The Experts below are selected from a list of 21 Experts worldwide ranked by ideXlab platform

Yuanfeen Tsai - One of the best experts on this subject based on the ideXlab platform.

  • effects of alcohol on the Mouse Killing Behavior of olfactory bulbectomized rats
    Chinese Journal of Physiology, 2008
    Co-Authors: Chihyuan Chiang, Hung Hsuchou, Yingjui Ho, Yuanfeen Tsai
    Abstract:

    The purpose of the current study was to evaluate the effects of chronic administration of alcohol on the olfactory bulbectomy (OBX)-induced Mouse-Killing Behavior (MKB), an animal model for screening antidepressants. The rats were divided into three groups, which were given alcohol (0, 0.5, or 1 g/kg/day) orally for 28 days. MKB was analyzed before and at the end of each week of the alcohol treatment. The results showed that chronic alcohol treatment produced a significant increase in the latency of MKB, implying that alcohol may have an antidepressant-like activity. This suggests that alcohol dependence or abuse in depressed patients may result from “self-medication”. Since it has been reported that OBX causes a decrease in the density of N-methyl-D-aspartate (NMDA) receptors in the brain and that alcohol is a potent and selective inhibitor of NMDA receptors, the possible role of NMDA receptors in this effect is discussed.

  • MK-801 suppresses muricidal Behavior but not locomotion in olfactory bulbectomized rats: involvement of NMDA receptors
    Pharmacology Biochemistry and Behavior, 2004
    Co-Authors: Yingjui Ho, Kuang-ho Chen, Yuanfeen Tsai
    Abstract:

    In rats, olfactory bulbectomy (OBX) causes changes in glutamatergic function in the amygdala (AMG) and induces Mouse-Killing Behavior (MKB). The medial AMG (mAMG) plays an important role in the initiation and maintenance of OBX-induced MKB. In the present study, systemic injection or intra-mAMG perfusion of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801) was used to determine the effects of MK-801, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, on the expression of OBX-induced MKB in male Wistar rats that had undergone OBX 1 month previously. The effects of MK-801 on locomotion in OBX rats were also examined using the open-field test. Intraperitoneal injection of MK-801 at doses of 0.10 and 0.15 mg/kg resulted in reversible suppression of MKB, the effect being maximal within 1 h after drug treatment, then gradually disappearing over 6 h. Locomotor distance in OBX rats was not affected using 0.10 mg/kg of MK-801, but increased after treatment with 0.15 mg/kg of MK-801; both doses, however, caused the rats to spend longer in the central area of the open field. MKB was also reversibly suppressed by local perfusion of 1 mM MK-801 at a rate of 1 Al/min into the mAMG through microdialysis probes. These results suggest that NMDA receptors, at least, in the mAMG, are involved in the expression of OBX-induced MKB.

Yingjui Ho - One of the best experts on this subject based on the ideXlab platform.

  • effects of alcohol on the Mouse Killing Behavior of olfactory bulbectomized rats
    Chinese Journal of Physiology, 2008
    Co-Authors: Chihyuan Chiang, Hung Hsuchou, Yingjui Ho, Yuanfeen Tsai
    Abstract:

    The purpose of the current study was to evaluate the effects of chronic administration of alcohol on the olfactory bulbectomy (OBX)-induced Mouse-Killing Behavior (MKB), an animal model for screening antidepressants. The rats were divided into three groups, which were given alcohol (0, 0.5, or 1 g/kg/day) orally for 28 days. MKB was analyzed before and at the end of each week of the alcohol treatment. The results showed that chronic alcohol treatment produced a significant increase in the latency of MKB, implying that alcohol may have an antidepressant-like activity. This suggests that alcohol dependence or abuse in depressed patients may result from “self-medication”. Since it has been reported that OBX causes a decrease in the density of N-methyl-D-aspartate (NMDA) receptors in the brain and that alcohol is a potent and selective inhibitor of NMDA receptors, the possible role of NMDA receptors in this effect is discussed.

  • MK-801 suppresses muricidal Behavior but not locomotion in olfactory bulbectomized rats: involvement of NMDA receptors
    Pharmacology Biochemistry and Behavior, 2004
    Co-Authors: Yingjui Ho, Kuang-ho Chen, Yuanfeen Tsai
    Abstract:

    In rats, olfactory bulbectomy (OBX) causes changes in glutamatergic function in the amygdala (AMG) and induces Mouse-Killing Behavior (MKB). The medial AMG (mAMG) plays an important role in the initiation and maintenance of OBX-induced MKB. In the present study, systemic injection or intra-mAMG perfusion of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801) was used to determine the effects of MK-801, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, on the expression of OBX-induced MKB in male Wistar rats that had undergone OBX 1 month previously. The effects of MK-801 on locomotion in OBX rats were also examined using the open-field test. Intraperitoneal injection of MK-801 at doses of 0.10 and 0.15 mg/kg resulted in reversible suppression of MKB, the effect being maximal within 1 h after drug treatment, then gradually disappearing over 6 h. Locomotor distance in OBX rats was not affected using 0.10 mg/kg of MK-801, but increased after treatment with 0.15 mg/kg of MK-801; both doses, however, caused the rats to spend longer in the central area of the open field. MKB was also reversibly suppressed by local perfusion of 1 mM MK-801 at a rate of 1 Al/min into the mAMG through microdialysis probes. These results suggest that NMDA receptors, at least, in the mAMG, are involved in the expression of OBX-induced MKB.

Miguel De La Guardia - One of the best experts on this subject based on the ideXlab platform.

