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A Karppinen - One of the best experts on this subject based on the ideXlab platform.
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rupatadine 10 mg in the treatment of immediate Mosquito Bite allergy
Journal of The European Academy of Dermatology and Venereology, 2012Co-Authors: A Karppinen, H Brummerkorvenkontio, T Reunala, I IzquierdoAbstract:Background People frequently experience wealing and delayed papules from Mosquito Bites. Wealing is mediated by antisaliva IgE antibodies and histamine. Rupatadine is a new antihistamine effective in allergic rhinitis and urticaria, but the effect on Mosquito-Bite allergy is not known. Objective To determine the effectiveness of rupatadine in inmediate Mosquito-Bite allergy-confirmed adult patients. Methods A double-blind, placebo-controlled, cross-over study was performed with rupatadine 10 mg and matched placebo in 30 Mosquito-Bite-sensitive adults. The mean age was 37 years and the subjects had suffered from harmful Mosquito Bites for a mean of 15 years. Either rupatadine or placebo was taken at 08:00 am for 4 days, followed by a 5 day wash out period and then alternative treatment was given for 4 days. On day 3, in both drug periods the subjects received two Aedes aegypti Mosquito-Bites on the forearm. The size of lesions and intensity of pruritus [visual analogue scale (VAS)] were measured after 15 min Bite reaction. Results Twenty-six subjects were analysed for efficacy. The size of the 15 min Bite reaction under placebo was of 106 mm2 and under rupatadine, of 55 mm2. This is a significant decrease (48%; P = 0.0003). The accompanying pruritus decreased from 60 (VAS; median) under placebo to 47.5 under rupatadine, which also is a significant (P = 0.019) difference. There was no significant (P = 0.263) difference in adverse events under rupatadine and placebo. Conclusion The present placebo-controlled study in Mosquito-Bite-sensitive adults shows that rupatadine 10 mg prophylactically given is an effective treatment for the Mosquito-Bite wealing and skin pruritus.
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levocetirizine for treatment of immediate and delayed Mosquito Bite reactions
Acta Dermato-venereologica, 2006Co-Authors: A Karppinen, H Brummerkorvenkontio, H. Kautiainen, L. Petman, J P Herve, T ReunalaAbstract:People frequently experience whealing and delayed papules from Mosquito Bites. Various antihistamines have previously been tried for the treatment of this condition. We performed a double-blind, placebo-controlled, cross-over study with levocetirizine 5 mg and matched placebo in 30 adults who were sensitive to Mosquito Bites. On the third treatment day the subjects received two Aedes aegypti Bites on the forearm. The size of the Bite lesions and the intensity of pruritus (visual analogue scale) were measured. Bite symptoms could be analysed in 28 subjects at 15 min and in 8 subjects at 24 h. Levocetirizine decreased the size of wheals by 60% (p < 0.001) and accompanying pruritus by 62% (p < 0.001) compared with placebo. The effect of levocetirizine increased in a linear fashion with the size of wheals and was most significant in the subjects with largest Bite lesions. Levocetirizine also decreased the size of 24-h Bite lesions by 71% (p=0.008) and accompanying pruritus by 56% (p=0.016). These results show that prophylactic levocetirizine 5 mg is an effective treatment for both immediate and delayed Mosquito Bite symptoms and is especially effective in subjects with large wheals.
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comparison of cetirizine ebastine and loratadine in the treatment of immediate Mosquito Bite allergy
Allergy, 2002Co-Authors: A Karppinen, H. Kautiainen, L. Petman, P Burri, T ReunalaAbstract:Background: People frequently experience whealing and delayed papules from Mosquito Bites. Whealing is mediated by antisaliva immunoglobulin (Ig)E antibodies and histamine. Cetirizine, ebastine and loratadine have earlier shown effects on Mosquito-Bite reactions but no comparative studies exist. Methods: A double-blind, placebo-controlled, cross-over study was performed with cetirizine 10 mg, ebastine 10 mg and loratadine 10 mg in 29 Mosquito-Bite-sensitive adults exposed to Aedes aegypti Mosquito-Bites. The size of the Bite lesion and the intensity of pruritus (visual analog scale) were measured at 15 min and 2, 6 and 24 h. Results: Cetirizine and ebastine, but not loratadine, decreased significantly the size of whealing (P < 0.01) and accompanying pruritus (P < 0.001) compared to placebo. Cetirizine was most effective on pruritus but caused more often sedation than ebastine or loratadine. The delayed Bite symptoms remained too faint for any statistical comparison. Conclusion: This comparative study in Mosquito-Bite-sensitive adults shows that cetirizine and ebastine decrease significantly whealing and accompanying pruritus, and that cetirizine seems to be the most effective against pruritus.
