The Experts below are selected from a list of 9 Experts worldwide ranked by ideXlab platform

S Aggestrup - One of the best experts on this subject based on the ideXlab platform.

  • Morning or evening Dosage of omeprazole for gastro oesophageal reflux disease
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: Jorn Hendel, L. Hendel, S Aggestrup
    Abstract:

    SUMMARY Background and aims: When routinely checking patients receiving omeprazole treatment for gastro-oesophageal reflux, we have been finding patients with surprisingly low nocturnal gastric pH. The aim of this study was to evaluate the impact of timing of the 40 mg omeprazole once daily regimen. Methods: We evaluated the difference in effect of 40 mg omeprazole, given as a Morning or evening dose, in 17 patients with gastro-oesophageal reflux disease. Gastric and oesophageal pH was recorded by portable 24-h two-channel pH-metry in a cross-over design of 14 days of Morning and 14 days of evening administration. Results: In five patients pathological reflux was abolished by both regimens, four only during Morning Dosage, and three only during evening Dosage. In the remaining five patients abolition of pathological reflux was not achieved. The therapeutic outcome and patient preference for Morning or evening administration were closely related to the individual oesophageal pH curves. Patients with reflux induced by physical activity had a clear preference for Morning Dosage, patients with nocturnal reflux showed a clear preference for evening Dosage. Gastric pH profiles showed a high inter-individual variation; paired statistics, however, revealed a significant impact of Dosage timing on the gastric pH profile. After Morning Dosage the work-day part (the first 7 h) of the gastric pH profile is 0.72 ± 0.91 (mean difference of pairs ± s.d.) higher than after evening Dosage (P < 0.01). After evening Dosage the gastric pH during the supine period is 0.64 ± 0.83 (mean difference of pairs ± s.d.) higher than after Morning Dosage (P= 0.02). Conclusion: The timing of a 40 mg omeprazole Dosage regimen has a clinically significant impact on the 24-h pH profile, and that—by relating to the patient 24-hour oesophageal pH-metry in combination with the patient symptomatology—the timing of this Dosage is highly important for therapeutic efficacy.

Jorn Hendel - One of the best experts on this subject based on the ideXlab platform.

  • Morning or evening Dosage of omeprazole for gastro oesophageal reflux disease
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: Jorn Hendel, L. Hendel, S Aggestrup
    Abstract:

    SUMMARY Background and aims: When routinely checking patients receiving omeprazole treatment for gastro-oesophageal reflux, we have been finding patients with surprisingly low nocturnal gastric pH. The aim of this study was to evaluate the impact of timing of the 40 mg omeprazole once daily regimen. Methods: We evaluated the difference in effect of 40 mg omeprazole, given as a Morning or evening dose, in 17 patients with gastro-oesophageal reflux disease. Gastric and oesophageal pH was recorded by portable 24-h two-channel pH-metry in a cross-over design of 14 days of Morning and 14 days of evening administration. Results: In five patients pathological reflux was abolished by both regimens, four only during Morning Dosage, and three only during evening Dosage. In the remaining five patients abolition of pathological reflux was not achieved. The therapeutic outcome and patient preference for Morning or evening administration were closely related to the individual oesophageal pH curves. Patients with reflux induced by physical activity had a clear preference for Morning Dosage, patients with nocturnal reflux showed a clear preference for evening Dosage. Gastric pH profiles showed a high inter-individual variation; paired statistics, however, revealed a significant impact of Dosage timing on the gastric pH profile. After Morning Dosage the work-day part (the first 7 h) of the gastric pH profile is 0.72 ± 0.91 (mean difference of pairs ± s.d.) higher than after evening Dosage (P < 0.01). After evening Dosage the gastric pH during the supine period is 0.64 ± 0.83 (mean difference of pairs ± s.d.) higher than after Morning Dosage (P= 0.02). Conclusion: The timing of a 40 mg omeprazole Dosage regimen has a clinically significant impact on the 24-h pH profile, and that—by relating to the patient 24-hour oesophageal pH-metry in combination with the patient symptomatology—the timing of this Dosage is highly important for therapeutic efficacy.

London W - One of the best experts on this subject based on the ideXlab platform.

