The Experts below are selected from a list of 48 Experts worldwide ranked by ideXlab platform

Yos S Morsi - One of the best experts on this subject based on the ideXlab platform.

  • Gentamicin-impregnated chitosan/nanohydroxyapatite/ethyl cellulose microspheres granules for chronic osteomyelitis therapy.
    Journal of biomedical materials research. Part A, 2010
    Co-Authors: Pujiang Shi, Yi Zuo, Qin Zou, Haohuai Liu, Li Zhang, Yos S Morsi
    Abstract:

    In this article gentamicin (GM) impregnated microspheres were used to extend the drug release time for the treatment of chronic osteomyelitis. The granules were prepared in solution and consisted of nanohydroxyapatite (nHA), chitosan (CS) and GM loaded ethyl cellulose (EC) microspheres. A rabbit model with chronic osteomyelitis was made by using staphylococcus aureus and Morrhuate Sodium and special inspection methods were used to test the curative effects of the granules, such as microbiological investigations, tissue, and X-ray observations. The granules were provided with excellent drug release properties, 49 days in vitro and 45 days in vivo, moreover, they showed almost no cytotoxic for fibroblast and osteoblast. The findings indicated that the GM-impregnated CS/nHA/EC microspheres granules showed outstanding curative effect. Generally, it can be concluded that the granules containing GM impregnated microspheres may be used effectively in the treatment of the chronic osteomyelitis. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010

  • Gentamicin-impregnated chitosan/nanohydroxyapatite/ethyl cellulose microspheres granules for chronic osteomyelitis therapy
    Journal of Biomedical Materials Research Part A, 2009
    Co-Authors: Pujiang Shi, Yi Zuo, Qin Zou, Haohuai Liu, Li Zhang, Yos S Morsi
    Abstract:

    In this article gentamicin (GM) impregnated microspheres were used to extend the drug release time for the treatment of chronic osteomyelitis. The granules were prepared in solution and consisted of nanohydroxyapatite (nHA), chitosan (CS) and GM loaded ethyl cellulose (EC) microspheres. A rabbit model with chronic osteomyelitis was made by using staphylococcus aureus and Morrhuate Sodium and special inspection methods were used to test the curative effects of the granules, such as microbiological investigations, tissue, and X-ray observations. The granules were provided with excellent drug release properties, 49 days in vitro and 45 days in vivo, moreover, they showed almost no cytotoxic for fibroblast and osteoblast. The findings indicated that the GM-impregnated CS/nHA/EC microspheres granules showed outstanding curative effect. Generally, it can be concluded that the granules containing GM impregnated microspheres may be used effectively in the treatment of the chronic osteomyelitis

Pujiang Shi - One of the best experts on this subject based on the ideXlab platform.

  • Gentamicin-impregnated chitosan/nanohydroxyapatite/ethyl cellulose microspheres granules for chronic osteomyelitis therapy.
    Journal of biomedical materials research. Part A, 2010
    Co-Authors: Pujiang Shi, Yi Zuo, Qin Zou, Haohuai Liu, Li Zhang, Yos S Morsi
    Abstract:

    In this article gentamicin (GM) impregnated microspheres were used to extend the drug release time for the treatment of chronic osteomyelitis. The granules were prepared in solution and consisted of nanohydroxyapatite (nHA), chitosan (CS) and GM loaded ethyl cellulose (EC) microspheres. A rabbit model with chronic osteomyelitis was made by using staphylococcus aureus and Morrhuate Sodium and special inspection methods were used to test the curative effects of the granules, such as microbiological investigations, tissue, and X-ray observations. The granules were provided with excellent drug release properties, 49 days in vitro and 45 days in vivo, moreover, they showed almost no cytotoxic for fibroblast and osteoblast. The findings indicated that the GM-impregnated CS/nHA/EC microspheres granules showed outstanding curative effect. Generally, it can be concluded that the granules containing GM impregnated microspheres may be used effectively in the treatment of the chronic osteomyelitis. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010

  • Gentamicin-impregnated chitosan/nanohydroxyapatite/ethyl cellulose microspheres granules for chronic osteomyelitis therapy
    Journal of Biomedical Materials Research Part A, 2009
    Co-Authors: Pujiang Shi, Yi Zuo, Qin Zou, Haohuai Liu, Li Zhang, Yos S Morsi
    Abstract:

    In this article gentamicin (GM) impregnated microspheres were used to extend the drug release time for the treatment of chronic osteomyelitis. The granules were prepared in solution and consisted of nanohydroxyapatite (nHA), chitosan (CS) and GM loaded ethyl cellulose (EC) microspheres. A rabbit model with chronic osteomyelitis was made by using staphylococcus aureus and Morrhuate Sodium and special inspection methods were used to test the curative effects of the granules, such as microbiological investigations, tissue, and X-ray observations. The granules were provided with excellent drug release properties, 49 days in vitro and 45 days in vivo, moreover, they showed almost no cytotoxic for fibroblast and osteoblast. The findings indicated that the GM-impregnated CS/nHA/EC microspheres granules showed outstanding curative effect. Generally, it can be concluded that the granules containing GM impregnated microspheres may be used effectively in the treatment of the chronic osteomyelitis

David Rabago - One of the best experts on this subject based on the ideXlab platform.

