The Experts below are selected from a list of 27 Experts worldwide ranked by ideXlab platform
Frederic Shapiro - One of the best experts on this subject based on the ideXlab platform.
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Osteopetrosis. Current clinical considerations.
Clinical orthopaedics and related research, 1993Co-Authors: Frederic ShapiroAbstract:Osteopetrosis is an inherited skeletal condition characterized by increased bone radiodensity. There are three clinical groups: infantile-malignant autosomal recessive, fatal within the first few years of life (in the absence of effective therapy); intermediate autosomal recessive, appears during the first decade of life but does not follow a malignant course; and autosomal dominant, with full-life expectancy but many orthopaedic problems. The infantile variant shows a Myelophthisic Anemia, granulocytopenia, and thrombocytopenia, and patients eventually die from infection or bleeding or both. Neurologic sequelae include cranial nerve compression (optic nerve, blindness; auditory nerve, deafness; facial nerve, paresis), hydrocephalus, convulsions, and mental retardation. Radiographs show uniform bone density without corticomedulary demarcation, broadened metaphyses, "bone within a bone" or endobone phenomena (tarsals, carpals, phalanges, vertebra, ilium), and thickened growth plates if there is superimposed rickets. Transverse pathologic fractures occur, often followed by massive periosteal bone formation. Computed tomographic scans, magnetic resonance imaging, and bone scans provide specific information. Iliac crest bone biopsy is valuable to quantitate osteoclast and marrow changes by light and electron microscopy. Medical treatments involve high-dose calcitriol to stimulate osteoclast differentiation and bone marrow transplantation to provide monocytic osteoclast precursors. Orthopaedic problems in the intermediate and autosomal dominant forms include increased fractures, coxa vara, long-bone bowing, hip and knee degenerative arthritis, and mandibular and long-bone osteomyelitis. Cranial nerve compression also occurs. Osteotomy, plating, intramedullary rodding, and joint arthroplasty can be done, but are difficult because of bone hardness.
Catherine L Kowalewski - One of the best experts on this subject based on the ideXlab platform.
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case of metastatic basal cell carcinoma to bone marrow resulting in Myelophthisic Anemia
American Journal of Dermatopathology, 2013Co-Authors: Catherine M Pham, Almas A Syed, Huma Siddiqui, Richard A Keller, Catherine L KowalewskiAbstract:Background: While basal cell carcinoma (BCC) remains the most common skin cancer, the incidence of metastasis is rare. Most cases of metastatic BCC have been to regional lymph nodes. Metastasis to bone marrow with Myelophthisic Anemia is especially rare. To our knowledge, there have been only 5 reported cases in literature. We report a sixth case. Observations: A 46-year-old male patient presented with an 8 × 7-cm ulcerated plaque on his chest, found to be morpheaform basal cell on pathology. Laboratory findings were notable for normocytic Anemia, thrombocytopenia, and elevated LDH. Further work up with bone marrow biopsy revealed tumor cells staining positive for CK AE1/AE3, BerEP4, CK7, CD56, and PIN-4. This confirmed the diagnosis of metastatic BCC (MBCC) to bone marrow. Conclusions: Although the rate of metastasis for BCC is rare, once it occurs, prognosis is poor. MBCC remains a challenge to treat. Therefore, it is critical to resolve the primary BCC and obtain vigilant follow-up, especially in patients with multiple risk factors for MBCC.
Catherine M Pham - One of the best experts on this subject based on the ideXlab platform.
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case of metastatic basal cell carcinoma to bone marrow resulting in Myelophthisic Anemia
American Journal of Dermatopathology, 2013Co-Authors: Catherine M Pham, Almas A Syed, Huma Siddiqui, Richard A Keller, Catherine L KowalewskiAbstract:Background: While basal cell carcinoma (BCC) remains the most common skin cancer, the incidence of metastasis is rare. Most cases of metastatic BCC have been to regional lymph nodes. Metastasis to bone marrow with Myelophthisic Anemia is especially rare. To our knowledge, there have been only 5 reported cases in literature. We report a sixth case. Observations: A 46-year-old male patient presented with an 8 × 7-cm ulcerated plaque on his chest, found to be morpheaform basal cell on pathology. Laboratory findings were notable for normocytic Anemia, thrombocytopenia, and elevated LDH. Further work up with bone marrow biopsy revealed tumor cells staining positive for CK AE1/AE3, BerEP4, CK7, CD56, and PIN-4. This confirmed the diagnosis of metastatic BCC (MBCC) to bone marrow. Conclusions: Although the rate of metastasis for BCC is rare, once it occurs, prognosis is poor. MBCC remains a challenge to treat. Therefore, it is critical to resolve the primary BCC and obtain vigilant follow-up, especially in patients with multiple risk factors for MBCC.
Kapoor S - One of the best experts on this subject based on the ideXlab platform.
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Osteopetrosis: A rare cause of Anemia - Review of literature
Wolters Kluwer Medknow Publications, 2009Co-Authors: Saluja S, Bhandari S, Aggarwal S, Kapoor SAbstract:Normocytic anaemia is caused either by hypoproliferation of haemopoietic tissue or increased destruction of red cell. Osteopetrosis is a rare cause of anaemia. The leading clinical features are pallor, growth failure, hepatosplenomegaly.On hematological examination, Anemia, thrombocytopenia, leucocytosis and Myelophthisic Anemia are commonly observed in this disease. We are highlighting osteopetrosis as a rare cause of Anemia presenting to us for evaluation of anemi
Elizabeth Guevara - One of the best experts on this subject based on the ideXlab platform.
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Myelophthisic Anemia in a patient with lobular breast carcinoma metastasized to the bone marrow
Cureus, 2018Co-Authors: Muhammad H Khan, Abdurraoof Patel, Purav Patel, Poras Patel, Elizabeth GuevaraAbstract:Breast tumors have a predilection for metastasizing to the bone leading to cells being displaced by the cancer cells subsequently producing immature leukocytes and erythrocytes in the peripheral blood. We present a case of a 57-year-old female who was found to have Myelophthisic Anemia secondary to stage four lobular breast carcinoma metastasized to the bone marrow after being misdiagnosed as having thrombotic thrombocytopenia purpura. Diagnosis of Myelophthisic Anemia requires a thorough workup and treatment is based upon secondary management of the malignancy.
