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Hiroto Hatabu - One of the best experts on this subject based on the ideXlab platform.
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diffusion weighted imaging of Mucinous Carcinoma of the breast evaluation of apparent diffusion coefficient and signal intensity in correlation with histologic findings
American Journal of Roentgenology, 2009Co-Authors: Reiko Woodhams, Satoko Kakita, Hirofumi Hata, Keiichi Iwabuchi, Shigeaki Umeoka, Carolyn E Mountford, Hiroto HatabuAbstract:Objective. The purposes of this study were to compare the apparent diffusion coefficient (ADC) of Mucinous Carcinoma of the breast with that of other breast tumors and to analyze correlations between signal intensity on diffusion-weighted images and the histologic features of Mucinous Carcinoma. Subjects and Methods. Two hundred seventy-six patients with 277 lesions, including 15 Mucinous Carcinomas (13 pure type, two mixed type), 204 other malignant tumors, and 58 benign lesions, were examined with 1.5-T MRI at b values of 0 and 1,500 s/mm2. The correlations between cellularity and ADC, homogeneity of signal intensity on diffusion-weighted images, and histopathologic findings were analyzed. The difference was statistically significant (p 0.05). The correlation between mean cellularity and the ADC of Mucinous Carcinoma was significant (ρs = -0.754; p = 0.001). The homogeneity of signal intensity on diffusion-weighted images correlated with the homogeneity of histologic structures of Mucinous Carcinoma (p < 0.001; κ = 0.826). Conclusion. Mucinous Carcinoma can be clearly differentiated from other breast tumors on the basis of ADC. The low signal intensity of Mucinous Carcinoma on diffusion-weighted images appears to reflect the presence of mucin and low cellularity. High signal intensity on diffusion-weighted images may reflect the presence of fibrovascular bundles, increased cell density, or a combination of these features.
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diffusion weighted imaging of Mucinous Carcinoma of the breast evaluation of apparent diffusion coefficient and signal intensity in correlation with histologic findings
American Journal of Roentgenology, 2009Co-Authors: Reiko Woodhams, Satoko Kakita, Hirofumi Hata, Keiichi Iwabuchi, Shigeaki Umeoka, Carolyn E Mountford, Hiroto HatabuAbstract:OBJECTIVE. The purposes of this study were to compare the apparent diffusion coefficient (ADC) of Mucinous Carcinoma of the breast with that of other breast tumors and to analyze correlations between signal intensity on diffusion-weighted images and the histologic features of Mucinous Carcinoma.SUBJECTS AND METHODS. Two hundred seventy-six patients with 277 lesions, including 15 Mucinous Carcinomas (13 pure type, two mixed type), 204 other malignant tumors, and 58 benign lesions, were examined with 1.5-T MRI at b values of 0 and 1,500 s/mm2. The correlations between cellularity and ADC, homogeneity of signal intensity on diffusion-weighted images, and histopathologic findings were analyzed. The difference was statistically significant (p < 0.05).RESULTS. The mean ADC of Mucinous Carcinoma (1.8 ± 0.4 × 10-3 mm2/s) was statistically higher than that of benign lesions (1.3± 0.3 × 10-3 mm2/s) and other malignant tumors (0.9 ± 0.2 × 10-3 mm2/s) (p < 0.001). The ADC of pure type Mucinous Carcinoma (1.8 ± 0.3 × ...
Reiko Woodhams - One of the best experts on this subject based on the ideXlab platform.
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diffusion weighted imaging of Mucinous Carcinoma of the breast evaluation of apparent diffusion coefficient and signal intensity in correlation with histologic findings
American Journal of Roentgenology, 2009Co-Authors: Reiko Woodhams, Satoko Kakita, Hirofumi Hata, Keiichi Iwabuchi, Shigeaki Umeoka, Carolyn E Mountford, Hiroto HatabuAbstract:Objective. The purposes of this study were to compare the apparent diffusion coefficient (ADC) of Mucinous Carcinoma of the breast with that of other breast tumors and to analyze correlations between signal intensity on diffusion-weighted images and the histologic features of Mucinous Carcinoma. Subjects and Methods. Two hundred seventy-six patients with 277 lesions, including 15 Mucinous Carcinomas (13 pure type, two mixed type), 204 other malignant tumors, and 58 benign lesions, were examined with 1.5-T MRI at b values of 0 and 1,500 s/mm2. The correlations between cellularity and ADC, homogeneity of signal intensity on diffusion-weighted images, and histopathologic findings were analyzed. The difference was statistically significant (p 0.05). The correlation between mean cellularity and the ADC of Mucinous Carcinoma was significant (ρs = -0.754; p = 0.001). The homogeneity of signal intensity on diffusion-weighted images correlated with the homogeneity of histologic structures of Mucinous Carcinoma (p < 0.001; κ = 0.826). Conclusion. Mucinous Carcinoma can be clearly differentiated from other breast tumors on the basis of ADC. The low signal intensity of Mucinous Carcinoma on diffusion-weighted images appears to reflect the presence of mucin and low cellularity. High signal intensity on diffusion-weighted images may reflect the presence of fibrovascular bundles, increased cell density, or a combination of these features.
