The Experts below are selected from a list of 81 Experts worldwide ranked by ideXlab platform

William L. Salzer - One of the best experts on this subject based on the ideXlab platform.

  • Antibiotic Dosing in Critically Ill Adult Patients Receiving Continuous Renal Replacement Therapy
    2014
    Co-Authors: Robin L. Trotman, John C. Williamson, Matthew D. Shoemaker, William L. Salzer
    Abstract:

    Continuous renal replacement therapy (CRRT) is now commonly used as a means of support for critically ill patients with renal failure. No recent comprehensive guidelines exist that provide antibiotic dosing recommendations for adult patients receiving CRRT. Doses used in intermittent hemodialysis cannot be directly applied to these patients, and antibiotic phar-macokinetics are different than those in patients with normal renal function. We reviewed the literature for studies involving the following antibiotics frequently used to treat critically ill adult patients receiving CRRT: vancomycin, linezolid, daptomycin, meropenem, imipenem-cilastatin, nafcillin, ampicillin-sulbactam, piperacillin-tazobactam, ticarcillin–clavulanic acid, cefa

  • Antibiotic dosing in critically ill adult patients receiving continuous renal replacement therapy. Clin. Infect. Dis
    2005
    Co-Authors: Robin L. Trotman, John C. Williamson, Matthew D. Shoemaker, William L. Salzer
    Abstract:

    Continuous renal replacement therapy (CRRT) is now commonly used as a means of support for critically ill patients with renal failure. No recent comprehensive guidelines exist that provide antibiotic dosing recommendations for adult patients receiving CRRT. Doses used in intermittent hemodialysis cannot be directly applied to these patients, and antibiotic phar-macokinetics are different than those in patients with normal renal function. We reviewed the literature for studies involving the following antibiotics frequently used to treat critically ill adult patients receiving CRRT: vancomycin, linezolid, daptomycin, meropenem, imipenem-cilastatin, nafcillin, ampicillin-sulbactam, piperacillin-tazobactam, ticarcillin–clavulanic acid, cefa

Robin L. Trotman - One of the best experts on this subject based on the ideXlab platform.

  • Antibiotic Dosing in Critically Ill Adult Patients Receiving Continuous Renal Replacement Therapy
    2014
    Co-Authors: Robin L. Trotman, John C. Williamson, Matthew D. Shoemaker, William L. Salzer
    Abstract:

    Continuous renal replacement therapy (CRRT) is now commonly used as a means of support for critically ill patients with renal failure. No recent comprehensive guidelines exist that provide antibiotic dosing recommendations for adult patients receiving CRRT. Doses used in intermittent hemodialysis cannot be directly applied to these patients, and antibiotic phar-macokinetics are different than those in patients with normal renal function. We reviewed the literature for studies involving the following antibiotics frequently used to treat critically ill adult patients receiving CRRT: vancomycin, linezolid, daptomycin, meropenem, imipenem-cilastatin, nafcillin, ampicillin-sulbactam, piperacillin-tazobactam, ticarcillin–clavulanic acid, cefa

  • Antibiotic dosing in critically ill adult patients receiving continuous renal replacement therapy. Clin. Infect. Dis
    2005
    Co-Authors: Robin L. Trotman, John C. Williamson, Matthew D. Shoemaker, William L. Salzer
    Abstract:

    Continuous renal replacement therapy (CRRT) is now commonly used as a means of support for critically ill patients with renal failure. No recent comprehensive guidelines exist that provide antibiotic dosing recommendations for adult patients receiving CRRT. Doses used in intermittent hemodialysis cannot be directly applied to these patients, and antibiotic phar-macokinetics are different than those in patients with normal renal function. We reviewed the literature for studies involving the following antibiotics frequently used to treat critically ill adult patients receiving CRRT: vancomycin, linezolid, daptomycin, meropenem, imipenem-cilastatin, nafcillin, ampicillin-sulbactam, piperacillin-tazobactam, ticarcillin–clavulanic acid, cefa

Marcus A Mall - One of the best experts on this subject based on the ideXlab platform.

  • hypertonic saline is effective in the prevention and treatment of mucus obstruction but not airway inflammation in mice with chronic obstructive lung disease
    American Journal of Respiratory Cell and Molecular Biology, 2013
    Co-Authors: Simon Y Graeber, Zhe Zhousuckow, J Schatterny, Stephanie Hirtz, Richard C Boucher, Marcus A Mall
    Abstract:

    Recent evidence suggests that inadequate hydration of airway surfaces is a common mechanism in the pathogenesis of airway mucus obstruction. Inhaled hypertonic saline (HS) induces osmotic water flux, improving hydration of airway surfaces. However, trials in patients with obstructive lung diseases are limited. The aim of this study was to investigate effects of HS on mucus obstruction and airway inflammation in the prevention and treatment of obstructive lung disease in vivo. We, therefore, used the β-epithelial Na(+) channel (βENaC)-overexpressing mouse as a model of chronic obstructive lung disease and determined effects of preventive and late therapy with 3% HS and 7% HS on pulmonary mortality, airway mucus obstruction, and inflammation. We found that preventive treatment with 3% HS and 7% HS improved growth, reduced mortality, and reduced mucus obstruction in neonatal βENaC-overexpressing mice. In adult βENaC-overexpressing mice with chronic lung disease, mucus obstruction was significantly reduced by 7% HS, but not by 3% HS. Treatment with HS triggered airway inflammation with elevated keratinocyte chemoattractant levels and neutrophils in airways from wild-type mice, but reduced keratinocyte chemoattractant in chronic neutrophilic inflammation in adult βENaC-overexpressing mice. Our data demonstrate that airway surface rehydration with HS provides an effective preventive and late therapy of mucus obstruction with no consistent effects on inflammation in chronic lung disease. These results suggest that, through mucokinetic effects, HS may be beneficial for patients with a spectrum of obstructive lung diseases, and that additional strategies are required for effective treatment of associated airway inflammation.

John C. Williamson - One of the best experts on this subject based on the ideXlab platform.

  • Antibiotic Dosing in Critically Ill Adult Patients Receiving Continuous Renal Replacement Therapy
    2014
    Co-Authors: Robin L. Trotman, John C. Williamson, Matthew D. Shoemaker, William L. Salzer
    Abstract:

    Continuous renal replacement therapy (CRRT) is now commonly used as a means of support for critically ill patients with renal failure. No recent comprehensive guidelines exist that provide antibiotic dosing recommendations for adult patients receiving CRRT. Doses used in intermittent hemodialysis cannot be directly applied to these patients, and antibiotic phar-macokinetics are different than those in patients with normal renal function. We reviewed the literature for studies involving the following antibiotics frequently used to treat critically ill adult patients receiving CRRT: vancomycin, linezolid, daptomycin, meropenem, imipenem-cilastatin, nafcillin, ampicillin-sulbactam, piperacillin-tazobactam, ticarcillin–clavulanic acid, cefa

  • Antibiotic dosing in critically ill adult patients receiving continuous renal replacement therapy. Clin. Infect. Dis
    2005
    Co-Authors: Robin L. Trotman, John C. Williamson, Matthew D. Shoemaker, William L. Salzer
    Abstract:

    Continuous renal replacement therapy (CRRT) is now commonly used as a means of support for critically ill patients with renal failure. No recent comprehensive guidelines exist that provide antibiotic dosing recommendations for adult patients receiving CRRT. Doses used in intermittent hemodialysis cannot be directly applied to these patients, and antibiotic phar-macokinetics are different than those in patients with normal renal function. We reviewed the literature for studies involving the following antibiotics frequently used to treat critically ill adult patients receiving CRRT: vancomycin, linezolid, daptomycin, meropenem, imipenem-cilastatin, nafcillin, ampicillin-sulbactam, piperacillin-tazobactam, ticarcillin–clavulanic acid, cefa

Matthew D. Shoemaker - One of the best experts on this subject based on the ideXlab platform.

  • Antibiotic Dosing in Critically Ill Adult Patients Receiving Continuous Renal Replacement Therapy
    2014
    Co-Authors: Robin L. Trotman, John C. Williamson, Matthew D. Shoemaker, William L. Salzer
    Abstract:

    Continuous renal replacement therapy (CRRT) is now commonly used as a means of support for critically ill patients with renal failure. No recent comprehensive guidelines exist that provide antibiotic dosing recommendations for adult patients receiving CRRT. Doses used in intermittent hemodialysis cannot be directly applied to these patients, and antibiotic phar-macokinetics are different than those in patients with normal renal function. We reviewed the literature for studies involving the following antibiotics frequently used to treat critically ill adult patients receiving CRRT: vancomycin, linezolid, daptomycin, meropenem, imipenem-cilastatin, nafcillin, ampicillin-sulbactam, piperacillin-tazobactam, ticarcillin–clavulanic acid, cefa

  • Antibiotic dosing in critically ill adult patients receiving continuous renal replacement therapy. Clin. Infect. Dis
    2005
    Co-Authors: Robin L. Trotman, John C. Williamson, Matthew D. Shoemaker, William L. Salzer
    Abstract:

    Continuous renal replacement therapy (CRRT) is now commonly used as a means of support for critically ill patients with renal failure. No recent comprehensive guidelines exist that provide antibiotic dosing recommendations for adult patients receiving CRRT. Doses used in intermittent hemodialysis cannot be directly applied to these patients, and antibiotic phar-macokinetics are different than those in patients with normal renal function. We reviewed the literature for studies involving the following antibiotics frequently used to treat critically ill adult patients receiving CRRT: vancomycin, linezolid, daptomycin, meropenem, imipenem-cilastatin, nafcillin, ampicillin-sulbactam, piperacillin-tazobactam, ticarcillin–clavulanic acid, cefa