The Experts below are selected from a list of 234 Experts worldwide ranked by ideXlab platform

Harlan M. Krumholz - One of the best experts on this subject based on the ideXlab platform.

Jeptha P. Curtis - One of the best experts on this subject based on the ideXlab platform.

Wang Shuying - One of the best experts on this subject based on the ideXlab platform.

  • clinical observation on the Motrin suspension and antondine injection in the treatment of upper respiratory tract infection with fever in children
    Gansu Medical Journal, 2012
    Co-Authors: Wang Shuying
    Abstract:

    Objective:To observe and compare the clinical efficacy of Motrin suspension and Antondine injection in the treatment of upper respiratory tract infection with fever in children. Methods: 100 selected patients of upper respiratory tract infections accompanied by fever symptoms ( axillary temperature≥39℃) were given oral Motrin suspension and Antondine injection respectively to observe defervescence and side effects after administration in different time periods. Results: 1 hour after administration, the speed of defervescence in two groups of children with fever was close to each other. The body temperature of children in Motrin suspension group was close to normal two hours later and maintained for 8 hours; the body temperature of children in Antondine injection group was slightly decreased but failed to fall to normal level, and rebounded after 4 hours. Motrin suspension was more effective than Antondine to relieve symptoms,such as sore throat and headache. Conclusion: Motrin suspension had powerful antipyretic action with a long duration,and more significant efficacy on relief of sore throat and headache.

Mircea Alexandru Mateescu - One of the best experts on this subject based on the ideXlab platform.

  • Two release rates from monolithic carboxymethyl starch tablets: formulation, characterization, and in vitro/in vivo evaluation
    Drug Delivery and Translational Research, 2017
    Co-Authors: Mircea Alexandru Mateescu
    Abstract:

    Most of non-steroidal anti-inflammatory drugs (NSAIDs) including ibuprofen at more than 1200 mg/day may generate gastrointestinal and cardiovascular side effects. Bilayer or multiparticulate devices have been developed for controlled release in order to prevent undesired side effects. A new “two release rate (2RR) monolithic tablets” approach is now proposed for controlled release of poorly soluble drugs, particularly NSAIDs. Ibuprofen was used as model drug. This concept is based on a calcium carboxymethyl-starch (CaCMS) complex as a novel, low-cost excipient for monolithic dosage forms easy to manufacture by direct compaction. The in vitro dissolution from CaCMS formulations (tablets containing 400 or 600 mg active principle) showed two distinct release rates: (i) an initial fast release (for 30 min in simulated gastric fluid) of about 200 mg ibuprofen, an amount similar to the dosage of conventional immediate-release form (Motrin® 200 mg), and (ii) a slow release of remaining about 200 or 400 mg for a period of 12 h. A preliminary in vivo study (beagle dogs) showed pharmacokinetic parameters of one single controlled-release dosage of ibuprofen (400 mg) formulated with CaCMS, near equivalence with multiple doses (three tablets of 200 mg ibuprofen) of conventional Motrin®. A marked reduction (with 33%) of administered dose (400 instead 600 mg) was achieved by the new formulation with equivalent therapeutic effects. This dose reduction may be beneficial and is expected to minimize side damage risks. Although the present study was limited to NSAIDs, the 2RR concept can be applied for other drugs, particularly for subjects unable to follow frequent administrations.

Dennis S. Peppas - One of the best experts on this subject based on the ideXlab platform.