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George N Williams - One of the best experts on this subject based on the ideXlab platform.
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metal ion and anion coordination in the thiamine ptii no2 4 2 system structures of a metal complex pt thiamine no2 3 and two salts h thiamine pt no2 4 2h2o and thiamine monophosphate 2 pt no2 4 2h2o
Inorganica Chimica Acta, 2001Co-Authors: Katsuyuki Aoki, Adegboye O Adeyemo, George N WilliamsAbstract:Abstract Reaction of thiamine or thiamine monophosphate (TMP) with K2Pt(NO2)4 afforded a metal complex, Pt(thiamine)(NO2)3 (1), and two salt-type compounds, (H-thiamine)[Pt(NO2)4]·2H2O (2) and (TMP)2[Pt(NO2)4]·2H2O (3), which were structurally characterized by X-ray diffraction. In 1, the square-planar Pt2+ ion is coordinated to the pyrimidine N(1′), a usual metal-binding site, and three NO2 − groups. The thiamine molecule exists as a Monovalent Cation in 1 and a divalent Cation in 2 while the TMP molecule is a Monovalent Cation in 3. In each compound, thiamine or TMP adopts the usual F conformation and forms two types of host–guest-like interactions with anions, which are of the bridging forms, C(2)H⋯anion⋯pyrimidine-ring and N(4′1)H⋯anion⋯thiazolium-ring. In 3, there is an additional anion–bridging interaction between the pyrimidine and thiazolium rings of TMP, being of the form C(6′)H⋯anion⋯thiazolium-ring. The salts 2 and 3 show similar hydrogen-bonded cyclic dimers of thiamine or TMP between which the anions are held. Results are compared with those of the other thiamine–platinum complexes.
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metal ion and anion coordination in the thiamine pt ii no2 4 2 system structures of a metal complex pt thiamine no2 3 and two salts h thiamine pt no2 4 center dot 2h 2 o and thiamine monophosphate 2 pt no2 4 center dot 2h 2 o
2001Co-Authors: Katsuyuki Aoki, Adegboye O Adeyemo, George N WilliamsAbstract:Reaction of thiamine or thiamine monophosphate (TMP) with K2Pt(NO2)(4) afforded a metal complex, Pt(thiamine)(NO2)(3) (1), and two salt-type compounds, (H-thiamine)[Pt(NO2)(4)]. 2H(2)O (2) and (TMP)(2)[Pt(NO2)(4)]. 2H(2)O (3), which were structurally characterized by X-ray diffraction. In 1, the square-planar Pt2+ ion is coordinated to the pyrimidine N(1'), a usual metal-binding site, and three NO2- groups. The thiamine molecule exists as a Monovalent Cation in 1 and a divalent Cation in 2 while the TMP molecule is a Monovalent Cation in 3. In each compound, thiamine or TMP adopts the usual F conformation and forms two types of host-guest-like interactions with anions, which are of the bridging forms, C(2)-H . . . anion . . . pyrimidine-ring and N(4'1)-H(...)anion(...)thiazolium-ring. In 3, there is an additional anion-bridging interaction between the pyrimidine and thiazolium rings of TMP, being of the form C(6')-H . . . anion . . . thiazolium-ring. The salts 2 and 3 show similar hydrogen-bonded cyclic dimers of thiamine or TMP between which the anions are held. Results are compared with those of the other thiamine-platinum complexes. (C) 2001 Elsevier Science B.V. All rights reserved.
Robert F Margolskee - One of the best experts on this subject based on the ideXlab platform.
