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Julia Yu Fong Chang - One of the best experts on this subject based on the ideXlab platform.
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anemia and hematinic deficiencies in oral Mucosal Disease patients with microcytosis
Journal of the Formosan Medical Association, 2017Co-Authors: Yuhsueh Wu, Yang Che Wu, Julia Yu Fong Chang, Hsinming ChenAbstract:Background/Purpose Patients with microcytosis (defined as mean corpuscular volume Methods The mean red blood cell (RBC) count, mean corpuscular volume, and RBC distribution width, as well as blood concentrations of hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine in 240 microcytosis patients and in 240 age- and sex-matched healthy control individuals were measured and compared. Results Microcytosis patients had significantly lower mean Hb, iron, and folic acid levels as well as significantly higher mean RBC count and RBC distribution width than healthy control individuals. Microcytosis patients also had significantly greater frequencies of Hb, iron, vitamin B12, and folic acid deficiencies as well as of RBC number > 5 × 10 12 /L, and abnormally high homocysteine levels than healthy control individuals. Moreover, 162 (67.5%) of the 240 microcytosis patients had anemia. Of 162 anemic microcytosis patients, 87 (53.7%) had iron deficiency anemia, 61 (37.7%) had thalassemia trait (TT)-induced anemia, and 14 (8.6%) had other microcytic anemia. Conclusion We conclude that approximately 45%, 4%, and 5% of microcytosis patients have iron, vitamin B12, and folic acid deficiencies, respectively, and approximately 10% of microcytosis patients have abnormally high homocysteine levels. Moreover, 67.5% of 240 microcytosis patients and 50.8% of 120 TT patients had anemia. Iron deficiency anemia is the most common type of anemia in microcytosis patients, followed by TT-induced anemia and other microcytic anemia.
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Anemia and hematinic deficiencies in oral Mucosal Disease patients with microcytosis
Elsevier, 2017Co-Authors: Julia Yu Fong Chang, Hsinming Chen, Andy SunAbstract:Patients with microcytosis (defined as mean corpuscular volume 5 × 1012/L, and abnormally high homocysteine levels than healthy control individuals. Moreover, 162 (67.5%) of the 240 microcytosis patients had anemia. Of 162 anemic microcytosis patients, 87 (53.7%) had iron deficiency anemia, 61 (37.7%) had thalassemia trait (TT)-induced anemia, and 14 (8.6%) had other microcytic anemia. Conclusion: We conclude that approximately 45%, 4%, and 5% of microcytosis patients have iron, vitamin B12, and folic acid deficiencies, respectively, and approximately 10% of microcytosis patients have abnormally high homocysteine levels. Moreover, 67.5% of 240 microcytosis patients and 50.8% of 120 TT patients had anemia. Iron deficiency anemia is the most common type of anemia in microcytosis patients, followed by TT-induced anemia and other microcytic anemia
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effective vitamin b12 treatment can reduce serum antigastric parietal cell antibody titer in patients with oral Mucosal Disease
Journal of the Formosan Medical Association, 2016Co-Authors: Julia Yu Fong Chang, Shihjung Cheng, Hsinming Chen, Chunpin ChiangAbstract:Background/purpose Patients with serum antigastric parietal cell antibody (GPCA) positivity may have vitamin B12 deficiency and some oral symptoms. This study assessed the changes of serum GPCA titer in GPCA-positive patients after effective vitamin B12 treatment. Methods Two hundred and ten GPCA-positive oral Mucosal Disease patients became oral symptom free (complete response) after 1.0–67.1 months of treatment with regular and continuous intramuscular injection of vitamin B12 once per week. The changes of serum GPCA titers after treatment were evaluated in these 210 patients. Results We found a significant drop of the GPCA positive rate from 100% to 42.9% in our 210 complete response patients after effective vitamin B12 treatment ( p p Conclusion Regular and continuous effective vitamin B12 treatment can reduce the relatively higher serum GPCA titers to significantly lower or undetectable levels in GPCA-positive patients.
