The Experts below are selected from a list of 45 Experts worldwide ranked by ideXlab platform
Ma Yanhua - One of the best experts on this subject based on the ideXlab platform.
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Analysis of distribution and drug resistance of 310 fungus strains resulting in deep infections
Medical Journal of the Chinese People's Armed Police Forces, 2005Co-Authors: Ma YanhuaAbstract:Objective To investigate the distribution and the drug resistance of the fungi which cause deep infections.Methods The isolated fungi were identified with ID32C and drug susceptibility tests were conducted by using ATB FUNGUS.Results Totally 9 species were identified from 310 strains of deep fungi,predominantly Candida albicans.The total sensitivities of 310 strains to 5-fluorocytosine,amphotericin B,and Mycomycin were 90%,but lower to miconazole,econazole,and ketoconazole.Conclusions The dominant pathogenic fungi which cause deep infection are Candida albicans,Candida tropicalis and Candida.krusei.5-Fluorocytosine,amphotericin B useful and Mycomycin are most effective against the pathogenic fungi and remain to be the most drugs to treat deep infections.
Chen Dong-mei - One of the best experts on this subject based on the ideXlab platform.
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Analysis of the distribution and drug susceptibility of 371 fungi strains resulting in deep infections.
China Tropical Medicine, 2004Co-Authors: Chen Dong-meiAbstract:Objective To investigate the distribution and drug resistance situation of the fungi which caused deep part infection. Methods The isolated fungi were indentified with API 20C AUX and drug susceptibility tests was conducted by using ATB FUNGUS. Results 228 strains of Candida albicans, 73 strains of Candida tropicalis, 38 strains of Candida glabrata, 12 strains of Candida papasilosis, 6 strains of Candida famata, 3 strains of Cryptococcus neofermans, 3 strains of Candida inconspicua, 2 strains of Candida guilliermondii were isolated. The total sensitivity of 371 strains of fungi to 5-fluorocytosine, amphotericin B, Mycomycin, miconazole, econazole, ketoconazole were 92%,97%,96%,57%,63%,69%,respectively. Conclusion The dominant pathogenic fungi which caused deep part infection were Candida albicans, Candida tropicalis and Candida glabrata. Amphotericin B, Mycomycin and 5-fluorocytosine were most sensitive to the pathogenic fungi and remain to be the most effective drug to cure deep part infection.
Guy T. Carter - One of the best experts on this subject based on the ideXlab platform.
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Isolation, characterization and structure of a new allenic polyine antibiotic produced by fungus LL-07F275.
The Journal of Antibiotics, 1995Co-Authors: Gerhard Schlingmann, Lisa Milne, Cedric J. Pearce, Donald B. Borders, Michael Greenstein, William M. Maiese, Guy T. CarterAbstract:Antibiotic 07F275 (1), produced by submerged fermentations of fungal culture LL-07F275, was isolated and characterized despite its inherent instability. Its UV spectrum was identical with that of nemotin, a member of the allenic polyacetylene family, but a molecular weight of 218 daltons indicated a new compound. Structure 1 was determined on the basis of spectroscopic evidence, particularly NMR. Since 1 is a thirteen carbon-containing allenic diyne, it is closely related to Mycomycin.
Gerhard Schlingmann - One of the best experts on this subject based on the ideXlab platform.
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Isolation, characterization and structure of a new allenic polyine antibiotic produced by fungus LL-07F275.
The Journal of Antibiotics, 1995Co-Authors: Gerhard Schlingmann, Lisa Milne, Cedric J. Pearce, Donald B. Borders, Michael Greenstein, William M. Maiese, Guy T. CarterAbstract:Antibiotic 07F275 (1), produced by submerged fermentations of fungal culture LL-07F275, was isolated and characterized despite its inherent instability. Its UV spectrum was identical with that of nemotin, a member of the allenic polyacetylene family, but a molecular weight of 218 daltons indicated a new compound. Structure 1 was determined on the basis of spectroscopic evidence, particularly NMR. Since 1 is a thirteen carbon-containing allenic diyne, it is closely related to Mycomycin.
Harry F Noller - One of the best experts on this subject based on the ideXlab platform.
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interaction of antibiotics with a and p site specific bases in 16s ribosomal rna
The EMBO Journal, 1991Co-Authors: J Woodcock, Danesh Moazed, Michael Cannon, J Davies, Harry F NollerAbstract:We have studied the interactions of the antibiotics apramycin, kasugamycin, myomycin, neamine and pactamycin with 16S rRNA by chemical probing of drug-ribosome complexes. Kasugamycin and pactamycin, which are believed to affect translational initiation, protect bases in common with P-site-bound tRNA. While kasugamycin protects A794 and G926, and causes enhanced reactivity of C795, pactamycin protects G693 and C795. All four of these bases were previously shown to be protected by P-site tRNA or by edeine, another P-site inhibitor. Apramycin and neamine, which both induce miscoding and inhibit translocation, protect A1408, G1419 and G1494, as was also found earlier for neomycin, gentamicin, kanamycin and paromomycin. A1408 and G1494 were previously shown to be protected by A-site tRNA. Surprisingly, myomycin fails to give strong protection of any bases in 16S rRNA, in spite of having an apparently identical target site and mode of action to streptomycin, which protects several bases in the 915 region. Instead, myomycin gives only weak protection of A1408. These results suggest that the binding site(s) of streptomycin and myomycin have yet to be identified.
