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José Roberto Lambertucci - One of the best experts on this subject based on the ideXlab platform.
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Schistosoma mansoni granulomas in the skeletal striated muscles in the murine model of neuroschistosomiasis: histological findings.
Memorias do Instituto Oswaldo Cruz, 2020Co-Authors: Thiago Andre Alves Fidelis, Paulo Marcos Zech Coelho, Geraldo Brasileiro-filho, Patrícia Martins Parreiras, Neusa Araújo, Marco Vinícius Chaud, Denicezar Angelo Baldo, Nelson Brancaccio Dos Santos, José Roberto LambertucciAbstract:Schistosomiasis mansoni presents many clinical manifestations during migration of schistosomes in their hosts, including diarrhea, hepatomegaly, splenomegaly, liver abscesses, skinlesions, brain tumors and Myeloradiculopathy. No lesions have been reported in skeletal striated muscles due to schistosomiasis mansoni in the literature. This short communication reports the histopathological findings on skeletal musculature in a murine model of neuroeschistosomiasis mansoni. Lesions were found in the tongue, masseter muscle, buccinator muscle, digastric muscle and temporalis muscle. Worm recovery was carried out to confirm the infection. We describe here, for the first time in the literature, injuries in the skeletal musculature due to Schistosoma mansoni nfection.
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Morbidity of schistosomiasis mansoni in the state of
2016Co-Authors: Minas Gerais Brazil, Sílvio Roberto Sousa-pereira, Ra Costa Drummond, Luciana Cristina, Santos Silva, Ronaldo Santos Do Amaral, Carlos Maurício Antunes, José Roberto LambertucciAbstract:Myeloradiculopathy has been implemented in the state of Minas Gerais by the local Health Department. The state was divided in 28 regional health centers and the local representatives have been trained to identify and direct patients with hepatosplenic schistosomiasis and neuroschistosomiasis to a reference center in Belo Horizonte, the capital of the state of Minas Gerais. Seventy five patients with hepatosplenic schistosomiasis and 54 with schistoso-mal Myeloradiculopathy have been referred and examined in the reference center in a period of time of 3 years. Schistosomal Myeloradiculopathy should be emphasized because the number of cases reported is increasing rapidly and when timely diagnosed and treated, they respond promptly to treatment. Left untreated, they die or become invalid for life. In our view, the time has come for more active investigation of the different aspects of morbidity caused by schistosomiasis mansoni in Brazil. Key words: schistosomiasis- hepatosplenic schistosomiasis- neuroschistosomiasis- magnetic resonance imaging-Myeloradiculopathy It has been estimated that 4 to 6 million people are infected by Schistosoma mansoni in Brazil and that the states of Minas Gerais and Bahia concentrate 70 % of the cases. Based on two national surveys of schistosomiasi
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Frequency of clinical manifestations of 22 patients with schistosomal Myeloradiculopathy.
2016Co-Authors: Júlia Fonseca De Morais Caporali, Denise Utsch Gonçalves, Ludimila Labanca, Leonardo Dornas De Oliveira, Guilherme Vaz De Melo Trindade, Thiago De Almeida Pereira, Pedro Henrique Diniz Cunha, Marina Santos Falci Mourão, José Roberto LambertucciAbstract:Frequency of clinical manifestations of 22 patients with schistosomal Myeloradiculopathy.
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Frequency of affected spinal cord segment of patients with schistosomal Myeloradiculopathy.
2016Co-Authors: Júlia Fonseca De Morais Caporali, Denise Utsch Gonçalves, Ludimila Labanca, Leonardo Dornas De Oliveira, Guilherme Vaz De Melo Trindade, Thiago De Almeida Pereira, Pedro Henrique Diniz Cunha, Marina Santos Falci Mourão, José Roberto LambertucciAbstract:Frequency of affected spinal cord segment of patients with schistosomal Myeloradiculopathy.
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Characteristics of patients with schistosomal Myeloradiculopathy (SMR) compared to healthy controls.