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Comparison of cetirizine, ebastine and loratadine in the treatment of immediate Mosquito-Bite allergy.
Allergy, 2002Co-Authors: A Karppinen, H. Kautiainen, L. Petman, P Burri, T ReunalaAbstract:Background: People frequently experience whealing and delayed papules from Mosquito Bites. Whealing is mediated by antisaliva immunoglobulin (Ig)E antibodies and histamine. Cetirizine, ebastine and loratadine have earlier shown effects on Mosquito-Bite reactions but no comparative studies exist. Methods: A double-blind, placebo-controlled, cross-over study was performed with cetirizine 10 mg, ebastine 10 mg and loratadine 10 mg in 29 Mosquito-Bite-sensitive adults exposed to Aedes aegypti Mosquito-Bites. The size of the Bite lesion and the intensity of pruritus (visual analog scale) were measured at 15 min and 2, 6 and 24 h. Results: Cetirizine and ebastine, but not loratadine, decreased significantly the size of whealing (P
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Loratadine in the treatment of Mosquito‐Bite‐sensitive children
Allergy, 2000Co-Authors: A Karppinen, T Reunala, H. Kautiainen, L. Petman, H. Brummer-korvenkontioAbstract:Background: Children frequently experience harmful whealing and delayed papules from Mosquito Bites. Whealing is mediated by antisaliva IgE antibodies and histamine, but the effect of antihistamines on Mosquito-Bite symptoms has not been evaluated in children. Methods: The effect of loratadine (0.3 mg/kg) was examined in 28 Mosquito-Bite-sensitive children (aged 2–11 years). The double-blind, placebo-controlled, crossover study was performed with exposure to Aedes aegypti laboratoryMosquitoes. The size of the Bite lesion and the intensity of pruritus (visual analog scale) were measured at 15 min and at 2, 6, and 24 h. Results: Loratadine decreased the size of the wheals by 45% (P
H Brummerkorvenkontio - One of the best experts on this subject based on the ideXlab platform.
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rupatadine 10 mg in the treatment of immediate Mosquito Bite allergy
Journal of The European Academy of Dermatology and Venereology, 2012Co-Authors: A Karppinen, H Brummerkorvenkontio, T Reunala, I IzquierdoAbstract:Background People frequently experience wealing and delayed papules from Mosquito Bites. Wealing is mediated by antisaliva IgE antibodies and histamine. Rupatadine is a new antihistamine effective in allergic rhinitis and urticaria, but the effect on Mosquito-Bite allergy is not known. Objective To determine the effectiveness of rupatadine in inmediate Mosquito-Bite allergy-confirmed adult patients. Methods A double-blind, placebo-controlled, cross-over study was performed with rupatadine 10 mg and matched placebo in 30 Mosquito-Bite-sensitive adults. The mean age was 37 years and the subjects had suffered from harmful Mosquito Bites for a mean of 15 years. Either rupatadine or placebo was taken at 08:00 am for 4 days, followed by a 5 day wash out period and then alternative treatment was given for 4 days. On day 3, in both drug periods the subjects received two Aedes aegypti Mosquito-Bites on the forearm. The size of lesions and intensity of pruritus [visual analogue scale (VAS)] were measured after 15 min Bite reaction. Results Twenty-six subjects were analysed for efficacy. The size of the 15 min Bite reaction under placebo was of 106 mm2 and under rupatadine, of 55 mm2. This is a significant decrease (48%; P = 0.0003). The accompanying pruritus decreased from 60 (VAS; median) under placebo to 47.5 under rupatadine, which also is a significant (P = 0.019) difference. There was no significant (P = 0.263) difference in adverse events under rupatadine and placebo. Conclusion The present placebo-controlled study in Mosquito-Bite-sensitive adults shows that rupatadine 10 mg prophylactically given is an effective treatment for the Mosquito-Bite wealing and skin pruritus.