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blood examination is necessary for oral Mucosal Disease patients
Journal of the Formosan Medical Association, 2016Co-Authors: Julia Yu Fong Chang, Chunpin ChiangAbstract:According to the World Health Organization (WHO), anemia or hemoglobin deficiency is defined as having a hemoglobin concentration 12.4 mM). Serum gastric parietal cell autoantibody (GPCA) positivity may induce destruction of gastric parietal cells and subsequently result in failure of production of intrinsic factor and absorption of vitamin B12 from the terminal ileum, finally leading to vitamin B12 deficiency. Because anemia and hematinic deficiencies may cause or aggravate oral Mucosal Diseases such as atrophic glossitis (AG), burning mouth syndrome (BMS), oral lichen planus (OLP), recurrent aphthous ulcerations (RAU), or oral submucous fibrosis (OSF), in our oral Mucosal Disease clinic, complete blood count, serum iron, vitamin B12, folic acid and homocysteine levels, and serum GPCA titers are usually examined to check whether patients with these 5 Diseases have microcytic, normocytic or macrocytic
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Effective vitamin B12 treatment can reduce serum antigastric parietal cell antibody titer in patients with oral Mucosal Disease
Elsevier, 2016Co-Authors: Andy Sun, Shihjung Cheng, Julia Yu Fong Chang, Hsinming Chen, Chunpin ChiangAbstract:Patients with serum antigastric parietal cell antibody (GPCA) positivity may have vitamin B12 deficiency and some oral symptoms. This study assessed the changes of serum GPCA titer in GPCA-positive patients after effective vitamin B12 treatment. Methods: Two hundred and ten GPCA-positive oral Mucosal Disease patients became oral symptom free (complete response) after 1.0–67.1 months of treatment with regular and continuous intramuscular injection of vitamin B12 once per week. The changes of serum GPCA titers after treatment were evaluated in these 210 patients. Results: We found a significant drop of the GPCA positive rate from 100% to 42.9% in our 210 complete response patients after effective vitamin B12 treatment (p
Chunpin Chiang - One of the best experts on this subject based on the ideXlab platform.
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effective vitamin b12 treatment can reduce serum antigastric parietal cell antibody titer in patients with oral Mucosal Disease
Journal of the Formosan Medical Association, 2016Co-Authors: Julia Yu Fong Chang, Shihjung Cheng, Hsinming Chen, Chunpin ChiangAbstract:Background/purpose Patients with serum antigastric parietal cell antibody (GPCA) positivity may have vitamin B12 deficiency and some oral symptoms. This study assessed the changes of serum GPCA titer in GPCA-positive patients after effective vitamin B12 treatment. Methods Two hundred and ten GPCA-positive oral Mucosal Disease patients became oral symptom free (complete response) after 1.0–67.1 months of treatment with regular and continuous intramuscular injection of vitamin B12 once per week. The changes of serum GPCA titers after treatment were evaluated in these 210 patients. Results We found a significant drop of the GPCA positive rate from 100% to 42.9% in our 210 complete response patients after effective vitamin B12 treatment ( p p Conclusion Regular and continuous effective vitamin B12 treatment can reduce the relatively higher serum GPCA titers to significantly lower or undetectable levels in GPCA-positive patients.
