growers’ mash, with Monosodium Glutamate added (120 mg/kg/day). 12 corresponding breeding rats (on standard feed without MSG) were controls. Chronic dosing with Monosodium Glutamate in albino Wistar rats (at a dose consistent with the human ADI) led to increased mortality, fertility impairment, and significant changes in major organ function tests and histology. 23 deaths were recorded in the rats fed with MSG additive, while mortality was zero in the control animals. Fertility was lower in rats on MSG (48 births) than in controls (117 births). The weight gain of the MSG rats was higher than in controls. Biochemical parameters and organ histology remained normal in control animals. In MSG-treated rats however, liver/renal function tests, fasting serum cholesterol and triglyceride, serum uric acid showed a significant rise at trimestrial time-points. Histology showed mild portal inflammation in MSG rats, with periglomerular fibrosis and interstitial nephritis in two rats, at 6–12 months.
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Chronic toxicity of low dose Monosodium Glutamate in albino Wistar rats.
BMC Research Notes, 2019Co-Authors: Josiah Okwudili Nnadozie, Udunma Olive Chijioke, Daniel Bankole Olusina, Patience Chiebonam Nwonu, Herbert Orji Mbagwu, Oc Okafor, Chioli Pascal ChijiokeAbstract:The objective of this study was to observe the effects of chronic dosing with Monosodium Glutamate on mortality, fertility, major organ functions and histology in albino Wistar rats. 6 male and 6 female rats (age 6 weeks) were bred in a cage, feeding on standard growers’ mash, with Monosodium Glutamate added (120 mg/kg/day). 12 corresponding breeding rats (on standard feed without MSG) were controls. Chronic dosing with Monosodium Glutamate in albino Wistar rats (at a dose consistent with the human ADI) led to increased mortality, fertility impairment, and significant changes in major organ function tests and histology. 23 deaths were recorded in the rats fed with MSG additive, while mortality was zero in the control animals. Fertility was lower in rats on MSG (48 births) than in controls (117 births). The weight gain of the MSG rats was higher than in controls. Biochemical parameters and organ histology remained normal in control animals. In MSG-treated rats however, liver/renal function tests, fasting serum cholesterol and triglyceride, serum uric acid showed a significant rise at trimestrial time-points. Histology showed mild portal inflammation in MSG rats, with periglomerular fibrosis and interstitial nephritis in two rats, at 6–12 months.
Fernando Carlos De Sousa - One of the best experts on this subject based on the ideXlab platform.
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Evaluation of body growth and myoenteric neurons of Wistar rats after neonatal treatment with Monosodium Glutamate
Acta Scientiarum. Biological Sciences, 2007Co-Authors: Maria Montserrat Diaz Pedrosa Furlan, Rosana Torrezan, Josy Fraccaro De Marins, Melina Rizzato Vismara, Fernando Carlos De SousaAbstract:This work aimed at evaluating how the neonatal treatment with Monosodium Glutamate reflects on body parameters and on myoenteric neurons of Wistar rats. Male rats were injected with Monosodium Glutamate during the first five postnatal days. Body growth was recorded until the age of 90 days, when the animals were killed. Fasting plasma glucose, caloric density and weight of organs were assayed. Gastric and duodenal whole-mounts stained with NADH diaphorase were observed for neuronal numbers and sizes. Growth, relative weight of organs and testicular caloric density of the injected rats were smaller than those of the controls, while their Lee index and relative fat content were greater. The number of duodenal neurons and the mean size of gastric neurons were smaller in the injected animals. These results are discussed in light of the endocrine, autonomic and behavioral changes stemming from the lesion of the hypothalamic arcuate nucleus by Monosodium Glutamate.