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levocetirizine for treatment of immediate and delayed Mosquito Bite reactions
Acta Dermato-venereologica, 2006Co-Authors: A Karppinen, H Brummerkorvenkontio, H. Kautiainen, L. Petman, J P Herve, T ReunalaAbstract:People frequently experience whealing and delayed papules from Mosquito Bites. Various antihistamines have previously been tried for the treatment of this condition. We performed a double-blind, placebo-controlled, cross-over study with levocetirizine 5 mg and matched placebo in 30 adults who were sensitive to Mosquito Bites. On the third treatment day the subjects received two Aedes aegypti Bites on the forearm. The size of the Bite lesions and the intensity of pruritus (visual analogue scale) were measured. Bite symptoms could be analysed in 28 subjects at 15 min and in 8 subjects at 24 h. Levocetirizine decreased the size of wheals by 60% (p < 0.001) and accompanying pruritus by 62% (p < 0.001) compared with placebo. The effect of levocetirizine increased in a linear fashion with the size of wheals and was most significant in the subjects with largest Bite lesions. Levocetirizine also decreased the size of 24-h Bite lesions by 71% (p=0.008) and accompanying pruritus by 56% (p=0.016). These results show that prophylactic levocetirizine 5 mg is an effective treatment for both immediate and delayed Mosquito Bite symptoms and is especially effective in subjects with large wheals.
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loratadine in the treatment of Mosquito Bite sensitive children
Allergy, 2000Co-Authors: A Karppinen, T Reunala, H. Kautiainen, L. Petman, H BrummerkorvenkontioAbstract:Background: Children frequently experience harmful whealing and delayed papules from Mosquito Bites. Whealing is mediated by antisaliva IgE antibodies and histamine, but the effect of antihistamines on Mosquito-Bite symptoms has not been evaluated in children. Methods: The effect of loratadine (0.3 mg/kg) was examined in 28 Mosquito-Bite-sensitive children (aged 2–11 years). The double-blind, placebo-controlled, crossover study was performed with exposure to Aedes aegypti laboratoryMosquitoes. The size of the Bite lesion and the intensity of pruritus (visual analog scale) were measured at 15 min and at 2, 6, and 24 h. Results: Loratadine decreased the size of the wheals by 45% (P<0.001, 25 children) and accompanying pruritus by 78% (P=0.011, 12 children) at 15 min compared to placebo. The size of the 24-h delayed Bite lesion also decreased significantly (P=0.004), but there was no change at 2 or 6 h. Loratadine was well tolerated and no marked side-effects were recorded. Conclusions: This study in children shows that prophylactically given loratadine decreases significantly the whealing and pruritus caused by Mosquito Bites and also reduces the size of the 24-h Bite lesions. Therefore, the therapeutic profile of loratadine extends from immediate to delayed allergic symptoms in Mosquito-Bite-sensitive children.
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histamine and leukotriene c4 release in cutaneous Mosquito Bite reactions
The Journal of Allergy and Clinical Immunology, 1996Co-Authors: Leena Horsmanheimo, H Brummerkorvenkontio, Guido Francois, Ilkka T Harvima, Rauno J Harvima, T ReunalaAbstract:Abstract BACKGROUND: Mosquito Bites are known to sensitize persons, and the most common cutaneous reactions are immediate wheals and delayed Bite papules. Anti-saliva IgE and IgG 4 antibodies are common in Mosquito-sensitive subjects, but mediator release in Bite reactions is not known. METHODS: We used the microdialysis technique to measure in vivo histamine and leukotriene C 4 release after Bite challenges in six Mosquito-sensitive subjects. One individual who was not sensitive to Bites volunteered as a control subject. RESULTS: Three of the six Mosquito-sensitive subjects had large wheals and showed clearly increased histamine concentrations 30 to 45 minutes after the Bites. The histamine levels declined to baseline value within 2 hours; thereafter, one subject showed a second increase in histamine concentration. Four of the six Mosquito-sensitive subjects showed increased leukotriene C 4 concentrations, and this mediator seemed to be released somewhat later than histamine. CONCLUSIONS: The increased histamine and leukotriene C 4 release observed in this study suggests that both mediators are involved in the early allergic response caused by Mosquito Bites. (J ALLERGY CLIN IMMUNOL 1996;98:408-11.)
