The Experts below are selected from a list of 132 Experts worldwide ranked by ideXlab platform
Claudia Malheiros Coutinhocamillo - One of the best experts on this subject based on the ideXlab platform.
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abstract 2867 egfr expression in t1 t2 oral tongue and floor of the Mouth Carcinoma
Cancer Research, 2014Co-Authors: Natalie Kelner, Clovis Antonio Lopes Pinto, Luiz Paulo Kowalski, Claudia Malheiros CoutinhocamilloAbstract:Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Epidermal growth factor receptor (EGFR) is a molecular maker that regulates the cell growth and plays an important role in tumor proliferation, invasion and metastasis formation. Objective: In this study we examined the association of immunohistochemical expression of EGFR with clinicopathological parameters, lymph node metastasis, regional recurrence and survival in selected cases of early squamous cell Carcinoma (SCC) of the oral tongue and floor of the Mouth. Methods: Patients with early stage SCC of oral tongue and floor of the Mouth were treated surgically at a single institution from 1980 to 2010. Specimens from 139 patients were analyzed for EGFR expression using monoclonal antibody. Results: This study included 139 patients, 96 men (69%), with ages ranging from 21 to 85 years old (mean, 58 years). The tumor site was the tongue in 105 cases (75.5%) and the floor of the Mouth in 34 (24.5%). With regard to pathological T-stage, 69 cases were pT1 (52.7%) and 62 were pT2 (47.3%). EGFR was overexpressed in 18 cases (13%) and was significantly associated with pT (p=0.017), thickness greater than 4mm (p=0.017), muscular invasion (p=0.014), desmoplastic reaction (p=0.021), inflammatory infiltrate (p=0.029), lymphatic embolization (p=0.016), mode of invasion (p=0.027) and perineural invasion (p=0.007). The overexpression of EGFR was also associated with lymph node metastasis (p=0.038) and regional recurrence (p=0.014). The cancer-specific survival in 5 years decreased from 90% in the group without EGFR expression to 75.3% in the EGFR overexpression group (p=0.019). Conclusion: The EGFR overexpression was associated with more aggressive pathological features, lymph node metastasis and regional recurrence in patients with early oral tongue and floor of the Mouth squamous cell Carcinoma. Citation Format: Natalie Kelner, Clovis Antonio Lopes Pinto, Luiz Paulo Kowalski, Claudia Malheiros Coutinho-Camillo. EGFR expression in T1/T2 oral tongue and floor of the Mouth Carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2867. doi:10.1158/1538-7445.AM2014-2867
Shawky F Karas - One of the best experts on this subject based on the ideXlab platform.
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Relationship of biopsy and final specimens in evaluation of tumor thickness in floor of Mouth Carcinoma.
The Laryngoscope, 1995Co-Authors: David E Karas, Soly Baredes, T S Chen, Shawky F KarasAbstract:A number of studies have suggested that tumor thickness may be a valuable prognostic indicator in the evaluation of head and neck cancers. This study examined the relationship between tumor thickness measured in preliminary biopsy specimens with the final specimens obtained in 31 patients with floor of Mouth epidermoid Carcinoma. There was a significant statistical correlation between biopsy and final specimens. The Pearson's product-moment correlation coefficient was 0.58, which corresponded to a significance level of P < .0005. The results of this study showed that those patients who had biopsies with a thickness less than or equal to 1 mm were likely to have final specimens with a thickness less than 2 mm. All patients with a thickness greater than 2 mm had a final specimen with a thickness greater than 3.5 mm. Modification of current biopsy techniques may result in values more predictive of final thickness measurements.
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relationship of biopsy and final specimens in evaluation of tumor thickness in floor of Mouth Carcinoma
Laryngoscope, 1995Co-Authors: David E Karas, Soly Baredes, Thomas Chen, Shawky F KarasAbstract:A number of studies have suggested that tumor thickness may be a valuable prognostic indicator in the evaluation of head and neck cancers. This study examined the relationship between tumor thickness measured in preliminary biopsy specimens with the final specimens obtained in 31 patients patients with floor of Mouth epidermoid Carcinoma. There was a significant statistical correlation between biopsy and final specimens. The Pearson's product-moment correlation coefficient was 0.58, which corresponded to a significance level of P<.0005. The results of this study showed that those patients who had biopsies with a thickness less than or equal to 1 mm were likely to have final specimens with a thickness less than 2 mm. All patients with a thickness greater than 2 mm had a final specimen with a thickness greater than 3.5 mm. Modification of current biopsy techniques may result in values more predictive of final thickness measurements
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Relationship of biopsy and final specimens in evaluation of tumor thickness in floor of Mouth Carcinoma
Laryngoscope, 1995Co-Authors: David E Karas, Soly Baredes, Thomas Chen, Shawky F KarasAbstract:A number of studies have suggested that tumor thickness may be a valuable prognostic indicator in the evaluation of head and neck cancers. This study examined the relationship between tumor thickness measured in preliminary biopsy specimens with the final specimens obtained in 31 patients patients with floor of Mouth epidermoid Carcinoma. There was a significant statistical correlation between biopsy and final specimens. The Pearson's product-moment correlation coefficient was 0.58, which corresponded to a significance level of P
Natalie Kelner - One of the best experts on this subject based on the ideXlab platform.