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Evaluation of body growth and myoenteric neurons of body growth and myoenteric neurons of body growth and myoenteric neurons of body growth and myoenteric neurons of Wistar Wistar rats after neonatal treatment with Monosodium Glutamate after neonatal
2007Co-Authors: Maria Montserrat, Diaz Pedrosa Furlan, Rosana Torrezan, Josy Fraccaro De Marins, Melina Rizzato Vismara, Fernando Carlos De SousaAbstract:This work aimed at evaluating how the neonatal treatment with Monosodium Glutamate reflects on body parameters and on myoenteric neurons of Wistar rats. Male rats were injected with Monosodium Glutamate during the first five postnatal days. Body growth was recorded until the age of 90 days, when the animals were killed. Fasting plasma glucose, caloric density and weight of organs were assayed. Gastric and duodenal whole-mounts stained with NADH diaphorase were observed for neuronal numbers and sizes. Growth, relative weight of organs and testicular caloric density of the injected rats were smaller than those of the controls, while their Lee index and relative fat content were greater. The number of duodenal neurons and the mean size of gastric neurons were smaller in the injected animals. These results are discussed in light of the endocrine, autonomic and behavioral changes stemming from the lesion of the hypothalamic arcuate nucleus by Monosodium Glutamate.
K Beyreuther - One of the best experts on this subject based on the ideXlab platform.
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Consensus meeting: Monosodium Glutamate – an update
European Journal of Clinical Nutrition, 2007Co-Authors: K Beyreuther, H K Biesalski, J D Fernstrom, P Grimm, W P Hammes, U Heinemann, O Kempski, P Stehle, H Steinhart, R WalkerAbstract:Objective: Update of the Hohenheim consensus on Monosodium Glutamate from 1997: Summary and evaluation of recent knowledge with respect to physiology and safety of Monosodium Glutamate. Design: Experts from a range of relevant disciplines received and considered a series of questions related to aspects of the topic. Setting: University of Hohenheim, Stuttgart, Germany. Method: The experts met and discussed the questions and arrived at a consensus. Conclusion: Total intake of Glutamate from food in European countries is generally stable and ranged from 5 to 12 g/day (free: ca. 1 g, protein-bound: ca. 10 g, added as flavor: ca. 0.4 g). L -Glutamate (GLU) from all sources is mainly used as energy fuel in enterocytes. A maximum intake of 16.000 mg/kg body weight is regarded as safe. The general use of Glutamate salts (Monosodium- L -Glutamate and others) as food additive can, thus, be regarded as harmless for the whole population. Even in unphysiologically high doses GLU will not trespass into fetal circulation. Further research work should, however, be done concerning the effects of high doses of a bolus supply at presence of an impaired blood brain barrier function. In situations with decreased appetite (e.g., elderly persons) palatability can be improved by low dose use of Monosodium- L -Glutamate.
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consensus meeting Monosodium Glutamate an update
European Journal of Clinical Nutrition, 2007Co-Authors: K Beyreuther, H K Biesalski, J D Fernstrom, P Grimm, W P Hammes, U Heinemann, O Kempski, P Stehle, H Steinhart, R WalkerAbstract:Update of the Hohenheim consensus on Monosodium Glutamate from 1997: Summary and evaluation of recent knowledge with respect to physiology and safety of Monosodium Glutamate. Experts from a range of relevant disciplines received and considered a series of questions related to aspects of the topic. University of Hohenheim, Stuttgart, Germany. The experts met and discussed the questions and arrived at a consensus. Total intake of Glutamate from food in European countries is generally stable and ranged from 5 to 12 g/day (free: ca. 1 g, protein-bound: ca. 10 g, added as flavor: ca. 0.4 g). L-Glutamate (GLU) from all sources is mainly used as energy fuel in enterocytes. A maximum intake of 16.000 mg/kg body weight is regarded as safe. The general use of Glutamate salts (Monosodium-L-Glutamate and others) as food additive can, thus, be regarded as harmless for the whole population. Even in unphysiologically high doses GLU will not trespass into fetal circulation. Further research work should, however, be done concerning the effects of high doses of a bolus supply at presence of an impaired blood brain barrier function. In situations with decreased appetite (e.g., elderly persons) palatability can be improved by low dose use of Monosodium-L-Glutamate.
