The Experts below are selected from a list of 639 Experts worldwide ranked by ideXlab platform
Masahiro Shirakawa - One of the best experts on this subject based on the ideXlab platform.
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nanodiamonds for bioapplications specific targeting strategies
Biochimica et Biophysica Acta, 2020Co-Authors: Daiki Terada, Takuya Genjo, Takuya F Segawa, Ryuji Igarashi, Masahiro ShirakawaAbstract:Abstract Background Nanodiamonds (NDs) provide a unique Multitasking System for drug delivery and fluorescent imaging in biological environments. Owing to their quantum properties, NDs are expected to be employed as multifunctional probes in the future for the accurate visualization of biophysical parameters such as temperature and magnetic fields. However, the use of NDs for the selective targeting of the biomolecules of interest within a complicated biological System remains a challenge. One of the most promising solutions is the appropriate surface design of NDs based on organic chemistry and biochemistry. The engineered NDs have high biocompatibility and dispersibility in a biological environment and hence undergo cellular uptake through specific pathways. Scope of review This review focuses on the selective targeting of NDs for biomedical and biophysical applications from the viewpoint of ND surface functionalizations and modifications. These pretreatments make possible the specific targeting of biomolecules of interest on or in a cell by NDs via a designed biochemical route. Major conclusions The surface of NDs is covalently or noncovalently modified with silica, polymers, or biomolecules to reshape them, control their size, and enhance the colloidal stability and biomolecular selectivity toward the biomolecules of interest. Electroporation, chemical treatment, injection, or endocytosis are the methods generally adopted to introduce NDs into living cells. The pathway, efficiency, and the cell viability depend on the selected method. General significance In the biomedical field, the surface modification facilitates specific delivery of a drug, leading to a higher therapeutic efficacy. In biophysical applications, the surface modification paves the way for the accurate measurement of physical parameters to gain a better understanding of various cell functions.
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Nanodiamonds for bioapplications–specific targeting strategies
Biochimica et Biophysica Acta, 2019Co-Authors: Daiki Terada, Takuya Genjo, Takuya F Segawa, Ryuji Igarashi, Masahiro ShirakawaAbstract:Abstract Background Nanodiamonds (NDs) provide a unique Multitasking System for drug delivery and fluorescent imaging in biological environments. Owing to their quantum properties, NDs are expected to be employed as multifunctional probes in the future for the accurate visualization of biophysical parameters such as temperature and magnetic fields. However, the use of NDs for the selective targeting of the biomolecules of interest within a complicated biological System remains a challenge. One of the most promising solutions is the appropriate surface design of NDs based on organic chemistry and biochemistry. The engineered NDs have high biocompatibility and dispersibility in a biological environment and hence undergo cellular uptake through specific pathways. Scope of review This review focuses on the selective targeting of NDs for biomedical and biophysical applications from the viewpoint of ND surface functionalizations and modifications. These pretreatments make possible the specific targeting of biomolecules of interest on or in a cell by NDs via a designed biochemical route. Major conclusions The surface of NDs is covalently or noncovalently modified with silica, polymers, or biomolecules to reshape them, control their size, and enhance the colloidal stability and biomolecular selectivity toward the biomolecules of interest. Electroporation, chemical treatment, injection, or endocytosis are the methods generally adopted to introduce NDs into living cells. The pathway, efficiency, and the cell viability depend on the selected method. General significance In the biomedical field, the surface modification facilitates specific delivery of a drug, leading to a higher therapeutic efficacy. In biophysical applications, the surface modification paves the way for the accurate measurement of physical parameters to gain a better understanding of various cell functions.
Takuya F Segawa - One of the best experts on this subject based on the ideXlab platform.
