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David B Reynolds - One of the best experts on this subject based on the ideXlab platform.
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biomimetic model of skeletal Muscle Isometric Contraction ii a phenomenological model of the skeletal Muscle excitation Contraction coupling process
Computers in Biology and Medicine, 2004Co-Authors: Amy T Neidharddoll, Chandler A Phillips, D W Repperger, David B ReynoldsAbstract:Abstract This paper describes a new macroscopic, phenomenological model of the skeletal Muscle excitation–Contraction coupling process, as represented by four principal and consecutive compartments (biophysical, biochemical, and biomechanical phases) characteristic of Isometric excitation–Contraction coupling in mammalian skeletal Muscle, and coupled by a system of simultaneous, first-order linear ordinary differential equations. The model is based upon biological compartmental transport kinetics and irreversible thermodynamic energy transformation, and represents a distinct improvement over other biomimetic models. The model was derived using physiological parameter data published in the literature, and validated using MATLAB R 12 TM .
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biomimetic model of skeletal Muscle Isometric Contraction i an energetic viscoelastic model for the skeletal Muscle Isometric force twitch
Computers in Biology and Medicine, 2004Co-Authors: Chandler A Phillips, Amy T Neidharddoll, D W Repperger, David B ReynoldsAbstract:This paper describes a revision of the Hill-type Muscle model so that it will describe the chemo-mechanical energy conversion process (energetic) and the internal-element sti2ness variation (viscoelastic) during a skeletal Muscle Isometric force twitch Contraction. The derivation of this energetic–viscoelastic model is described by a 3rst-order linear ordinary di2erential equation with constant energetic and viscoelastic coe5cients. The model has been implemented as part of a biomimetic model, which describes the excitation–Contraction coupling necessary to drive the energetic–viscoelastic model. Finally, the energetic–viscoelastic model is validated by comparing its Isometric force–time pro3le with that of various Muscles reported in the literature. ? 2003 Elsevier Ltd. All rights reserved.
Yusuf Kenan Daglioglu - One of the best experts on this subject based on the ideXlab platform.
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Therapeutic Potential of Pterostilbene and Resveratrol on Biomechanic, Biochemical, and Histological Parameters in Streptozotocin-Induced Diabetic Rats
Hindawi Limited, 2018Co-Authors: Bora Tastekin, Aykut Pelit, Sait Polat, Abdullah Tuli, Leman Sencar, Mustafa Muhlis Alparslan, Yusuf Kenan DagliogluAbstract:Aims. The aim of this study was to investigate the effects of pterostilbene (PTS) (trans-3,5-dimethoxy-4′-hydroxystilbene) and resveratrol (RSV) (trans-3,5,4′ trihydroxystilbene) applied at different doses for the treatment of streptozotocin- (STZ-) induced diabetic rats. Materials and Methods. At the end of the 5-week experimental period, the right gastrocnemius Muscles of the rats were examined biomechanically, while the left ones were examined histologically. In addition, blood glucose, serum insulin, and malondialdehyde (MDA) levels were analyzed in blood samples taken from the rats. Results. The skeletal Muscle Isometric Contraction forces, which showed a decrease with diabetes, were observed to increase with antioxidant applications. Blood glucose, serum insulin, and MDA levels in diabetic rats approached normal levels after applying PTS. When the electron microscopic images of the rat skeletal Muscle were examined, those in the combination treatment group were observed to show a better enhancement in the skeletal Muscle morphological structure compared to the other diabetic and treatment groups. Conclusion. According to the findings, we suggest that these antioxidant treatments might have good therapeutic nutraceutical potential for some Muscle diseases that coexist with diabetes. These treatments should be comprehensively investigated in the future
Daglioglu Y.k. - One of the best experts on this subject based on the ideXlab platform.