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blood examination is necessary for oral Mucosal Disease patients
Journal of the Formosan Medical Association, 2016Co-Authors: Julia Yu Fong Chang, Chunpin ChiangAbstract:According to the World Health Organization (WHO), anemia or hemoglobin deficiency is defined as having a hemoglobin concentration 12.4 mM). Serum gastric parietal cell autoantibody (GPCA) positivity may induce destruction of gastric parietal cells and subsequently result in failure of production of intrinsic factor and absorption of vitamin B12 from the terminal ileum, finally leading to vitamin B12 deficiency. Because anemia and hematinic deficiencies may cause or aggravate oral Mucosal Diseases such as atrophic glossitis (AG), burning mouth syndrome (BMS), oral lichen planus (OLP), recurrent aphthous ulcerations (RAU), or oral submucous fibrosis (OSF), in our oral Mucosal Disease clinic, complete blood count, serum iron, vitamin B12, folic acid and homocysteine levels, and serum GPCA titers are usually examined to check whether patients with these 5 Diseases have microcytic, normocytic or macrocytic
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Effective vitamin B12 treatment can reduce serum antigastric parietal cell antibody titer in patients with oral Mucosal Disease
Elsevier, 2016Co-Authors: Andy Sun, Shihjung Cheng, Julia Yu Fong Chang, Hsinming Chen, Chunpin ChiangAbstract:Patients with serum antigastric parietal cell antibody (GPCA) positivity may have vitamin B12 deficiency and some oral symptoms. This study assessed the changes of serum GPCA titer in GPCA-positive patients after effective vitamin B12 treatment. Methods: Two hundred and ten GPCA-positive oral Mucosal Disease patients became oral symptom free (complete response) after 1.0–67.1 months of treatment with regular and continuous intramuscular injection of vitamin B12 once per week. The changes of serum GPCA titers after treatment were evaluated in these 210 patients. Results: We found a significant drop of the GPCA positive rate from 100% to 42.9% in our 210 complete response patients after effective vitamin B12 treatment (p
Hsinming Chen - One of the best experts on this subject based on the ideXlab platform.
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anemia and hematinic deficiencies in oral Mucosal Disease patients with microcytosis
Journal of the Formosan Medical Association, 2017Co-Authors: Yuhsueh Wu, Yang Che Wu, Julia Yu Fong Chang, Hsinming ChenAbstract:Background/Purpose Patients with microcytosis (defined as mean corpuscular volume Methods The mean red blood cell (RBC) count, mean corpuscular volume, and RBC distribution width, as well as blood concentrations of hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine in 240 microcytosis patients and in 240 age- and sex-matched healthy control individuals were measured and compared. Results Microcytosis patients had significantly lower mean Hb, iron, and folic acid levels as well as significantly higher mean RBC count and RBC distribution width than healthy control individuals. Microcytosis patients also had significantly greater frequencies of Hb, iron, vitamin B12, and folic acid deficiencies as well as of RBC number > 5 × 10 12 /L, and abnormally high homocysteine levels than healthy control individuals. Moreover, 162 (67.5%) of the 240 microcytosis patients had anemia. Of 162 anemic microcytosis patients, 87 (53.7%) had iron deficiency anemia, 61 (37.7%) had thalassemia trait (TT)-induced anemia, and 14 (8.6%) had other microcytic anemia. Conclusion We conclude that approximately 45%, 4%, and 5% of microcytosis patients have iron, vitamin B12, and folic acid deficiencies, respectively, and approximately 10% of microcytosis patients have abnormally high homocysteine levels. Moreover, 67.5% of 240 microcytosis patients and 50.8% of 120 TT patients had anemia. Iron deficiency anemia is the most common type of anemia in microcytosis patients, followed by TT-induced anemia and other microcytic anemia.
