The Experts below are selected from a list of 12 Experts worldwide ranked by ideXlab platform
Bruno Sarmento - One of the best experts on this subject based on the ideXlab platform.
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mucoadhesive polymers in the design of nano Drug delivery systems for Administration by non parenteral routes a review
Progress in Polymer Science, 2014Co-Authors: Alejandro Sosnik, Jose Neves, Bruno SarmentoAbstract:Abstract The presence of a mucus layer that covers the surface of a variety of organs has been capitalized to develop mucoadhesive dosage forms that remain in the Administration site for prolonged times, increasing the local and/or systemic bioavailability of the administered Drug. The emergence of micro and nanotechnologies together with the implementation of non-invasive and painless Administration routes has revolutionized the pharmaceutical market and the treatment of disease. Aiming to overcome the main drawbacks of the oral route and to maintain patient compliance high, the engineering of innovative Drug delivery systems administrable by Mucosal routes has come to light and gained the interest of the scientific community due to the possibility to dramatically change pharmacokinetics. In addition, to achieve the goal of Mucosal Drug Administration, the development of biomaterials has been refined to fit specific applications. The present review initially describes the potential of nano-Drug delivery systems conceived for Mucosal Administration by diverse non-parenteral routes ( e.g. , oral, inhalatory, etc. ). Then, the benefit of the incorporation of mucoadhesive polymers into the structure of these innovative pharmaceutical products to prolong their residence time in the Administration site and the release of the Drug cargo will be discussed with focus in the developments of the last decade. In addition, the regulatory status of the most extensively used mucoadhesive polymers will be emphasized. Finally, a thorough overview of the different pharmaceutical applications of mucoadhesive polymers will be addressed.
Steven H. Neau - One of the best experts on this subject based on the ideXlab platform.
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Rheological and mucoadhesive characterization of poly(vinylpyrrolidone) hydrogels designed for nasal Mucosal Drug delivery
Archives of Pharmacal Research, 2011Co-Authors: Ibrahim A. Alsarra, Amel Y. Hamed, Fars K. Alanazi, Steven H. NeauAbstract:Poly(vinylpyrrolidone) (PVP) hydrogels were crosslinked by gamma irradiation to add structure and rigidity, and then rheological and mucoadhesive properties were evaluated. The effects of PVP concentration, radiation dose, and additives, such as poly(ethylene glycol) (PEG) and glycerol, on rheological properties were investigated. In an oscillatory analysis, an increase in polymer concentrations increased the storage modulus (G′) and the loss modulus (G″) but decreased the loss tangent (tan δ < 1). The relationships between G′or G″ and the frequency levelled off at higher frequencies, which is indicative of polymer chain entanglement and network formation. Each of the 6% PVP hydrogels exhibited plastic flow with rheopectic behavior. PVP concentration, radiation dose, and the presence of PEG or glycerol influenced the rheological and mucoadhesive properties of the hydrogels. However, adding acyclovir to the formulation did not have a profound effect on the rheological behavior of the hydrogels. The results suggest that a 3% PVP hydrogel with 1% PEG crosslinked with 20 kGy is the most appropriate hydrogel. The results demonstrated the successful complementary application of oscillatory and flow rheometry to characterize and develop a hydrogel for Mucosal Drug Administration.
Alejandro Sosnik - One of the best experts on this subject based on the ideXlab platform.
