The Experts below are selected from a list of 75696 Experts worldwide ranked by ideXlab platform
Shigeru Fujita - One of the best experts on this subject based on the ideXlab platform.
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A case of Weber–Christian disease associated with Myelodysplastic Syndrome
Modern Rheumatology, 2004Co-Authors: Nobumasa Hojo, Hitoshi Hasegawa, Kikue Iwamasa, Satoko Hojo, Shigeru FujitaAbstract:We report the case of a 73-year-old man with Myelodysplastic Syndrome (MDS) who developed Weber–Christian disease (WCD). Bone marrow aspirates showed refractory anemia with abnormal karyotypes such as trisomy 8, trisomy 8 and 14, and trisomy 8, 9, and 14. The patient had intermittent fever associated with multiple tender erythematous nodules on the skin. A biopsy sample taken from a nodule revealed focal subcutaneous infiltration of neutrophils and necrotizing fat tissue. We diagnosed the patient as having lobular panniculitis associated with Myelodysplastic Syndrome. The serum levels of soluble interleukin-2 (IL-2) receptor, interferon-Γ, IL-1-Β, IL-6 and tumor necrosis factor-Α were elevated in the active state but returned to normal after prednisolone therapy. This finding appears to implicate a T-cell immune response in the pathogenesis of Weber–Christian disease.
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A case of Weber-Christian disease associated with Myelodysplastic Syndrome.
Modern rheumatology, 2004Co-Authors: Nobumasa Hojo, Hitoshi Hasegawa, Kikue Iwamasa, Satoko Hojo, Shigeru FujitaAbstract:We report the case of a 73-year-old man with Myelodysplastic Syndrome (MDS) who developed Weber–Christian disease (WCD). Bone marrow aspirates showed refractory anemia with abnormal karyotypes such as trisomy 8, trisomy 8 and 14, and trisomy 8, 9, and 14. The patient had intermittent fever associated with multiple tender erythematous nodules on the skin. A biopsy sample taken from a nodule revealed focal subcutaneous infiltration of neutrophils and necrotizing fat tissue. We diagnosed the patient as having lobular panniculitis associated with Myelodysplastic Syndrome. The serum levels of soluble interleukin-2 (IL-2) receptor, interferon-Γ, IL-1-Β, IL-6 and tumor necrosis factor-Α were elevated in the active state but returned to normal after prednisolone therapy. This finding appears to implicate a T-cell immune response in the pathogenesis of Weber–Christian disease.
Nobumasa Hojo - One of the best experts on this subject based on the ideXlab platform.
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A case of Weber–Christian disease associated with Myelodysplastic Syndrome
Modern Rheumatology, 2004Co-Authors: Nobumasa Hojo, Hitoshi Hasegawa, Kikue Iwamasa, Satoko Hojo, Shigeru FujitaAbstract:We report the case of a 73-year-old man with Myelodysplastic Syndrome (MDS) who developed Weber–Christian disease (WCD). Bone marrow aspirates showed refractory anemia with abnormal karyotypes such as trisomy 8, trisomy 8 and 14, and trisomy 8, 9, and 14. The patient had intermittent fever associated with multiple tender erythematous nodules on the skin. A biopsy sample taken from a nodule revealed focal subcutaneous infiltration of neutrophils and necrotizing fat tissue. We diagnosed the patient as having lobular panniculitis associated with Myelodysplastic Syndrome. The serum levels of soluble interleukin-2 (IL-2) receptor, interferon-Γ, IL-1-Β, IL-6 and tumor necrosis factor-Α were elevated in the active state but returned to normal after prednisolone therapy. This finding appears to implicate a T-cell immune response in the pathogenesis of Weber–Christian disease.
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A case of Weber-Christian disease associated with Myelodysplastic Syndrome.
Modern rheumatology, 2004Co-Authors: Nobumasa Hojo, Hitoshi Hasegawa, Kikue Iwamasa, Satoko Hojo, Shigeru FujitaAbstract:We report the case of a 73-year-old man with Myelodysplastic Syndrome (MDS) who developed Weber–Christian disease (WCD). Bone marrow aspirates showed refractory anemia with abnormal karyotypes such as trisomy 8, trisomy 8 and 14, and trisomy 8, 9, and 14. The patient had intermittent fever associated with multiple tender erythematous nodules on the skin. A biopsy sample taken from a nodule revealed focal subcutaneous infiltration of neutrophils and necrotizing fat tissue. We diagnosed the patient as having lobular panniculitis associated with Myelodysplastic Syndrome. The serum levels of soluble interleukin-2 (IL-2) receptor, interferon-Γ, IL-1-Β, IL-6 and tumor necrosis factor-Α were elevated in the active state but returned to normal after prednisolone therapy. This finding appears to implicate a T-cell immune response in the pathogenesis of Weber–Christian disease.
Per Ljungman - One of the best experts on this subject based on the ideXlab platform.
