The Experts below are selected from a list of 243 Experts worldwide ranked by ideXlab platform

Kevin L Kilgore - One of the best experts on this subject based on the ideXlab platform.

  • counted cycles method to measure the Block inception time of kilohertz frequency mammalian Motor Nerve Block
    Journal of Neuroscience Methods, 2020
    Co-Authors: Niloy Bhadra, Emily Foldes, M R Gerges, Douglas Michael Ackermann, Kevin L Kilgore
    Abstract:

    Abstract Background Kilohertz frequency alternating currents (KHFAC) produce rapid Nerve conduction Block of mammalian peripheral Nerves and have potential clinical applications in reducing Nerve hyperactivity. However, there are no experimental measurements of the Block inception time (BIT) for the complete Block of mammalian Motor axons, i.e. the time from the start of delivery of the KHFAC to the axons reaching a fully Blocked state. New method A “counted cycles” method (CCM) was designed to exploit characteristics of the onset response, which is typical of KHFAC Block, to measure the BIT with a millisecond time resolution. Randomized and repeated experiments were conducted in an in-vivo rodent model, using trains of KHFAC over a range of complete cycle counts at three frequencies (10, 20, and 40 kHz). Results Complete Motor Nerve conduction Block was obtained in the rat sciatic Nerve (N = 4) with an average BIT range of 5 ms–10 ms. The fastest BIT measured was 2.5 ms–5 ms. There was no statistical difference between the Block inception times for the three frequencies tested. Comparison with existing methods There are no comparable methods to measure the KHFAC BIT. Conclusion The KHFAC BIT is faster than previously estimated. KHFAC Motor Nerve Block is established in milliseconds. These results may assist in the design of methods to eliminate the onset response produced by KHFAC Nerve Block.

  • Block of mammalian Motor Nerve conduction using high frequency alternating current
    International IEEE EMBS Conference on Neural Engineering, 2005
    Co-Authors: Niloy Bhadra, Kevin L Kilgore
    Abstract:

    High frequency alternating current waveforms have been shown to produce a rapidly reversible Nerve Block in animal models. Acute in-vivo experiments were carried out in a rat model. A Blocking electrode was placed on the sciatic Nerve and Motor Nerve Block quantified by measuring force output of the gastrocnemius muscle. Sinusoidal waveforms in the range of 10 kHz to 30 kHz were tested. The results indicate that a 100% Nerve Block of Motor activity can be accomplished at all the frequencies tested. The Block is complete and quickly reversible. Block thresholds (peak to peak voltage of the waveform) were measured and showed a linear relationship to frequency. Block was obtained with the lowest voltage at 10 KHz. It was also demonstrated that the Block is not produced indirectly through fatigue. This type of Nerve Block may have multiple applications in the treatment of spasticity and pain

Brigitte Perrouinverbe - One of the best experts on this subject based on the ideXlab platform.

  • unstable gait due to spasticity of the rectus femoris gait analysis and Motor Nerve Block
    Annals of Physical and Rehabilitation Medicine, 2012
    Co-Authors: Raphael Gross, Fabien Leboeuf, O Remyneris, Brigitte Perrouinverbe
    Abstract:

    We present the case of a 54 year-old man presenting with a right Brown-Sequard plus syndrome (BSPS) after a traumatic cervical spinal cord injury. After being operated on with selective tibial neurotomy and triceps surae lengthening because of a right spastic equinus foot, he developed a gait disorder at high speed. The patient complained about an instability of the right knee. Observational gait analysis exhibited an oscillating, flexion/extension motion of the right knee during stance, which was confirmed by gait analysis. Dynamic electromyographic recordings exhibited a clonus of the right rectus femoris (RF) during stance. The spastic activity of the RF and the abnormal knee motion totally reversed after a Motor Nerve Block of the RF, as well as after botulinum toxin type A injection into the RF. We emphasize that complex, spastic gait disorders can benefit from a comprehensive assessment including gait analysis and Nerve Blocks.

Raphael Gross - One of the best experts on this subject based on the ideXlab platform.

  • unstable gait due to spasticity of the rectus femoris gait analysis and Motor Nerve Block
    Annals of Physical and Rehabilitation Medicine, 2012
    Co-Authors: Raphael Gross, Fabien Leboeuf, O Remyneris, Brigitte Perrouinverbe
    Abstract:

    We present the case of a 54 year-old man presenting with a right Brown-Sequard plus syndrome (BSPS) after a traumatic cervical spinal cord injury. After being operated on with selective tibial neurotomy and triceps surae lengthening because of a right spastic equinus foot, he developed a gait disorder at high speed. The patient complained about an instability of the right knee. Observational gait analysis exhibited an oscillating, flexion/extension motion of the right knee during stance, which was confirmed by gait analysis. Dynamic electromyographic recordings exhibited a clonus of the right rectus femoris (RF) during stance. The spastic activity of the RF and the abnormal knee motion totally reversed after a Motor Nerve Block of the RF, as well as after botulinum toxin type A injection into the RF. We emphasize that complex, spastic gait disorders can benefit from a comprehensive assessment including gait analysis and Nerve Blocks.