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nanodiamonds for bioapplications specific targeting strategies
Biochimica et Biophysica Acta, 2020Co-Authors: Daiki Terada, Takuya Genjo, Takuya F Segawa, Ryuji Igarashi, Masahiro ShirakawaAbstract:Abstract Background Nanodiamonds (NDs) provide a unique Multitasking System for drug delivery and fluorescent imaging in biological environments. Owing to their quantum properties, NDs are expected to be employed as multifunctional probes in the future for the accurate visualization of biophysical parameters such as temperature and magnetic fields. However, the use of NDs for the selective targeting of the biomolecules of interest within a complicated biological System remains a challenge. One of the most promising solutions is the appropriate surface design of NDs based on organic chemistry and biochemistry. The engineered NDs have high biocompatibility and dispersibility in a biological environment and hence undergo cellular uptake through specific pathways. Scope of review This review focuses on the selective targeting of NDs for biomedical and biophysical applications from the viewpoint of ND surface functionalizations and modifications. These pretreatments make possible the specific targeting of biomolecules of interest on or in a cell by NDs via a designed biochemical route. Major conclusions The surface of NDs is covalently or noncovalently modified with silica, polymers, or biomolecules to reshape them, control their size, and enhance the colloidal stability and biomolecular selectivity toward the biomolecules of interest. Electroporation, chemical treatment, injection, or endocytosis are the methods generally adopted to introduce NDs into living cells. The pathway, efficiency, and the cell viability depend on the selected method. General significance In the biomedical field, the surface modification facilitates specific delivery of a drug, leading to a higher therapeutic efficacy. In biophysical applications, the surface modification paves the way for the accurate measurement of physical parameters to gain a better understanding of various cell functions.
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Nanodiamonds for bioapplications–specific targeting strategies
Biochimica et Biophysica Acta, 2019Co-Authors: Daiki Terada, Takuya Genjo, Takuya F Segawa, Ryuji Igarashi, Masahiro ShirakawaAbstract:Abstract Background Nanodiamonds (NDs) provide a unique Multitasking System for drug delivery and fluorescent imaging in biological environments. Owing to their quantum properties, NDs are expected to be employed as multifunctional probes in the future for the accurate visualization of biophysical parameters such as temperature and magnetic fields. However, the use of NDs for the selective targeting of the biomolecules of interest within a complicated biological System remains a challenge. One of the most promising solutions is the appropriate surface design of NDs based on organic chemistry and biochemistry. The engineered NDs have high biocompatibility and dispersibility in a biological environment and hence undergo cellular uptake through specific pathways. Scope of review This review focuses on the selective targeting of NDs for biomedical and biophysical applications from the viewpoint of ND surface functionalizations and modifications. These pretreatments make possible the specific targeting of biomolecules of interest on or in a cell by NDs via a designed biochemical route. Major conclusions The surface of NDs is covalently or noncovalently modified with silica, polymers, or biomolecules to reshape them, control their size, and enhance the colloidal stability and biomolecular selectivity toward the biomolecules of interest. Electroporation, chemical treatment, injection, or endocytosis are the methods generally adopted to introduce NDs into living cells. The pathway, efficiency, and the cell viability depend on the selected method. General significance In the biomedical field, the surface modification facilitates specific delivery of a drug, leading to a higher therapeutic efficacy. In biophysical applications, the surface modification paves the way for the accurate measurement of physical parameters to gain a better understanding of various cell functions.
Daiki Terada - One of the best experts on this subject based on the ideXlab platform.
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nanodiamonds for bioapplications specific targeting strategies
Biochimica et Biophysica Acta, 2020Co-Authors: Daiki Terada, Takuya Genjo, Takuya F Segawa, Ryuji Igarashi, Masahiro ShirakawaAbstract:Abstract Background Nanodiamonds (NDs) provide a unique Multitasking System for drug delivery and fluorescent imaging in biological environments. Owing to their quantum properties, NDs are expected to be employed as multifunctional probes in the future for the accurate visualization of biophysical parameters such as temperature and magnetic fields. However, the use of NDs for the selective targeting of the biomolecules of interest within a complicated biological System remains a challenge. One of the most promising solutions is the appropriate surface design of NDs based on organic chemistry and biochemistry. The engineered NDs have high biocompatibility and dispersibility in a biological environment and hence undergo cellular uptake through specific pathways. Scope of review This review focuses on the selective targeting of NDs for biomedical and biophysical applications from the viewpoint of ND surface functionalizations and modifications. These pretreatments make possible the specific targeting of biomolecules of interest on or in a cell by NDs via a designed biochemical route. Major conclusions The surface of NDs is covalently or noncovalently modified with silica, polymers, or biomolecules to reshape them, control their size, and enhance the colloidal stability and biomolecular selectivity toward the biomolecules of interest. Electroporation, chemical treatment, injection, or endocytosis are the methods generally adopted to introduce NDs into living cells. The pathway, efficiency, and the cell viability depend on the selected method. General significance In the biomedical field, the surface modification facilitates specific delivery of a drug, leading to a higher therapeutic efficacy. In biophysical applications, the surface modification paves the way for the accurate measurement of physical parameters to gain a better understanding of various cell functions.
