The Experts below are selected from a list of 321 Experts worldwide ranked by ideXlab platform
Patrice Martin - One of the best experts on this subject based on the ideXlab platform.
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biochemical and transcriptomic analyses of two bovine skeletal Muscles in charolais bulls divergently selected for Muscle Growth
Meat Science, 2005Co-Authors: K Sudre, Isabelle Cassarmalek, A Listrat, Yasuko Ueda, C Leroux, C Jurie, Charles Auffray, Gilles Renand, Patrice MartinAbstract:This work aimed to investigate the consequences of Muscle Growth selection on Muscle characteristics. An oxidative Muscle (Rectus abdominis, RA) and a glycolytic one (Semitendinosus, ST) were studied in two groups of six extreme young Charolais bulls of high or low Muscle Growth. Mitochondrial activity was lower in Muscles of bulls with high Muscle Growth. Transcriptomic studies allowed the identification of putatively differentially expressed genes. The differential expression between genetic types of two genes in RA (a heat shock protein and a thyroid receptor interacting protein) and of seven genes in ST (including LEU5, tropomyosin 2, and sarcosin) was confirmed by different statistical approaches or Northern blot analysis, as well as the differential expression of five genes (including PSMD4 and DPM synthase) between RA and ST. Both biochemical and transcriptomic results indicate that selection on Muscle Growth potential is associated with reduced slow-oxidative Muscle characteristics. Further studies are required to understand the physiological importance of genes whose expression is changed by selection.
Dahai Zhu - One of the best experts on this subject based on the ideXlab platform.
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Systematic identification of genes involved in divergent skeletal Muscle Growth rates of broiler and layer chickens
BMC Genomics, 2009Co-Authors: Qi Zheng, Ning Du Yang, Xiu-jie Wang, Ying Chen, Dahai ZhuAbstract:BackgroundThe genetic closeness and divergent Muscle Growth rates of broilers and layers make them great models for myogenesis study. In order to discover the molecular mechanisms determining the divergent Muscle Growth rates and Muscle mass control in different chicken lines, we systematically identified differentially expressed genes between broiler and layer skeletal Muscle cells during different developmental stages by microarray hybridization experiment.ResultsTaken together, 543 differentially expressed genes were identified between broilers and layers across different developmental stages. We found that differential regulation of slow-type Muscle gene expression, satellite cell proliferation and differentiation, protein degradation rate and genes in some metabolic pathways could give great contributions to the divergent Muscle Growth rates of the two chicken lines. Interestingly, the expression profiles of a few differentially expressed genes were positively or negatively correlated with the Growth rates of broilers and layers, indicating that those genes may function in regulating Muscle Growth during development.ConclusionThe multiple Muscle cell Growth regulatory processes identified by our study implied that complicated molecular networks involved in the regulation of chicken Muscle Growth. These findings will not only offer genetic information for identifying candidate genes for chicken breeding, but also provide new clues for deciphering mechanisms underlining Muscle development in vertebrates.
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Systematic identification of genes involved in divergent skeletal Muscle Growth rates of broiler and layer chickens.
BMC genomics, 2009Co-Authors: Qi Zheng, Xiu-jie Wang, Ning Du Yang, Ying Chen, Yong Zhang, Dahai ZhuAbstract:The genetic closeness and divergent Muscle Growth rates of broilers and layers make them great models for myogenesis study. In order to discover the molecular mechanisms determining the divergent Muscle Growth rates and Muscle mass control in different chicken lines, we systematically identified differentially expressed genes between broiler and layer skeletal Muscle cells during different developmental stages by microarray hybridization experiment. Taken together, 543 differentially expressed genes were identified between broilers and layers across different developmental stages. We found that differential regulation of slow-type Muscle gene expression, satellite cell proliferation and differentiation, protein degradation rate and genes in some metabolic pathways could give great contributions to the divergent Muscle Growth rates of the two chicken lines. Interestingly, the expression profiles of a few differentially expressed genes were positively or negatively correlated with the Growth rates of broilers and layers, indicating that those genes may function in regulating Muscle Growth during development. The multiple Muscle cell Growth regulatory processes identified by our study implied that complicated molecular networks involved in the regulation of chicken Muscle Growth. These findings will not only offer genetic information for identifying candidate genes for chicken breeding, but also provide new clues for deciphering mechanisms underlining Muscle development in vertebrates.
Gilles Renand - One of the best experts on this subject based on the ideXlab platform.
