The Experts below are selected from a list of 2400 Experts worldwide ranked by ideXlab platform
Jeffrey L Medeiros - One of the best experts on this subject based on the ideXlab platform.
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optimized immunohistochemical panel to differentiate Myeloid Sarcoma from blastic plasmacytoid dendritic cell neoplasm
Modern Pathology, 2014Co-Authors: Nikhil A Sangle, Jeffrey L Medeiros, Robert L Schmidt, Jay L Patel, Archana M Agarwal, Sherrie L Perkins, Mohamed E SalamaAbstract:Optimized immunohistochemical panel to differentiate Myeloid Sarcoma from blastic plasmacytoid dendritic cell neoplasm
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Myeloid Sarcoma of the head and neck region
Archives of Pathology & Laboratory Medicine, 2013Co-Authors: Jane Zhou, Diana Bell, Jeffrey L MedeirosAbstract:Context.—Myeloid Sarcoma of the head and neck region can pose diagnostic challenges because of the low frequency of Myeloid Sarcoma and the potential for tumors of almost any lineage to occur in th...
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Myeloid Sarcoma involving the gynecologic tract
American Journal of Clinical Pathology, 2006Co-Authors: Mar Garcia, Michael T Deavers, Ronald J Knoblock, Weina Chen, Apostolia Maria Tsimberidou, John T Manning, Jeffrey L MedeirosAbstract:Myeloid Sarcoma can involve any anatomic site, but involvement of the gynecologic tract is uncommon. We describe 11 women, 17 to 60 years old, with Myeloid Sarcoma involving the gynecologic tract, including 5 patients in whom Myeloid Sarcoma presented as an isolated mass. The uterus was the most frequently involved anatomic site, in 8 patients (5 corpus, 3 cervix). Each neoplasm diffusely infiltrated normal structures, and, cytologically 7 tumors were immature, 3 were differentiated, and 1 was blastic. In 9 cases assessed, immunohistochemical stains showed that all neoplasms were positive for myeloperoxidase and lysozyme; CD117 was positive in 7 of 8 cases, and cytochemical staining for naphthol AS-D chloroacetate was positive in all 6 neoplasms analyzed. Following chemotherapy, complete remission and long-term survival were achieved in a subset of patients, as was particularly true for 2 patients (cases 8 and 10), with complete remission 12.5 and 31 years after diagnosis, respectively.
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Myeloid Sarcoma involving the gynecologic tract a report of 11 cases and review of the literature
American Journal of Clinical Pathology, 2006Co-Authors: Mar Garcia, Michael T Deavers, Ronald J Knoblock, Weina Chen, Apostolia Maria Tsimberidou, John T Manning, Jeffrey L MedeirosAbstract:Myeloid Sarcoma can involve any anatomic site, but involvement of the gynecologic tract is uncommon. We describe 11 women, 17 to 60 years old, with Myeloid Sarcoma involving the gynecologic tract, including 5 patients in whom Myeloid Sarcoma presented as an isolated mass. The uterus was the most frequently involved anatomic site, in 8 patients (5 corpus, 3 cervix). Each neoplasm diffusely infiltrated normal structures, and, cytologically 7 tumors were immature, 3 were differentiated, and 1 was blastic. In 9 cases assessed, immunohistochemical stains showed that all neoplasms were positive for myeloperoxidase and lysozyme; CD117 was positive in 7 of 8 cases, and cytochemical staining for naphthol AS-D chloroacetate was positive in all 6 neoplasms analyzed. Following chemotherapy, complete remission and long-term survival were achieved in a subset of patients, as was particularly true for 2 patients (cases 8 and 10), with complete remission 12.5 and 31 years after diagnosis, respectively. Myeloid Sarcoma is a tumor of myeloblasts or immature Myeloid cells involving an extramedullary anatomic site. 1 These neoplasms are known by a variety of other names in the literature, including granulocytic Sarcoma, monocytic Sarcoma, extramedullary Myeloid cell tumor, myeloblastoma, and chloroma. 1-4 Most often, Myeloid Sarcoma occurs in a patient with a history of acute Myeloid leukemia (AML) or in association with an antecedent myeloproliferative disorder or myelodysplastic syndrome. Less commonly, Myeloid Sarcoma can manifest initially as an isolated mass; in many of these
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Myeloid Sarcoma of appendix mimicking acute appendicitis
Archives of Pathology & Laboratory Medicine, 2005Co-Authors: Eugenio Americo Palominoportilla, Jose R. Valbuena, Maria Del Pilar Quinonesavila, Jeffrey L MedeirosAbstract:CONTEXT: Myeloid Sarcoma is a neoplasm of immature Myeloid cells involving an extramedullary anatomic site that is usually, although not always, associated with acute Myeloid leukemia. Any extramedullary site can be involved by Myeloid Sarcoma, but involvement of the cecal appendix is uncommon, and symptoms mimicking acute appendicitis as a result of appendiceal involvement are rare. OBJECTIVE: To describe the clinicopathologic features of 2 patients with Myeloid Sarcoma involving the appendix who presented with right lower quadrant pain suggestive of acute appendicitis and prompting appendectomy. DESIGN: Clinical information for both patients was obtained from the medical record. Routine hematoxylin-eosin-stained slides, naphthol-ASD-chloroacetate stain, and immunohistochemical stains for Myeloid, B-cell, and T-cell antigens were prepared. RESULTS: Peripheral blood and bone marrow were infiltrated by coexistent acute Myeloid leukemia in case 1 but were negative for leukemia in case 2. In case 2, the patient had a history of acute Myeloid leukemia that had been treated by an allogenic bone marrow transplant 7 months earlier. Histologic examination of the appendix revealed poorly differentiated Myeloid Sarcoma in both cases. Each neoplasm was positive for chloroacetate esterase, myeloperoxidase, lysozyme, and CD43 and was negative for CD3 and CD20. CONCLUSIONS: Myeloid Sarcoma involving the appendix can rarely cause pain or other symptoms mimicking acute appendicitis. A high index of suspicion combined with the use of cytochemical and immunohistochemical studies are helpful in establishing the diagnosis.