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Consensus meeting: Monosodium Glutamate – an update
European journal of clinical nutrition, 2006Co-Authors: K Beyreuther, H K Biesalski, J D Fernstrom, P Grimm, W P Hammes, U Heinemann, O Kempski, P Stehle, H Steinhart, R WalkerAbstract:Update of the Hohenheim consensus on Monosodium Glutamate from 1997: Summary and evaluation of recent knowledge with respect to physiology and safety of Monosodium Glutamate. Experts from a range of relevant disciplines received and considered a series of questions related to aspects of the topic. University of Hohenheim, Stuttgart, Germany. The experts met and discussed the questions and arrived at a consensus. Total intake of Glutamate from food in European countries is generally stable and ranged from 5 to 12 g/day (free: ca. 1 g, protein-bound: ca. 10 g, added as flavor: ca. 0.4 g). L-Glutamate (GLU) from all sources is mainly used as energy fuel in enterocytes. A maximum intake of 16.000 mg/kg body weight is regarded as safe. The general use of Glutamate salts (Monosodium-L-Glutamate and others) as food additive can, thus, be regarded as harmless for the whole population. Even in unphysiologically high doses GLU will not trespass into fetal circulation. Further research work should, however, be done concerning the effects of high doses of a bolus supply at presence of an impaired blood brain barrier function. In situations with decreased appetite (e.g., elderly persons) palatability can be improved by low dose use of Monosodium-L-Glutamate.
Josiah Okwudili Nnadozie - One of the best experts on this subject based on the ideXlab platform.
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Chronic toxicity of low dose Monosodium Glutamate in albino Wistar rats
BMC Research Notes, 2019Co-Authors: Josiah Okwudili Nnadozie, Udunma Olive Chijioke, Okechukwu Charles Okafor, Daniel Bankole Olusina, Patience Chiebonam Nwonu, Herbert Orji Mbagwu, Chioli Pascal ChijiokeAbstract:Objective The objective of this study was to observe the effects of chronic dosing with Monosodium Glutamate on mortality, fertility, major organ functions and histology in albino Wistar rats. Results 6 male and 6 female rats (age 6 weeks) were bred in a cage, feeding on standard growers’ mash, with Monosodium Glutamate added (120 mg/kg/day). 12 corresponding breeding rats (on standard feed without MSG) were controls. Chronic dosing with Monosodium Glutamate in albino Wistar rats (at a dose consistent with the human ADI) led to increased mortality, fertility impairment, and significant changes in major organ function tests and histology. 23 deaths were recorded in the rats fed with MSG additive, while mortality was zero in the control animals. Fertility was lower in rats on MSG (48 births) than in controls (117 births). The weight gain of the MSG rats was higher than in controls. Biochemical parameters and organ histology remained normal in control animals. In MSG-treated rats however, liver/renal function tests, fasting serum cholesterol and triglyceride, serum uric acid showed a significant rise at trimestrial time-points. Histology showed mild portal inflammation in MSG rats, with periglomerular fibrosis and interstitial nephritis in two rats, at 6–12 months.
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Chronic toxicity of low dose Monosodium Glutamate in albino Wistar rats.
BMC Research Notes, 2019Co-Authors: Josiah Okwudili Nnadozie, Udunma Olive Chijioke, Daniel Bankole Olusina, Patience Chiebonam Nwonu, Herbert Orji Mbagwu, Oc Okafor, Chioli Pascal ChijiokeAbstract:The objective of this study was to observe the effects of chronic dosing with Monosodium Glutamate on mortality, fertility, major organ functions and histology in albino Wistar rats. 6 male and 6 female rats (age 6 weeks) were bred in a cage, feeding on standard growers’ mash, with Monosodium Glutamate added (120 mg/kg/day). 12 corresponding breeding rats (on standard feed without MSG) were controls. Chronic dosing with Monosodium Glutamate in albino Wistar rats (at a dose consistent with the human ADI) led to increased mortality, fertility impairment, and significant changes in major organ function tests and histology. 23 deaths were recorded in the rats fed with MSG additive, while mortality was zero in the control animals. Fertility was lower in rats on MSG (48 births) than in controls (117 births). The weight gain of the MSG rats was higher than in controls. Biochemical parameters and organ histology remained normal in control animals. In MSG-treated rats however, liver/renal function tests, fasting serum cholesterol and triglyceride, serum uric acid showed a significant rise at trimestrial time-points. Histology showed mild portal inflammation in MSG rats, with periglomerular fibrosis and interstitial nephritis in two rats, at 6–12 months.