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diffusion weighted imaging of Mucinous Carcinoma of the breast evaluation of apparent diffusion coefficient and signal intensity in correlation with histologic findings
American Journal of Roentgenology, 2009Co-Authors: Reiko Woodhams, Satoko Kakita, Hirofumi Hata, Keiichi Iwabuchi, Shigeaki Umeoka, Carolyn E Mountford, Hiroto HatabuAbstract:OBJECTIVE. The purposes of this study were to compare the apparent diffusion coefficient (ADC) of Mucinous Carcinoma of the breast with that of other breast tumors and to analyze correlations between signal intensity on diffusion-weighted images and the histologic features of Mucinous Carcinoma.SUBJECTS AND METHODS. Two hundred seventy-six patients with 277 lesions, including 15 Mucinous Carcinomas (13 pure type, two mixed type), 204 other malignant tumors, and 58 benign lesions, were examined with 1.5-T MRI at b values of 0 and 1,500 s/mm2. The correlations between cellularity and ADC, homogeneity of signal intensity on diffusion-weighted images, and histopathologic findings were analyzed. The difference was statistically significant (p < 0.05).RESULTS. The mean ADC of Mucinous Carcinoma (1.8 ± 0.4 × 10-3 mm2/s) was statistically higher than that of benign lesions (1.3± 0.3 × 10-3 mm2/s) and other malignant tumors (0.9 ± 0.2 × 10-3 mm2/s) (p < 0.001). The ADC of pure type Mucinous Carcinoma (1.8 ± 0.3 × ...
Frederick C Koerner - One of the best experts on this subject based on the ideXlab platform.
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endocrine mucin producing sweat gland Carcinoma twelve new cases suggest that it is a precursor of some invasive Mucinous Carcinomas
The American Journal of Surgical Pathology, 2005Co-Authors: Artur Zembowicz, Zeina Tannous, Martin C Mihm, Christine F Garcia, Frederick C Koerner, Ben Z PilchAbstract:Endocrine mucin-producing sweat gland Carcinoma (EMPSGC) is an underrecognized low-grade Carcinoma with predilection to the eyelid. Only 4 cases of this entity have been described in the literature. Here, we describe 12 cases of EMPSGC. The lesions were twice as frequent in females than males with an average age of 70 years (range, 48-84 years). Clinically, they presented as a slowly growing cyst or swelling. The most common site of occurrence was the lower eyelid (8 cases). Two lesions occurred on the upper eyelid and 2 on the cheek. Histologically, they were well-circumscribed, typically multinodular tumors with solid or partially cystic nodules, frequently showing areas of papillary architecture. Focal cribriform arrangements were also present. The nodules were formed by uniform small- to medium-sized oval to polygonal epithelial cells with lightly eosinophilic to bluish cytoplasm. The nuclei were bland with diffusely stippled chromatin and inconspicuous nucleoli. Intracytoplasmic and extracellular mucin was usually present. Mitotic activity was present but never brisk. All tumors examined immunohistochemically expressed at least one neuroendocrine marker, synaptophysin or chromogranin. CD57 and neuron specific enolase, secondary markers of neuroendocrine differentiation, were expressed in most cases. All tumors tested expressed estrogen and progesterone receptors, cytokeratin 7, low molecular cytokeratin Cam5.2, and epithelial membrane antigen and were negative for cytokeratin 20 and S-100 protein. Calponin, smooth muscle actin, and p63 immunohistochemical stains did not disclose myoepithelial cells around larger tumor nests in most cases, supporting the notion that EMPSGC is an invasive Carcinoma. In 10 cases, cystic areas lined by benign epithelium indistinguishable from eccrine ducts were present. In some foci, the benign ductal epithelium was undermined or replaced by Carcinoma in situ with similar cytologic features to the solid or papillary areas of EMPSGC. Myoepithelial cells were preserved in the areas of in situ Carcinoma. In 6 cases, EMPSGC was associated with invasive Mucinous Carcinoma. In situ Carcinoma and Mucinous Carcinoma also expressed neuroendocrine markers. Clinical follow-up showed no recurrences or metastases, consistent with low-grade Carcinoma. The series provides histologic evidence for a multistage progression of noninvasive sweat gland neuroendocrine Carcinoma to EMPSGC and then to Mucinous Carcinoma of the eyelid. Although the data from this series support the notion that the prognosis of EMPSGC and Mucinous Carcinoma is good, longer follow-up is needed for better understanding of their pathogenesis and clinical behavior.
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endocrine mucin producing sweat gland Carcinoma a cutaneous neoplasm analogous to solid papillary Carcinoma of breast
The American Journal of Surgical Pathology, 1997Co-Authors: Andrea Flieder, Frederick C Koerner, Ben Z Pilch, Horacio M MalufAbstract:We describe two cases of a distinctive in situ and invasive cutaneous adnexal neoplasm occurring in the eyelid. Mucinous Carcinoma represented the invasive portion of the tumor in one case, whereas the other infiltrated in small solid nests. The in situ component is identical to the recently described solid papillary Carcinoma of the breast (endocrine ductal Carcinoma in situ). Both tumors produced intra- and extracellular mucin, exhibited endocrine differentiation by immunohistochemistry and ultrastructural analysis, and were positive for estrogen and progesterone receptors.
