The Experts below are selected from a list of 111 Experts worldwide ranked by ideXlab platform

Ismail Ilker Delice - One of the best experts on this subject based on the ideXlab platform.

  • Asymptotic stability of constant time headway driving strategy with Multiple Driver reaction delays
    2009 American Control Conference, 2009
    Co-Authors: Rifat Sipahi, Silviu-iulian Niculescu, Ismail Ilker Delice
    Abstract:

    This paper addresses the asymptotic stability of a continuous-time deterministic car-following model with respect to different driving strategies. More precisely, the model takes into account a constant time headway driving behavior as well as the presence of Multiple decision-making and actuation delays in describing the Drivers' actions. The stability analysis of the corresponding derived models is challenging and we will focus on characterizing the stability regions in the delay parameter space. Such a problem depicts some interesting properties in terms of delays that simplify the overall analysis leading to some simple frequency-sweeping based algorithms as well as to various practical interpretations of the results in terms of Drivers' behaviors. Illustrative examples complete the presentation.

  • ACC - Asymptotic stability of constant time headway driving strategy with Multiple Driver reaction delays
    2009 American Control Conference, 2009
    Co-Authors: Rifat Sipahi, Silviu-iulian Niculescu, Ismail Ilker Delice
    Abstract:

    This paper addresses the asymptotic stability of a continuous-time deterministic car-following model with respect to different driving strategies. More precisely, the model takes into account a constant time headway driving behavior as well as the presence of Multiple decision-making and actuation delays in describing the Drivers' actions. The stability analysis of the corresponding derived models is challenging and we will focus on characterizing the stability regions in the delay parameter space. Such a problem depicts some interesting properties in terms of delays that simplify the overall analysis leading to some simple frequency-sweeping based algorithms as well as to various practical interpretations of the results in terms of Drivers' behaviors. Illustrative examples complete the presentation.

Rifat Sipahi - One of the best experts on this subject based on the ideXlab platform.

  • Asymptotic stability of constant time headway driving strategy with Multiple Driver reaction delays
    2009 American Control Conference, 2009
    Co-Authors: Rifat Sipahi, Silviu-iulian Niculescu, Ismail Ilker Delice
    Abstract:

    This paper addresses the asymptotic stability of a continuous-time deterministic car-following model with respect to different driving strategies. More precisely, the model takes into account a constant time headway driving behavior as well as the presence of Multiple decision-making and actuation delays in describing the Drivers' actions. The stability analysis of the corresponding derived models is challenging and we will focus on characterizing the stability regions in the delay parameter space. Such a problem depicts some interesting properties in terms of delays that simplify the overall analysis leading to some simple frequency-sweeping based algorithms as well as to various practical interpretations of the results in terms of Drivers' behaviors. Illustrative examples complete the presentation.

  • ACC - Asymptotic stability of constant time headway driving strategy with Multiple Driver reaction delays
    2009 American Control Conference, 2009
    Co-Authors: Rifat Sipahi, Silviu-iulian Niculescu, Ismail Ilker Delice
    Abstract:

    This paper addresses the asymptotic stability of a continuous-time deterministic car-following model with respect to different driving strategies. More precisely, the model takes into account a constant time headway driving behavior as well as the presence of Multiple decision-making and actuation delays in describing the Drivers' actions. The stability analysis of the corresponding derived models is challenging and we will focus on characterizing the stability regions in the delay parameter space. Such a problem depicts some interesting properties in terms of delays that simplify the overall analysis leading to some simple frequency-sweeping based algorithms as well as to various practical interpretations of the results in terms of Drivers' behaviors. Illustrative examples complete the presentation.

Silviu-iulian Niculescu - One of the best experts on this subject based on the ideXlab platform.

  • Asymptotic stability of constant time headway driving strategy with Multiple Driver reaction delays
    2009 American Control Conference, 2009
    Co-Authors: Rifat Sipahi, Silviu-iulian Niculescu, Ismail Ilker Delice
    Abstract:

    This paper addresses the asymptotic stability of a continuous-time deterministic car-following model with respect to different driving strategies. More precisely, the model takes into account a constant time headway driving behavior as well as the presence of Multiple decision-making and actuation delays in describing the Drivers' actions. The stability analysis of the corresponding derived models is challenging and we will focus on characterizing the stability regions in the delay parameter space. Such a problem depicts some interesting properties in terms of delays that simplify the overall analysis leading to some simple frequency-sweeping based algorithms as well as to various practical interpretations of the results in terms of Drivers' behaviors. Illustrative examples complete the presentation.