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relationships between Muscle Growth potential intramuscular fat content and different indicators of Muscle fibre types in young charolais bulls
Animal Science Journal, 2012Co-Authors: J F Hocquette, Isabelle Cassarmalek, C Jurie, D Bauchart, Brigitte Picard, Gilles RenandAbstract:: Genetic selection in favor of Muscle Growth at the expense of fat should affect characteristics of Muscles, and therefore beef quality. This study was conducted with two extreme groups of six animals selected among 64 Charolais young bulls ranked according to their genetic potential for Muscle Growth. Muscle characteristics were assessed in Rectus abdominis (RA, slow oxidative) and Semitendinosus (ST, fast glycolytic) Muscles. Intramuscular fat content and proportions of myosin heavy chains I (slow) and IIA (fast oxido-glycolytic) and certain indicators of oxidative metabolism (activities of citrate synthase (CS), isocitrate dehydrogenase and cytochrome-c oxidase (COX); expression of H-fatty acid binding protein (FABP)) were higher in RA than in ST Muscle. Genetic selection for Muscle Growth reduced intramuscular fat content and the activities of some oxidative metabolism indicators (namely CS, COX only). The positive correlation between Muscle triacylglycerol content and A-FABP messenger RNA level (a marker of adipocyte differentiation) (r = 0.53, P < 0.05) suggests that A-FABP may be a good marker of the ability of bovines to deposit intramuscular fat. In conclusion, the metabolic Muscle characteristics which respond to the selection process in favor of Muscle Growth clearly differ from the Muscle characteristics which allow Muscle types to be differentiated.
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Relationships between Muscle Growth potential, intramuscular fat content and different indicators of Muscle fibre types in young Charolais bulls
Animal Science Journal, 2012Co-Authors: J F Hocquette, D Bauchart, Brigitte Picard, Isabelle Cassar-malek, Catherine Jurie, Gilles RenandAbstract:Genetic selection in favor of Muscle Growth at the expense of fat should affect characteristics of Muscles, and therefore beef quality. This study was conducted with two extreme groups of six animals selected among 64 Charolais young bulls ranked according to their genetic potential for Muscle Growth. Muscle characteristics were assessed in Rectus abdominis (RA, slow oxidative) and Semitendinosus (ST, fast glycolytic) Muscles. Intramuscular fat content and proportions of myosin heavy chains I (slow) and IIA (fast oxido-glycolytic) and certain indicators of oxidative metabolism (activities of citrate synthase (CS), isocitrate dehydrogenase and cytochrome-c oxidase (COX); expression of H-fatty acid binding protein (FABP)) were higher in RA than in ST Muscle. Genetic selection for Muscle Growth reduced intramuscular fat content and the activities of some oxidative metabolism indicators (namely CS, COX only). The positive correlation between Muscle triacylglycerol content and A-FABP messenger RNA level (a marker of adipocyte differentiation) (r = 0.53, P
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biochemical and transcriptomic analyses of two bovine skeletal Muscles in charolais bulls divergently selected for Muscle Growth
Meat Science, 2005Co-Authors: K Sudre, Isabelle Cassarmalek, A Listrat, Yasuko Ueda, C Leroux, C Jurie, Charles Auffray, Gilles Renand, Patrice MartinAbstract:This work aimed to investigate the consequences of Muscle Growth selection on Muscle characteristics. An oxidative Muscle (Rectus abdominis, RA) and a glycolytic one (Semitendinosus, ST) were studied in two groups of six extreme young Charolais bulls of high or low Muscle Growth. Mitochondrial activity was lower in Muscles of bulls with high Muscle Growth. Transcriptomic studies allowed the identification of putatively differentially expressed genes. The differential expression between genetic types of two genes in RA (a heat shock protein and a thyroid receptor interacting protein) and of seven genes in ST (including LEU5, tropomyosin 2, and sarcosin) was confirmed by different statistical approaches or Northern blot analysis, as well as the differential expression of five genes (including PSMD4 and DPM synthase) between RA and ST. Both biochemical and transcriptomic results indicate that selection on Muscle Growth potential is associated with reduced slow-oxidative Muscle characteristics. Further studies are required to understand the physiological importance of genes whose expression is changed by selection.
Qi Zheng - One of the best experts on this subject based on the ideXlab platform.
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Systematic identification of genes involved in divergent skeletal Muscle Growth rates of broiler and layer chickens
BMC Genomics, 2009Co-Authors: Qi Zheng, Ning Du Yang, Xiu-jie Wang, Ying Chen, Dahai ZhuAbstract:BackgroundThe genetic closeness and divergent Muscle Growth rates of broilers and layers make them great models for myogenesis study. In order to discover the molecular mechanisms determining the divergent Muscle Growth rates and Muscle mass control in different chicken lines, we systematically identified differentially expressed genes between broiler and layer skeletal Muscle cells during different developmental stages by microarray hybridization experiment.ResultsTaken together, 543 differentially expressed genes were identified between broilers and layers across different developmental stages. We found that differential regulation of slow-type Muscle gene expression, satellite cell proliferation and differentiation, protein degradation rate and genes in some metabolic pathways could give great contributions to the divergent Muscle Growth rates of the two chicken lines. Interestingly, the expression profiles of a few differentially expressed genes were positively or negatively correlated with the Growth rates of broilers and layers, indicating that those genes may function in regulating Muscle Growth during development.ConclusionThe multiple Muscle cell Growth regulatory processes identified by our study implied that complicated molecular networks involved in the regulation of chicken Muscle Growth. These findings will not only offer genetic information for identifying candidate genes for chicken breeding, but also provide new clues for deciphering mechanisms underlining Muscle development in vertebrates.
