The Experts below are selected from a list of 237 Experts worldwide ranked by ideXlab platform
Henry E. Ekperigin - One of the best experts on this subject based on the ideXlab platform.
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Mycotoxicosis in Food Producing Animals
The Veterinary clinics of North America. Food animal practice, 1999Co-Authors: Katherine Hollinger, Henry E. EkperiginAbstract:Mycotoxins are toxic secondary metabolites of fungi. Diseases caused by mycotoxins are collectively referred to as Mycotoxicosis. Disease is usually initiated after ingestion of feeds containing toxic doses of mycotoxins. Signs and symptoms vary and depend on the animal, the organ system involved, and on the dose and type of mycotoxins ingested. The symptoms can range from acute death, immunosuppression to skin lesions or to signs of hepatotoxicity, nephrotoxicity, neurotoxicity, or genotoxicity. In addition to concerns over adverse effects of mycotoxins on food animals consuming mycotoxin-contaminated feeds, there is also a public health concern over the potential for human beings to consume animal-derived food products such as meat, milk, or eggs, containing residues of those mycotoxins or their metabolites.
Zhou Hong-cha - One of the best experts on this subject based on the ideXlab platform.
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Expression of p53and NF-κB of ovaries in SD rats with zearalenone Mycotoxicosis
Chinese journal of veterinary science, 2013Co-Authors: Zhou Hong-chaAbstract:The objective of this study was to determine the expression of p53and NF-κB in the ovaries of SD rats exposed to zearalenone(ZEA).Ten-week-old SD rats which were used to determine the expression of p53and NF-κB were treated with 5mg/kg i.p.of ZEA and euthanized at 3,6,12,24,48,72and 96hafter treatment.Histopathologically,ovarian follicles were affected selectively and apotosis cell were found in granular layer in ovarian follicle.Immunohistochemic analysis revealed the expression of p53and NF-κB in experiment groups and control groups,with dynamic changes over time.p53expression increased at 3,6,12hand reduced after 12hof treatment compared to control groups(P0.05).In all test group,NF-κB increased at 3hand reduced after 3h,compared to control groups(P0.05).Zearalenone Mycotoxicosis induced ovarian follicles damage and granulosa cell apotosis in rats.p53and NF-κB lay an important role in apoptosis of granulosa cells in the rats with zearalenone Mycotoxicosis.
David C. Thut - One of the best experts on this subject based on the ideXlab platform.
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Hypovolemic shock in acute lethal T-2 Mycotoxicosis.
Toxicology and applied pharmacology, 1991Co-Authors: Herbert L. Borison, Mary L. Goodheart, David C. ThutAbstract:Experiments were performed on pentobarbital-anesthetized cats to test the hypothesis that hypovolemia rather than cardiac failure is responsible for the acute lethal toxicity of the trichothecene mycotoxin, T-2 toxin (T2T). Measurements were made on mean arterial blood pressure (MAP), arterial pulse pressure (PP), and heart rate (HR) in eight otherwise untreated cats given T2T (2 mg/kg iv) and in three cats similarly injected with T2T but then transfused with plasma and blood. The transfusions to their available extent significantly delayed or counteracted the development of mycotoxic shock (i.e., depressed MAP and PP) and prevented or reversed a rise in the hematocrit. HR remained stable under all conditions. Plasmapheresis followed by whole-blood removal was found best to simulate mechanistically the mycotoxic shock syndrome in six blood donor cats free of T2T. It is concluded that hypovolemia with polycythemia resulting from plasma leakage and internal bleeding accounts for acute lethal T-2 Mycotoxicosis.
Li Yin-qian - One of the best experts on this subject based on the ideXlab platform.
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Expression of Bax and Bcl-2 Mycotoxicosis of ovaries in SD rats exposured zearalenone
Chinese journal of veterinary science, 2012Co-Authors: Li Yin-qianAbstract:Ten-week-old SD rats were treated with a single dosage intraperitoneal injection of zearalenone(ZEA)(5 mg/kg),and then the rats were euthanized to isolate the ovary tissues at 3,6,12,24 and 48 h after treatment,respectively.Immunohistochemistry method was used to determine the expression of Bax and Bcl-2 in ovary tissues of rats.Histopathological observation found that ovarian tissues have different degree damages and apoptosis cells were observed in granular layer of ovarian follicle.SP analysis showed that the Bcl-2 and Bax were expressed,and presented dynamic changes as time went on in both groups and control group.The expression of Bax in the groups of 3,6 and 12 h after treat ment with ZEA showed a significantly increase compared with the control group(P0.05),while the expression decreased by degrees after treated with ZEA in the groups of 24 and 48 h.The expression of Bcl-2 showed there was no statistical difference compared with control group.ZEA Mycotoxicosis can result in the damage of ovarian follicles and apoptosis of granulosa cells in rats.Bcl-2 and Bax play an important role in apoptosis of granulosa cells in the rats with ZEA Mycotoxicosis.
Katherine Hollinger - One of the best experts on this subject based on the ideXlab platform.
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Mycotoxicosis in Food Producing Animals
The Veterinary clinics of North America. Food animal practice, 1999Co-Authors: Katherine Hollinger, Henry E. EkperiginAbstract:Mycotoxins are toxic secondary metabolites of fungi. Diseases caused by mycotoxins are collectively referred to as Mycotoxicosis. Disease is usually initiated after ingestion of feeds containing toxic doses of mycotoxins. Signs and symptoms vary and depend on the animal, the organ system involved, and on the dose and type of mycotoxins ingested. The symptoms can range from acute death, immunosuppression to skin lesions or to signs of hepatotoxicity, nephrotoxicity, neurotoxicity, or genotoxicity. In addition to concerns over adverse effects of mycotoxins on food animals consuming mycotoxin-contaminated feeds, there is also a public health concern over the potential for human beings to consume animal-derived food products such as meat, milk, or eggs, containing residues of those mycotoxins or their metabolites.