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passive transfer of cutaneous Mosquito Bite hypersensitivity by ige anti saliva antibodies
The Journal of Allergy and Clinical Immunology, 1994Co-Authors: T Reunala, H Brummerkorvenkontio, L Rasanen, Guido Francois, Timo PalosuoAbstract:Abstract Background: Mosquito Bites frequently cause cutaneous wheal and flare reactions, and recent immunoblotting studies have shown specific anti-saliva IgE antibodies in many persons who have such reactions. Objective: The study was designed to show that human serum containing Mosquito saliva-specific IgE antibodies can produce histamine release in vitro and whealing in vivo. Methods: Two Mosquito Bite-tolerant subjects had Bite challenges and Prausnitz-Kustner tests with heated and unheated serum from one patient with Aedes Mosquito allergy. Immunoblotting and basophil histamine release tests were performed with the patient's and subjects' sera. Results: Both Mosquito Bite-tolerant subjects had positive Prausnitz-Kustner reactions, which indicated a successful transfer of cutaneous Mosquito hypersensitivity. The ordinary and passive basophil histamine release tests also produced positive results with Aedes communis antigens. Conclusion: The results of the Prausnitz-Kustner test, immunoblotting, and basophil histamine release tests are consistent with the hypothesis that Mosquito Bite whealing is mediated by specific anti-saliva IgE antibodies.
T Reunala - One of the best experts on this subject based on the ideXlab platform.
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levocetirizine for treatment of immediate and delayed Mosquito Bite reactions
Acta Dermato-venereologica, 2006Co-Authors: A Karppinen, H Brummerkorvenkontio, H. Kautiainen, L. Petman, J P Herve, T ReunalaAbstract:People frequently experience whealing and delayed papules from Mosquito Bites. Various antihistamines have previously been tried for the treatment of this condition. We performed a double-blind, placebo-controlled, cross-over study with levocetirizine 5 mg and matched placebo in 30 adults who were sensitive to Mosquito Bites. On the third treatment day the subjects received two Aedes aegypti Bites on the forearm. The size of the Bite lesions and the intensity of pruritus (visual analogue scale) were measured. Bite symptoms could be analysed in 28 subjects at 15 min and in 8 subjects at 24 h. Levocetirizine decreased the size of wheals by 60% (p < 0.001) and accompanying pruritus by 62% (p < 0.001) compared with placebo. The effect of levocetirizine increased in a linear fashion with the size of wheals and was most significant in the subjects with largest Bite lesions. Levocetirizine also decreased the size of 24-h Bite lesions by 71% (p=0.008) and accompanying pruritus by 56% (p=0.016). These results show that prophylactic levocetirizine 5 mg is an effective treatment for both immediate and delayed Mosquito Bite symptoms and is especially effective in subjects with large wheals.
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comparison of cetirizine ebastine and loratadine in the treatment of immediate Mosquito Bite allergy
Allergy, 2002Co-Authors: A Karppinen, H. Kautiainen, L. Petman, P Burri, T ReunalaAbstract:Background: People frequently experience whealing and delayed papules from Mosquito Bites. Whealing is mediated by antisaliva immunoglobulin (Ig)E antibodies and histamine. Cetirizine, ebastine and loratadine have earlier shown effects on Mosquito-Bite reactions but no comparative studies exist. Methods: A double-blind, placebo-controlled, cross-over study was performed with cetirizine 10 mg, ebastine 10 mg and loratadine 10 mg in 29 Mosquito-Bite-sensitive adults exposed to Aedes aegypti Mosquito-Bites. The size of the Bite lesion and the intensity of pruritus (visual analog scale) were measured at 15 min and 2, 6 and 24 h. Results: Cetirizine and ebastine, but not loratadine, decreased significantly the size of whealing (P < 0.01) and accompanying pruritus (P < 0.001) compared to placebo. Cetirizine was most effective on pruritus but caused more often sedation than ebastine or loratadine. The delayed Bite symptoms remained too faint for any statistical comparison. Conclusion: This comparative study in Mosquito-Bite-sensitive adults shows that cetirizine and ebastine decrease significantly whealing and accompanying pruritus, and that cetirizine seems to be the most effective against pruritus.