  • Dextrose and Morrhuate Sodium Injections (Prolotherapy) for Knee Osteoarthritis: A Prospective Open-Label Trial
    Journal of alternative and complementary medicine (New York N.Y.), 2014
    Co-Authors: David Rabago, Jeffrey J. Patterson, Marlon P. Mundt, Aleksandra Zgierska, Luke Fortney, Jessica Grettie, Richard Kijowski
    Abstract:

    Abstract Objectives: This study determined whether injection with hypertonic dextrose and Morrhuate Sodium (prolotherapy) using a pragmatic, clinically determined injection schedule for knee osteoarthritis (KOA) results in improved knee pain, function, and stiffness compared to baseline status. Design: This was a prospective three-arm uncontrolled study with 1-year follow-up. Setting: The setting was outpatient. Participants: The participants were 38 adults who had at least 3 months of symptomatic KOA and who were in the control groups of a prior prolotherapy randomized controlled trial (RCT) (Prior-Control), were ineligible for the RCT (Prior-Ineligible), or were eligible but declined the RCT (Prior-Declined). Intervention: The injection sessions at occurred at 1, 5, and 9 weeks with as-needed treatment at weeks 13 and 17. Extra-articular injections of 15% dextrose and 5% Morrhuate Sodium were done at peri-articular tendon and ligament insertions. A single intra-articular injection of 6 mL 25% dextrose w...

  • Hypertonic dextrose and Morrhuate Sodium injections (prolotherapy) for lateral epicondylosis (tennis elbow): results of a single-blind, pilot-level, randomized controlled trial.
    American journal of physical medicine & rehabilitation, 2013
    Co-Authors: David Rabago, Aleksandra Zgierska, Jessica Grettie, Ken Lee, Michael Ryan, Amrish O. Chourasia, Mary E. Sesto, Rick Kijowski, John Wilson, Daniel Miller
    Abstract:

    Chronic lateral epicondylosis (CLE, “tennis elbow”) is a common, debilitating and expensive1 condition accounting for 4-7 of every 1,000 primary care office visits annually. Among industrial workers, the prevalence of CLE reaches 30%,2 with symptoms duration of six months to two years, regardless of therapy.3, 4 While CLE is often self-limited, up to 20% of cases are refractory to conservative care.5 CLE and other chronic tendinopathies are now understood to be non-inflammatory conditions6 characterized by collagen degeneration, fibroblast proliferation, mucoid degeneration and neovascularization.7-9 While the source of pain is not known, relative rest, physical therapy, non-steroidal anti-inflammatory drugs (NSAIDs), surgery and other forms of treatment have been assessed, but none is uniformly effective, and none has been shown to address the underlying degenerative pathophysiology.10 Corticosteroid injections, while effective in the short term, may result in worse outcomes than watchful waiting in the long term.11 Indeed, content experts have suggested that CLE is best viewed as self-limited condition and that “wait and see” may be a reasonable approach.12 Prolotherapy (PrT) is an injection-based technique for treatment of chronic musculoskeletal pain including tendinopathy.13 Hypertonic dextrose and Morrhuate Sodium are common injectants14 used in prior pilot-level RCTs.15, 16 Preliminary evidence, although promising, is limited by lack of validated primary outcome measures, short follow-up or lack of comparison to a “wait-and-see” control group. Therefore, the study team conducted a 3-arm randomized controlled trial (RCT) to test the hypotheses that adults with symptomatic CLE receiving PrT with either hypertonic dextrose (PrT-D) or combined dextrose and Morrhuate Sodium (PrT-DM) will have greater improvement in elbow-related quality-of-life, biomechanical and MRI-based or ultrasound-based outcomes than those in a wait-and-see control group.

  • P02.23. The efficacy of prolotherapy using dextrose-Morrhuate for lateral epicondylosis: a pilot randomized controlled trial
    BMC Complementary and Alternative Medicine, 2012
    Co-Authors: David Rabago, Aleksandra Zgierska, Richard Kijowski, Ken Lee, Amrish O. Chourasia, Mary E. Sesto, Michael D. Ryan, D Miller, John J. Wilson
    Abstract:

    Methods The study design was a 2-arm non-blinded randomized controlled trial. Group 1 received dextrose prolotherapy and Group 2 was a waitlist control. Nineteen adults seen with at least 3 months of symptomatic CLE in 22 elbows refractory to prior care received ultrasound-guided injections of 20% dextrose-Morrhuate Sodium (Group 1) solution at baseline, 4, and 8 weeks. Waitlist subjects (Group 2) were followed and discouraged from starting new care. Primary outcome measure was Patient-rated Tennis Elbow Evaluation [PRTEE, (100 points) assessed at baseline, 4, 8 and 16 weeks]. Prolotherapy participants were additionally assessed at 32 weeks. Secondary measures included dynamometer-assessed pain free grip strength and participant satisfaction.