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Nanodiamonds for bioapplications–specific targeting strategies
Biochimica et Biophysica Acta, 2019Co-Authors: Daiki Terada, Takuya Genjo, Takuya F Segawa, Ryuji Igarashi, Masahiro ShirakawaAbstract:Abstract Background Nanodiamonds (NDs) provide a unique Multitasking System for drug delivery and fluorescent imaging in biological environments. Owing to their quantum properties, NDs are expected to be employed as multifunctional probes in the future for the accurate visualization of biophysical parameters such as temperature and magnetic fields. However, the use of NDs for the selective targeting of the biomolecules of interest within a complicated biological System remains a challenge. One of the most promising solutions is the appropriate surface design of NDs based on organic chemistry and biochemistry. The engineered NDs have high biocompatibility and dispersibility in a biological environment and hence undergo cellular uptake through specific pathways. Scope of review This review focuses on the selective targeting of NDs for biomedical and biophysical applications from the viewpoint of ND surface functionalizations and modifications. These pretreatments make possible the specific targeting of biomolecules of interest on or in a cell by NDs via a designed biochemical route. Major conclusions The surface of NDs is covalently or noncovalently modified with silica, polymers, or biomolecules to reshape them, control their size, and enhance the colloidal stability and biomolecular selectivity toward the biomolecules of interest. Electroporation, chemical treatment, injection, or endocytosis are the methods generally adopted to introduce NDs into living cells. The pathway, efficiency, and the cell viability depend on the selected method. General significance In the biomedical field, the surface modification facilitates specific delivery of a drug, leading to a higher therapeutic efficacy. In biophysical applications, the surface modification paves the way for the accurate measurement of physical parameters to gain a better understanding of various cell functions.
Kang G Shin - One of the best experts on this subject based on the ideXlab platform.
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improving wait free algorithms for interprocess communication in embedded real time Systems
USENIX Annual Technical Conference, 2002Co-Authors: Hai Huang, Padmanabhan Pillai, Kang G ShinAbstract:Concurrency management is a basic requirement for interprocess communication in any Multitasking System. This usually takes the form of lock-based or other blocking algorithms. In real-time and/or time-sensitive Systems, the less-predictable timing behavior of lock-based mechanisms and the additional task-execution dependency make synchronization undesirable. Recent research has provided non-blocking and wait-free algorithms for interprocess communication, particularly in the domain of single-writer, multiple-reader semantics, but these algorithms typically incur high costs in terms of computation or space complexity, or both. In this paper, we propose a general transformation mechanism that takes advantage of temporal characteristics of the System to reduce both time and space overheads of current single-writer, multiple-reader algorithms. We show a 17–66% execution time reduction along with a 14– 70% memory space reduction when three wait-free algorithms are improved by applying our transformation. We present three new algorithms for wait-free, single-writer, multiple-reader communication along with detailed performance evaluation of nine algorithms under various experimental conditions.