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histamine and leukotriene c4 release in cutaneous Mosquito Bite reactions
The Journal of Allergy and Clinical Immunology, 1996Co-Authors: Leena Horsmanheimo, H Brummerkorvenkontio, Guido Francois, Ilkka T Harvima, Rauno J Harvima, T ReunalaAbstract:Abstract BACKGROUND: Mosquito Bites are known to sensitize persons, and the most common cutaneous reactions are immediate wheals and delayed Bite papules. Anti-saliva IgE and IgG 4 antibodies are common in Mosquito-sensitive subjects, but mediator release in Bite reactions is not known. METHODS: We used the microdialysis technique to measure in vivo histamine and leukotriene C 4 release after Bite challenges in six Mosquito-sensitive subjects. One individual who was not sensitive to Bites volunteered as a control subject. RESULTS: Three of the six Mosquito-sensitive subjects had large wheals and showed clearly increased histamine concentrations 30 to 45 minutes after the Bites. The histamine levels declined to baseline value within 2 hours; thereafter, one subject showed a second increase in histamine concentration. Four of the six Mosquito-sensitive subjects showed increased leukotriene C 4 concentrations, and this mediator seemed to be released somewhat later than histamine. CONCLUSIONS: The increased histamine and leukotriene C 4 release observed in this study suggests that both mediators are involved in the early allergic response caused by Mosquito Bites. (J ALLERGY CLIN IMMUNOL 1996;98:408-11.)
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passive transfer of cutaneous Mosquito Bite hypersensitivity by ige anti saliva antibodies
The Journal of Allergy and Clinical Immunology, 1994Co-Authors: T Reunala, H Brummerkorvenkontio, L Rasanen, Guido Francois, Timo PalosuoAbstract:Abstract Background: Mosquito Bites frequently cause cutaneous wheal and flare reactions, and recent immunoblotting studies have shown specific anti-saliva IgE antibodies in many persons who have such reactions. Objective: The study was designed to show that human serum containing Mosquito saliva-specific IgE antibodies can produce histamine release in vitro and whealing in vivo. Methods: Two Mosquito Bite-tolerant subjects had Bite challenges and Prausnitz-Kustner tests with heated and unheated serum from one patient with Aedes Mosquito allergy. Immunoblotting and basophil histamine release tests were performed with the patient's and subjects' sera. Results: Both Mosquito Bite-tolerant subjects had positive Prausnitz-Kustner reactions, which indicated a successful transfer of cutaneous Mosquito hypersensitivity. The ordinary and passive basophil histamine release tests also produced positive results with Aedes communis antigens. Conclusion: The results of the Prausnitz-Kustner test, immunoblotting, and basophil histamine release tests are consistent with the hypothesis that Mosquito Bite whealing is mediated by specific anti-saliva IgE antibodies.
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Immunology and treatment of Mosquito Bites.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1990Co-Authors: T Reunala, H. Brummer-korvenkontio, L Rasanen, P Lappalainen, T. PalosuoAbstract:Cutaneous reactions to Mosquito Bites are usually pruritic weals and delayed papules. Arthus-type local and systemic symptoms can also occur but anaphylactic reactions are very rare. Both clinical and experimental evidence suggest that the various Bite reactions result from sensitization to the Mosquito saliva injected into the skin during feeding. Recent immunoblot studies have shown both IgG- and IgE-class anti-Mosquito antibodies, but their species-specificity and clinical importance is at present unknown. In addition to an Arthus-type mechanism, both cutaneous late-phase reactivity and cell-mediated immunity may be involved in the pathophysiology of delayed Mosquito-Bite lesions. Cutaneous sensitization to Mosquito Bites can be divided into five different stages ranging from the stages of immediate wealing and delayed Bite papules, to the stage of non-reactivity. No desensitization treatment is generally available for Mosquito allergy but it has recently been shown that cetirizine, a potent non-sedating antihistamine, is effective against the wealing and pruritus caused by Mosquito Bites.