Yi Zuo - One of the best experts on this subject based on the ideXlab platform.

  • Gentamicin-impregnated chitosan/nanohydroxyapatite/ethyl cellulose microspheres granules for chronic osteomyelitis therapy.
    Journal of biomedical materials research. Part A, 2010
    Co-Authors: Pujiang Shi, Yi Zuo, Qin Zou, Haohuai Liu, Li Zhang, Yos S Morsi
    Abstract:

    In this article gentamicin (GM) impregnated microspheres were used to extend the drug release time for the treatment of chronic osteomyelitis. The granules were prepared in solution and consisted of nanohydroxyapatite (nHA), chitosan (CS) and GM loaded ethyl cellulose (EC) microspheres. A rabbit model with chronic osteomyelitis was made by using staphylococcus aureus and Morrhuate Sodium and special inspection methods were used to test the curative effects of the granules, such as microbiological investigations, tissue, and X-ray observations. The granules were provided with excellent drug release properties, 49 days in vitro and 45 days in vivo, moreover, they showed almost no cytotoxic for fibroblast and osteoblast. The findings indicated that the GM-impregnated CS/nHA/EC microspheres granules showed outstanding curative effect. Generally, it can be concluded that the granules containing GM impregnated microspheres may be used effectively in the treatment of the chronic osteomyelitis. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010

  • Gentamicin-impregnated chitosan/nanohydroxyapatite/ethyl cellulose microspheres granules for chronic osteomyelitis therapy
    Journal of Biomedical Materials Research Part A, 2009
    Co-Authors: Pujiang Shi, Yi Zuo, Qin Zou, Haohuai Liu, Li Zhang, Yos S Morsi
    Abstract:

    In this article gentamicin (GM) impregnated microspheres were used to extend the drug release time for the treatment of chronic osteomyelitis. The granules were prepared in solution and consisted of nanohydroxyapatite (nHA), chitosan (CS) and GM loaded ethyl cellulose (EC) microspheres. A rabbit model with chronic osteomyelitis was made by using staphylococcus aureus and Morrhuate Sodium and special inspection methods were used to test the curative effects of the granules, such as microbiological investigations, tissue, and X-ray observations. The granules were provided with excellent drug release properties, 49 days in vitro and 45 days in vivo, moreover, they showed almost no cytotoxic for fibroblast and osteoblast. The findings indicated that the GM-impregnated CS/nHA/EC microspheres granules showed outstanding curative effect. Generally, it can be concluded that the granules containing GM impregnated microspheres may be used effectively in the treatment of the chronic osteomyelitis

Qin Zou - One of the best experts on this subject based on the ideXlab platform.

  • Gentamicin-impregnated chitosan/nanohydroxyapatite/ethyl cellulose microspheres granules for chronic osteomyelitis therapy.
    Journal of biomedical materials research. Part A, 2010
    Co-Authors: Pujiang Shi, Yi Zuo, Qin Zou, Haohuai Liu, Li Zhang, Yos S Morsi
    Abstract:

    In this article gentamicin (GM) impregnated microspheres were used to extend the drug release time for the treatment of chronic osteomyelitis. The granules were prepared in solution and consisted of nanohydroxyapatite (nHA), chitosan (CS) and GM loaded ethyl cellulose (EC) microspheres. A rabbit model with chronic osteomyelitis was made by using staphylococcus aureus and Morrhuate Sodium and special inspection methods were used to test the curative effects of the granules, such as microbiological investigations, tissue, and X-ray observations. The granules were provided with excellent drug release properties, 49 days in vitro and 45 days in vivo, moreover, they showed almost no cytotoxic for fibroblast and osteoblast. The findings indicated that the GM-impregnated CS/nHA/EC microspheres granules showed outstanding curative effect. Generally, it can be concluded that the granules containing GM impregnated microspheres may be used effectively in the treatment of the chronic osteomyelitis. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010

  • Gentamicin-impregnated chitosan/nanohydroxyapatite/ethyl cellulose microspheres granules for chronic osteomyelitis therapy
    Journal of Biomedical Materials Research Part A, 2009
    Co-Authors: Pujiang Shi, Yi Zuo, Qin Zou, Haohuai Liu, Li Zhang, Yos S Morsi
    Abstract:

    In this article gentamicin (GM) impregnated microspheres were used to extend the drug release time for the treatment of chronic osteomyelitis. The granules were prepared in solution and consisted of nanohydroxyapatite (nHA), chitosan (CS) and GM loaded ethyl cellulose (EC) microspheres. A rabbit model with chronic osteomyelitis was made by using staphylococcus aureus and Morrhuate Sodium and special inspection methods were used to test the curative effects of the granules, such as microbiological investigations, tissue, and X-ray observations. The granules were provided with excellent drug release properties, 49 days in vitro and 45 days in vivo, moreover, they showed almost no cytotoxic for fibroblast and osteoblast. The findings indicated that the GM-impregnated CS/nHA/EC microspheres granules showed outstanding curative effect. Generally, it can be concluded that the granules containing GM impregnated microspheres may be used effectively in the treatment of the chronic osteomyelitis