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Upa Kukongviriyapan - One of the best experts on this subject based on the ideXlab platform.

  • Mulberry Leaf extract increases adiponectin in murine 3T3-L1 adipocytes.
    Nutrition Research, 2012
    Co-Authors: Jarinyaporn Naowaboot, Choon Hee Chung, Patchareewan Pannangpetch, Ran Choi, Bo Hwan Kim, Mi Young Lee, Upa Kukongviriyapan
    Abstract:

    We have previously shown that Mulberry Leaf extract (MA) causes blood glucose levels to decrease in rats with streptozotocin-induced diabetes while enhancing glucose uptake by isolated fat cells. We hypothesized that the antidiabetic activity of MA is mediated via enhancement of adiponectin secretion and adipogenesis, which consequently decreases blood glucose. In the present study, we aimed to elucidate the molecular basis for the observed antidiabetic activity using murine 3T3-L1 preadipocyte cultures. We found that treatment of differentiating 3T3-L1 cells with MA at concentrations of 5, 15, and 45 μg/mL increased expression of adiponectin messenger RNA from 1.4-fold (control) to 1.5-, 1.95-, and 2.2-fold above basal values, respectively, while causing adiponectin secretion to increase from 70 ± 7.4 ng/mL to 100 ± 1.4, 138 ± 2.0, and 176 ± 21.4 ng/mL, respectively. Furthermore, we observed an increase in both lipid accumulation and messenger RNA expression of transcription factors, such as CCAAT/enhancer-binding protein α and peroxisome proliferator-activated receptor γ; and of the fatty acid-binding protein aP2 in differentiated 3T3-L1 cells pretreated with MA. Our findings indicate that the stimulatory effects of Mulberry Leaf extract on adipocyte proliferation and differentiation likely occur through up-regulation of adipogenic transcription factors and downstream gene expression. Such effects of Mulberry Leaf extract on adiponectin secretion and adipocyte activity may account for, at least in part, the antidiabetic effects of consumption of beverages containing Mulberry leaves.

  • Antihyperglycemic, Antioxidant and Antiglycation Activities of Mulberry Leaf Extract in Streptozotocin-Induced Chronic Diabetic Rats
    Plant Foods for Human Nutrition, 2009
    Co-Authors: Jarinyaporn Naowaboot, Patchareewan Pannangpetch, Veerapol Kukongviriyapan, Bunkerd Kongyingyoes, Upa Kukongviriyapan
    Abstract:

    In Thailand, beverages containing Mulberry Leaf ( Morus alba L.) are believed to promote good health, especially in people with diabetes. We examined the effects of long-term administration of an ethanolic extract of Mulberry Leaf (MA) on blood glucose, oxidative damage, and glycation in streptozotocin-induced diabetic rats. Daily administration of 1 g/kg MA for six weeks decreased blood glucose by 22%, which was comparable to the effect of 4 U/kg insulin. Lipid peroxidation, measured as malondialdehyde and lipid hydroperoxide concentrations (3.50 ± 0.33 and 3.76 ± 0.18 μM, respectively) decreased significantly ( P  

Jarinyaporn Naowaboot - One of the best experts on this subject based on the ideXlab platform.

  • Mulberry Leaf extract increases adiponectin in murine 3T3-L1 adipocytes.
    Nutrition Research, 2012
    Co-Authors: Jarinyaporn Naowaboot, Choon Hee Chung, Patchareewan Pannangpetch, Ran Choi, Bo Hwan Kim, Mi Young Lee, Upa Kukongviriyapan
    Abstract:

    We have previously shown that Mulberry Leaf extract (MA) causes blood glucose levels to decrease in rats with streptozotocin-induced diabetes while enhancing glucose uptake by isolated fat cells. We hypothesized that the antidiabetic activity of MA is mediated via enhancement of adiponectin secretion and adipogenesis, which consequently decreases blood glucose. In the present study, we aimed to elucidate the molecular basis for the observed antidiabetic activity using murine 3T3-L1 preadipocyte cultures. We found that treatment of differentiating 3T3-L1 cells with MA at concentrations of 5, 15, and 45 μg/mL increased expression of adiponectin messenger RNA from 1.4-fold (control) to 1.5-, 1.95-, and 2.2-fold above basal values, respectively, while causing adiponectin secretion to increase from 70 ± 7.4 ng/mL to 100 ± 1.4, 138 ± 2.0, and 176 ± 21.4 ng/mL, respectively. Furthermore, we observed an increase in both lipid accumulation and messenger RNA expression of transcription factors, such as CCAAT/enhancer-binding protein α and peroxisome proliferator-activated receptor γ; and of the fatty acid-binding protein aP2 in differentiated 3T3-L1 cells pretreated with MA. Our findings indicate that the stimulatory effects of Mulberry Leaf extract on adipocyte proliferation and differentiation likely occur through up-regulation of adipogenic transcription factors and downstream gene expression. Such effects of Mulberry Leaf extract on adiponectin secretion and adipocyte activity may account for, at least in part, the antidiabetic effects of consumption of beverages containing Mulberry leaves.

  • Antihyperglycemic, Antioxidant and Antiglycation Activities of Mulberry Leaf Extract in Streptozotocin-Induced Chronic Diabetic Rats
    Plant Foods for Human Nutrition, 2009
    Co-Authors: Jarinyaporn Naowaboot, Patchareewan Pannangpetch, Veerapol Kukongviriyapan, Bunkerd Kongyingyoes, Upa Kukongviriyapan
    Abstract:

    In Thailand, beverages containing Mulberry Leaf ( Morus alba L.) are believed to promote good health, especially in people with diabetes. We examined the effects of long-term administration of an ethanolic extract of Mulberry Leaf (MA) on blood glucose, oxidative damage, and glycation in streptozotocin-induced diabetic rats. Daily administration of 1 g/kg MA for six weeks decreased blood glucose by 22%, which was comparable to the effect of 4 U/kg insulin. Lipid peroxidation, measured as malondialdehyde and lipid hydroperoxide concentrations (3.50 ± 0.33 and 3.76 ± 0.18 μM, respectively) decreased significantly ( P  

Bunkerd Kongyingyoes - One of the best experts on this subject based on the ideXlab platform.