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Anemia and hematinic deficiencies in oral Mucosal Disease patients with microcytosis
Elsevier, 2017Co-Authors: Julia Yu Fong Chang, Hsinming Chen, Andy SunAbstract:Patients with microcytosis (defined as mean corpuscular volume 5 × 1012/L, and abnormally high homocysteine levels than healthy control individuals. Moreover, 162 (67.5%) of the 240 microcytosis patients had anemia. Of 162 anemic microcytosis patients, 87 (53.7%) had iron deficiency anemia, 61 (37.7%) had thalassemia trait (TT)-induced anemia, and 14 (8.6%) had other microcytic anemia. Conclusion: We conclude that approximately 45%, 4%, and 5% of microcytosis patients have iron, vitamin B12, and folic acid deficiencies, respectively, and approximately 10% of microcytosis patients have abnormally high homocysteine levels. Moreover, 67.5% of 240 microcytosis patients and 50.8% of 120 TT patients had anemia. Iron deficiency anemia is the most common type of anemia in microcytosis patients, followed by TT-induced anemia and other microcytic anemia
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effective vitamin b12 treatment can reduce serum antigastric parietal cell antibody titer in patients with oral Mucosal Disease
Journal of the Formosan Medical Association, 2016Co-Authors: Julia Yu Fong Chang, Shihjung Cheng, Hsinming Chen, Chunpin ChiangAbstract:Background/purpose Patients with serum antigastric parietal cell antibody (GPCA) positivity may have vitamin B12 deficiency and some oral symptoms. This study assessed the changes of serum GPCA titer in GPCA-positive patients after effective vitamin B12 treatment. Methods Two hundred and ten GPCA-positive oral Mucosal Disease patients became oral symptom free (complete response) after 1.0–67.1 months of treatment with regular and continuous intramuscular injection of vitamin B12 once per week. The changes of serum GPCA titers after treatment were evaluated in these 210 patients. Results We found a significant drop of the GPCA positive rate from 100% to 42.9% in our 210 complete response patients after effective vitamin B12 treatment ( p p Conclusion Regular and continuous effective vitamin B12 treatment can reduce the relatively higher serum GPCA titers to significantly lower or undetectable levels in GPCA-positive patients.
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Effective vitamin B12 treatment can reduce serum antigastric parietal cell antibody titer in patients with oral Mucosal Disease
Elsevier, 2016Co-Authors: Andy Sun, Shihjung Cheng, Julia Yu Fong Chang, Hsinming Chen, Chunpin ChiangAbstract:Patients with serum antigastric parietal cell antibody (GPCA) positivity may have vitamin B12 deficiency and some oral symptoms. This study assessed the changes of serum GPCA titer in GPCA-positive patients after effective vitamin B12 treatment. Methods: Two hundred and ten GPCA-positive oral Mucosal Disease patients became oral symptom free (complete response) after 1.0–67.1 months of treatment with regular and continuous intramuscular injection of vitamin B12 once per week. The changes of serum GPCA titers after treatment were evaluated in these 210 patients. Results: We found a significant drop of the GPCA positive rate from 100% to 42.9% in our 210 complete response patients after effective vitamin B12 treatment (p
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hematinic deficiencies and anemia statuses in oral Mucosal Disease patients with folic acid deficiency
Journal of the Formosan Medical Association, 2015Co-Authors: Julia Yu Fong Chang, Shihjung Cheng, Yang Che Wu, Hsinming ChenAbstract:Background/Purpose Folic acid deficiency (FAD) may result in macrocytic anemia. This study assessed the hematinic deficiencies and anemia statuses in oral Mucosal Disease patients with FAD (defined as folic acid ≤ 6 ng/mL). Methods The blood hemoglobin (Hb), iron, vitamin B 12 , and folic acid concentrations, serum gastric parietal cell antibody level, and mean corpuscular volume (MCV) in 198 oral Mucosal Disease patients with FAD were measured. Based on World Health Organization (WHO) criteria, anemia or Hb deficiency was defined as having an Hb concentration of 12 5.0 × 10 12 /L, and Mentzer index (MCV/RBC) Results We found that by WHO definitions, 73 (36.9%), 41 (20.7%), and 10 (5.1%) of our 198 FAD patients had concomitant Hb, iron, and vitamin B 12 deficiencies, respectively. Of 73 anemic FAD patients, three had macrocytic anemia due to FAD, one had pernicious anemia, 14 had iron deficiency anemia, eight had thalassemia trait, and the resting 47 had normocytic anemia. Conclusion In addition to macrocytic anemia (2.0%), FAD patients may have concomitant normocytic (23.7%) or microcytic (11.1%) anemia.
Shihjung Cheng - One of the best experts on this subject based on the ideXlab platform.
