The Experts below are selected from a list of 312 Experts worldwide ranked by ideXlab platform
J. Van De Vlekkert - One of the best experts on this subject based on the ideXlab platform.
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Combining MRI and Muscle Biopsy improves diagnostic accuracy in subacute-onset idiopathic inflammatory myopathy.
Muscle & nerve, 2015Co-Authors: J. Van De Vlekkert, M. De Visser, Mario Maas, Jessica E. Hoogendijk, Ivo N. Van SchaikAbstract:Introduction: In 10-20% of patients with subacute- onset idiopathic inflammatory myopathy (IIM), Muscle Biopsy is normal or shows nonspecific findings. MRI can be used as a tri- age test before Muscle Biopsy and as an add-on test if the Biopsy is nondiagnostic. Methods: MRI scans of skeletal Muscles and Muscle biopsies were evaluated prospectively in 48 patients suspected to have IIM. The interpretations of MRI and Muscle Biopsy were compared with the definite diagnosis (based on European Neuromuscular Centre criteria and response to corticosteroids). Results: The false negative rate (FNR) of all Muscle biopsies was 0.23. Biopsies of a Muscle showing hyperintensity on MRI (as triage test) had an FNR of 0.19. The result of MRI as an add-on test in patients with a nondiagnostic Muscle Biopsy decreased the FNR from 0.23 to 0.06. Conclusions: We recommend both MRI and Muscle Biopsy in patients suspected of having IIM. Muscle Nerve 51: 253-258, 2015 Adult subacute-onset idiopathic inflammatory myopathies (IIM) are subclassified into polymyosi- tis (PM), dermatomyositis (DM), nonspecific myo- sitis (NSM), and necrotizing autoimmune
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P.21.4 Combining MRI and Muscle Biopsy improves diagnostic accuracy in subacute-onset idiopathic inflammatory myopathy
Neuromuscular Disorders, 2013Co-Authors: M. De Visser, J. Van De Vlekkert, Mario Maas, Jessica E. Hoogendijk, I.n. SchaikAbstract:In approximately 10–20% of patients suffering from subacute-onset idiopathic inflammatory myopathy (IIM) Muscle Biopsy is normal or shows non-specific findings. MRI can be used as triage test prior to a Muscle Biopsy and as add-on test if a Muscle Biopsy has proven to be non-diagnostic. A prospective study was performed on forty-eight consecutive patients with subacute-onset IIM of whom MRI scans of the skeletal Muscles and Muscle biopsies were systematically evaluated. The results of MRI, Muscle Biopsy findings and definite diagnosis including response to treatment which was considered the gold standard were collected and compared. The false negative rate of all Muscle biopsies was 0.23. Biopsies taken from a Muscle showing hyperintensity on MRI (as triage test) had a false negative rate of 0.19. Using the result of MRI as add-on test in patients with a non-diagnostic Muscle Biopsy decreased the false negative rate to 0.06. MRI has a high diagnostic accuracy as add-on test to the Muscle Biopsy in patients with a negative or non-specific Muscle Biopsy but otherwise a clinical presentation consistent with a diagnosis of subacute-onset IIM. Our results also suggest that MRI may be useful as triage test in reducing false negative Muscle Biopsy results. Therefore, in patients presumed to have a subacute-onset IIM it is recommended to perform both MRI and a Muscle Biopsy.
M. De Visser - One of the best experts on this subject based on the ideXlab platform.
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Combining MRI and Muscle Biopsy improves diagnostic accuracy in subacute-onset idiopathic inflammatory myopathy.