2016Co-Authors: Júlia Fonseca De Morais Caporali, Denise Utsch Gonçalves, Ludimila Labanca, Leonardo Dornas De Oliveira, Guilherme Vaz De Melo Trindade, Thiago De Almeida Pereira, Pedro Henrique Diniz Cunha, Marina Santos Falci Mourão, José Roberto LambertucciAbstract:Characteristics of patients with schistosomal Myeloradiculopathy (SMR) compared to healthy controls.
Parag Sancheti - One of the best experts on this subject based on the ideXlab platform.
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Correlation between Preoperative Magnetic Resonance Imaging Signal Intensity Changes and Clinical Outcomes in Patients Surgically Treated for Cervical Myeloradiculopathy
Asian spine journal, 2017Co-Authors: Chaitanya Baban Chikhale, Ketan Khurjekar, Ashok Shyam, Parag SanchetiAbstract:STUDY DESIGN This was a single surgeon, single center-based retrospective study with prospective data collection. PURPOSE To assess the correlation between T2-weighted magnetic resonance imaging (MRI) signal intensity (SI) changes and factors such as age, duration of symptoms, baseline modified Japanese Orthopedic Association (mJOA) score and to determine its prognostic value in predicting recovery after surgery. OVERVIEW OF LITERATURE Whether intramedullary cord T2-weighted MRI SI changes can predict operative outcomes of cervical Myeloradiculopathy remains debatable, with only a few prospective studies analyzing the same. METHODS Forty-six consecutive patients who underwent cervical Myeloradiculopathy were included and were followed up for an average of 1 year. Preoperative T2-weighted MRI SI grading was performed for all patients. The correlation between MRI SI changes and age, duration of symptoms, preoperative mJOA score, and mJOA score at 1-year follow-up were analyzed. RESULTS Fifteen patients had single-level (21.73%) or double-level (10.86%) prolapsed discs; 54.34% had degenerative cervical spondylosis with canal stenosis or multilevel disc prolapse and 13.07% had ossified posterior longitudinal ligaments. The mean age was 56.17±9.53 years (range, 35-81 years). The mean baseline mJOA score was 10.83±2.58 (range, 6-16), which postoperatively improved to 13.59±2.28 (range, 8-17; p
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correlation between preoperative magnetic resonance imaging signal intensity changes and clinical outcomes in patients surgically treated for cervical Myeloradiculopathy
Asian Spine Journal, 2017Co-Authors: Chaitanya Baban Chikhale, Ketan Khurjekar, Ashok Shyam, Parag SanchetiAbstract:STUDY DESIGN This was a single surgeon, single center-based retrospective study with prospective data collection. PURPOSE To assess the correlation between T2-weighted magnetic resonance imaging (MRI) signal intensity (SI) changes and factors such as age, duration of symptoms, baseline modified Japanese Orthopedic Association (mJOA) score and to determine its prognostic value in predicting recovery after surgery. OVERVIEW OF LITERATURE Whether intramedullary cord T2-weighted MRI SI changes can predict operative outcomes of cervical Myeloradiculopathy remains debatable, with only a few prospective studies analyzing the same. METHODS Forty-six consecutive patients who underwent cervical Myeloradiculopathy were included and were followed up for an average of 1 year. Preoperative T2-weighted MRI SI grading was performed for all patients. The correlation between MRI SI changes and age, duration of symptoms, preoperative mJOA score, and mJOA score at 1-year follow-up were analyzed. RESULTS Fifteen patients had single-level (21.73%) or double-level (10.86%) prolapsed discs; 54.34% had degenerative cervical spondylosis with canal stenosis or multilevel disc prolapse and 13.07% had ossified posterior longitudinal ligaments. The mean age was 56.17±9.53 years (range, 35-81 years). The mean baseline mJOA score was 10.83±2.58 (range, 6-16), which postoperatively improved to 13.59±2.28 (range, 8-17; p<0.001). There was a statistically significant correlation between mJOA score at 1 year and MRI T2 SI grading (p=0.017). CONCLUSIONS Patients with longer symptom durations had high grades of intramedullary cord T2-weighted MRI SI changes. Age and preoperative neurological status were not significantly correlated with the existence of intramedullary cord SI changes. However, patients without or with mild and diffuse intramedullary cord T2-weighted MRI SI changes had better postoperative neurological recovery than those with sharp and focal SI changes.