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USENIX Annual Technical Conference, General Track - Improving Wait-Free Algorithms for Interprocess Communication in Embedded Real-Time Systems
2002Co-Authors: Hai Huang, Padmanabhan Pillai, Kang G ShinAbstract:Concurrency management is a basic requirement for interprocess communication in any Multitasking System. This usually takes the form of lock-based or other blocking algorithms. In real-time and/or time-sensitive Systems, the less-predictable timing behavior of lock-based mechanisms and the additional task-execution dependency make synchronization undesirable. Recent research has provided non-blocking and wait-free algorithms for interprocess communication, particularly in the domain of single-writer, multiple-reader semantics, but these algorithms typically incur high costs in terms of computation or space complexity, or both. In this paper, we propose a general transformation mechanism that takes advantage of temporal characteristics of the System to reduce both time and space overheads of current single-writer, multiple-reader algorithms. We show a 17–66% execution time reduction along with a 14– 70% memory space reduction when three wait-free algorithms are improved by applying our transformation. We present three new algorithms for wait-free, single-writer, multiple-reader communication along with detailed performance evaluation of nine algorithms under various experimental conditions.
Takuya Genjo - One of the best experts on this subject based on the ideXlab platform.
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nanodiamonds for bioapplications specific targeting strategies
Biochimica et Biophysica Acta, 2020Co-Authors: Daiki Terada, Takuya Genjo, Takuya F Segawa, Ryuji Igarashi, Masahiro ShirakawaAbstract:Abstract Background Nanodiamonds (NDs) provide a unique Multitasking System for drug delivery and fluorescent imaging in biological environments. Owing to their quantum properties, NDs are expected to be employed as multifunctional probes in the future for the accurate visualization of biophysical parameters such as temperature and magnetic fields. However, the use of NDs for the selective targeting of the biomolecules of interest within a complicated biological System remains a challenge. One of the most promising solutions is the appropriate surface design of NDs based on organic chemistry and biochemistry. The engineered NDs have high biocompatibility and dispersibility in a biological environment and hence undergo cellular uptake through specific pathways. Scope of review This review focuses on the selective targeting of NDs for biomedical and biophysical applications from the viewpoint of ND surface functionalizations and modifications. These pretreatments make possible the specific targeting of biomolecules of interest on or in a cell by NDs via a designed biochemical route. Major conclusions The surface of NDs is covalently or noncovalently modified with silica, polymers, or biomolecules to reshape them, control their size, and enhance the colloidal stability and biomolecular selectivity toward the biomolecules of interest. Electroporation, chemical treatment, injection, or endocytosis are the methods generally adopted to introduce NDs into living cells. The pathway, efficiency, and the cell viability depend on the selected method. General significance In the biomedical field, the surface modification facilitates specific delivery of a drug, leading to a higher therapeutic efficacy. In biophysical applications, the surface modification paves the way for the accurate measurement of physical parameters to gain a better understanding of various cell functions.
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Nanodiamonds for bioapplications–specific targeting strategies
Biochimica et Biophysica Acta, 2019Co-Authors: Daiki Terada, Takuya Genjo, Takuya F Segawa, Ryuji Igarashi, Masahiro ShirakawaAbstract:Abstract Background Nanodiamonds (NDs) provide a unique Multitasking System for drug delivery and fluorescent imaging in biological environments. Owing to their quantum properties, NDs are expected to be employed as multifunctional probes in the future for the accurate visualization of biophysical parameters such as temperature and magnetic fields. However, the use of NDs for the selective targeting of the biomolecules of interest within a complicated biological System remains a challenge. One of the most promising solutions is the appropriate surface design of NDs based on organic chemistry and biochemistry. The engineered NDs have high biocompatibility and dispersibility in a biological environment and hence undergo cellular uptake through specific pathways. Scope of review This review focuses on the selective targeting of NDs for biomedical and biophysical applications from the viewpoint of ND surface functionalizations and modifications. These pretreatments make possible the specific targeting of biomolecules of interest on or in a cell by NDs via a designed biochemical route. Major conclusions The surface of NDs is covalently or noncovalently modified with silica, polymers, or biomolecules to reshape them, control their size, and enhance the colloidal stability and biomolecular selectivity toward the biomolecules of interest. Electroporation, chemical treatment, injection, or endocytosis are the methods generally adopted to introduce NDs into living cells. The pathway, efficiency, and the cell viability depend on the selected method. General significance In the biomedical field, the surface modification facilitates specific delivery of a drug, leading to a higher therapeutic efficacy. In biophysical applications, the surface modification paves the way for the accurate measurement of physical parameters to gain a better understanding of various cell functions.