  • Testosterone and aggressiveness.
    Medical Science Monitor, 2005
    Co-Authors: Marco Giammanco, Garden Tabacchi, Danila Di Majo, Santo Giammanco, Miguel De La Guardia
    Abstract:

    Aggressiveness is an ancestral Behavior common to all animal species. Its neurophysiological mechanisms are similar in all vertebrates. Males are generally more aggressive than females. In this review, aggressive Behavior in rodents, monkeys, and man and the role of testosterone and brain serotonin levels have been considered. Interspecific aggressiveness in rats has been studied considering the Mouse-Killing Behavior; the neonatal androgenization of females increases adult Mouse-Killing as does the administration of testosterone in adults. Intraspecific aggressiveness was studied by putting two or more male rats (or mice) in the same cage; the condition of subjection or dominance is influenced by testosterone. In monkeys, testosterone is related to aggressiveness and dominance and, during the mating season, increases in testosterone levels and aggressive attitude are observed. In men, higher testosterone levels were obtained in perpetrators of violent crimes, in men from the army with antisocial Behaviors, in subjects with impulsive Behaviors, alcoholics and suicidals, in athletes using steroids, and during competitions. Aggressive and dominant Behavior are distinguished. Testosterone influences both of these, even if man is usually inclined to affirm his power without causing physical damage. Testosterone receptors are mainly in some hypothalamic neurons, where it is aromatized into estrogens, which determine the increase in aggressiveness. A relation between testosterone levels and diencephalic serotonin has been shown: in fact, the lack of serotonin increases aggressive Behaviors both in animals and man. Testosterone also increases ADH levels in the medial amygdala, lateral hypothalamus, and preoptical medial area, involved in aggressive Behaviors. Language: en

  • Testosterone and aggressiveness.
    Medical science monitor : international medical journal of experimental and clinical research, 2005
    Co-Authors: Marco Giammanco, Garden Tabacchi, Danila Di Majo, Santo Giammanco, Miguel De La Guardia
    Abstract:

    Aggressiveness is an ancestral Behavior common to all animal species. Its neurophysiological mechanisms are similar in all vertebrates. Males are generally more aggressive than females. In this review, aggressive Behavior in rodents, monkeys, and man and the role of testosterone and brain serotonin levels have been considered. Interspecific aggressiveness in rats has been studied considering the Mouse-Killing Behavior; the neonatal androgenization of females increases adult Mouse-Killing as does the administration of testosterone in adults. Intraspecific aggressiveness was studied by putting two or more male rats (or mice) in the same cage; the condition of subjection or dominance is influenced by testosterone. In monkeys, testosterone is related to aggressiveness and dominance and, during the mating season, increases in testosterone levels and aggressive attitude are observed. In men, higher testosterone levels were obtained in perpetrators of violent crimes, in men from the army with antisocial Behaviors, in subjects with impulsive Behaviors, alcoholics and suicidals, in athletes using steroids, and during competitions. Aggressive and dominant Behavior are distinguished. Testosterone influences both of these, even if man is usually inclined to affirm his power without causing physical damage. Testosterone receptors are mainly in some hypothalamic neurons, where it is aromatized into estrogens, which determine the increase in aggressiveness. A relation between testosterone levels and diencephalic serotonin has been shown: in fact, the lack of serotonin increases aggressive Behaviors both in animals and man. Testosterone also increases ADH levels in the medial amygdala, lateral hypothalamus, and preoptical medial area, involved in aggressive Behaviors.

Chihyuan Chiang - One of the best experts on this subject based on the ideXlab platform.

  • effects of alcohol on the Mouse Killing Behavior of olfactory bulbectomized rats
    Chinese Journal of Physiology, 2008
    Co-Authors: Chihyuan Chiang, Hung Hsuchou, Yingjui Ho, Yuanfeen Tsai
    Abstract:

    The purpose of the current study was to evaluate the effects of chronic administration of alcohol on the olfactory bulbectomy (OBX)-induced Mouse-Killing Behavior (MKB), an animal model for screening antidepressants. The rats were divided into three groups, which were given alcohol (0, 0.5, or 1 g/kg/day) orally for 28 days. MKB was analyzed before and at the end of each week of the alcohol treatment. The results showed that chronic alcohol treatment produced a significant increase in the latency of MKB, implying that alcohol may have an antidepressant-like activity. This suggests that alcohol dependence or abuse in depressed patients may result from “self-medication”. Since it has been reported that OBX causes a decrease in the density of N-methyl-D-aspartate (NMDA) receptors in the brain and that alcohol is a potent and selective inhibitor of NMDA receptors, the possible role of NMDA receptors in this effect is discussed.

Michel Paris - One of the best experts on this subject based on the ideXlab platform.

  • Measurement of the Three Phases of Muricidal Behavior Induced by Δ9-Tetrahydrocannabinol in Isolated, Fasting Rats
    Physiology & Behavior, 1998
    Co-Authors: Bac P, Nicole Pages, Christine Herrenknecht, Michel Paris
    Abstract:

    Abstract Δ9-Tetrahydrocannabinol (THC) has long been recognized as inducing Mouse-Killing Behavior (muricidal Behavior) in starving, isolated rats after a single injection. We showed that when the Killing tendency was increased by THC, a preliminary contact with a Mouse decreased the probability of muricidal Behavior. By quantifying the three phases of the muricidal Behavior in either nonkiller or naive THC-treated rats, we showed that the duration of each step was notably increased as compared to untreated natural killer rats, mainly the attack on the dead Mouse, indicating increased aggressiveness. Finally, no significant changes were observed in the duration of the three phases in natural killer rats when the muricide assays were repeated every hour. In contrast, in THC-treated rats—either naive or nonkiller—all three phases decreased with the assay repetition to levels comparable to those of natural killer rats, suggesting that the killer Behavior was progressively acquired for the six assays. These changes could be a useful model to study the central effects of THC and either its agonists or antagonists.