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loss of high frequency glucose induced ca2 oscillations in pancreatic islets correlates with impaired glucose tolerance in trpm5 mice
Proceedings of the National Academy of Sciences of the United States of America, 2010Co-Authors: Barbara Colsoul, Anica Schraenen, Katleen Lemaire, Roel Quintens, Leentje Van Lommel, Andrei Segal, Grzegorz Owsianik, Karel Talavera, Thomas Voets, Robert F MargolskeeAbstract:Glucose homeostasis is critically dependent on insulin release from pancreatic β-cells, which is strictly regulated by glucose-induced oscillations in membrane potential (Vm) and the cytosolic calcium level ([Ca2+]cyt). We propose that TRPM5, a Ca2+-activated Monovalent Cation channel, is a positive regulator of glucose-induced insulin release. Immunofluorescence revealed expression of TRPM5 in pancreatic islets. A Ca2+-activated nonselective Cation current with TRPM5-like properties is significantly reduced in Trpm5−/− cells. Ca2+-imaging and electrophysiological analysis show that glucose-induced oscillations of Vm and [Ca2+]cyt have on average a reduced frequency in Trpm5−/− islets, specifically due to a lack of fast oscillations. As a consequence, glucose-induced insulin release from Trpm5−/− pancreatic islets is significantly reduced, resulting in an impaired glucose tolerance in Trpm5−/− mice.
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loss of high frequency glucose induced ca2 oscillations in pancreatic islets correlates with impaired glucose tolerance in trpm5 mice
Proceedings of the National Academy of Sciences of the United States of America, 2010Co-Authors: Barbara Colsoul, Anica Schraenen, Katleen Lemaire, Roel Quintens, Andrei Segal, Grzegorz Owsianik, Karel Talavera, Thomas Voets, Leentje Van Lommel, Robert F MargolskeeAbstract:Glucose homeostasis is critically dependent on insulin release from pancreatic beta-cells, which is strictly regulated by glucose-induced oscillations in membrane potential (V(m)) and the cytosolic calcium level ([Ca(2+)](cyt)). We propose that TRPM5, a Ca(2+)-activated Monovalent Cation channel, is a positive regulator of glucose-induced insulin release. Immunofluorescence revealed expression of TRPM5 in pancreatic islets. A Ca(2+)-activated nonselective Cation current with TRPM5-like properties is significantly reduced in Trpm5(-/-) cells. Ca(2+)-imaging and electrophysiological analysis show that glucose-induced oscillations of V(m) and [Ca(2+)](cyt) have on average a reduced frequency in Trpm5(-/-) islets, specifically due to a lack of fast oscillations. As a consequence, glucose-induced insulin release from Trpm5(-/-) pancreatic islets is significantly reduced, resulting in an impaired glucose tolerance in Trpm5(-/-) mice.
Katsuyuki Aoki - One of the best experts on this subject based on the ideXlab platform.
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metal ion and anion coordination in the thiamine ptii no2 4 2 system structures of a metal complex pt thiamine no2 3 and two salts h thiamine pt no2 4 2h2o and thiamine monophosphate 2 pt no2 4 2h2o
Inorganica Chimica Acta, 2001Co-Authors: Katsuyuki Aoki, Adegboye O Adeyemo, George N WilliamsAbstract:Abstract Reaction of thiamine or thiamine monophosphate (TMP) with K2Pt(NO2)4 afforded a metal complex, Pt(thiamine)(NO2)3 (1), and two salt-type compounds, (H-thiamine)[Pt(NO2)4]·2H2O (2) and (TMP)2[Pt(NO2)4]·2H2O (3), which were structurally characterized by X-ray diffraction. In 1, the square-planar Pt2+ ion is coordinated to the pyrimidine N(1′), a usual metal-binding site, and three NO2 − groups. The thiamine molecule exists as a Monovalent Cation in 1 and a divalent Cation in 2 while the TMP molecule is a Monovalent Cation in 3. In each compound, thiamine or TMP adopts the usual F conformation and forms two types of host–guest-like interactions with anions, which are of the bridging forms, C(2)H⋯anion⋯pyrimidine-ring and N(4′1)H⋯anion⋯thiazolium-ring. In 3, there is an additional anion–bridging interaction between the pyrimidine and thiazolium rings of TMP, being of the form C(6′)H⋯anion⋯thiazolium-ring. The salts 2 and 3 show similar hydrogen-bonded cyclic dimers of thiamine or TMP between which the anions are held. Results are compared with those of the other thiamine–platinum complexes.