  • ACC - Asymptotic stability of constant time headway driving strategy with Multiple Driver reaction delays
    2009 American Control Conference, 2009
    Co-Authors: Rifat Sipahi, Silviu-iulian Niculescu, Ismail Ilker Delice
    Abstract:

    This paper addresses the asymptotic stability of a continuous-time deterministic car-following model with respect to different driving strategies. More precisely, the model takes into account a constant time headway driving behavior as well as the presence of Multiple decision-making and actuation delays in describing the Drivers' actions. The stability analysis of the corresponding derived models is challenging and we will focus on characterizing the stability regions in the delay parameter space. Such a problem depicts some interesting properties in terms of delays that simplify the overall analysis leading to some simple frequency-sweeping based algorithms as well as to various practical interpretations of the results in terms of Drivers' behaviors. Illustrative examples complete the presentation.

Daniel Temko - One of the best experts on this subject based on the ideXlab platform.

  • somatic pole exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis determining Driver mutational landscape clonal neoantigen burden and immune response
    The Journal of Pathology, 2018
    Co-Authors: Daniel Temko, Inge C Van Gool, Emily Rayner, Mark A Glaire, Seiko Makino, Matthew A Brown, Laura Chegwidden, Claire Palles, Jeroen Depreeuw
    Abstract:

    Genomic instability, which is a hallmark of cancer, is generally thought to occur in the middle to late stages of tumourigenesis, following the acquisition of permissive molecular aberrations such as TP53 mutation or whole genome doubling. Tumours with somatic POLE exonuclease domain mutations are notable for their extreme genomic instability (their mutation burden is among the highest in human cancer), distinct mutational signature, lymphocytic infiltrate, and excellent prognosis. To what extent these characteristics are determined by the timing of POLE mutations in oncogenesis is unknown. Here, we have shown that pathogenic POLE mutations are detectable in non-malignant precursors of endometrial and colorectal cancer. Using genome and exome sequencing, we found that Multiple Driver mutations in POLE-mutant cancers show the characteristic POLE mutational signature, including those in genes conventionally regarded as initiators of tumourigenesis. In POLE-mutant cancers, the proportion of monoclonal predicted neoantigens was similar to that in other cancers, but the absolute number was much greater. We also found that the prominent CD8+ T-cell infiltrate present in POLE-mutant cancers was evident in their precursor lesions. Collectively, these data indicate that somatic POLE mutations are early, quite possibly initiating, events in the endometrial and colorectal cancers in which they occur. The resulting early onset of genomic instability may account for the striking immune response and excellent prognosis of these tumours, as well as their early presentation. © 2018 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

Jeroen Depreeuw - One of the best experts on this subject based on the ideXlab platform.

  • somatic pole exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis determining Driver mutational landscape clonal neoantigen burden and immune response
    The Journal of Pathology, 2018
    Co-Authors: Daniel Temko, Inge C Van Gool, Emily Rayner, Mark A Glaire, Seiko Makino, Matthew A Brown, Laura Chegwidden, Claire Palles, Jeroen Depreeuw
    Abstract:

    Genomic instability, which is a hallmark of cancer, is generally thought to occur in the middle to late stages of tumourigenesis, following the acquisition of permissive molecular aberrations such as TP53 mutation or whole genome doubling. Tumours with somatic POLE exonuclease domain mutations are notable for their extreme genomic instability (their mutation burden is among the highest in human cancer), distinct mutational signature, lymphocytic infiltrate, and excellent prognosis. To what extent these characteristics are determined by the timing of POLE mutations in oncogenesis is unknown. Here, we have shown that pathogenic POLE mutations are detectable in non-malignant precursors of endometrial and colorectal cancer. Using genome and exome sequencing, we found that Multiple Driver mutations in POLE-mutant cancers show the characteristic POLE mutational signature, including those in genes conventionally regarded as initiators of tumourigenesis. In POLE-mutant cancers, the proportion of monoclonal predicted neoantigens was similar to that in other cancers, but the absolute number was much greater. We also found that the prominent CD8+ T-cell infiltrate present in POLE-mutant cancers was evident in their precursor lesions. Collectively, these data indicate that somatic POLE mutations are early, quite possibly initiating, events in the endometrial and colorectal cancers in which they occur. The resulting early onset of genomic instability may account for the striking immune response and excellent prognosis of these tumours, as well as their early presentation. © 2018 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.