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solid papillary Carcinoma of the breast a form of intraductal Carcinoma with endocrine differentiation frequently associated with Mucinous Carcinoma
The American Journal of Surgical Pathology, 1995Co-Authors: Horacio M Maluf, Frederick C KoernerAbstract:We report 20 examples of a distinctive form of intraductal papillary Carcinoma frequently associated with both Mucinous Carcinoma and infiltrating ductal Carcinoma, not otherwise specified. All the patients were in the seventh decade of life or older. The clinical presentation and macroscopic appearance suggested a benign lesion in most cases. The tumors grew in a solid papillary pattern and displayed low-grade cytological features as well as intracellular and extracellular mucin. Endocrine differentiation was demonstrated by the Grimelius stain in 11 of 17 cases and by the chromogranin immunohistochemical technique in eight of 14 cases. Lymph node metastases were not observed, but pulmonary metastasis occurred in one case. All the tumors were positive for estrogen receptors. We postulate that these lesions are the preinvasive counterpart of Mucinous Carcinomas with endocrine differentiation.
Horacio M Maluf - One of the best experts on this subject based on the ideXlab platform.
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endocrine mucin producing sweat gland Carcinoma a cutaneous neoplasm analogous to solid papillary Carcinoma of breast
The American Journal of Surgical Pathology, 1997Co-Authors: Andrea Flieder, Frederick C Koerner, Ben Z Pilch, Horacio M MalufAbstract:We describe two cases of a distinctive in situ and invasive cutaneous adnexal neoplasm occurring in the eyelid. Mucinous Carcinoma represented the invasive portion of the tumor in one case, whereas the other infiltrated in small solid nests. The in situ component is identical to the recently described solid papillary Carcinoma of the breast (endocrine ductal Carcinoma in situ). Both tumors produced intra- and extracellular mucin, exhibited endocrine differentiation by immunohistochemistry and ultrastructural analysis, and were positive for estrogen and progesterone receptors.
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solid papillary Carcinoma of the breast a form of intraductal Carcinoma with endocrine differentiation frequently associated with Mucinous Carcinoma
The American Journal of Surgical Pathology, 1995Co-Authors: Horacio M Maluf, Frederick C KoernerAbstract:We report 20 examples of a distinctive form of intraductal papillary Carcinoma frequently associated with both Mucinous Carcinoma and infiltrating ductal Carcinoma, not otherwise specified. All the patients were in the seventh decade of life or older. The clinical presentation and macroscopic appearance suggested a benign lesion in most cases. The tumors grew in a solid papillary pattern and displayed low-grade cytological features as well as intracellular and extracellular mucin. Endocrine differentiation was demonstrated by the Grimelius stain in 11 of 17 cases and by the chromogranin immunohistochemical technique in eight of 14 cases. Lymph node metastases were not observed, but pulmonary metastasis occurred in one case. All the tumors were positive for estrogen receptors. We postulate that these lesions are the preinvasive counterpart of Mucinous Carcinomas with endocrine differentiation.
Massimo Loda - One of the best experts on this subject based on the ideXlab platform.
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distinct molecular features of colorectal Carcinoma with signet ring cell component and colorectal Carcinoma with Mucinous component
Modern Pathology, 2006Co-Authors: Shuji Ogino, Jeffrey A Meyerhardt, Mohan Brahmandam, Mami Cantor, Chungdak Namgyal, Takako Kawasaki, Gregory J Kirkner, Massimo LodaAbstract:Signet ring cell Carcinoma and Mucinous Carcinoma are distinct subtypes of colorectal adenoCarcinoma. The morphologic and molecular spectra of colorectal Carcinomas with various signet ring cell components and colorectal Carcinomas with various Mucinous components, compared to non-Mucinous adenoCarcinomas, have not been examined. The study groups consisted of 39 Carcinomas with various signet ring cell components ('the signet group'), 167 Carcinomas with various Mucinous components ('the Mucinous group'), and 457 nonMucinous adenoCarcinoma. We visually estimated the amounts of signet ring cell and Mucinous components in tumors, and subclassified the signet and Mucinous groups according to the amount of each component ( or = 50%). We sequenced BRAF and KRAS, analyzed for microsatellite instability (MSI) and 18q loss of heterozygosity (LOH), and performed immunohistochemistry for TP53, cyclooxygenase-2 (COX2), MLH1, O-6-methylguanine DNA methyltransferase (MGMT), p16 (CDKN2A), and fatty acid synthase (FASN). Signet ring cell Carcinoma (> or = 50% signet ring cell tumors) and or = 50% Mucinous tumors and or = 50% signet ring cell or Mucinous Carcinoma, respectively. Signet ring cell Carcinoma and Mucinous Carcinoma are related subtypes of colorectal adenoCarcinoma, but have molecular features distinct from each other.