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effective vitamin b12 treatment can reduce serum antigastric parietal cell antibody titer in patients with oral Mucosal Disease
Journal of the Formosan Medical Association, 2016Co-Authors: Julia Yu Fong Chang, Shihjung Cheng, Hsinming Chen, Chunpin ChiangAbstract:Background/purpose Patients with serum antigastric parietal cell antibody (GPCA) positivity may have vitamin B12 deficiency and some oral symptoms. This study assessed the changes of serum GPCA titer in GPCA-positive patients after effective vitamin B12 treatment. Methods Two hundred and ten GPCA-positive oral Mucosal Disease patients became oral symptom free (complete response) after 1.0–67.1 months of treatment with regular and continuous intramuscular injection of vitamin B12 once per week. The changes of serum GPCA titers after treatment were evaluated in these 210 patients. Results We found a significant drop of the GPCA positive rate from 100% to 42.9% in our 210 complete response patients after effective vitamin B12 treatment ( p p Conclusion Regular and continuous effective vitamin B12 treatment can reduce the relatively higher serum GPCA titers to significantly lower or undetectable levels in GPCA-positive patients.
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Effective vitamin B12 treatment can reduce serum antigastric parietal cell antibody titer in patients with oral Mucosal Disease
Elsevier, 2016Co-Authors: Andy Sun, Shihjung Cheng, Julia Yu Fong Chang, Hsinming Chen, Chunpin ChiangAbstract:Patients with serum antigastric parietal cell antibody (GPCA) positivity may have vitamin B12 deficiency and some oral symptoms. This study assessed the changes of serum GPCA titer in GPCA-positive patients after effective vitamin B12 treatment. Methods: Two hundred and ten GPCA-positive oral Mucosal Disease patients became oral symptom free (complete response) after 1.0–67.1 months of treatment with regular and continuous intramuscular injection of vitamin B12 once per week. The changes of serum GPCA titers after treatment were evaluated in these 210 patients. Results: We found a significant drop of the GPCA positive rate from 100% to 42.9% in our 210 complete response patients after effective vitamin B12 treatment (p
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hematinic deficiencies and anemia statuses in oral Mucosal Disease patients with folic acid deficiency
Journal of the Formosan Medical Association, 2015Co-Authors: Julia Yu Fong Chang, Shihjung Cheng, Yang Che Wu, Hsinming ChenAbstract:Background/Purpose Folic acid deficiency (FAD) may result in macrocytic anemia. This study assessed the hematinic deficiencies and anemia statuses in oral Mucosal Disease patients with FAD (defined as folic acid ≤ 6 ng/mL). Methods The blood hemoglobin (Hb), iron, vitamin B 12 , and folic acid concentrations, serum gastric parietal cell antibody level, and mean corpuscular volume (MCV) in 198 oral Mucosal Disease patients with FAD were measured. Based on World Health Organization (WHO) criteria, anemia or Hb deficiency was defined as having an Hb concentration of 12 5.0 × 10 12 /L, and Mentzer index (MCV/RBC) Results We found that by WHO definitions, 73 (36.9%), 41 (20.7%), and 10 (5.1%) of our 198 FAD patients had concomitant Hb, iron, and vitamin B 12 deficiencies, respectively. Of 73 anemic FAD patients, three had macrocytic anemia due to FAD, one had pernicious anemia, 14 had iron deficiency anemia, eight had thalassemia trait, and the resting 47 had normocytic anemia. Conclusion In addition to macrocytic anemia (2.0%), FAD patients may have concomitant normocytic (23.7%) or microcytic (11.1%) anemia.