N. V. Todd - One of the best experts on this subject based on the ideXlab platform.
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Cervical Myelopathy in Rheumatoid Arthritis
Neurology research international, 2011Co-Authors: N. Mukerji, N. V. ToddAbstract:Involvement of the cervical spine is common in rheumatoid arthritis. Clinical presentation can be variable, and symptoms may be due to neck pain or compressive Myeloradiculopathy. We discuss the pathology, grading systems, clinical presentation, indications for surgery and surgical management of cervical myelopathy related to rheumatoid arthritis in this paper. We describe our surgical technique and results. We recommend early consultation for surgical management when involvement of the cervical spine is suspected in rheumatoid arthritis. Even patients with advanced cervical myelopathy should be discussed for surgical treatment, since in our experience improvement in function after surgery is common.
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doi:10.1155/2011/153628 Review Article Cervical Myelopathy in Rheumatoid Arthritis
2011Co-Authors: N. Mukerji, N. V. ToddAbstract:License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Involvement of the cervical spine is common in rheumatoid arthritis. Clinical presentation can be variable, and symptoms may be due to neck pain or compressive Myeloradiculopathy. We discuss the pathology, grading systems, clinical presentation, indications for surgery and surgical management of cervical myelopathy related to rheumatoid arthritis in this paper. We describe our surgical technique and results. We recommend early consultation for surgical management when involvement of the cervical spine is suspected in rheumatoid arthritis. Even patients with advanced cervical myelopathy should be discussed for surgical treatment, since in our experience improvement in function after surgery is common. 1
Jennifer L. Lyons - One of the best experts on this subject based on the ideXlab platform.
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Myeloradiculopathy associated with chikungunya virus infection
Journal of neurovirology, 2015Co-Authors: Anna M. Bank, Ayush Batra, Rene A. Colorado, Jennifer L. LyonsAbstract:Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that is endemic to parts of Africa, South and Southeast Asia, and more recently the Caribbean. Patients typically present with fever, rash, and arthralgias, though neurologic symptoms, primarily encephalitis, have been described. We report the case of a 47-year-old woman who was clinically diagnosed with CHIKV while traveling in the Dominican Republic and presented 10 days later with left lower extremity weakness, a corresponding enhancing thoracic spinal cord lesion, and positive CHIKV serologies. She initially responded to corticosteroids, followed by relapsing symptoms and gradual clinical improvement. The time lapse between acute CHIKV infection and the onset of myelopathic sequelae suggests an immune-mediated phenomenon rather than direct activity of the virus itself. Chikungunya virus should be considered in the differential diagnosis of myelopathy in endemic areas. The progression of symptoms despite corticosteroid administration suggests more aggressive immunomodulatory therapies may be warranted at disease onset.