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metal ion and anion coordination in the thiamine pt ii no2 4 2 system structures of a metal complex pt thiamine no2 3 and two salts h thiamine pt no2 4 center dot 2h 2 o and thiamine monophosphate 2 pt no2 4 center dot 2h 2 o
2001Co-Authors: Katsuyuki Aoki, Adegboye O Adeyemo, George N WilliamsAbstract:Reaction of thiamine or thiamine monophosphate (TMP) with K2Pt(NO2)(4) afforded a metal complex, Pt(thiamine)(NO2)(3) (1), and two salt-type compounds, (H-thiamine)[Pt(NO2)(4)]. 2H(2)O (2) and (TMP)(2)[Pt(NO2)(4)]. 2H(2)O (3), which were structurally characterized by X-ray diffraction. In 1, the square-planar Pt2+ ion is coordinated to the pyrimidine N(1'), a usual metal-binding site, and three NO2- groups. The thiamine molecule exists as a Monovalent Cation in 1 and a divalent Cation in 2 while the TMP molecule is a Monovalent Cation in 3. In each compound, thiamine or TMP adopts the usual F conformation and forms two types of host-guest-like interactions with anions, which are of the bridging forms, C(2)-H . . . anion . . . pyrimidine-ring and N(4'1)-H(...)anion(...)thiazolium-ring. In 3, there is an additional anion-bridging interaction between the pyrimidine and thiazolium rings of TMP, being of the form C(6')-H . . . anion . . . thiazolium-ring. The salts 2 and 3 show similar hydrogen-bonded cyclic dimers of thiamine or TMP between which the anions are held. Results are compared with those of the other thiamine-platinum complexes. (C) 2001 Elsevier Science B.V. All rights reserved.
Adegboye O Adeyemo - One of the best experts on this subject based on the ideXlab platform.
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metal ion and anion coordination in the thiamine ptii no2 4 2 system structures of a metal complex pt thiamine no2 3 and two salts h thiamine pt no2 4 2h2o and thiamine monophosphate 2 pt no2 4 2h2o
Inorganica Chimica Acta, 2001Co-Authors: Katsuyuki Aoki, Adegboye O Adeyemo, George N WilliamsAbstract:Abstract Reaction of thiamine or thiamine monophosphate (TMP) with K2Pt(NO2)4 afforded a metal complex, Pt(thiamine)(NO2)3 (1), and two salt-type compounds, (H-thiamine)[Pt(NO2)4]·2H2O (2) and (TMP)2[Pt(NO2)4]·2H2O (3), which were structurally characterized by X-ray diffraction. In 1, the square-planar Pt2+ ion is coordinated to the pyrimidine N(1′), a usual metal-binding site, and three NO2 − groups. The thiamine molecule exists as a Monovalent Cation in 1 and a divalent Cation in 2 while the TMP molecule is a Monovalent Cation in 3. In each compound, thiamine or TMP adopts the usual F conformation and forms two types of host–guest-like interactions with anions, which are of the bridging forms, C(2)H⋯anion⋯pyrimidine-ring and N(4′1)H⋯anion⋯thiazolium-ring. In 3, there is an additional anion–bridging interaction between the pyrimidine and thiazolium rings of TMP, being of the form C(6′)H⋯anion⋯thiazolium-ring. The salts 2 and 3 show similar hydrogen-bonded cyclic dimers of thiamine or TMP between which the anions are held. Results are compared with those of the other thiamine–platinum complexes.
