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Talmir Augusto Faria Brizola Dos Santos - One of the best experts on this subject based on the ideXlab platform.

  • Subfornical organ mediates pressor effect of angiotensin: Influence of nitric oxide synthase inhibitors, AT1 and AT2 angiotensin antagonist's receptors
    Journal of the American Society of Hypertension : JASH, 2008
    Co-Authors: Wilson Abrão Saad, Luiz Antonio De Arruda Camargo, Ismael Francisco Motta Siqueira Guarda, Talmir Augusto Faria Brizola Dos Santos
    Abstract:

    Abstract We investigated the influence of voltage-dependent calcium channels and nitric oxide (NO) on angiotensin II (ANG II)-pressor effect injected into subfornical organ (SFO). The influence of NO on nifedipine antipressor action has also been studied by utilizing N W -nitro-L-arginine methyl ester (L-NAME) (20 μg × 0.2 μl −1 ) a nitric oxide synthase inhibitor (NOSI) and 7-nitroindazole (7-NIT) (20 μg × 0.2 μl −1 ), a specific neuronal nitric oxide synthase inhibitor (nNOSI). We have also investigated the role of losartan and PD123319, selective ANG II AT 1 and AT 2 receptor nonpeptide antagonists, in the pressor effect of ANG II and in the effect of L-NAME and 7-NIT, injected into the SFO. Adult male Holtzman rats (220 to 280 g) were anesthetized with ketamine (80 mg/kg −1 of body weight) plus xylazine (7 mg/kg −1 of body weight), placed in a stereotaxic apparatus (David Kopf model for rats), and implanted with cannula into the SFO. Direct mean arterial blood pressure (MAP) was recorded in conscious rats in a test cage, without access to food or water. The previously implanted catheter into femoral artery was connected to a Statham (P23 Db) pressure transducer (Statham-Gould, Valley View, OH) coupled to a Multichannel Recorder (PowerLab Multirecord). MAP increased after ANG II injection. Pre-treatment with nifidipine (50 μg × 0.2 μl −1 or 100 μg × 0.2 μl −1 ) followed by 25 pmol × 0.2 μl −1 of ANG II, decreased ANG II-pressor effect. L-NAME and 7-NIT increased the elevation in MAP induced by ANG II, which was blocked by the prior injection of nifedipine. The AT 1 angiotensin antagonist losartan injected into the SFO blocked the effect of ANG II and the effects of L-NAME and 7-NIT while PD123319 did not. These results provide evidence that ANG II-pressor effect is influenced by nitrergic pathways that utilize L-type calcium channels in the SFO.

Wilson Abrão Saad - One of the best experts on this subject based on the ideXlab platform.

  • Subfornical organ mediates pressor effect of angiotensin: Influence of nitric oxide synthase inhibitors, AT1 and AT2 angiotensin antagonist's receptors
    Journal of the American Society of Hypertension : JASH, 2008
    Co-Authors: Wilson Abrão Saad, Luiz Antonio De Arruda Camargo, Ismael Francisco Motta Siqueira Guarda, Talmir Augusto Faria Brizola Dos Santos
    Abstract:

    Abstract We investigated the influence of voltage-dependent calcium channels and nitric oxide (NO) on angiotensin II (ANG II)-pressor effect injected into subfornical organ (SFO). The influence of NO on nifedipine antipressor action has also been studied by utilizing N W -nitro-L-arginine methyl ester (L-NAME) (20 μg × 0.2 μl −1 ) a nitric oxide synthase inhibitor (NOSI) and 7-nitroindazole (7-NIT) (20 μg × 0.2 μl −1 ), a specific neuronal nitric oxide synthase inhibitor (nNOSI). We have also investigated the role of losartan and PD123319, selective ANG II AT 1 and AT 2 receptor nonpeptide antagonists, in the pressor effect of ANG II and in the effect of L-NAME and 7-NIT, injected into the SFO. Adult male Holtzman rats (220 to 280 g) were anesthetized with ketamine (80 mg/kg −1 of body weight) plus xylazine (7 mg/kg −1 of body weight), placed in a stereotaxic apparatus (David Kopf model for rats), and implanted with cannula into the SFO. Direct mean arterial blood pressure (MAP) was recorded in conscious rats in a test cage, without access to food or water. The previously implanted catheter into femoral artery was connected to a Statham (P23 Db) pressure transducer (Statham-Gould, Valley View, OH) coupled to a Multichannel Recorder (PowerLab Multirecord). MAP increased after ANG II injection. Pre-treatment with nifidipine (50 μg × 0.2 μl −1 or 100 μg × 0.2 μl −1 ) followed by 25 pmol × 0.2 μl −1 of ANG II, decreased ANG II-pressor effect. L-NAME and 7-NIT increased the elevation in MAP induced by ANG II, which was blocked by the prior injection of nifedipine. The AT 1 angiotensin antagonist losartan injected into the SFO blocked the effect of ANG II and the effects of L-NAME and 7-NIT while PD123319 did not. These results provide evidence that ANG II-pressor effect is influenced by nitrergic pathways that utilize L-type calcium channels in the SFO.