  • Controlled inpatient study of tienilic acid in treatment of gout and hypertension
    2016
    Co-Authors: J A Reardon, J T Scott, London W, Charing Cross Hospital
    Abstract:

    SUMMARY Under inpatient controlled conditions 4 patients with gout and hypertension were treated with varying doses of tienilic acid, a new uricosuric diuretic. Plasma urate levels were reduced by an average of 50 0 in association with significantly increased urinary urate excretion. A twice-daily regimen was considerably more effective than a single Morning Dosage in reduction of plasma urate, though both regimens were equally effective in antihypertensive potency. The single daily regimen produced greater diurnal fluctuations in plasma urate and was more frequently associated with the development ' of acute gout attacks. Attention has previously been drawn to the un-usually high prevalence of hypertension among patients with gout.1-5 While a diastolic blood pressure of 90 mmHg or greater is found in approxi-mately 21 % of a similar nongouty population (males, aged 25-65), up to 50 % of patients with gout will be so affected.6 Thiazide diuretics, a group of drugs commonly used for hypertension, elevate th

L. Hendel - One of the best experts on this subject based on the ideXlab platform.

  • Morning or evening Dosage of omeprazole for gastro oesophageal reflux disease
    Alimentary Pharmacology & Therapeutics, 2007
    Co-Authors: Jorn Hendel, L. Hendel, S Aggestrup
    Abstract:

    SUMMARY Background and aims: When routinely checking patients receiving omeprazole treatment for gastro-oesophageal reflux, we have been finding patients with surprisingly low nocturnal gastric pH. The aim of this study was to evaluate the impact of timing of the 40 mg omeprazole once daily regimen. Methods: We evaluated the difference in effect of 40 mg omeprazole, given as a Morning or evening dose, in 17 patients with gastro-oesophageal reflux disease. Gastric and oesophageal pH was recorded by portable 24-h two-channel pH-metry in a cross-over design of 14 days of Morning and 14 days of evening administration. Results: In five patients pathological reflux was abolished by both regimens, four only during Morning Dosage, and three only during evening Dosage. In the remaining five patients abolition of pathological reflux was not achieved. The therapeutic outcome and patient preference for Morning or evening administration were closely related to the individual oesophageal pH curves. Patients with reflux induced by physical activity had a clear preference for Morning Dosage, patients with nocturnal reflux showed a clear preference for evening Dosage. Gastric pH profiles showed a high inter-individual variation; paired statistics, however, revealed a significant impact of Dosage timing on the gastric pH profile. After Morning Dosage the work-day part (the first 7 h) of the gastric pH profile is 0.72 ± 0.91 (mean difference of pairs ± s.d.) higher than after evening Dosage (P < 0.01). After evening Dosage the gastric pH during the supine period is 0.64 ± 0.83 (mean difference of pairs ± s.d.) higher than after Morning Dosage (P= 0.02). Conclusion: The timing of a 40 mg omeprazole Dosage regimen has a clinically significant impact on the 24-h pH profile, and that—by relating to the patient 24-hour oesophageal pH-metry in combination with the patient symptomatology—the timing of this Dosage is highly important for therapeutic efficacy.

J A Reardon - One of the best experts on this subject based on the ideXlab platform.

  • Controlled inpatient study of tienilic acid in treatment of gout and hypertension
    2016
    Co-Authors: J A Reardon, J T Scott, London W, Charing Cross Hospital
    Abstract:

    SUMMARY Under inpatient controlled conditions 4 patients with gout and hypertension were treated with varying doses of tienilic acid, a new uricosuric diuretic. Plasma urate levels were reduced by an average of 50 0 in association with significantly increased urinary urate excretion. A twice-daily regimen was considerably more effective than a single Morning Dosage in reduction of plasma urate, though both regimens were equally effective in antihypertensive potency. The single daily regimen produced greater diurnal fluctuations in plasma urate and was more frequently associated with the development ' of acute gout attacks. Attention has previously been drawn to the un-usually high prevalence of hypertension among patients with gout.1-5 While a diastolic blood pressure of 90 mmHg or greater is found in approxi-mately 21 % of a similar nongouty population (males, aged 25-65), up to 50 % of patients with gout will be so affected.6 Thiazide diuretics, a group of drugs commonly used for hypertension, elevate th