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Therapeutic Potential of Pterostilbene and Resveratrol on Biomechanic, Biochemical, and Histological Parameters in Streptozotocin-Induced Diabetic Rats
'Hindawi Limited', 2018Co-Authors: Tastekin B., Pelit A., Polat S., Tuli A., Sencar L., Alparslan M.m., Daglioglu Y.k.Abstract:Aims. The aim of this study was to investigate the effects of pterostilbene (PTS) (trans-3,5-dimethoxy-4'-hydroxystilbene) and resveratrol (RSV) (trans-3,5,4' trihydroxystilbene) applied at different doses for the treatment of streptozotocin- (STZ-) induced diabetic rats. Materials and Methods. At the end of the 5-week experimental period, the right gastrocnemius Muscles of the rats were examined biomechanically, while the left ones were examined histologically. In addition, blood glucose, serum insulin, and malondialdehyde (MDA) levels were analyzed in blood samples taken from the rats. Results. The skeletal Muscle Isometric Contraction forces, which showed a decrease with diabetes, were observed to increase with antioxidant applications. Blood glucose, serum insulin, and MDA levels in diabetic rats approached normal levels after applying PTS. When the electron microscopic images of the rat skeletal Muscle were examined, those in the combination treatment group were observed to show a better enhancement in the skeletal Muscle morphological structure compared to the other diabetic and treatment groups. Conclusion. According to the findings, we suggest that these antioxidant treatments might have good therapeutic nutraceutical potential for some Muscle diseases that coexist with diabetes. These treatments should be comprehensively investigated in the future. © 2018 Bora Tastekin et al.The research was supported by the C¸ ukurova University Scientific Research Foundation (Project no. TSA-2016-4958). Thanks are due to the Sabinsa Corporation for the supply of antioxidants
Xun Chen - One of the best experts on this subject based on the ideXlab platform.
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upper limb end effector force estimation during multi Muscle Isometric Contraction tasks using hd semg and deep belief network
Frontiers in Neuroscience, 2020Co-Authors: Xiang Chen, Shuai Cao, Xu Zhang, Xun ChenAbstract:In this study, research was carried out on the end-effector force estimation of two representative multi-Muscle Contraction tasks: elbow flexion and palm-pressing. The aim was to ascertain whether an individual Muscle or a combination of Muscles is more suitable for the end-effector force estimation. High-density surface electromyography (HD-sEMG) signals were collected from four primary Muscle areas of the upper arm and forearm: the biceps brachii (BB), brachialis (BR), triceps brachii (TB), brachioradialis (BRD), and extensor digitorum communis (EDC). The wrist pulling and palm-pressing forces were measured in elbow flexion and palm-pressing tasks, respectively. The deep belief network (DBN) was adopted to establish the relation between HD-sEMG and the measured force. The representative signals of the four primary areas, which were considered as the input signal of the force estimation model, were extracted by HD-sEMG using the principle component analysis (PCA) algorithm, and fed separately or together into the DBN. An index termed mean impact value (MIV) was proposed to describe the priority of different Muscle groups for estimating the end-effector force. The experimental results demonstrated that, in multi-Muscle Isometric Contraction tasks, the dominant Muscles with the highest activation degree could track variations in the end-effector force more effectively, and are more suitable than a combination of Muscles. The main contributions of this research are as follows: (1) To fuse the activation information from different Muscles effectively, DBN was adopted to establish the relationship between HD-sEMG and the generated force, and achieved highly accurate force estimation. (2) Based on the well-trained DBN force estimation model, an index termed MIV was presented to evaluate the priority of Muscles for estimating the generated force.
Amy T Neidharddoll - One of the best experts on this subject based on the ideXlab platform.
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biomimetic model of skeletal Muscle Isometric Contraction ii a phenomenological model of the skeletal Muscle excitation Contraction coupling process
Computers in Biology and Medicine, 2004Co-Authors: Amy T Neidharddoll, Chandler A Phillips, D W Repperger, David B ReynoldsAbstract:Abstract This paper describes a new macroscopic, phenomenological model of the skeletal Muscle excitation–Contraction coupling process, as represented by four principal and consecutive compartments (biophysical, biochemical, and biomechanical phases) characteristic of Isometric excitation–Contraction coupling in mammalian skeletal Muscle, and coupled by a system of simultaneous, first-order linear ordinary differential equations. The model is based upon biological compartmental transport kinetics and irreversible thermodynamic energy transformation, and represents a distinct improvement over other biomimetic models. The model was derived using physiological parameter data published in the literature, and validated using MATLAB R 12 TM .
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biomimetic model of skeletal Muscle Isometric Contraction i an energetic viscoelastic model for the skeletal Muscle Isometric force twitch
Computers in Biology and Medicine, 2004Co-Authors: Chandler A Phillips, Amy T Neidharddoll, D W Repperger, David B ReynoldsAbstract:This paper describes a revision of the Hill-type Muscle model so that it will describe the chemo-mechanical energy conversion process (energetic) and the internal-element sti2ness variation (viscoelastic) during a skeletal Muscle Isometric force twitch Contraction. The derivation of this energetic–viscoelastic model is described by a 3rst-order linear ordinary di2erential equation with constant energetic and viscoelastic coe5cients. The model has been implemented as part of a biomimetic model, which describes the excitation–Contraction coupling necessary to drive the energetic–viscoelastic model. Finally, the energetic–viscoelastic model is validated by comparing its Isometric force–time pro3le with that of various Muscles reported in the literature. ? 2003 Elsevier Ltd. All rights reserved.