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metal ion and anion coordination in the thiamine pt ii no2 4 2 system structures of a metal complex pt thiamine no2 3 and two salts h thiamine pt no2 4 center dot 2h 2 o and thiamine monophosphate 2 pt no2 4 center dot 2h 2 o
2001Co-Authors: Katsuyuki Aoki, Adegboye O Adeyemo, George N WilliamsAbstract:Reaction of thiamine or thiamine monophosphate (TMP) with K2Pt(NO2)(4) afforded a metal complex, Pt(thiamine)(NO2)(3) (1), and two salt-type compounds, (H-thiamine)[Pt(NO2)(4)]. 2H(2)O (2) and (TMP)(2)[Pt(NO2)(4)]. 2H(2)O (3), which were structurally characterized by X-ray diffraction. In 1, the square-planar Pt2+ ion is coordinated to the pyrimidine N(1'), a usual metal-binding site, and three NO2- groups. The thiamine molecule exists as a Monovalent Cation in 1 and a divalent Cation in 2 while the TMP molecule is a Monovalent Cation in 3. In each compound, thiamine or TMP adopts the usual F conformation and forms two types of host-guest-like interactions with anions, which are of the bridging forms, C(2)-H . . . anion . . . pyrimidine-ring and N(4'1)-H(...)anion(...)thiazolium-ring. In 3, there is an additional anion-bridging interaction between the pyrimidine and thiazolium rings of TMP, being of the form C(6')-H . . . anion . . . thiazolium-ring. The salts 2 and 3 show similar hydrogen-bonded cyclic dimers of thiamine or TMP between which the anions are held. Results are compared with those of the other thiamine-platinum complexes. (C) 2001 Elsevier Science B.V. All rights reserved.
Barbara Colsoul - One of the best experts on this subject based on the ideXlab platform.
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loss of high frequency glucose induced ca2 oscillations in pancreatic islets correlates with impaired glucose tolerance in trpm5 mice
Proceedings of the National Academy of Sciences of the United States of America, 2010Co-Authors: Barbara Colsoul, Anica Schraenen, Katleen Lemaire, Roel Quintens, Leentje Van Lommel, Andrei Segal, Grzegorz Owsianik, Karel Talavera, Thomas Voets, Robert F MargolskeeAbstract:Glucose homeostasis is critically dependent on insulin release from pancreatic β-cells, which is strictly regulated by glucose-induced oscillations in membrane potential (Vm) and the cytosolic calcium level ([Ca2+]cyt). We propose that TRPM5, a Ca2+-activated Monovalent Cation channel, is a positive regulator of glucose-induced insulin release. Immunofluorescence revealed expression of TRPM5 in pancreatic islets. A Ca2+-activated nonselective Cation current with TRPM5-like properties is significantly reduced in Trpm5−/− cells. Ca2+-imaging and electrophysiological analysis show that glucose-induced oscillations of Vm and [Ca2+]cyt have on average a reduced frequency in Trpm5−/− islets, specifically due to a lack of fast oscillations. As a consequence, glucose-induced insulin release from Trpm5−/− pancreatic islets is significantly reduced, resulting in an impaired glucose tolerance in Trpm5−/− mice.
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loss of high frequency glucose induced ca2 oscillations in pancreatic islets correlates with impaired glucose tolerance in trpm5 mice
Proceedings of the National Academy of Sciences of the United States of America, 2010Co-Authors: Barbara Colsoul, Anica Schraenen, Katleen Lemaire, Roel Quintens, Andrei Segal, Grzegorz Owsianik, Karel Talavera, Thomas Voets, Leentje Van Lommel, Robert F MargolskeeAbstract:Glucose homeostasis is critically dependent on insulin release from pancreatic beta-cells, which is strictly regulated by glucose-induced oscillations in membrane potential (V(m)) and the cytosolic calcium level ([Ca(2+)](cyt)). We propose that TRPM5, a Ca(2+)-activated Monovalent Cation channel, is a positive regulator of glucose-induced insulin release. Immunofluorescence revealed expression of TRPM5 in pancreatic islets. A Ca(2+)-activated nonselective Cation current with TRPM5-like properties is significantly reduced in Trpm5(-/-) cells. Ca(2+)-imaging and electrophysiological analysis show that glucose-induced oscillations of V(m) and [Ca(2+)](cyt) have on average a reduced frequency in Trpm5(-/-) islets, specifically due to a lack of fast oscillations. As a consequence, glucose-induced insulin release from Trpm5(-/-) pancreatic islets is significantly reduced, resulting in an impaired glucose tolerance in Trpm5(-/-) mice.