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Systematic identification of genes involved in divergent skeletal Muscle Growth rates of broiler and layer chickens.
BMC genomics, 2009Co-Authors: Qi Zheng, Xiu-jie Wang, Ning Du Yang, Ying Chen, Yong Zhang, Dahai ZhuAbstract:The genetic closeness and divergent Muscle Growth rates of broilers and layers make them great models for myogenesis study. In order to discover the molecular mechanisms determining the divergent Muscle Growth rates and Muscle mass control in different chicken lines, we systematically identified differentially expressed genes between broiler and layer skeletal Muscle cells during different developmental stages by microarray hybridization experiment. Taken together, 543 differentially expressed genes were identified between broilers and layers across different developmental stages. We found that differential regulation of slow-type Muscle gene expression, satellite cell proliferation and differentiation, protein degradation rate and genes in some metabolic pathways could give great contributions to the divergent Muscle Growth rates of the two chicken lines. Interestingly, the expression profiles of a few differentially expressed genes were positively or negatively correlated with the Growth rates of broilers and layers, indicating that those genes may function in regulating Muscle Growth during development. The multiple Muscle cell Growth regulatory processes identified by our study implied that complicated molecular networks involved in the regulation of chicken Muscle Growth. These findings will not only offer genetic information for identifying candidate genes for chicken breeding, but also provide new clues for deciphering mechanisms underlining Muscle development in vertebrates.
Isabelle Cassarmalek - One of the best experts on this subject based on the ideXlab platform.
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relationships between Muscle Growth potential intramuscular fat content and different indicators of Muscle fibre types in young charolais bulls
Animal Science Journal, 2012Co-Authors: J F Hocquette, Isabelle Cassarmalek, C Jurie, D Bauchart, Brigitte Picard, Gilles RenandAbstract:: Genetic selection in favor of Muscle Growth at the expense of fat should affect characteristics of Muscles, and therefore beef quality. This study was conducted with two extreme groups of six animals selected among 64 Charolais young bulls ranked according to their genetic potential for Muscle Growth. Muscle characteristics were assessed in Rectus abdominis (RA, slow oxidative) and Semitendinosus (ST, fast glycolytic) Muscles. Intramuscular fat content and proportions of myosin heavy chains I (slow) and IIA (fast oxido-glycolytic) and certain indicators of oxidative metabolism (activities of citrate synthase (CS), isocitrate dehydrogenase and cytochrome-c oxidase (COX); expression of H-fatty acid binding protein (FABP)) were higher in RA than in ST Muscle. Genetic selection for Muscle Growth reduced intramuscular fat content and the activities of some oxidative metabolism indicators (namely CS, COX only). The positive correlation between Muscle triacylglycerol content and A-FABP messenger RNA level (a marker of adipocyte differentiation) (r = 0.53, P < 0.05) suggests that A-FABP may be a good marker of the ability of bovines to deposit intramuscular fat. In conclusion, the metabolic Muscle characteristics which respond to the selection process in favor of Muscle Growth clearly differ from the Muscle characteristics which allow Muscle types to be differentiated.
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biochemical and transcriptomic analyses of two bovine skeletal Muscles in charolais bulls divergently selected for Muscle Growth
Meat Science, 2005Co-Authors: K Sudre, Isabelle Cassarmalek, A Listrat, Yasuko Ueda, C Leroux, C Jurie, Charles Auffray, Gilles Renand, Patrice MartinAbstract:This work aimed to investigate the consequences of Muscle Growth selection on Muscle characteristics. An oxidative Muscle (Rectus abdominis, RA) and a glycolytic one (Semitendinosus, ST) were studied in two groups of six extreme young Charolais bulls of high or low Muscle Growth. Mitochondrial activity was lower in Muscles of bulls with high Muscle Growth. Transcriptomic studies allowed the identification of putatively differentially expressed genes. The differential expression between genetic types of two genes in RA (a heat shock protein and a thyroid receptor interacting protein) and of seven genes in ST (including LEU5, tropomyosin 2, and sarcosin) was confirmed by different statistical approaches or Northern blot analysis, as well as the differential expression of five genes (including PSMD4 and DPM synthase) between RA and ST. Both biochemical and transcriptomic results indicate that selection on Muscle Growth potential is associated with reduced slow-oxidative Muscle characteristics. Further studies are required to understand the physiological importance of genes whose expression is changed by selection.