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hematinic deficiencies and pernicious anemia in oral Mucosal Disease patients with macrocytosis
Journal of the Formosan Medical Association, 2015Co-Authors: Julia Yu Fong Chang, Shihjung Cheng, Yang Che Wu, Hsinming ChenAbstract:Background/purpose Macrocytosis is defined as having the mean corpuscular volume (MCV) ≥ 100 fL. This study assessed hematinic deficiencies and pernicious anemia (PA) in oral Mucosal Disease patients with macrocytosis. Methods The blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine concentrations and MCV in 60 oral Mucosal Disease patients with macrocytosis were measured and compared with the corresponding data in 120 age- and sex-matched healthy control participants. PA was defined by the World Health Organization (WHO) as having an Hb concentration Results We found that 30 (50.0%), 7 (11.7%), 24 (40.0%), and three (5.0%) oral Mucosal Disease patients with macrocytosis had deficiencies of Hb (men 12.3 μM) and serum GPCA positivity, respectively. Macrocytosis patients had a significantly higher frequency of Hb, iron, or vitamin B12 deficiency, of abnormally elevated blood homocysteine level, and of GPCA positivity than healthy control participants ( p Conclusion Only 16.7% of oral Mucosal Disease patients with macrocytosis are discovered to have PA by the WHO definition.
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blood profile of oral Mucosal Disease patients with both vitamin b12 and iron deficiencies
Journal of the Formosan Medical Association, 2015Co-Authors: Julia Yu Fong Chang, Shihjung Cheng, Yang Che Wu, Hsinming ChenAbstract:Background/Purpose Vitamin B 12 and iron deficiencies lead to macrocytosis [mean corpuscular volume (MCV) ≥ 100 fL] and microcytosis (MCV 12 and iron deficiencies. Methods The blood hemoglobin (Hb), iron, vitamin B 12 , folic acid and homocysteine concentrations, MCV, and serum GPCA in 149 patients with both vitamin B 12 and iron deficiencies were measured and compared with the corresponding data in 149 age- and sex-matched healthy control subjects. Results We found that 54 (36.2%), 16 (10.7%), 44 (29.5%), and 36 (24.2%) patients with both vitamin B 12 and iron deficiencies had Hb deficiency (men 12.6 μM), and serum GPCA positivity, respectively. Patients with both vitamin B 12 and iron deficiencies had a significantly higher frequency of Hb deficiency, abnormally elevated blood homocysteine level, and serum GPCA positivity than healthy control subjects (all p values 12 and iron deficiencies, 10 (6.7%) had high MCV (≥ 100 fL), 108 (72.5%) had normal MCV (between 80 fL and 99 fL), and 31 (20.8%) had low MCV ( Conclusion Approximately 73%, 30%, and 24% of patients with both vitamin B 12 and iron deficiencies are found to have normal MCV, abnormally high blood homocysteine level, and serum GPCA positivity, respectively.
Sun Andy - One of the best experts on this subject based on the ideXlab platform.
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Effective vitamin B12 treatment can reduce serum antigastric parietal cell antibody titer in patients with oral Mucosal Disease
2017Co-Authors: Sun AndyAbstract:Background/purpose: Patients with serum antigastric parietal cell antibody (GPCA) positivity may have vitamin B12 deficiency and some oral symptoms. This study assessed the changes of serum GPCA titer in GPCA-positive patients after effective vitamin B12 treatment. ;Methods: Two hundred and ten GPCA-positive oral Mucosal Disease patients became oral symptom free (complete response) after 1.0-67.1 months of treatment with regular and continuous intramuscular injection of vitamin B12 once per week. The changes of serum GPCA titers after treatment were evaluated in these 210 patients. ;Results: We found a significant drop of the GPCA positive rate from 100% to 42.9% in our 210 complete response patients after effective vitamin B12 treatment (p < 0.001). When 210 patients were further divided into seven subgroups according to the low to high serum GPCA titers, we noted that the higher serum GPCA titers decreased to significantly lower levels after treatment in all seven subgroups (all p < 0.001). However, serum GPCA titers increased to significantly higher levels in 46 GPCA-positive