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Risk factors for therapy-related Myelodysplastic Syndrome and acute myeloid leukemia treated with allogeneic stem cell transplantation
Haematologica, 2009Co-Authors: Nicolaus Kröger, Axel Zander, Judith Dierlamm, Anja Van Biezen, Jacqueline Cornish, Agnès Devergie, Tapani Ruutu, Dietger Niederwieser, Ronald Brand, Per LjungmanAbstract:BACKGROUND: After successful treatment of malignant diseases, therapy-related Myelodysplastic Syndrome and acute myeloid leukemia have emerged as significant problems. DESIGN AND METHODS: The aim of this study was to investigate outcome and risk factors in patients with therapy-related Myelodysplastic Syndrome or acute myeloid leukemia who underwent allogeneic stem cell transplantation. Between 1981 and 2006, 461 patients with therapy-related Myelodysplastic Syndrome or acute myeloid, a median age of 40 years and a history of solid tumor (n=163), malignant lymphoma (n=133), or other hematologic diseases (n=57) underwent stem cell transplantation and their data were reported to the European Group for Blood and Marrow Transplantation. RESULTS: The cumulative incidence of non-relapse mortality and relapse at 3 years was 37% and 31%, respectively. In a multivariate analysis significant factors for relapse were not being in complete remission at the time of transplantation (p=0.002), abnormal cytogenetics (p=0.005), higher patients' age (p=0.03) and therapy-related Myelodysplastic Syndrome (p=0.04), while higher non-relapse mortality was influenced by higher patients' age. Furthermore, there was a marked reduction in non-relapse mortality per calendar year during the study period (p
Satoko Hojo - One of the best experts on this subject based on the ideXlab platform.
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A case of Weber–Christian disease associated with Myelodysplastic Syndrome
Modern Rheumatology, 2004Co-Authors: Nobumasa Hojo, Hitoshi Hasegawa, Kikue Iwamasa, Satoko Hojo, Shigeru FujitaAbstract:We report the case of a 73-year-old man with Myelodysplastic Syndrome (MDS) who developed Weber–Christian disease (WCD). Bone marrow aspirates showed refractory anemia with abnormal karyotypes such as trisomy 8, trisomy 8 and 14, and trisomy 8, 9, and 14. The patient had intermittent fever associated with multiple tender erythematous nodules on the skin. A biopsy sample taken from a nodule revealed focal subcutaneous infiltration of neutrophils and necrotizing fat tissue. We diagnosed the patient as having lobular panniculitis associated with Myelodysplastic Syndrome. The serum levels of soluble interleukin-2 (IL-2) receptor, interferon-Γ, IL-1-Β, IL-6 and tumor necrosis factor-Α were elevated in the active state but returned to normal after prednisolone therapy. This finding appears to implicate a T-cell immune response in the pathogenesis of Weber–Christian disease.
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A case of Weber-Christian disease associated with Myelodysplastic Syndrome.
Modern rheumatology, 2004Co-Authors: Nobumasa Hojo, Hitoshi Hasegawa, Kikue Iwamasa, Satoko Hojo, Shigeru FujitaAbstract:We report the case of a 73-year-old man with Myelodysplastic Syndrome (MDS) who developed Weber–Christian disease (WCD). Bone marrow aspirates showed refractory anemia with abnormal karyotypes such as trisomy 8, trisomy 8 and 14, and trisomy 8, 9, and 14. The patient had intermittent fever associated with multiple tender erythematous nodules on the skin. A biopsy sample taken from a nodule revealed focal subcutaneous infiltration of neutrophils and necrotizing fat tissue. We diagnosed the patient as having lobular panniculitis associated with Myelodysplastic Syndrome. The serum levels of soluble interleukin-2 (IL-2) receptor, interferon-Γ, IL-1-Β, IL-6 and tumor necrosis factor-Α were elevated in the active state but returned to normal after prednisolone therapy. This finding appears to implicate a T-cell immune response in the pathogenesis of Weber–Christian disease.
Kikue Iwamasa - One of the best experts on this subject based on the ideXlab platform.
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A case of Weber–Christian disease associated with Myelodysplastic Syndrome
Modern Rheumatology, 2004Co-Authors: Nobumasa Hojo, Hitoshi Hasegawa, Kikue Iwamasa, Satoko Hojo, Shigeru FujitaAbstract:We report the case of a 73-year-old man with Myelodysplastic Syndrome (MDS) who developed Weber–Christian disease (WCD). Bone marrow aspirates showed refractory anemia with abnormal karyotypes such as trisomy 8, trisomy 8 and 14, and trisomy 8, 9, and 14. The patient had intermittent fever associated with multiple tender erythematous nodules on the skin. A biopsy sample taken from a nodule revealed focal subcutaneous infiltration of neutrophils and necrotizing fat tissue. We diagnosed the patient as having lobular panniculitis associated with Myelodysplastic Syndrome. The serum levels of soluble interleukin-2 (IL-2) receptor, interferon-Γ, IL-1-Β, IL-6 and tumor necrosis factor-Α were elevated in the active state but returned to normal after prednisolone therapy. This finding appears to implicate a T-cell immune response in the pathogenesis of Weber–Christian disease.
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A case of Weber-Christian disease associated with Myelodysplastic Syndrome.
Modern rheumatology, 2004Co-Authors: Nobumasa Hojo, Hitoshi Hasegawa, Kikue Iwamasa, Satoko Hojo, Shigeru FujitaAbstract:We report the case of a 73-year-old man with Myelodysplastic Syndrome (MDS) who developed Weber–Christian disease (WCD). Bone marrow aspirates showed refractory anemia with abnormal karyotypes such as trisomy 8, trisomy 8 and 14, and trisomy 8, 9, and 14. The patient had intermittent fever associated with multiple tender erythematous nodules on the skin. A biopsy sample taken from a nodule revealed focal subcutaneous infiltration of neutrophils and necrotizing fat tissue. We diagnosed the patient as having lobular panniculitis associated with Myelodysplastic Syndrome. The serum levels of soluble interleukin-2 (IL-2) receptor, interferon-Γ, IL-1-Β, IL-6 and tumor necrosis factor-Α were elevated in the active state but returned to normal after prednisolone therapy. This finding appears to implicate a T-cell immune response in the pathogenesis of Weber–Christian disease.