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Myeloradiculopathy associated with chikungunya virus infection (P6.301)
Neurology, 2015Co-Authors: Anna M. Bank, Ayush Batra, Rene A. Colorado, Jennifer L. LyonsAbstract:OBJECTIVE: To describe neurologic sequelae of chikungunya virus (CHIKV) infection. BACKGROUND: CHIKV is a mosquito-borne alphavirus that is endemic to parts of Africa, Southeast Asia, and more recently the Caribbean. Although patients typically present with fevers and joint pain, neurologic symptoms such as encephalitis can occur. Myeloradiculopathy has rarely been reported. DESIGN/METHODS: Case report. RESULTS: A 47-year-old woman experienced fevers, rash, and diarrhea while traveling in the Dominican Republic and was diagnosed with CHIKV disease clinically by a local physician. Ten days later she developed left leg weakness and decreased sensation below the umbilicus. She subsequently developed left hip flexion, knee extension, and knee flexion weakness, with minimal movement against gravity. Sensation was decreased in all modalities up to the T12 level. Reflexes were preserved. MRI demonstrated intramedullary enhancement dorsally from T12 to L1 spinal levels. Cerebrospinal fluid (CSF) studies showed 22 WBCs (90[percnt] lymphocytes), 2 RBCs, and elevated protein to 68 mg/dL. Serum CHIKV IgG and IgM were detected at 1:1280. Other causes of infectious, metabolic, malignant, and immune-mediated myelitis were ruled out. She was treated with a five-day course of intravenous methylprednisolone and improved, regaining her ability to walk short distances, but with residual lower extremity weakness and impaired sensation. She returned six weeks later with new right-sided lower extremity pain. MRI showed cauda equina enhancement and persistence of the thoracic lesion. CSF revealed 9 WBCs (97[percnt] lymphocytes), no RBCs, and protein of 91 mg/dL. She was treated with two days of intravenous methylprednisolone with minimal improvement. CONCLUSIONS: Given the time lapse between the acute infection and the neurologic sequelae, an immune-mediated phenomenon secondary to CHIKV is expected. Optimal treatment and prognosis have not been well described, but the progression after corticosteroid administration suggests that alternative immunomodulatory therapies may be warranted at initial clinical onset. Disclosure: Dr. Bank has nothing to disclose. Dr. Batra has nothing to disclose. Dr. Colorado has nothing to disclose. Dr. Lyons has received personal compensation in an editorial capacity for Current Infectious Disease Reports.
Michael G Fehlings - One of the best experts on this subject based on the ideXlab platform.
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Surgical treatment of cervical Myeloradiculopathy associated with movement disorders: indications, technique, and clinical outcome.
Journal of spinal disorders & techniques, 2005Co-Authors: Albert S Wong, Eric M Massicotte, Michael G FehlingsAbstract:Movement disorders may be associated with advanced cervical Myeloradiculopathy, which represents a major management challenge. We report on eight patients with movement disorders causing progressive cervical Myeloradiculopathy who were treated successfully by cervical decompression and reconstruction. The mean age of our patients was 44 years with a male/female ratio of 3:1. The average duration of symptoms prior to presentation was 10 months. The most common levels decompressed and reconstructed were C3-C4 and C4-C5. Six cases showed improvement, and two cases showed stabilization of neurologic status at a mean follow-up of 21 months. Our management strategy and results are interpreted in the context of a systematic review of the literature in which 78 cases are reported. Movement disorders cause premature cervical spondylosis most commonly involving the C3-C4 and C4-C5 levels. Ventral pathology with kyphotic angulation requires corpectomy or discectomy with or without posterior decompression and reconstruction. Decompression should always be combined with segmental internal fixation. Perioperative use of botulinum toxin and halo vest immobilization can increase the rate of clinical success but requires vigilance to minimize complications. Laminectomy with lateral mass fixation may be used successfully in the absence of kyphotic deformity.
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Surgical treatment of cervical Myeloradiculopathy associated with movement disorders: indications, technique, and clinical outcome.
Journal of Spinal Disorders & Techniques, 2005Co-Authors: Albert S Wong, Eric M Massicotte, Michael G FehlingsAbstract:Objective: Movement disorders may be associated with advanced cervical Myeloradiculopathy, which represents a major management challenge. We report on eight patients with movement disorders causing progressive cervical Myeloradiculopathy who were treated successfully by cervical decompression and reconstruction. Results: The mean age of our patients was 44 years with a male/female ratio of 3:1. The average duration of symptoms prior to presentation was 10 months. The most common levels decompressed and reconstructed were C3-C4 and C4-C5. Six cases showed improvement, and two cases showed stabilization of neurologic status at a mean follow-up of 21 months. Our management strategy and results are interpreted in the context of a systematic review of the literature in which 78 cases are reported. Conclusions: Movement disorders cause premature cervical spondylosis most commonly involving the C3-C4 and C4-C5 levels. Ventral pathology with kyphotic angulation requires corpectomy or discectomy with or without posterior decompression and reconstruction. Decompression should always be combined with segmental internal fixation. Perioperative use of botulinum toxin and halo vest immobilization can increase the rate of clinical success but requires vigilance to minimize complications. Laminectomy with lateral mass fixation may be used successfully in the absence of kyphotic deformity.
