Morphologic

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Savitri Shrivastava - One of the best experts on this subject based on the ideXlab platform.

Munesh Tomar - One of the best experts on this subject based on the ideXlab platform.

S. Radhakrishnan - One of the best experts on this subject based on the ideXlab platform.

Thomas M Link - One of the best experts on this subject based on the ideXlab platform.

  • local 3d scaling properties for the analysis of trabecular bone extracted from high resolution magnetic resonance imaging of human trabecular bone comparison with bone mineral density in the prediction of biomechanical strength in vitro
    Investigative Radiology, 2003
    Co-Authors: Holger F Boehm, Christoph W Raeth, Roberto Monetti, Dirk Mueller, David C Newitt, S Majumdar, Ernst J Rummeny, G E Morfill, Thomas M Link
    Abstract:

    RATIONALE AND OBJECTIVES A novel, nonlinear Morphologic measure [DeltaP(alpha)] based on local 3D scaling properties was applied to high-resolution magnetic resonance images (HR-MRI) of human trabecular bone to predict biomechanical strength in vitro. METHODS We extracted DeltaP(alpha) and traditional Morphologic parameters (apparent trabecular volume fraction, apparent trabecular separation) from HR-MR images of 32 femoral and 13 spinal bone specimens. Furthermore, bone mineral density (BMD) and maximum compressive strength (MCS) were determined. The Morphologic measures were compared with BMD in predicting the biomechanical strength. RESULTS In the vertebral (femoral) specimens, R2 for MCS versus DeltaP(alpha) was 0.87 (0.61) (P < 0.001). Correlation between BMD and MCS was 0.53 (P = 0.05) (0.79 [P < 0.001]) for the vertebral (femoral) specimens. For the femoral specimens, prediction of MCS could be improved further by combining BMD and Morphologic parameters by multiple regression (R2 = 0.88). CONCLUSIONS Morphologic measures extracted from HR-MRI considering local 3D-scaling properties can be used to predict biomechanical properties of bone in vitro. They are superior to 2-dimensional standard linear morphometric measures and, depending on the anatomic location, more reliably predict bone strength as measured by MCS than does BMD.

Richard R. Gacek - One of the best experts on this subject based on the ideXlab platform.

  • Morphologic Correlates for Laryngeal Reinnervation
    The Laryngoscope, 2001
    Co-Authors: Richard R. Gacek
    Abstract:

    Objective: To describe Morphologic correlates for laryngeal reinnervation. Study Design: Review of anatomic experiments dealing with laryngeal innervation performed over a 25-year period. Methods: Description of results from experimental studies on the cat and human laryngeal muscles and nerve supply. Results: Despite separation of abductor and adductor laryngeal motor neurons in the central nervous system, the mixture of abductor and adductor axons in the recurrent laryngeal nerve indicates that selective re-innervation of an individual laryngeal muscle must be accomplished at the neuromuscular junction (NMJ) of the muscle. The optimal time for a reinnervating neural source to re-occupy vacated NMJ is at the time of denervation. If the reinnervation procedure is attempted long (>1 mo) after denervation, extraneous end plates of other neural systems must be eliminated to provide vacant NMJ. The nerve muscle pedicle (NMP) concept is an effective model for reinnervation of a laryngeal muscle provided its activity pattern is similar to that of the denervated muscle and its insertion into vacated NMJ is timely. Conclusion: NMP offers a logical method for selective laryngeal muscle reinnervation. Critical to the success of NMP are the physiological input to the NMP and timing of NMP implantation.

  • Morphologic correlates for laryngeal reinnervation.
    The Laryngoscope, 2001
    Co-Authors: Richard R. Gacek
    Abstract:

    To describe Morphologic correlates for laryngeal reinnervation. Review of anatomic experiments dealing with laryngeal innervation performed over a 25-year period. Description of results from experimental studies on the cat and human laryngeal muscles and nerve supply. Despite separation of abductor and adductor laryngeal motor neurons in the central nervous system, the mixture of abductor and adductor axons in the recurrent laryngeal nerve indicates that selective re-innervation of an individual laryngeal muscle must be accomplished at the neuromuscular junction (NMJ) of the muscle. The optimal time for a reinnervating neural source to re-occupy vacated NMJ is at the time of denervation. If the reinnervation procedure is attempted long (>1 mo) after denervation, extraneous end plates of other neural systems must be eliminated to provide vacant NMJ. The nerve muscle pedicle (NMP) concept is an effective model for reinnervation of a laryngeal muscle provided its activity pattern is similar to that of the denervated muscle and its insertion into vacated NMJ is timely. NMP offers a logical method for selective laryngeal muscle reinnervation. Critical to the success of NMP are the physiological input to the NMP and timing of NMP implantation.