control patients receiving only oral administration of two vitamin BC capsules (containing 10 mg of vitamin B12) plus deficient hematinic supplements per day after a follow-up period of 2.7-27 months. A maintenance vitamin B12 treatment once a month could retain the GPCA-negative status in 87% of treated-to GPCA-negative patients compared with those (10%) without further maintenance vitamin B12 treatment. ;Conclusion: Regular and continuous effective vitamin B12 treatment can reduce the relatively higher serum GPCA titers to significantly lower or undetectable levels in GPCA-positive patients. Copyright (C) 2016, Formosan Medical Association. Published by Elsevier Taiwan LLC
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Effective vitamin B12 treatment can reduce serum antigastric parietal cell antibody titer in patients with oral Mucosal Disease
Formosan Medical Association. Published by Elsevier Taiwan LLC., 2016Co-Authors: Sun Andy, Chang, Julia Yu-fong, Wang Yi-ping, Cheng Shih-jung, Chen Hsin-ming, Chiang Chun-pinAbstract:Background/purposePatients with serum antigastric parietal cell antibody (GPCA) positivity may have vitamin B12 deficiency and some oral symptoms. This study assessed the changes of serum GPCA titer in GPCA-positive patients after effective vitamin B12 treatment.MethodsTwo hundred and ten GPCA-positive oral Mucosal Disease patients became oral symptom free (complete response) after 1.0–67.1 months of treatment with regular and continuous intramuscular injection of vitamin B12 once per week. The changes of serum GPCA titers after treatment were evaluated in these 210 patients.ResultsWe found a significant drop of the GPCA positive rate from 100% to 42.9% in our 210 complete response patients after effective vitamin B12 treatment (p
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Hematinic deficiencies and anemia statuses in oral Mucosal Disease patients with folic acid deficiency
Published by Elsevier (Singapore) Pte Ltd., 2015Co-Authors: Chang, Julia Yu-fong, Wu Yang-che, Wang Yi-ping, Cheng Shih-jung, Chen Hsin-ming, Sun AndyAbstract:Background/PurposeFolic acid deficiency (FAD) may result in macrocytic anemia. This study assessed the hematinic deficiencies and anemia statuses in oral Mucosal Disease patients with FAD (defined as folic acid ≤ 6 ng/mL).MethodsThe blood hemoglobin (Hb), iron, vitamin B12, and folic acid concentrations, serum gastric parietal cell antibody level, and mean corpuscular volume (MCV) in 198 oral Mucosal Disease patients with FAD were measured. Based on World Health Organization (WHO) criteria, anemia or Hb deficiency was defined as having an Hb concentration of
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Hematinic deficiencies and pernicious anemia in oral Mucosal Disease patients with macrocytosis
Published by Elsevier (Singapore) Pte Ltd., 2015Co-Authors: Chang, Julia Yu-fong, Wu Yang-che, Wang Yi-ping, Cheng Shih-jung, Chen Hsin-ming, Sun AndyAbstract:Background/purposeMacrocytosis is defined as having the mean corpuscular volume (MCV) ≥ 100 fL. This study assessed hematinic deficiencies and pernicious anemia (PA) in oral Mucosal Disease patients with macrocytosis.MethodsThe blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine concentrations and MCV in 60 oral Mucosal Disease patients with macrocytosis were measured and compared with the corresponding data in 120 age- and sex-matched healthy control participants. PA was defined by the World Health Organization (WHO) as having an Hb concentration < 13 g/dL for men and < 12 g/dL for women, an MCV ≥ 100 fL, a serum vitamin B12 level < 200 pg/mL, and serum gastric parietal cell antibody (GPCA) positivity.ResultsWe found that 30 (50.0%), 7 (11.7%), 24 (40.0%), and three (5.0%) oral Mucosal Disease patients with macrocytosis had deficiencies of Hb (men
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Blood profile of oral Mucosal Disease patients with both vitamin B12 and iron deficiencies
Published by Elsevier (Singapore) Pte Ltd., 2015Co-Authors: Chang, Julia Yu-fong, Wu Yang-che, Wang Yi-ping, Cheng Shih-jung, Chen Hsin-ming, Sun AndyAbstract:Background/PurposeVitamin B12 and iron deficiencies lead to macrocytosis [mean corpuscular volume (MCV) ≥ 100 fL] and microcytosis (MCV