  • Research Article Subfornical organ mediates pressor effect of angiotensin: Influence of nitric oxide synthase inhibitors, AT 1 and AT 2 angiotensin antagonist's receptors
    2008
    Co-Authors: Wilson Abrão Saad, Luiz Antonio De Arruda, Ismael Francisco, Motta Siqueira Guarda
    Abstract:

    We investigated the influence of voltage-dependent calcium channels and nitric oxide (NO) on angiotensin II (ANG II)-pressor effect injected into subfornical organ (SFO). The influence of NO on nifedipine antipressor action has also been studied by utilizing N W -nitro-L-arginine methyl ester (L-NAME) (20 g 0.2 l 1 ) a nitric oxide synthase inhibitor (NOSI) and 7-nitroindazole (7-NIT) (20 g 0.2 l 1 ), a specific neuronal nitric oxide synthase inhibitor (nNOSI). We have also investigated the role of losartan and PD123319, selective ANG II AT1 and AT2 receptor nonpeptide antagonists, in the pressor effect of ANG II and in the effect of L-NAME and 7-NIT, injected into the SFO. Adult male Holtzman rats (220 to 280 g) were anesthetized with ketamine (80 mg/kg 1 of body weight) plus xylazine (7 mg/kg 1 of body weight), placed in a stereotaxic apparatus (David Kopf model for rats), and implanted with cannula into the SFO. Direct mean arterial blood pressure (MAP) was recorded in conscious rats in a test cage, without access to food or water. The previously implanted catheter into femoral artery was connected to a Statham (P23 Db) pressure transducer (Statham-Gould, Valley View, OH) coupled to a Multichannel Recorder (PowerLab Multirecord). MAP increased after ANG II injection. Pre-treatment with nifidipine (50 g 0.2 l 1 or 100 g 0.2 l 1 ) followed by 25 pmol 0.2 l 1 of ANG II, decreased ANG II-pressor effect. L-NAME and 7-NIT increased the elevation in MAP induced by ANG II, which was blocked by the prior injection of nifedipine. The AT1 angiotensin antagonist losartan injected into the SFO blocked the effect of ANG II and the effects of L-NAME and 7-NIT while PD123319 did not. These results provide evidence that ANG II-pressor effect is influenced by nitrergic pathways that utilize L-type calcium channels in the SFO. J Am Soc Hypertens 2008;2(5): 326‐331. © 2008 American

Luiz Antonio De Arruda Camargo - One of the best experts on this subject based on the ideXlab platform.

  • Subfornical organ mediates pressor effect of angiotensin: Influence of nitric oxide synthase inhibitors, AT1 and AT2 angiotensin antagonist's receptors
    Journal of the American Society of Hypertension : JASH, 2008
    Co-Authors: Wilson Abrão Saad, Luiz Antonio De Arruda Camargo, Ismael Francisco Motta Siqueira Guarda, Talmir Augusto Faria Brizola Dos Santos
    Abstract:

    Abstract We investigated the influence of voltage-dependent calcium channels and nitric oxide (NO) on angiotensin II (ANG II)-pressor effect injected into subfornical organ (SFO). The influence of NO on nifedipine antipressor action has also been studied by utilizing N W -nitro-L-arginine methyl ester (L-NAME) (20 μg × 0.2 μl −1 ) a nitric oxide synthase inhibitor (NOSI) and 7-nitroindazole (7-NIT) (20 μg × 0.2 μl −1 ), a specific neuronal nitric oxide synthase inhibitor (nNOSI). We have also investigated the role of losartan and PD123319, selective ANG II AT 1 and AT 2 receptor nonpeptide antagonists, in the pressor effect of ANG II and in the effect of L-NAME and 7-NIT, injected into the SFO. Adult male Holtzman rats (220 to 280 g) were anesthetized with ketamine (80 mg/kg −1 of body weight) plus xylazine (7 mg/kg −1 of body weight), placed in a stereotaxic apparatus (David Kopf model for rats), and implanted with cannula into the SFO. Direct mean arterial blood pressure (MAP) was recorded in conscious rats in a test cage, without access to food or water. The previously implanted catheter into femoral artery was connected to a Statham (P23 Db) pressure transducer (Statham-Gould, Valley View, OH) coupled to a Multichannel Recorder (PowerLab Multirecord). MAP increased after ANG II injection. Pre-treatment with nifidipine (50 μg × 0.2 μl −1 or 100 μg × 0.2 μl −1 ) followed by 25 pmol × 0.2 μl −1 of ANG II, decreased ANG II-pressor effect. L-NAME and 7-NIT increased the elevation in MAP induced by ANG II, which was blocked by the prior injection of nifedipine. The AT 1 angiotensin antagonist losartan injected into the SFO blocked the effect of ANG II and the effects of L-NAME and 7-NIT while PD123319 did not. These results provide evidence that ANG II-pressor effect is influenced by nitrergic pathways that utilize L-type calcium channels in the SFO.

Ismael Francisco Motta Siqueira Guarda - One of the best experts on this subject based on the ideXlab platform.

  • Subfornical organ mediates pressor effect of angiotensin: Influence of nitric oxide synthase inhibitors, AT1 and AT2 angiotensin antagonist's receptors
    Journal of the American Society of Hypertension : JASH, 2008
    Co-Authors: Wilson Abrão Saad, Luiz Antonio De Arruda Camargo, Ismael Francisco Motta Siqueira Guarda, Talmir Augusto Faria Brizola Dos Santos
    Abstract:

    Abstract We investigated the influence of voltage-dependent calcium channels and nitric oxide (NO) on angiotensin II (ANG II)-pressor effect injected into subfornical organ (SFO). The influence of NO on nifedipine antipressor action has also been studied by utilizing N W -nitro-L-arginine methyl ester (L-NAME) (20 μg × 0.2 μl −1 ) a nitric oxide synthase inhibitor (NOSI) and 7-nitroindazole (7-NIT) (20 μg × 0.2 μl −1 ), a specific neuronal nitric oxide synthase inhibitor (nNOSI). We have also investigated the role of losartan and PD123319, selective ANG II AT 1 and AT 2 receptor nonpeptide antagonists, in the pressor effect of ANG II and in the effect of L-NAME and 7-NIT, injected into the SFO. Adult male Holtzman rats (220 to 280 g) were anesthetized with ketamine (80 mg/kg −1 of body weight) plus xylazine (7 mg/kg −1 of body weight), placed in a stereotaxic apparatus (David Kopf model for rats), and implanted with cannula into the SFO. Direct mean arterial blood pressure (MAP) was recorded in conscious rats in a test cage, without access to food or water. The previously implanted catheter into femoral artery was connected to a Statham (P23 Db) pressure transducer (Statham-Gould, Valley View, OH) coupled to a Multichannel Recorder (PowerLab Multirecord). MAP increased after ANG II injection. Pre-treatment with nifidipine (50 μg × 0.2 μl −1 or 100 μg × 0.2 μl −1 ) followed by 25 pmol × 0.2 μl −1 of ANG II, decreased ANG II-pressor effect. L-NAME and 7-NIT increased the elevation in MAP induced by ANG II, which was blocked by the prior injection of nifedipine. The AT 1 angiotensin antagonist losartan injected into the SFO blocked the effect of ANG II and the effects of L-NAME and 7-NIT while PD123319 did not. These results provide evidence that ANG II-pressor effect is influenced by nitrergic pathways that utilize L-type calcium channels in the SFO.

W. Reiter - One of the best experts on this subject based on the ideXlab platform.

  • ICASSP - Digital signal processing techniques in truck tire vibration and sound analysis
    ICASSP '76. IEEE International Conference on Acoustics Speech and Signal Processing, 1
    Co-Authors: A C Eberhardt, W. Reiter
    Abstract:

    Digital signal processing has some significant advantages in analysis of vibration and sound data. The authors have assembled a multiple channel vibration and sound data acquisition and analysis system that includes FM radio telemetry capability. The FM Multichannel Recorder of the data acquisition link is interfaced with a large digital computer through a digital waveform Recorder and minicomputer. Signal processing is accomplished with software that provides for analysis in both the time and frequency domains. The system components are described. The capability of digital signal processing in cross spectral analysis and in the separation of random and periodic components of signals is discussed. Results of such analyses for truck tire vibration and sound signals are presented.