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mucoadhesive polymers in the design of nano Drug delivery systems for Administration by non parenteral routes a review
Progress in Polymer Science, 2014Co-Authors: Alejandro Sosnik, Jose Neves, Bruno SarmentoAbstract:Abstract The presence of a mucus layer that covers the surface of a variety of organs has been capitalized to develop mucoadhesive dosage forms that remain in the Administration site for prolonged times, increasing the local and/or systemic bioavailability of the administered Drug. The emergence of micro and nanotechnologies together with the implementation of non-invasive and painless Administration routes has revolutionized the pharmaceutical market and the treatment of disease. Aiming to overcome the main drawbacks of the oral route and to maintain patient compliance high, the engineering of innovative Drug delivery systems administrable by Mucosal routes has come to light and gained the interest of the scientific community due to the possibility to dramatically change pharmacokinetics. In addition, to achieve the goal of Mucosal Drug Administration, the development of biomaterials has been refined to fit specific applications. The present review initially describes the potential of nano-Drug delivery systems conceived for Mucosal Administration by diverse non-parenteral routes ( e.g. , oral, inhalatory, etc. ). Then, the benefit of the incorporation of mucoadhesive polymers into the structure of these innovative pharmaceutical products to prolong their residence time in the Administration site and the release of the Drug cargo will be discussed with focus in the developments of the last decade. In addition, the regulatory status of the most extensively used mucoadhesive polymers will be emphasized. Finally, a thorough overview of the different pharmaceutical applications of mucoadhesive polymers will be addressed.
Ibrahim A. Alsarra - One of the best experts on this subject based on the ideXlab platform.
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Rheological and mucoadhesive characterization of poly(vinylpyrrolidone) hydrogels designed for nasal Mucosal Drug delivery
Archives of Pharmacal Research, 2011Co-Authors: Ibrahim A. Alsarra, Amel Y. Hamed, Fars K. Alanazi, Steven H. NeauAbstract:Poly(vinylpyrrolidone) (PVP) hydrogels were crosslinked by gamma irradiation to add structure and rigidity, and then rheological and mucoadhesive properties were evaluated. The effects of PVP concentration, radiation dose, and additives, such as poly(ethylene glycol) (PEG) and glycerol, on rheological properties were investigated. In an oscillatory analysis, an increase in polymer concentrations increased the storage modulus (G′) and the loss modulus (G″) but decreased the loss tangent (tan δ < 1). The relationships between G′or G″ and the frequency levelled off at higher frequencies, which is indicative of polymer chain entanglement and network formation. Each of the 6% PVP hydrogels exhibited plastic flow with rheopectic behavior. PVP concentration, radiation dose, and the presence of PEG or glycerol influenced the rheological and mucoadhesive properties of the hydrogels. However, adding acyclovir to the formulation did not have a profound effect on the rheological behavior of the hydrogels. The results suggest that a 3% PVP hydrogel with 1% PEG crosslinked with 20 kGy is the most appropriate hydrogel. The results demonstrated the successful complementary application of oscillatory and flow rheometry to characterize and develop a hydrogel for Mucosal Drug Administration.
Jose Neves - One of the best experts on this subject based on the ideXlab platform.
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mucoadhesive polymers in the design of nano Drug delivery systems for Administration by non parenteral routes a review
Progress in Polymer Science, 2014Co-Authors: Alejandro Sosnik, Jose Neves, Bruno SarmentoAbstract:Abstract The presence of a mucus layer that covers the surface of a variety of organs has been capitalized to develop mucoadhesive dosage forms that remain in the Administration site for prolonged times, increasing the local and/or systemic bioavailability of the administered Drug. The emergence of micro and nanotechnologies together with the implementation of non-invasive and painless Administration routes has revolutionized the pharmaceutical market and the treatment of disease. Aiming to overcome the main drawbacks of the oral route and to maintain patient compliance high, the engineering of innovative Drug delivery systems administrable by Mucosal routes has come to light and gained the interest of the scientific community due to the possibility to dramatically change pharmacokinetics. In addition, to achieve the goal of Mucosal Drug Administration, the development of biomaterials has been refined to fit specific applications. The present review initially describes the potential of nano-Drug delivery systems conceived for Mucosal Administration by diverse non-parenteral routes ( e.g. , oral, inhalatory, etc. ). Then, the benefit of the incorporation of mucoadhesive polymers into the structure of these innovative pharmaceutical products to prolong their residence time in the Administration site and the release of the Drug cargo will be discussed with focus in the developments of the last decade. In addition, the regulatory status of the most extensively used mucoadhesive polymers will be emphasized. Finally, a thorough overview of the different pharmaceutical applications of mucoadhesive polymers will be addressed.