Muscle & nerve, 2015Co-Authors: J. Van De Vlekkert, M. De Visser, Mario Maas, Jessica E. Hoogendijk, Ivo N. Van SchaikAbstract:Introduction: In 10-20% of patients with subacute- onset idiopathic inflammatory myopathy (IIM), Muscle Biopsy is normal or shows nonspecific findings. MRI can be used as a tri- age test before Muscle Biopsy and as an add-on test if the Biopsy is nondiagnostic. Methods: MRI scans of skeletal Muscles and Muscle biopsies were evaluated prospectively in 48 patients suspected to have IIM. The interpretations of MRI and Muscle Biopsy were compared with the definite diagnosis (based on European Neuromuscular Centre criteria and response to corticosteroids). Results: The false negative rate (FNR) of all Muscle biopsies was 0.23. Biopsies of a Muscle showing hyperintensity on MRI (as triage test) had an FNR of 0.19. The result of MRI as an add-on test in patients with a nondiagnostic Muscle Biopsy decreased the FNR from 0.23 to 0.06. Conclusions: We recommend both MRI and Muscle Biopsy in patients suspected of having IIM. Muscle Nerve 51: 253-258, 2015 Adult subacute-onset idiopathic inflammatory myopathies (IIM) are subclassified into polymyosi- tis (PM), dermatomyositis (DM), nonspecific myo- sitis (NSM), and necrotizing autoimmune
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P.21.4 Combining MRI and Muscle Biopsy improves diagnostic accuracy in subacute-onset idiopathic inflammatory myopathy
Neuromuscular Disorders, 2013Co-Authors: M. De Visser, J. Van De Vlekkert, Mario Maas, Jessica E. Hoogendijk, I.n. SchaikAbstract:In approximately 10–20% of patients suffering from subacute-onset idiopathic inflammatory myopathy (IIM) Muscle Biopsy is normal or shows non-specific findings. MRI can be used as triage test prior to a Muscle Biopsy and as add-on test if a Muscle Biopsy has proven to be non-diagnostic. A prospective study was performed on forty-eight consecutive patients with subacute-onset IIM of whom MRI scans of the skeletal Muscles and Muscle biopsies were systematically evaluated. The results of MRI, Muscle Biopsy findings and definite diagnosis including response to treatment which was considered the gold standard were collected and compared. The false negative rate of all Muscle biopsies was 0.23. Biopsies taken from a Muscle showing hyperintensity on MRI (as triage test) had a false negative rate of 0.19. Using the result of MRI as add-on test in patients with a non-diagnostic Muscle Biopsy decreased the false negative rate to 0.06. MRI has a high diagnostic accuracy as add-on test to the Muscle Biopsy in patients with a negative or non-specific Muscle Biopsy but otherwise a clinical presentation consistent with a diagnosis of subacute-onset IIM. Our results also suggest that MRI may be useful as triage test in reducing false negative Muscle Biopsy results. Therefore, in patients presumed to have a subacute-onset IIM it is recommended to perform both MRI and a Muscle Biopsy.
Ivo N. Van Schaik - One of the best experts on this subject based on the ideXlab platform.
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Combining MRI and Muscle Biopsy improves diagnostic accuracy in subacute-onset idiopathic inflammatory myopathy.
Muscle & nerve, 2015Co-Authors: J. Van De Vlekkert, M. De Visser, Mario Maas, Jessica E. Hoogendijk, Ivo N. Van SchaikAbstract:Introduction: In 10-20% of patients with subacute- onset idiopathic inflammatory myopathy (IIM), Muscle Biopsy is normal or shows nonspecific findings. MRI can be used as a tri- age test before Muscle Biopsy and as an add-on test if the Biopsy is nondiagnostic. Methods: MRI scans of skeletal Muscles and Muscle biopsies were evaluated prospectively in 48 patients suspected to have IIM. The interpretations of MRI and Muscle Biopsy were compared with the definite diagnosis (based on European Neuromuscular Centre criteria and response to corticosteroids). Results: The false negative rate (FNR) of all Muscle biopsies was 0.23. Biopsies of a Muscle showing hyperintensity on MRI (as triage test) had an FNR of 0.19. The result of MRI as an add-on test in patients with a nondiagnostic Muscle Biopsy decreased the FNR from 0.23 to 0.06. Conclusions: We recommend both MRI and Muscle Biopsy in patients suspected of having IIM. Muscle Nerve 51: 253-258, 2015 Adult subacute-onset idiopathic inflammatory myopathies (IIM) are subclassified into polymyosi- tis (PM), dermatomyositis (DM), nonspecific myo- sitis (NSM), and necrotizing autoimmune
Jean-baptiste Chanson - One of the best experts on this subject based on the ideXlab platform.
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is deltoid Muscle Biopsy useful in isolated camptocormia a prospective study
European Journal of Neurology, 2016Co-Authors: Jean-baptiste Chanson, B Lannes, Andoni EchanizlagunaAbstract:Background and purpose Camptocormia is a marked anterior curvature of the thoracolumbar spine that may be caused by parkinsonism, amyotrophic lateral sclerosis (ALS), myasthenia gravis (MG) and Muscle disease. The interest of a systematic Muscle Biopsy has not been evaluated until now. In our study, the aim was to prospectively evaluate the proportion of patients with isolated camptocormia without ALS, MG and parkinsonism who have an underlying myopathy. Methods Twenty consecutive patients (75% female, mean age 70 years) with isolated camptocormia were enrolled in a single centre in this 5-year prospective study. ALS, MG and parkinsonism had been excluded in all cases. A left deltoid Muscle Biopsy was performed in all patients and processed with standard techniques for histology and immunohistochemistry. Additional biochemical and genetic studies were performed when pathological analysis was consistent with myopathy. Results A myopathy was identified in seven patients (35%). Three patients presented with mitochondrial myopathy, including two patients harbouring a heterozygous POLG gene pathogenic variant and one patient with a heterozygous RRM2B gene pathogenic variant. Two patients presented with an inflammatory myopathy, including one with anti-PM/Scl antibodies. One patient presented with facioscapulohumeral muscular dystrophy and one patient with an MYH7 gene-related myofibrillar myopathy. No obvious myopathy was found in the 13 remaining cases. Discussion In this prospective study, an underlying myopathy was found in 35% of patients with isolated camptocormia. These results suggest that a Muscle Biopsy should be systematically performed in patients with isolated camptocormia when ALS, MG and parkinsonism have been excluded.