Changsoo Park - One of the best experts on this subject based on the ideXlab platform.
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epstein barr virus infected natural killer cell lymphoma in a patient with hypersensitivity to Mosquito Bite
Journal of Infection, 2006Co-Authors: Young Hyeh Ko, Changsoo ParkAbstract:Summary Hypersensitivity to Mosquito Bite (HMB) can occur in association with chronic Epstein–Barr virus (EBV) infection and natural killer (NK) cell leukaemia/lymphoma, which was named ‘Tokura-Ishihara disease'. This disease is very rare and most previous reports have been documented in Japan. We present a patient who suffered from of pustules on skin, high fever, myalgia and multiple lymph node enlargements after Mosquito Bite from childhood. Recently, multiple lymph nodes were palpable on his both inguinal area. Peripheral blood smear (PBS) revealed many large granular lymphocytes and the skin lesion showed a dense dermal and subcutaneous infiltrate of lymphocytes. The lymph nodes and perinodal adipose tissue were infiltrated by atypical lymphoid cells in which EBER-positive signals were identified by in situ hybridization using EBV encoded RNA-1 probe. He was diagnosed as having Tokura-Ishihara disease and receives chemotherapy now. Here, we report a case of this disease with a precise pathological description on the lymph node biopsy.
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Epstein–Barr virus infected natural killer cell lymphoma in a patient with hypersensitivity to Mosquito Bite
Journal of Infection, 2005Co-Authors: Young Hyeh Ko, Changsoo ParkAbstract:Summary Hypersensitivity to Mosquito Bite (HMB) can occur in association with chronic Epstein–Barr virus (EBV) infection and natural killer (NK) cell leukaemia/lymphoma, which was named ‘Tokura-Ishihara disease'. This disease is very rare and most previous reports have been documented in Japan. We present a patient who suffered from of pustules on skin, high fever, myalgia and multiple lymph node enlargements after Mosquito Bite from childhood. Recently, multiple lymph nodes were palpable on his both inguinal area. Peripheral blood smear (PBS) revealed many large granular lymphocytes and the skin lesion showed a dense dermal and subcutaneous infiltrate of lymphocytes. The lymph nodes and perinodal adipose tissue were infiltrated by atypical lymphoid cells in which EBER-positive signals were identified by in situ hybridization using EBV encoded RNA-1 probe. He was diagnosed as having Tokura-Ishihara disease and receives chemotherapy now. Here, we report a case of this disease with a precise pathological description on the lymph node biopsy.
Tomocho Matsuse - One of the best experts on this subject based on the ideXlab platform.
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a case of exaggerated Mosquito Bite hypersensitivity with epstein barr virus positive inflammatory cells in the Bite lesion
Acta Dermato-venereologica, 2001Co-Authors: Tokuya Ohsawa, Tsukasa Morimura, Yoshitaka Hagari, Tetsuji Kawakami, Motoyuki Mihara, Kazumitsu Hirai, Kazufumi Ikuta, Masanao Murakami, Takeshi Sairenji, Tomocho MatsuseAbstract:We describe a unique patient with Mosquito-Bite hypersensitivity who had extremely high titres of Epstein-Barr virus antibodies. For many years he developed intractable ulcers on the sites of Mosquito-Bite. Epstein-Barr virus infection was detected in almost all inflammatory cells in the ulcers and in the peripheral blood lymphocytes by using in situ hybridization to Epstein-Barr virus-encoded small ribonucleic acids and by polymerase chain reaction to Epstein-Barr virus DNA. The inflammatory cells in the ulcers were positive for T-cell marker. Our results suggest that the Epstein-Barr virus infection in T cells may participate in the pathogenesis of exaggerated Mosquito hypersensitivity and in delayed healing of ulcers on the sites of Mosquito-Bite.