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abstract 2867 egfr expression in t1 t2 oral tongue and floor of the Mouth Carcinoma
Cancer Research, 2014Co-Authors: Natalie Kelner, Clovis Antonio Lopes Pinto, Luiz Paulo Kowalski, Claudia Malheiros CoutinhocamilloAbstract:Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Epidermal growth factor receptor (EGFR) is a molecular maker that regulates the cell growth and plays an important role in tumor proliferation, invasion and metastasis formation. Objective: In this study we examined the association of immunohistochemical expression of EGFR with clinicopathological parameters, lymph node metastasis, regional recurrence and survival in selected cases of early squamous cell Carcinoma (SCC) of the oral tongue and floor of the Mouth. Methods: Patients with early stage SCC of oral tongue and floor of the Mouth were treated surgically at a single institution from 1980 to 2010. Specimens from 139 patients were analyzed for EGFR expression using monoclonal antibody. Results: This study included 139 patients, 96 men (69%), with ages ranging from 21 to 85 years old (mean, 58 years). The tumor site was the tongue in 105 cases (75.5%) and the floor of the Mouth in 34 (24.5%). With regard to pathological T-stage, 69 cases were pT1 (52.7%) and 62 were pT2 (47.3%). EGFR was overexpressed in 18 cases (13%) and was significantly associated with pT (p=0.017), thickness greater than 4mm (p=0.017), muscular invasion (p=0.014), desmoplastic reaction (p=0.021), inflammatory infiltrate (p=0.029), lymphatic embolization (p=0.016), mode of invasion (p=0.027) and perineural invasion (p=0.007). The overexpression of EGFR was also associated with lymph node metastasis (p=0.038) and regional recurrence (p=0.014). The cancer-specific survival in 5 years decreased from 90% in the group without EGFR expression to 75.3% in the EGFR overexpression group (p=0.019). Conclusion: The EGFR overexpression was associated with more aggressive pathological features, lymph node metastasis and regional recurrence in patients with early oral tongue and floor of the Mouth squamous cell Carcinoma. Citation Format: Natalie Kelner, Clovis Antonio Lopes Pinto, Luiz Paulo Kowalski, Claudia Malheiros Coutinho-Camillo. EGFR expression in T1/T2 oral tongue and floor of the Mouth Carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2867. doi:10.1158/1538-7445.AM2014-2867
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Abstract 2867: EGFR expression in T1/T2 oral tongue and floor of the Mouth Carcinoma
Cancer Research, 2014Co-Authors: Natalie Kelner, Clovis Antonio Lopes Pinto, Luiz Paulo Kowalski, Cláudia Malheiros Coutinho-camilloAbstract:Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Epidermal growth factor receptor (EGFR) is a molecular maker that regulates the cell growth and plays an important role in tumor proliferation, invasion and metastasis formation. Objective: In this study we examined the association of immunohistochemical expression of EGFR with clinicopathological parameters, lymph node metastasis, regional recurrence and survival in selected cases of early squamous cell Carcinoma (SCC) of the oral tongue and floor of the Mouth. Methods: Patients with early stage SCC of oral tongue and floor of the Mouth were treated surgically at a single institution from 1980 to 2010. Specimens from 139 patients were analyzed for EGFR expression using monoclonal antibody. Results: This study included 139 patients, 96 men (69%), with ages ranging from 21 to 85 years old (mean, 58 years). The tumor site was the tongue in 105 cases (75.5%) and the floor of the Mouth in 34 (24.5%). With regard to pathological T-stage, 69 cases were pT1 (52.7%) and 62 were pT2 (47.3%). EGFR was overexpressed in 18 cases (13%) and was significantly associated with pT (p=0.017), thickness greater than 4mm (p=0.017), muscular invasion (p=0.014), desmoplastic reaction (p=0.021), inflammatory infiltrate (p=0.029), lymphatic embolization (p=0.016), mode of invasion (p=0.027) and perineural invasion (p=0.007). The overexpression of EGFR was also associated with lymph node metastasis (p=0.038) and regional recurrence (p=0.014). The cancer-specific survival in 5 years decreased from 90% in the group without EGFR expression to 75.3% in the EGFR overexpression group (p=0.019). Conclusion: The EGFR overexpression was associated with more aggressive pathological features, lymph node metastasis and regional recurrence in patients with early oral tongue and floor of the Mouth squamous cell Carcinoma. Citation Format: Natalie Kelner, Clovis Antonio Lopes Pinto, Luiz Paulo Kowalski, Claudia Malheiros Coutinho-Camillo. EGFR expression in T1/T2 oral tongue and floor of the Mouth Carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2867. doi:10.1158/1538-7445.AM2014-2867
Andreas Kolk - One of the best experts on this subject based on the ideXlab platform.