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Electromyography and Muscle Biopsy in chronic isolated Myalgia: A prospective study.
Muscle & nerve, 2016Co-Authors: Andoni Echaniz-laguna, Jean-baptiste ChansonAbstract:Introduction Chronic Muscle pain affects approximately 10% of the general population. It is unknown whether electromyographic (EMG) examination or Muscle Biopsy is most useful in this situation. Methods In a 7-year, single-center prospective study we investigated the EMG and Muscle pathology characteristics of patients with: (1) diffuse Muscle pain lasting >1 year; (2) normal clinical examination; (3) normal extensive blood tests; and (4) no evidence of a coexisting disorder. Results One hundred eighty consecutive patients were enrolled. In 178 patients (99%), EMG studies and Muscle biopsies were normal. In 2 patients (1%), EMG studies demonstrated myotonia, and Muscle Biopsy showed mild myopathic features; 1 patient had myotonic dystrophy type 2, and the other had SCN4A-related Muscle channelopathy. Conclusions In this prospective study, EMG was an excellent screening test for diagnosing Muscle disease in clinically normal patients with chronic diffuse Muscle pain, and Muscle Biopsy was not useful. Muscle Nerve 54: 321–324, 2016
Jessica E. Hoogendijk - One of the best experts on this subject based on the ideXlab platform.
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Combining MRI and Muscle Biopsy improves diagnostic accuracy in subacute-onset idiopathic inflammatory myopathy.
Muscle & nerve, 2015Co-Authors: J. Van De Vlekkert, M. De Visser, Mario Maas, Jessica E. Hoogendijk, Ivo N. Van SchaikAbstract:Introduction: In 10-20% of patients with subacute- onset idiopathic inflammatory myopathy (IIM), Muscle Biopsy is normal or shows nonspecific findings. MRI can be used as a tri- age test before Muscle Biopsy and as an add-on test if the Biopsy is nondiagnostic. Methods: MRI scans of skeletal Muscles and Muscle biopsies were evaluated prospectively in 48 patients suspected to have IIM. The interpretations of MRI and Muscle Biopsy were compared with the definite diagnosis (based on European Neuromuscular Centre criteria and response to corticosteroids). Results: The false negative rate (FNR) of all Muscle biopsies was 0.23. Biopsies of a Muscle showing hyperintensity on MRI (as triage test) had an FNR of 0.19. The result of MRI as an add-on test in patients with a nondiagnostic Muscle Biopsy decreased the FNR from 0.23 to 0.06. Conclusions: We recommend both MRI and Muscle Biopsy in patients suspected of having IIM. Muscle Nerve 51: 253-258, 2015 Adult subacute-onset idiopathic inflammatory myopathies (IIM) are subclassified into polymyosi- tis (PM), dermatomyositis (DM), nonspecific myo- sitis (NSM), and necrotizing autoimmune
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P.21.4 Combining MRI and Muscle Biopsy improves diagnostic accuracy in subacute-onset idiopathic inflammatory myopathy
Neuromuscular Disorders, 2013Co-Authors: M. De Visser, J. Van De Vlekkert, Mario Maas, Jessica E. Hoogendijk, I.n. SchaikAbstract:In approximately 10–20% of patients suffering from subacute-onset idiopathic inflammatory myopathy (IIM) Muscle Biopsy is normal or shows non-specific findings. MRI can be used as triage test prior to a Muscle Biopsy and as add-on test if a Muscle Biopsy has proven to be non-diagnostic. A prospective study was performed on forty-eight consecutive patients with subacute-onset IIM of whom MRI scans of the skeletal Muscles and Muscle biopsies were systematically evaluated. The results of MRI, Muscle Biopsy findings and definite diagnosis including response to treatment which was considered the gold standard were collected and compared. The false negative rate of all Muscle biopsies was 0.23. Biopsies taken from a Muscle showing hyperintensity on MRI (as triage test) had a false negative rate of 0.19. Using the result of MRI as add-on test in patients with a non-diagnostic Muscle Biopsy decreased the false negative rate to 0.06. MRI has a high diagnostic accuracy as add-on test to the Muscle Biopsy in patients with a negative or non-specific Muscle Biopsy but otherwise a clinical presentation consistent with a diagnosis of subacute-onset IIM. Our results also suggest that MRI may be useful as triage test in reducing false negative Muscle Biopsy results. Therefore, in patients presumed to have a subacute-onset IIM it is recommended to perform both MRI and a Muscle Biopsy.