Fang Li - One of the best experts on this subject based on the ideXlab platform.
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fdg pet ct findings of intracardiac Myeloid Sarcoma
Clinical Nuclear Medicine, 2016Co-Authors: Fang LiAbstract:: Myeloid Sarcoma is a rare entity, and cardiac involvement is even rarer. We presented here the FDG PET/CT findings of a 66-year-old man with a 3-month history of cough and progressive dyspnea. FDG PET/CT scan demonstrated nonuniform FDG uptake in the cardiac walls and pericardium. Biopsy of the heart revealed Myeloid Sarcoma. In addition, bone marrow biopsy demonstrated the acute Myeloid leukemia.
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FDG PET/CT Findings of Intracardiac Myeloid Sarcoma.
Clinical Nuclear Medicine, 2016Co-Authors: Fang LiAbstract:: Myeloid Sarcoma is a rare entity, and cardiac involvement is even rarer. We presented here the FDG PET/CT findings of a 66-year-old man with a 3-month history of cough and progressive dyspnea. FDG PET/CT scan demonstrated nonuniform FDG uptake in the cardiac walls and pericardium. Biopsy of the heart revealed Myeloid Sarcoma. In addition, bone marrow biopsy demonstrated the acute Myeloid leukemia.
Jane Zhou - One of the best experts on this subject based on the ideXlab platform.
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Myeloid Sarcoma of the head and neck region
Archives of Pathology & Laboratory Medicine, 2013Co-Authors: Jane Zhou, Diana Bell, Jeffrey L MedeirosAbstract:Context.—Myeloid Sarcoma of the head and neck region can pose diagnostic challenges because of the low frequency of Myeloid Sarcoma and the potential for tumors of almost any lineage to occur in th...
Diana Bell - One of the best experts on this subject based on the ideXlab platform.
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Myeloid Sarcoma of the head and neck region
Archives of Pathology & Laboratory Medicine, 2013Co-Authors: Jane Zhou, Diana Bell, Jeffrey L MedeirosAbstract:Context.—Myeloid Sarcoma of the head and neck region can pose diagnostic challenges because of the low frequency of Myeloid Sarcoma and the potential for tumors of almost any lineage to occur in th...
Andrew P Lieberman - One of the best experts on this subject based on the ideXlab platform.
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aggressive Myeloid Sarcoma causing recurrent spinal cord compression
World Neurosurgery, 2015Co-Authors: Jacob R Joseph, Andrew P Lieberman, Andrew D Wilkinson, Nathanael G Bailey, C Tsien, Daniel A OrringerAbstract:Objective Myeloid Sarcoma is a rare extramedullary solid tumor comprised of immature Myeloid precursor cells, most commonly associated with acute myelogenous leukemia (AML). We present the case of a patient with a history of Shwachman-Diamond syndrome and AML who presented with Myeloid Sarcoma causing acute spinal cord compression. Case Description The patient was a 20-year-old man who presented with acute onset weakness and numbness in his lower extremities. Magnetic resonance imaging revealed a thoracic dorsal epidural mass. Despite the history of AML, we elected to forego image-guided biopsy and up-front radiation due to the rapidly progressive nature of his myelopathy. Immediate surgical decompression was performed, but the patient had recurrence of tumor leading to further compression 13 days postoperatively. Subsequently, emergent radiation was performed, leading to resolution of cord compression and local disease control. Conclusions To our knowledge, there are no randomized controlled trials examining the appropriate timing for postoperative radiation. Because most typical neuro-oncologic cases have no need for immediate postoperative radiation, our practice has been to wait 14 days to initiate postoperative radiation to ensure wound healing. One unique feature of our case was the rapid recurrence of symptoms due to tumor progression. Given this observation, we believe that radiation therapy should be considered as soon as possible after confirmatory pathology diagnosis for patients presenting with neurological compromise due to Myeloid Sarcoma of the spine.
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pineal region Myeloid Sarcoma
Journal of Clinical Neuroscience, 2012Co-Authors: Thomas J Wilson, Khoi D Than, Hemant Parmar, Andrew P Lieberman, Juan Valdivia, Stephen E SullivanAbstract:The overwhelming majority of pineal region tumors are malignant germ cell tumors, pineal cell tumors, or glial tumors. To our knowledge we report the first patient with Myeloid Sarcoma in the pineal region. Myeloid Sarcomas are composed of immature granulocytic precursor cells and are associated with acute myelogenous leukemia. Thus, Myeloid Sarcoma should be considered in the differential diagnosis of pineal region masses in patients with a known history of acute myelogenous leukemia.