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a worldwide comparison of the management of t1 and t2 anterior floor of the Mouth and tongue squamous cell Carcinoma extent of surgical resection and reconstructive measures
Journal of Cranio-maxillofacial Surgery, 2017Co-Authors: Katinka Kansy, A A Mueller, Thomas Mucke, Friederike Koersgen, Klaus Dietrich Wolff, H F Zeilhofer, Frank Holzle, Winnie Pradel, Matthias Schneider, Andreas KolkAbstract:Abstract Introduction Microvascular surgery following tumor resection has become an important field of oral maxillofacial surgery (OMFS). Following the results on general aspects of current reconstructive practice in German-speaking countries, Europe and worldwide, this paper presents specific concepts for the management of resection and reconstruction of T1/T2 squamous cell Carcinoma (SCC) of the anterior floor of the Mouth and tongue. Methods The DOESAK questionnaire was distributed in three different phases to a growing number of maxillofacial units worldwide. Within this survey, clinical patient settings were presented to participants and center-specific treatment strategies were evaluated. Results A total of 188 OMFS units from 36 different countries documented their treatment strategies for T1/T2 anterior floor of the Mouth squamous cell Carcinoma and tongue Carcinoma. For floor of Mouth Carcinoma close to the mandible, a wide variety of concepts are presented: subperiosteal removal of the tumor versus continuity resection of the mandible and reconstruction ranging from locoregional closure to microvascular bony reconstruction. For T2 tongue Carcinoma, concepts are more uniform. Conclusion These results demonstrate the lack of evidence and the controversy of different guidelines for the extent of safety margins and underline the crucial need of global prospective randomized trials on this topic to finally obtain evidence for a common guideline based on a strong community of OMFS units.
Robin L Wagner - One of the best experts on this subject based on the ideXlab platform.
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floor of Mouth Carcinoma the management of the clinically negative neck
Archives of Otolaryngology-head & Neck Surgery, 1995Co-Authors: William F Mcguirt, Jonas T Johnson, Eugene N Myers, Robert E Rothfield, Robin L WagnerAbstract:Objectives: Examine the management of the clinically negative neck and evaluate the role of elective neck dissection in patients with squamous Carcinoma of the floor of the Mouth. Design: Retrospective analysis of a cohort of patients with squamous Carcinoma of the floor of the Mouth and NO stage disease of the neck who were treated between 1973 and 1992. The mean follow-up was 6 years. Patients: The cohort consisted of 129 patients. Excluded from analysis were patients without evidence of disease but less than 3 years of follow-up and those with uncertain resection margins. Intervention: Resection of the floor of the Mouth lesion with or without marginal mandibulectomy. Elective lymphadenectomy was performed in 26 (23%) of the 129 patients. Outcome Measure: Estimates were obtained of survival according to mode of therapy, classification of treatment modality, determinate cure, locoregional failure, salvage, and occult disease by clinical stage. Results: Occult disease was detected in 23% of the patients who underwent elective neck dissection. Recurrence in the neck occurred in 36% of 103 patients who received follow-up but did not undergo elective neck dissection. The determinate survival at 3 years was 100% for patients with occult disease who underwent elective neck dissection. Overall, 96% of the patients who were treated with elective neck dissection were cured; 85% of the patients who received no initial treatment of the neck were cured; and 59% of the patients with failure in the neck were salvaged. Conclusions: A more aggressive approach to the neck with NO disease may be warranted. Selective neck dissection allows early removal of occult metastases with acceptable morbidity. In elective dissection for clinically and histologically negative necks, the high rate of survival may result from the removal of metastatic Carcinoma that was missed in the histopathologic sampling process. (Arch Otolaryngol Head Neck Surg. 1995;121:278-282)