  • Unstable gait due to spasticity of the rectus femoris: gait analysis and Motor Nerve Block.
    Annals of physical and rehabilitation medicine, 2012
    Co-Authors: Raphael Gross, Fabien Leboeuf, O Rémy-néris, B Perrouin-verbe
    Abstract:

    We present the case of a 54 year-old man presenting with a right Brown-Séquard plus syndrome (BSPS) after a traumatic cervical spinal cord injury. After being operated on with selective tibial neurotomy and triceps surae lengthening because of a right spastic equinus foot, he developed a gait disorder at high speed. The patient complained about an instability of the right knee. Observational gait analysis exhibited an oscillating, flexion/extension motion of the right knee during stance, which was confirmed by gait analysis. Dynamic electromyographic recordings exhibited a clonus of the right rectus femoris (RF) during stance. The spastic activity of the RF and the abnormal knee motion totally reversed after a Motor Nerve Block of the RF, as well as after botulinum toxin type A injection into the RF. We emphasize that complex, spastic gait disorders can benefit from a comprehensive assessment including gait analysis and Nerve Blocks.

Ho Jung Sohn - One of the best experts on this subject based on the ideXlab platform.

  • comparison of sensory and Motor Nerve Block in epidural anesthesia using a different concentrations of ropivacaine for cesarean section
    Korean Journal of Anesthesiology, 2003
    Co-Authors: Jun Kwon Choi, Ho Jung Sohn
    Abstract:

    Background: The aim of this study was to evaluate the sensory and Motor Nerve Block achieved by epidural anesthesia using 0.475% ropivacaine and 0.75% ropivacaine. Methods: Fifty-six patients undergoing cesarean section were randomly allocated to group I (0.75% ropivacaine) or group II (0.475% ropivacaine). We assessed changes in sensory and Motor Block using the Bromage scale over 180 minutes after epidural anesthesia. The incidence of nausea, vomiting and the total dosage of ephedrine used were also recorded. Sensory changes, Motor Blockade and the total dosage of ephedrine used were compared using the t-test (P ＜ 0.05). Results: No significant differences were found between the two groups at the sensory Block level except at 30 and 60 minutes after epidural anesthesia. However, the Motor Blockade of group I was significantly more intense than that of group II at 15, 20, 25, 30, 60, 120 and 180 minutes after epidural anesthesia. No significant differences were observed between the two groups in the incidences of nausea, vomiting or the total dosage of ephedrine used. Conclusions: The use of 0.475% ropivacaine instead of 0.75% ropivacaine in epidural anesthesia for cesarean section did not reduce the incidence of nausea, vomiting or the total dosage of ephedrine used. The sensory Block achieved using 0.75% ropivacaine was similar, but the Motor Blockade achieved using 0.475% ropivacaine was less intense with a shorter duration and an earlier recovery to normal than that of 0.75% ropivacaine. These results suggest that 0.475% ropivacaine may be more useful in epidural anesthesia for cesarean section than 0.75% ropivacaine.

Fabien Leboeuf - One of the best experts on this subject based on the ideXlab platform.

  • unstable gait due to spasticity of the rectus femoris gait analysis and Motor Nerve Block
    Annals of Physical and Rehabilitation Medicine, 2012
    Co-Authors: Raphael Gross, Fabien Leboeuf, O Remyneris, Brigitte Perrouinverbe
    Abstract:

    We present the case of a 54 year-old man presenting with a right Brown-Sequard plus syndrome (BSPS) after a traumatic cervical spinal cord injury. After being operated on with selective tibial neurotomy and triceps surae lengthening because of a right spastic equinus foot, he developed a gait disorder at high speed. The patient complained about an instability of the right knee. Observational gait analysis exhibited an oscillating, flexion/extension motion of the right knee during stance, which was confirmed by gait analysis. Dynamic electromyographic recordings exhibited a clonus of the right rectus femoris (RF) during stance. The spastic activity of the RF and the abnormal knee motion totally reversed after a Motor Nerve Block of the RF, as well as after botulinum toxin type A injection into the RF. We emphasize that complex, spastic gait disorders can benefit from a comprehensive assessment including gait analysis and Nerve Blocks.

  • Unstable gait due to spasticity of the rectus femoris: gait analysis and Motor Nerve Block.
    Annals of physical and rehabilitation medicine, 2012
    Co-Authors: Raphael Gross, Fabien Leboeuf, O Rémy-néris, B Perrouin-verbe
    Abstract:

    We present the case of a 54 year-old man presenting with a right Brown-Séquard plus syndrome (BSPS) after a traumatic cervical spinal cord injury. After being operated on with selective tibial neurotomy and triceps surae lengthening because of a right spastic equinus foot, he developed a gait disorder at high speed. The patient complained about an instability of the right knee. Observational gait analysis exhibited an oscillating, flexion/extension motion of the right knee during stance, which was confirmed by gait analysis. Dynamic electromyographic recordings exhibited a clonus of the right rectus femoris (RF) during stance. The spastic activity of the RF and the abnormal knee motion totally reversed after a Motor Nerve Block of the RF, as well as after botulinum toxin type A injection into the RF. We emphasize that complex, spastic gait disorders can benefit from a comprehensive assessment including gait analysis and Nerve Blocks.