  • Antihyperglycemic, Antioxidant and Antiglycation Activities of Mulberry Leaf Extract in Streptozotocin-Induced Chronic Diabetic Rats
    Plant Foods for Human Nutrition, 2009
    Co-Authors: Jarinyaporn Naowaboot, Patchareewan Pannangpetch, Veerapol Kukongviriyapan, Bunkerd Kongyingyoes, Upa Kukongviriyapan
    Abstract:

    In Thailand, beverages containing Mulberry Leaf ( Morus alba L.) are believed to promote good health, especially in people with diabetes. We examined the effects of long-term administration of an ethanolic extract of Mulberry Leaf (MA) on blood glucose, oxidative damage, and glycation in streptozotocin-induced diabetic rats. Daily administration of 1 g/kg MA for six weeks decreased blood glucose by 22%, which was comparable to the effect of 4 U/kg insulin. Lipid peroxidation, measured as malondialdehyde and lipid hydroperoxide concentrations (3.50 ± 0.33 and 3.76 ± 0.18 μM, respectively) decreased significantly ( P  

Veerapol Kukongviriyapan - One of the best experts on this subject based on the ideXlab platform.

  • Antihyperglycemic, Antioxidant and Antiglycation Activities of Mulberry Leaf Extract in Streptozotocin-Induced Chronic Diabetic Rats
    Plant Foods for Human Nutrition, 2009
    Co-Authors: Jarinyaporn Naowaboot, Patchareewan Pannangpetch, Veerapol Kukongviriyapan, Bunkerd Kongyingyoes, Upa Kukongviriyapan
    Abstract:

    In Thailand, beverages containing Mulberry Leaf ( Morus alba L.) are believed to promote good health, especially in people with diabetes. We examined the effects of long-term administration of an ethanolic extract of Mulberry Leaf (MA) on blood glucose, oxidative damage, and glycation in streptozotocin-induced diabetic rats. Daily administration of 1 g/kg MA for six weeks decreased blood glucose by 22%, which was comparable to the effect of 4 U/kg insulin. Lipid peroxidation, measured as malondialdehyde and lipid hydroperoxide concentrations (3.50 ± 0.33 and 3.76 ± 0.18 μM, respectively) decreased significantly ( P  

Patchareewan Pannangpetch - One of the best experts on this subject based on the ideXlab platform.

  • Mulberry Leaf extract increases adiponectin in murine 3T3-L1 adipocytes.
    Nutrition Research, 2012
    Co-Authors: Jarinyaporn Naowaboot, Choon Hee Chung, Patchareewan Pannangpetch, Ran Choi, Bo Hwan Kim, Mi Young Lee, Upa Kukongviriyapan
    Abstract:

    We have previously shown that Mulberry Leaf extract (MA) causes blood glucose levels to decrease in rats with streptozotocin-induced diabetes while enhancing glucose uptake by isolated fat cells. We hypothesized that the antidiabetic activity of MA is mediated via enhancement of adiponectin secretion and adipogenesis, which consequently decreases blood glucose. In the present study, we aimed to elucidate the molecular basis for the observed antidiabetic activity using murine 3T3-L1 preadipocyte cultures. We found that treatment of differentiating 3T3-L1 cells with MA at concentrations of 5, 15, and 45 μg/mL increased expression of adiponectin messenger RNA from 1.4-fold (control) to 1.5-, 1.95-, and 2.2-fold above basal values, respectively, while causing adiponectin secretion to increase from 70 ± 7.4 ng/mL to 100 ± 1.4, 138 ± 2.0, and 176 ± 21.4 ng/mL, respectively. Furthermore, we observed an increase in both lipid accumulation and messenger RNA expression of transcription factors, such as CCAAT/enhancer-binding protein α and peroxisome proliferator-activated receptor γ; and of the fatty acid-binding protein aP2 in differentiated 3T3-L1 cells pretreated with MA. Our findings indicate that the stimulatory effects of Mulberry Leaf extract on adipocyte proliferation and differentiation likely occur through up-regulation of adipogenic transcription factors and downstream gene expression. Such effects of Mulberry Leaf extract on adiponectin secretion and adipocyte activity may account for, at least in part, the antidiabetic effects of consumption of beverages containing Mulberry leaves.

  • Antihyperglycemic, Antioxidant and Antiglycation Activities of Mulberry Leaf Extract in Streptozotocin-Induced Chronic Diabetic Rats
    Plant Foods for Human Nutrition, 2009
    Co-Authors: Jarinyaporn Naowaboot, Patchareewan Pannangpetch, Veerapol Kukongviriyapan, Bunkerd Kongyingyoes, Upa Kukongviriyapan
    Abstract:

    In Thailand, beverages containing Mulberry Leaf ( Morus alba L.) are believed to promote good health, especially in people with diabetes. We examined the effects of long-term administration of an ethanolic extract of Mulberry Leaf (MA) on blood glucose, oxidative damage, and glycation in streptozotocin-induced diabetic rats. Daily administration of 1 g/kg MA for six weeks decreased blood glucose by 22%, which was comparable to the effect of 4 U/kg insulin. Lipid peroxidation, measured as malondialdehyde and lipid hydroperoxide concentrations (3.50 ± 0.33 and 3.76 ± 0.18 μM, respectively) decreased significantly ( P